Reactome | STAM2 [cytosol]

STAM2 [cytosol]

Stable Identifier

R-HSA-182965

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Signal transducing adapter molecule 2

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Listeria monocytogenes entry into host cells (Homo sapiens)
    - InlB-mediated entry of Listeria monocytogenes into host cell (Homo sapiens)
      - EPS15 and HGS bind CBL-monoubiquitinated MET engaged with Listeria InlB (Homo sapiens)
        
        EPS15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
        
        InlB:MonoUb-K,p-4Y-MET:GRB2-1:p-Y-CBL:CIN85:endophilin:EPS15:HGS:STAM [plasma membrane] (Homo sapiens)
        
        EPS15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by EGFR (Homo sapiens)
    - EGFR downregulation (Homo sapiens)
      - CBL-mediated ubiquitination of CIN85 (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Homo sapiens)
        
        EPS15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Homo sapiens)
        
        EPS15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
      - EGFR binds EPS15, EPN1, EPS15L1 (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Homo sapiens)
        
        EPS15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
        
        EPS15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
      - EGFR non-clathrin mediated endocytosis (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Homo sapiens)
        
        EPS15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
        
        EPS15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
      - EGFR phosphorylates EPS15 (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Homo sapiens)
        
        EPS15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
      - PTPN3 dephosphorylates EPS15 (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:EPS15:HGS:STAM [plasma membrane] (Homo sapiens)
        
        EPS15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:EPN1:EPS15L1:p-EPS15:HGS:STAM [plasma membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
      - Sprouty sequesters CBL away from active EGFR (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Homo sapiens)
        
        EPS15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:SPRY1/2:Endophilin:Epsin:Eps15L1:EPS15 [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Homo sapiens)
        
        EPS15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
  - Signaling by MET (Homo sapiens)
    - Negative regulation of MET activity (Homo sapiens)
      - EPS15 and HGS bind ubiquitinated MET (Homo sapiens)
        
        EPS15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
        
        HGF:MonoUb-K,p-4Y-MET dimer:GRB2:p-Y-CBL,(HGF:MonoUb-K,p-Y1003,4Y-METdimer:p-Y-CBL):CIN85:endophillin:EPS15:HGS:STAM,(MET:Ub-LRIG1:EPS15:HGS:STAM) [plasma membrane] (Homo sapiens)
        
        EPS15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - Clathrin-mediated endocytosis (Homo sapiens)
    - Auxilin recruits HSPA8:ATP to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
    - BAR domain proteins recruit dynamin (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
    - CLASP proteins and cargo are recruited to the nascent clathrin-coated pit (Homo sapiens)
      - CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
    - Cargo recognition for clathrin-mediated endocytosis (Homo sapiens)
      - Epsin family proteins bind ubiquitinated cargo (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
    - Clathrin recruits PIK3C2A (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
    - Clathrin recruits auxilins to the clathrin-coated vesicle (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
    - Clathrin-associated PIK3C2A phosphorylates PI(4)P to PI(3,4)P2 (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
    - Dissociation of AAK1 and dephosphorylation of AP-2 mu2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
    - Dissociation of clathrin-associated proteins (Homo sapiens)
      - CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilinGGC-RAB5:GTP:GAPVD1 [clathrin-coated vesicle membrane] (Homo sapiens)
        
        PI(4)P:ITSNs:EPS15:REPS1:NECAPs:AP-2:SGIP1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
    - Dynamin-mediated GTP hydrolysis promotes vesicle scission (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
    - Endophilins recruit synaptojanins to the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
    - F- and N- BAR domain proteins bind the clathrin-coated pit (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:PIK3C2A [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:FCHO1,2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
    - HSPA8-mediated ATP hydrolysis promotes vesicle uncoating (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin:HSPA8:ATP [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
    - RAB5 and GAPVD1 bind AP-2 (Homo sapiens)
      - PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        PI(4)P:p-T156 AP-2:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GDP:SYNJs:auxilin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        CLASP proteins:cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        ubiquitinated cargo [clathrin-coated vesicle membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [clathrin-coated vesicle membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
    - SNX9 recruits components of the actin polymerizing machinery (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
    - SYNJ hydrolyze PI(4,5)P2 to PI(4)P (Homo sapiens)
      - PI(4)P:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
      - PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP:SYNJs [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers:DNM:GTP [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins:ARP2/3 complex:WASL:f-actin:HIP dimers [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:p-T156 AP-2:clathrin:ITSNs:EPS15:REPS1:SGIP1:NECAPs:AAK1:CLASP proteins:cargo:F-BAR proteins:BAR domain proteins [plasma membrane] (Homo sapiens)
        
        PI(4,5)P2:ITSNs:EPS15:REPS1:clathrin:NECAPs:p-T156 AP-2:SGIP1:CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        CLASP proteins:cargo [plasma membrane] (Homo sapiens)
        
        EPS15,EPN1,EPN2:ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        ubiquitinated cargo [plasma membrane] (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:GRB2:CIN85:Endophilin:Epsin:EPS15L1:p-EPS15:HGS:STAM:Clathrin [plasma membrane] (Homo sapiens)
        
        p-Eps15:HGS:STAM [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
  - Endosomal Sorting Complex Required For Transport (ESCRT) (Homo sapiens)
    - Cargo Recognition And Sorting (Homo sapiens)
      - ESCRT-0 [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)
      - ESCRT-0/Cargo Complex [endosome membrane] (Homo sapiens)
        
        ESCRT-0 [cytosol] (Homo sapiens)
        
        STAM [cytosol] (Homo sapiens)
        
        STAM2 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:O75886 STAM2

Gene Names

STAM2, HBP

Chain

chain:1-525

Reference Genes

BioGPS Gene:10254 STAM2

COSMIC (genes):STAM2 STAM2

CTD Gene:10254 STAM2

dbSNP Gene:10254 STAM2

ENSEMBL:ENSG00000115145 STAM2

ENSEMBL_homo_sapiens_GENE:ENSG00000115145 STAM2

HGNC:11358 STAM2

KEGG Gene (Homo sapiens):10254 STAM2

Monarch:10254 STAM2

NCBI Gene:10254 STAM2

OMIM:606244 STAM2

UCSC:O75886 STAM2

Reference Transcript

RefSeq:NM_005843.5 STAM2

Other Identifiers

10254

11731592_at

11731593_a_at

11731594_at

11731595_x_at

16903794

1X2Q

1X5B

208194_s_at

209649_at

215044_s_at

228254_3p_at

228254_at

242569_at

2581431

2581432

2581433

2581434

2581435

2581436

2581438

2581440

2581443

2581445

2581446

2581447

2581450

2581451

2581452

2581453

2581454

2581455

2581456

2581458

2581459

2L0T

35528

35529

38525_at

50573_r_at

5CRV

5IXF

60468_at

8055890

A_23_P209215

A_24_P62860

AAC63963

AAC63964

AAH28740

AAY14712

AC079790

AF042273

AF042274

AK292265

AK292847

AL133600

BAF84954

BAF85536

BC028740

CAB63735

CCDS2196

CH471058

EAX11490

EAX11492

ENSG00000115145

ENSP00000263904

ENST00000263904

EntrezGene:10254

g5032126_3p_a_at

g6599205_3p_at

GE535132

GE56632

GO:0003674

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005768

GO:0005829

GO:0006810

GO:0006886

GO:0006914

GO:0007165

GO:0008150

GO:0009056

GO:0015031

GO:0016020

GO:0016192

GO:0016197

GO:0016236

GO:0022607

GO:0031410

GO:0031901

GO:0032991

GO:0033565

GO:0036258

GO:0042059

GO:0043226

GO:0043231

GO:0061024

HGNC:11358

HPA035528

HPA035529

Hs.114624.0.A1_3p_at

Hs.114624.0.A1_3p_x_at

Hs.123778.0.A1_3p_at

Hs.306650.0.S1_3p_s_at

ILMN_1781135

IPR001452

IPR002014

IPR003903

IPR008942

IPR035675

IPR036028

MIM:606244

NM_005843

NP_005834

PF00018

PF00790

PF02809

PH_hs_0027585

PR00452

PR00499

SM00288

SM00326

SM00726

STAM2

STAM2-201

TC02002432.hg

uc002tyc.4

UPI0000071984

XR_001738586

Participant Of

hasMember

STAM [cytosol]

hasComponent

USP8:STAM2:HGS [cytosol]

Other forms of this molecule

Ub-STAM2 [cytosol]

Inferred To

STAM2 [cytosol] (Bos taurus)

STAM2 [cytosol] (Caenorhabditis elegans)

STAM2 [cytosol] (Canis familiaris)

STAM2 [cytosol] (Danio rerio)

STAM2 [cytosol] (Dictyostelium discoideum)

STAM2 [cytosol] (Drosophila melanogaster)

STAM2 [cytosol] (Gallus gallus)

STAM2 [cytosol] (Mus musculus)

STAM2 [cytosol] (Rattus norvegicus)

STAM2 [cytosol] (Saccharomyces cerevisiae)

STAM2 [cytosol] (Schizosaccharomyces pombe)

STAM2 [cytosol] (Sus scrofa)

STAM2 [cytosol] (Taeniopygia guttata)

STAM2 [cytosol] (Xenopus tropicalis)

Homologues of STAM2 [cytosol] (Gallus gallus)

Homologues of STAM2 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_005834.4

OpenTargets

ENSG00000115145

GeneCards

O75886

DOCK Blaster

5CRV

PRO

O75886

BRENDA (Homo sapiens)

3.4.19

PDB

1X5B, 1X2Q, 2L0T, 5IXF, 5CRV

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13094 LCP2	2	LCP2 [cytosol] (R-HSA-202306) p-Y113,128,145-LCP2 [cytosol] (R-HSA-202175)	0.774	8
UniProt:O95630 STAMBP	1	STAMBP [cytosol] (R-HSA-5693063)	0.712	4
UniProt:Q969R5 L3MBTL2	2	SUMO2-K675,K700-L3MBTL2 [nucleoplasm] (R-HSA-6804480) L3MBTL2 [nucleoplasm] (R-HSA-6804477)	0.621	3
UniProt:P23458 JAK1	6	JAK1 [endosome] (R-HSA-8983168) p-Y1022,Y1023-JAK1 [cytosol] (R-HSA-9005335) p-JAK1 [cytosol] (R-HSA-8950711) JAK1 [cytosol] (R-HSA-451898) p-Y-JAK1 [cytosol] (R-HSA-451921) p-Y1034-JAK1 [cytosol] (R-HSA-1112543)	0.502	2
UniProt:O00311 CDC7	1	CDC7 [nucleoplasm] (R-HSA-51781)	0.488	2
UniProt:P00533 EGFR	58	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.463	2