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nascent Spike [endoplasmic reticulum lumen]
Stable Identifier
R-COV-9694796
Type
Protein [EntityWithAccessionedSequence]
Species
Severe acute respiratory syndrome coronavirus 2
Compartment
endoplasmic reticulum lumen
Synonyms
P0DTC2
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
Translation of structural proteins (Homo sapiens)
Maturation of spike protein (Homo sapiens)
Spike protein gets N-glycosylated (Homo sapiens)
nascent Spike [endoplasmic reticulum lumen] (Severe acute respiratory syndrome coronavirus 2)
mRNA2 is translated to Spike (Homo sapiens)
nascent Spike [endoplasmic reticulum lumen] (Severe acute respiratory syndrome coronavirus 2)
External Reference Information
External Reference
UniProt:P0DTC2 S
Gene Names
S, 2
Chain
signal peptide:1-12, chain:13-1273, chain:13-685, chain:686-1273, chain:816-1273
Reference Genes
BioGPS Gene:43740568 S
Monarch:43740568 S
NCBI Gene:43740568 S
Reference Transcript
RefSeq:NC_045512.2 S
Participant Of
output
mRNA2 is translated to Spike
input
Spike protein gets N-glycosylated
Other forms of this molecule
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum lumen]
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
complex N-glycan-PALM-Spike S1 Fragment [virion membrane]
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
fully glycosylated Spike [virion membrane]
Disease
Name
Identifier
Synonyms
COVID-19
0080600
2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
RefSeq
YP_009724390.1
PDB
6VSB
,
6ZP1
,
7BZ5
,
6ZER
,
6ZOX
,
6X2A
,
7C2L
,
6ZOZ
,
6X2C
,
6XS6
,
6XC2
,
6M17
,
7C8V
,
6W41
,
6ZGG
,
6XEY
,
6WPT
,
6VYB
,
6ZFO
,
6XKL
,
6YZ7
,
7C01
,
6XR8
,
6XCN
,
6M1V
,
6LZG
,
6XC3
,
6XC7
,
6LVN
,
6X6P
,
6LXT
,
7BYR
,
6YLA
,
6ZP2
,
6X29
,
6ZOY
,
6XDG
,
7C8W
,
6X2B
,
6ZCZ
,
6YOR
,
6VXX
,
6ZGE
,
6WPS
,
6XRA
,
6ZP0
,
6M0J
,
7BWJ
,
6ZGI
,
6YZ5
,
6Z2M
,
6VW1
,
6XCM
,
6XE1
,
6XC4
,
6Z43
,
6YM0
,
6ZDH
,
7CAN
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9BYF1 ACE2
5
ACE2 [endocytic vesicle membrane]
(R-HSA-9698958)
ACE2(18-805) [plasma membrane]
(R-HSA-2022344)
glycosylated-ACE2 [endocytic vesicle membrane]
(R-HSA-9686721)
glycosylated-ACE2 [plasma membrane]
(R-HSA-9683480)
ACE2 [endoplasmic reticulum lumen]
(R-HSA-9683474)
0.991
84
UniProt:P0DTC2 S
16
tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9697006)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696997)
di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696920)
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment]
(R-COV-9696943)
nascent Spike [endoplasmic reticulum lumen]
(R-COV-9694796)
14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9694459)
Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696892)
high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen]
(R-COV-9696875)
high-mannose N-glycan folded Spike [endoplasmic reticulum lumen]
(R-COV-9696880)
high-mannose N-glycan-PALM-Spike [endoplasmic reticulum lumen]
(R-COV-9696917)
complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]
(R-COV-9694343)
complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane]
(R-COV-9694745)
complex N-glycan-PALM-Spike S1 Fragment [virion membrane]
(R-COV-9694638)
complex N-glycan-PALM-Spike S2 Fragment [virion membrane]
(R-COV-9694791)
fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9698330)
fully glycosylated Spike [virion membrane]
(R-COV-9698327)
0.937
13
UniProt:P09958 FURIN
4
FURIN [Golgi lumen]
(R-HSA-448351)
FURIN [plasma membrane]
(R-HSA-2159856)
FURIN [extracellular region]
(R-HSA-1181103)
FURIN [Golgi membrane]
(R-HSA-157049)
0.801
4
UniProt:Q9H2X3 CLC4M
0.71
5
UniProt:Q9NNX6 CD209
1
CD209 [plasma membrane]
(R-HSA-2079928)
0.683
4
UniProt:Q7Z5G4 GOLGA7
3
GOLGA7 [tertiary granule lumen]
(R-HSA-6800164)
GOLGA7 [extracellular region]
(R-HSA-6800449)
GOLGA7 [Golgi membrane]
(R-HSA-9647777)
0.643
3
UniProt:Q9C0B5 ZDHC5
0.643
3
UniProt:P35613 BSG
2
BSG [Golgi membrane]
(R-HSA-204478)
BSG [plasma membrane]
(R-HSA-197673)
0.618
5
UniProt:Q8IUN9-2 CLEC10A
0.558
3
UniProt:Q61830 Mrc1
4
Mrc1 [plasma membrane]
(R-MMU-1216515)
Mrc1 [plasma membrane]
(R-MMU-1236776)
Mrc1 [clathrin-coated endocytic vesicle membrane]
(R-MMU-1236818)
Mrc1 [early endosome membrane]
(R-MMU-1236785)
0.558
2
lipopolysaccharide [ChEBI:16412]
5
LPS [cell wall]
(R-ALL-6803081)
LPS [endocytic vesicle lumen]
(R-ALL-2239413)
LPS [endosome lumen]
(R-ALL-2201311)
LPS [plasma membrane]
(R-ALL-433850)
LPS [extracellular region]
(R-ALL-166005)
0.558
3
cholesterol [ChEBI:16113]
20
CHOL [lipid droplet]
(R-ALL-163586)
cholesterol [endocytic vesicle lumen]
(R-ALL-2239405)
CHOL [lysosomal membrane]
(R-ALL-8876478)
cholesterol [endosome lumen]
(R-ALL-171083)
cholesterol [endosome membrane]
(R-ALL-171135)
cholesterol [clathrin-coated endocytic vesicle membrane]
(R-ALL-171069)
CHOL [smooth endoplasmic reticulum]
(R-ALL-8866305)
CHOL [lysosomal lumen]
(R-ALL-8848047)
CHOL [mitochondrial matrix]
(R-ALL-193840)
CHOL [transport vesicle membrane]
(R-ALL-216762)
CHOL [early endosome]
(R-ALL-2429660)
CHOL [endoplasmic reticulum lumen]
(R-ALL-174672)
CHOL [cornified envelope]
(R-ALL-8847704)
CHOL [mitochondrial outer membrane]
(R-ALL-8951853)
CHOL [cytosol]
(R-ALL-176478)
cholesterol [mitochondrial intermembrane space]
(R-ALL-196084)
CHOL [mitochondrial inner membrane]
(R-ALL-193156)
CHOL [plasma membrane]
(R-ALL-171095)
CHOL [endoplasmic reticulum membrane]
(R-ALL-193384)
CHOL [extracellular region]
(R-ALL-171149)
0.558
3
UniProt:Q96D42 HAVR1
0.524
5
linoleic acid [ChEBI:17351]
6
LINA [cytosol]
(R-ALL-1132021)
LINA [endoplasmic reticulum lumen]
(R-ALL-2046044)
LINA [extracellular region]
(R-ALL-879520)
LINA [early endosome]
(R-ALL-879655)
LINA [lipid droplet]
(R-ALL-2864095)
LINA [nucleoplasm]
(R-ALL-400158)
0.522
2
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