Reactome | p-S129-SNCA [cytosol]

p-S129-SNCA [cytosol]

Stable Identifier

R-HSA-9836432

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Alpha-synuclein, SYUA_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P37840 SNCA

Gene Names

SNCA, NACP, PARK1

Chain

chain:1-140

Reference Genes

BioGPS Gene:6622 SNCA

COSMIC (genes):SNCA SNCA

CTD Gene:6622 SNCA

dbSNP Gene:6622 SNCA

ENSEMBL:ENSG00000145335 SNCA

ENSEMBL_homo_sapiens_GENE:ENSG00000145335.17 SNCA

HGNC:11138 SNCA

KEGG Gene (Homo sapiens):6622 SNCA

Monarch:6622 SNCA

NCBI Gene:6622 SNCA

OMIM:163890 SNCA

UCSC:P37840 SNCA

Reference Transcript

Other Identifiers

11731446_s_at

11731447_x_at

11731448_a_at

11739782_a_at

11753730_a_at

11753731_x_at

11754090_a_at

16977986

204466_PM_s_at

204466_s_at

204467_PM_s_at

204467_s_at

207827_PM_x_at

207827_x_at

211546_PM_x_at

211546_x_at

236081_PM_at

236081_at

2777711

2777712

2777715

2777716

2777717

2777718

2777719

2777722

2777744

2777746

2777749

2777750

2777751

2777752

2777753

2777754

2777756

3468050

37291_r_at

44191_at

6622

8101762

A_23_P29939

A_32_P109653

GE57593

GO:0000122

GO:0000149

GO:0000287

GO:0000976

GO:0001774

GO:0001921

GO:0001956

GO:0001963

GO:0002376

GO:0003677

GO:0003779

GO:0003824

GO:0004860

GO:0005507

GO:0005509

GO:0005515

GO:0005543

GO:0005576

GO:0005615

GO:0005634

GO:0005737

GO:0005739

GO:0005764

GO:0005773

GO:0005829

GO:0005856

GO:0005886

GO:0005938

GO:0005975

GO:0006091

GO:0006351

GO:0006355

GO:0006469

GO:0006629

GO:0006631

GO:0006638

GO:0006644

GO:0006790

GO:0006914

GO:0006919

GO:0006954

GO:0007005

GO:0007006

GO:0007010

GO:0007268

GO:0007269

GO:0008092

GO:0008198

GO:0008270

GO:0008289

GO:0008344

GO:0009410

GO:0010040

GO:0010517

GO:0010642

GO:0012501

GO:0014048

GO:0014059

GO:0015629

GO:0016020

GO:0016079

GO:0016082

GO:0016192

GO:0016234

GO:0016491

GO:0019894

GO:0022898

GO:0023052

GO:0030163

GO:0030424

GO:0030426

GO:0030544

GO:0030672

GO:0031092

GO:0031115

GO:0031410

GO:0031623

GO:0031648

GO:0032026

GO:0032410

GO:0032496

GO:0032769

GO:0032991

GO:0033138

GO:0034330

GO:0034341

GO:0034599

GO:0035493

GO:0035543

GO:0036211

GO:0040012

GO:0042393

GO:0042416

GO:0042417

GO:0042775

GO:0042802

GO:0042995

GO:0043014

GO:0043025

GO:0043027

GO:0043030

GO:0043065

GO:0043066

GO:0043154

GO:0043226

GO:0043524

GO:0043679

GO:0045202

GO:0045807

GO:0045920

GO:0045921

GO:0046872

GO:0046928

GO:0048156

GO:0048168

GO:0048169

GO:0048471

GO:0048488

GO:0048489

GO:0048856

GO:0050729

GO:0050806

GO:0050808

GO:0050812

GO:0050877

GO:0051179

GO:0051219

GO:0051259

GO:0051262

GO:0051281

GO:0051402

GO:0051583

GO:0051585

GO:0051612

GO:0051621

GO:0051622

GO:0055065

GO:0055085

GO:0055086

GO:0060079

GO:0060090

GO:0060291

GO:0060732

GO:0061024

GO:0065003

GO:0070495

GO:0070555

GO:0070840

GO:0071280

GO:0071872

GO:0071902

GO:0097435

GO:0098542

GO:0098772

GO:0098794

GO:0099512

GO:1901135

GO:1902957

GO:1903136

GO:1903284

GO:1903285

GO:1903421

GO:1903426

GO:1904377

GO:1904715

GO:1905606

GO:1990000

GO:2000377

HMNXSV003001866

HMNXSV003022460

Hs.21374.0.A1_3p_at

Hs.76930.1.A1_3p_a_at

ILMN_1701933

ILMN_1766165

PH_hs_0004441

TC04001383.hg

U46901_at

g556211_3p_x_at

g556213_3p_a_at

g6806896_3p_a_at

Participates

as an output of

p-PKR dimer phosphorylates SNCA (Homo sapiens)

Other forms of this molecule

SNCA A30P [cytosol]

SNCA [extracellular region]

Ub-SNCA [cytosol]

SNCA [cytosol]

Inferred To

phospho-snca [cytosol] (Xenopus tropicalis)

phospho-SNCA [cytosol] (Canis familiaris)

phospho-SNCA [cytosol] (Gallus gallus)

phospho-p-S129-SNCA [cytosol] (Bos taurus)

phospho-p-S129-SNCA [cytosol] (Mus musculus)

phospho-p-S129-SNCA [cytosol] (Rattus norvegicus)

phospho-p-S129-SNCA [cytosol] (Sus scrofa)

Modified Residues

Name

O-phospho-L-serine at 129

Coordinate

129

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

XP_016864052.1, NP_000336.1, XP_016864051.1, NP_001139527.1, NP_001139526.1, XP_011530510.1, NP_009292.1

Guide to Pharmacology - Targets

3285

OpenTargets

ENSG00000145335

ZINC - Substances

SYUA_HUMAN

ZINC target

P37840

PRO

P37840

PDB

7XO2, 5CRW, 8B9V, 7YNQ, 7UAK, 8BQV, 3Q28, 6RTB, 6L4S, 8G0L, 7V4C, 8CZ1, 8BQW, 7WO0, 7YNS, 4R0W, 8HZB, 3Q25, 8H04, 6PEO, 8H03, 8CYW, 8CEB, 8RRR, 7LC9, 7V48, 8OJR, 8HZC, 6OSL, 7V49, 6CU7, 8CE7, 7YNF, 6XYQ, 7NCG, 8JEX, 3Q27, 6SST, 8RI9, 8HZS, 3Q26, 6UFR, 4ZNN, 6I42, 8OQI, 7NCI, 7YK8, 6SSX, 7YNL, 7YNN, 2X6M, 8CZ2, 7NCK, 4R0U, 6RT0, 8H05, 7YNP, 7C1D, 7XJX, 8CYX, 6PES, 8A9L, 7WMM, 7OZG, 8RQM, 8CYT, 7OZH, 2JN5, 4BXL, 6L1T, 8ADW, 7XO3, 8JLY, 4RIL, 7V4B, 6A6B, 4RIK, 7E0F, 7V4D, 8OG0, 8CZ3, 8JEY, 7WNZ, 7V47, 6LRQ, 8GF7, 7XO0, 6CU8, 6L1U, 2M55, 6XYO, 8AEX, 8JJV, 2N0A, 6XYP, 7V4A, 7NCA, 8CYY, 7L7H, 6OSJ, 3Q29, 8CZ0, 7YNR, 8A4L, 7YK2, 6OSM, 6H6B, 7YNG, 8CYV, 7NCH, 8ADS, 8CYR, 7STX, 7YNT, 7NCJ, 7YNM, 6CT7, 8CYS, 2KKW, 8ADU, 8CZ6, 8ADV, 7XO1, 1XQ8, 7YNO, 8FPT

HPA

ENSG00000145335-SNCA

GeneCards

P37840

Ensembl

ENST00000345009, ENST00000394991, ENST00000420646, ENST00000673718, ENSP00000338345, ENSP00000421485, ENSP00000500990, ENSP00000396241, ENSP00000343683, ENSP00000422238, ENST00000336904, ENST00000394986, ENST00000618500, ENST00000394989, ENST00000505199, ENSP00000378442, ENST00000508895, ENSG00000145335, ENSP00000484044, ENSP00000426955, ENST00000506244, ENSP00000378437, ENSP00000378440

Pharos - Targets

P37840

ZINC - Predictions - Purchasable

SYUA_HUMAN

Orphanet

15532

HMDB Protein

HMDBP02388

Interactors (186)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.99	51
UniProt:Q9Y6H5 SNCAIP	3	PolyUb-SNCAIP [cytosol] (R-HSA-5667104) K63Ub-SNCAIP [cytosol] (R-HSA-5667114) SNCAIP [cytosol] (R-HSA-5333629)	0.825	22
UniProt:P02649 APOE	10	APOE [early endosome] (R-HSA-2429687) APOE [endosome lumen] (R-HSA-174804) APOE [endosome membrane] (R-HSA-174766) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [plasma membrane] (R-HSA-174615) APOE-4 [extracellular region] (R-HSA-9711070) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE [extracellular region] (R-HSA-174646) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [endoplasmic reticulum lumen] (R-HSA-6784908)	0.809	11
UniProt:P08107 HSP71			0.74	7
UniProt:O94811 TPPP			0.719	8
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.681	12
UniProt:P10909 CLU	4	CLU(23-449) [extracellular region] (R-HSA-349732) CLU(23-449) [platelet alpha granule lumen] (R-HSA-349733) CLU(228-449) [extracellular region] (R-HSA-6810626) CLU(23-227) [extracellular region] (R-HSA-6810660)	0.662	4
UniProt:Q07812 BAX	3	BAX [cytosol] (R-HSA-139916) BAX activated [cytosol] (R-HSA-139907) BAX [mitochondrial outer membrane] (R-HSA-139949)	0.659	4
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.659	6
UniProt:O75920-2 SERF1A			0.655	4
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.646	4
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.633	4
UniProt:P63027 VAMP2	20	VAMP2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869129) VAMP2 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-379363) VAMP2 [plasma membrane] (R-HSA-210516) VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917738) VAMP2 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-210365) VAMP2 [synaptic vesicle membrane] (R-HSA-181517) VAMP2(59-116) [synaptic vesicle membrane] (R-HSA-5250891) VAMP2(2-58) [cytosol] (R-HSA-194815) VAMP2(2-76) [cytosol] (R-HSA-194802) VAMP2(77-116) [synaptic vesicle membrane] (R-HSA-5228355) VAMP2(60-116) [synaptic vesicle membrane] (R-HSA-5250615) VAMP2(2-59) [cytosol] (R-HSA-194797) VAMP2(82-116) [synaptic vesicle membrane] (R-HSA-5250961) VAMP2(2-81) [cytosol] (R-HSA-5250970) VAMP2 [secretory granule membrane] (R-HSA-376363) VAMP2 [cytosol] (R-HSA-9609882) VAMP2 [endoplasmic reticulum membrane] (R-HSA-9609886) VAMP2 [cytoplasmic vesicle membrane] (R-HSA-1449630) VAMP2 [lysosomal membrane] (R-HSA-432703) VAMP2 [Golgi membrane] (R-HSA-375425)	0.632	5
UniProt:Q9UI14 PRAF1			0.626	4
UniProt:P02647 APOA1	11	APOA1(25-266) [secretory granule lumen] (R-HSA-350761) APOA1(25-267) [cytosol] (R-HSA-2395781) APOA1(25-267) [early endosome] (R-HSA-2429641) APOA1(25-267) [endoplasmic reticulum lumen] (R-HSA-174640) APOA1(19-266) [extracellular region] (R-HSA-264771) APOA1(25-266) [plasma membrane] (R-HSA-216742) Variant apolipoprotein AI [extracellular region] (R-HSA-976865) APOA1(25-266) [endocytic vesicle lumen] (R-HSA-2239460) p-APOA1 [endoplasmic reticulum lumen] (R-HSA-8957081) APOA1 [endoplasmic reticulum lumen] (R-HSA-8956724) APOA1(25-266) [extracellular region] (R-HSA-174720)	0.623	3
UniProt:Q7Z7K6 CENPV			0.61	4
UniProt:P00519 ABL1	6	p-Y393-ABL1 [cytosol] (R-HSA-9865161) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) ABL1 [nucleoplasm] (R-HSA-5686579) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576)	0.602	3
GDP [ChEBI:17552]	7	GDP [lysosomal membrane] (R-ALL-9628545) GDP [cytoplasmic vesicle membrane] (R-ALL-1996292) GDP [cilium] (R-ALL-5617810) GDP [platelet dense granule lumen] (R-ALL-114622) GDP [nucleoplasm] (R-ALL-111349) GDP [plasma membrane] (R-ALL-114549) GDP [endoplasmic reticulum lumen] (R-ALL-1467290)	0.582	5
UniProt:P00441 SOD1	5	SOD1 [extracellular region] (R-HSA-350705) 2xHC-SOD1 [mitochondrial intermembrane space] (R-HSA-3777108) SOD1 [mitochondrial intermembrane space] (R-HSA-3777082) 2xHC-SOD1 [cytosol] (R-HSA-3299726) SOD1 [cytosol] (R-HSA-350697)	0.567	9
UniProt:P00519-1 ABL1			0.558	6
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) N [plasma membrane] (R-COV-9694356) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [cytosol] (R-COV-9694300) p-S188,206-N [cytosol] (R-COV-9729324) p-8S-N [cytosol] (R-COV-9729335) p-8S,2T-N [cytosol] (R-COV-9729277) p-11S,2T-N [cytosol] (R-COV-9729264) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340)	0.558	2
UniProt:Q16650 TBR1			0.556	3
UniProt:Q8IUI8 CRLF3			0.556	3
UniProt:Q9UHY8 FEZ2			0.556	3
UniProt:O60479 DLX3			0.556	3
UniProt:Q07817 BCL2L1	2	BCL2L1 [cytosol] (R-HSA-50771) BCL2L1 [mitochondrial outer membrane] (R-HSA-114236)	0.556	3
UniProt:O15392 BIRC5	3	ub-BIRC5 [cytosol] (R-HSA-8955933) BIRC5 [nucleoplasm] (R-HSA-4655344) BIRC5 [cytosol] (R-HSA-50851)	0.556	3
UniProt:P68363 TUBA1B	9	AcK-TUBA1B [cytosol] (R-HSA-5618285) Ac K40 TUBA1B [axonemal microtubule] (R-HSA-5624854) TUBA1B folding intermediate [cytosol] (R-HSA-392797) TUBA1B unfolded [cytosol] (R-HSA-392781) L-isoglutamyl polyglycyl-TUBA1B [cytosol] (R-HSA-8867436) Polyglutamyl-TUBA1B [cytosol] (R-HSA-8867435) TUBA1B(1-450) [cytosol] (R-HSA-8955581) TUBA1B [axonemal microtubule] (R-HSA-5610434) TUBA1B [cytosol] (R-HSA-191691)	0.556	3
UniProt:Q8WVJ9 TWIST2	1	TWIST2 [nucleoplasm] (R-HSA-445444)	0.556	3
UniProt:Q9H2C1 LHX5			0.556	3
UniProt:P62826 RAN	2	RAN [nucleoplasm] (R-HSA-165528) RAN [cytosol] (R-HSA-165540)	0.556	3
UniProt:Q8N895 ZN366			0.556	3
UniProt:Q9HCE7-2 SMURF1			0.556	3
UniProt:P10636-6 MAPT			0.556	3
UniProt:Q16143 SNCB	1	SNCB [cytosol] (R-HSA-5660390)	0.556	3
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.556	3
UniProt:Q6VY07 PACS1	1	PACS1 [cytosol] (R-HSA-167634)	0.556	3
UniProt:Q71DI3 H3C15	20	2xAcK-HIST2H3A [nucleoplasm] (R-HSA-427525) Me1K5-HIST2H3A [nucleoplasm] (R-HSA-9677679) Me2aR27-HIST2H3A [nucleoplasm] (R-HSA-5229057) Me2aR18-HIST2H3A [nucleoplasm] (R-HSA-5229063) Me2sR9-HIST2H3A [nucleoplasm] (R-HSA-5211327) Me2sR3-HIST2H3A [nucleoplasm] (R-HSA-5218930) AcK9,14-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8870892) AcK14,18,79-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8871273) AcK9,14,18-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871304) AcK14,18-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871292) AcK9,14,18,79-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8865607) AcK14,18-p-S10-HIST2H3A [nucleoplasm] (R-HSA-8871296) AcK14,18,79-p-T11-HIST2H3A [nucleoplasm] (R-HSA-8871290) AcK14,18-p-T11-HIST2H3A [nucleoplasm] (R-HSA-8871302) AcK14,18,79-p-S10,T11-HIST2H3A [nucleoplasm] (R-HSA-8871289) Me2K28-HIST2H3A [nucleoplasm] (R-HSA-4754197) MeK37-HIST2H3A [nucleoplasm] (R-HSA-4722131) MeK80-HIST2H3A [nucleoplasm] (R-HSA-5649805) Me3K80-HIST2H3A [nucleoplasm] (R-HSA-5649798) Me2K80-HIST2H3A [nucleoplasm] (R-HSA-5649803)	0.556	3
UniProt:O00203 AP3B1	4	AP3B1 [Golgi membrane] (R-HSA-434335) AP3B1 [cytoplasmic vesicle membrane] (R-HSA-434197) AP3B1(1-859)-BRAF(381-766) fusion [cytosol] (R-HSA-6802269) AP3B1(1-859)-p-BRAF(381-766) fusion [cytosol] (R-HSA-6802516)	0.556	3
UniProt:Q8N6F8 MET27			0.556	3
UniProt:Q9Y483-4 MTF2			0.556	3
UniProt:Q9Y3D2 MSRB2	1	MSRB2 [cytosol] (R-HSA-5676906)	0.556	3
UniProt:Q96D59 RN183			0.556	3
UniProt:P19474 TRIM21	1	TRIM21 [cytosol] (R-HSA-976051)	0.556	3
UniProt:P46379-2 BAG6			0.556	3
UniProt:P55212 CASP6	5	CASP6 (1-293) [cytosol] (R-HSA-6798132) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128)	0.556	3
UniProt:Q8N5U6 RNF10			0.556	3
UniProt:Q9H0Y0 ATG10	2	GlyK166-ATG10 [cytosol] (R-HSA-5683572) ATG10 [cytosol] (R-HSA-5671733)	0.556	3
UniProt:O96013-2 PAK4			0.556	3
UniProt:P57052 RBM11			0.556	3
UniProt:Q6PCB6 ABHD17C	1	ABHD17C [plasma membrane] (R-HSA-9647774)	0.556	3
UniProt:Q16352 AINX			0.556	3
UniProt:Q8N594 MPND			0.556	3
UniProt:P23497-2 SP100			0.556	3
UniProt:O75400-2 PRPF40A			0.556	3
UniProt:Q9UIH9 KLF15	1	KLF15 [nucleoplasm] (R-HSA-8878735)	0.556	3
UniProt:Q8TC29 ENKUR			0.556	3
UniProt:Q9HCC6 HES4			0.556	3
UniProt:Q6ZNA4-2 Q6ZNA42			0.556	3
UniProt:O75398 DEAF1			0.556	3
UniProt:Q9HD42 CHMP1A	1	CHMP1A [cytosol] (R-HSA-917721)	0.556	3
UniProt:O43236 SEPT4			0.556	3
UniProt:Q9NR21-5 PARP11			0.556	3
UniProt:Q9BSL1 UBAC1	1	UBAC1 [cytosol] (R-HSA-8851644)	0.556	3
UniProt:O60260-5 PRKN			0.556	8
UniProt:P63010-2 AP2B1			0.556	3
UniProt:Q9H0E2 TOLLIP	4	TOLLIP [cytosol] (R-HSA-446885) TOLLIP [azurophil granule lumen] (R-HSA-6799709) TOLLIP [extracellular region] (R-HSA-6800448) TOLLIP [specific granule lumen] (R-HSA-6799719)	0.556	3
UniProt:Q96FW1 OTUB1	2	OTUB1 [cytosol] (R-HSA-933411) OTUB1 [nucleoplasm] (R-HSA-6783242)	0.556	3
UniProt:Q13113 PDZ1I			0.556	3
UniProt:Q6ZTN6-2 ANKRD13D			0.556	3
UniProt:O14713 ITBP1			0.556	3
UniProt:Q16740 CLPP	1	CLPP [mitochondrial matrix] (R-HSA-9838002)	0.556	3
UniProt:P13473-2 P134732			0.556	3
IntAct:EBI-25849442 CCSB			0.556	3
UniProt:Q0VDC6 Q0VDC6			0.556	3
UniProt:Q8NDP9 Q8NDP9			0.556	3
IntAct:EBI-25830852 RZPDO839G03145			0.556	3
UniProt:Q6DN90-2 Q6DN902			0.556	3
UniProt:Q9ULX5 RN112			0.556	3
UniProt:Q8N5S9-2 Q8N5S92			0.556	3
UniProt:O75446 SAP30	1	SAP30 [nucleoplasm] (R-HSA-351693)	0.556	3
UniProt:P62191 PSMC1	2	PSMC1 [nucleoplasm] (R-HSA-174338) PSMC1 [cytosol] (R-HSA-68768)	0.556	3
UniProt:Q8TBB1 LNX1	1	LNX1 [cytosol] (R-HSA-8851641)	0.556	3
UniProt:Q13702-2 Q137022			0.556	3
UniProt:Q8WUW1 BRK1	1	BRK1 [cytosol] (R-HSA-1671645)	0.556	3
UniProt:Q9NV79 PCMD2			0.556	3
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.556	3
UniProt:P28347-2 TEAD1			0.556	3
UniProt:Q6PIV2 FOXR1			0.556	3
UniProt:Q92797-2 Q927972			0.556	3
UniProt:Q9BYQ4 KRTAP9-2	1	KRTAP9-2 [cytosol] (R-HSA-6809965)	0.556	3
UniProt:P06241-3 FYN			0.556	3
UniProt:O75604-3 USP2			0.556	3
UniProt:Q9UNS2 COPS3	2	COPS3 [cytosol] (R-HSA-416973) COPS3 [nucleoplasm] (R-HSA-5697017)	0.556	3
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.556	3
UniProt:P62879 GNB2	4	GNB2 [cytosol] (R-HSA-6814421) Partially folded GNB2 [cytosol] (R-HSA-8850536) Unfolded GNB2 [cytosol] (R-HSA-6814202) GNB2 [plasma membrane] (R-HSA-164335)	0.556	3
UniProt:Q92876 KLK6			0.556	3
UniProt:P07437 TUBB	3	TUBB [cytosol] (R-HSA-9020816) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [extracellular region] (R-HSA-380317)	0.556	3
UniProt:Q99932-2 SPAG8			0.556	3
UniProt:P62987 UBA52	20	UBA52(1-76) [endocytic vesicle membrane] (R-HSA-939236) Ub-33-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783187) Ub-63-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783039) Ub-6-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783072) Ub-11-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783059) Ub-48-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783049) Ub-29-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783030) Ub-27-UBA52(1-76) [mitochondrial outer membrane] (R-HSA-6783043) N6-glycyl-L-lysine-UBA52(1-76) [cytosol] (R-HSA-8869043) adenylatedG76-UBA52(1-76) [nucleoplasm] (R-HSA-8852114) UBA52(1-128) [cytosol] (R-HSA-8853517) adenylatedG76-UBA52(1-76) [cytosol] (R-HSA-8852112) Ub-48-UBA52(1-76) [endoplasmic reticulum membrane] (R-HSA-8943067) Ub-48-UBA52(1-76) [lysosomal membrane] (R-HSA-9762994) Ub-48-UBA52(1-76) [endocytic vesicle membrane] (R-HSA-9763054) UBA52(1-76) [endosome membrane] (R-HSA-939189) UBA52(1-76) [plasma membrane] (R-HSA-3149452) RPL40 [cytosol] (R-HSA-72476) Ub-29-UBA52(1-76) [cytosol] (R-HSA-5689209) Ub-6-UBA52(1-76) [cytosol] (R-HSA-5689082)	0.556	3
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.556	3
UniProt:Q96RL1-2 UIMC1			0.556	3
UniProt:O43167-2 O431672			0.556	3
UniProt:Q9Y2M5 KLHL20	1	KLHL20 [cytosol] (R-HSA-976032)	0.556	3
UniProt:O15381-5 O153815			0.556	3
UniProt:A2RU56 A2RU56			0.556	3
UniProt:A4FUJ8 A4FUJ8			0.556	3
UniProt:P02795 MT2A	1	MT2A [cytosol] (R-HSA-1031707)	0.556	3
UniProt:P48730-2 CSNK1D			0.556	3
UniProt:Q0P5N6 ARL16			0.556	3
UniProt:P02792 FTL	4	FTL [azurophil granule lumen] (R-HSA-6799149) FTL [cytosol] (R-HSA-434215) FTL [endocytic vesicle lumen] (R-HSA-2299671) FTL [extracellular region] (R-HSA-2187214)	0.556	3
UniProt:Q6ZR37 PKHG7			0.556	3
UniProt:Q15554-4 Q155544			0.556	3
UniProt:Q04323-2 UBXN1			0.556	3
UniProt:Q969S8 HDAC10	1	HDAC10 [nucleoplasm] (R-HSA-351579)	0.556	3
UniProt:Q9UJ41-4 RABGEF1			0.556	3
UniProt:Q8WUU4 ZN296			0.556	3
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.556	6
IntAct:EBI-25875427 CCSB			0.556	3
UniProt:Q9GZS3 SKIC8	2	WDR61 [cytosol] (R-HSA-8931534) WDR61 [nucleoplasm] (R-HSA-8866696)	0.556	3
UniProt:Q2NKQ1-4 SGSM1			0.556	3
UniProt:P40337-2 VHL			0.556	3
UniProt:P68431 HIST1H3G	20	2xAcK-HIST1H3A [nucleoplasm] (R-HSA-427507) Me1K5-H3C1 [nucleoplasm] (R-HSA-9677683) Ack-Me3K5-HIST1H3A [nucleoplasm] (R-HSA-4551293) AcK-Me3K10-HIST1H3A [nucleoplasm] (R-HSA-4551291) AcK-Me3K28-HIST1H3A [nucleoplasm] (R-HSA-4551292) Me2aR27-HIST1H3A [nucleoplasm] (R-HSA-5229052) Me2aR18-HIST1H3A [nucleoplasm] (R-HSA-5229062) Me2sR9-HIST1H3A [nucleoplasm] (R-HSA-5211328) Me2sR3-HIST1H3A [nucleoplasm] (R-HSA-5218935) AcK9,14-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8870893) AcK14,18,79-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871271) AcK9,14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871306) AcK14,18-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871294) AcK9,14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8865596) AcK14,18-p-S10-HIST1H3A [nucleoplasm] (R-HSA-8871295) AcK14,18,79-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871288) AcK14,18-p-T11-HIST1H3A [nucleoplasm] (R-HSA-8871299) AcK14,18,79-p-S10,T11-HIST1H3A [nucleoplasm] (R-HSA-8871286) Me2K28-HIST1H3A [nucleoplasm] (R-HSA-4754193) MeK37-HIST1H3A [nucleoplasm] (R-HSA-4722135)	0.556	3
UniProt:O95777 LSM8	1	LSM8 [nucleoplasm] (R-HSA-6806779)	0.556	3
UniProt:Q8NBB4-2 ZSCAN1			0.556	3
UniProt:Q9UPM6 LHX6			0.556	3
UniProt:P99999 CYCS	6	AcK-CYCS [mitochondrial intermembrane space] (R-HSA-5688308) Cytochrome c (oxidised) [mitochondrial inner membrane] (R-HSA-352607) CYCS [cytosol] (R-HSA-53259) CYCS [mitochondrial intermembrane space] (R-HSA-114244) apo-CYCS [mitochondrial inner membrane] (R-HSA-352608) Cytochrome c (reduced) [mitochondrial inner membrane] (R-HSA-352609)	0.556	3
UniProt:Q5SZD1 CF141			0.556	3
UniProt:Q8TCT7-2 SPPL2B			0.556	3
UniProt:Q13501 SQSTM1	7	SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.556	3
UniProt:Q8WXK3 ASB13	1	ASB13 [cytosol] (R-HSA-975427)	0.556	3
UniProt:Q8IYW5 RNF168	2	monoSUMO1-RNF168 [nucleoplasm] (R-HSA-4551750) RNF168 [nucleoplasm] (R-HSA-4551605)	0.556	3
UniProt:Q9UBQ0-2 VPS29			0.556	3
UniProt:Q96JM7-2 L3MBTL3			0.556	3
UniProt:O00472 ELL2	1	ELL2 [nucleoplasm] (R-HSA-6807506)	0.556	3
UniProt:Q8NHS9 SPT22			0.556	3
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.556	3
UniProt:Q68EA5 ZNF57			0.556	3
UniProt:Q8TD91-2 MAGEC3			0.556	3
IntAct:EBI-25835277 CCSB			0.556	3
UniProt:P80217-2 IFI35			0.556	3
UniProt:Q9NP61 ARFGAP3	1	ARFGAP3 [cytosol] (R-HSA-6807740)	0.556	3
UniProt:Q8WVV9-3 Q8WVV93			0.556	3
UniProt:Q86WS3 OOSP2			0.556	3
IntAct:EBI-25831191 CCSB			0.556	3
UniProt:Q8WVD3 RNF138	1	RNF138 [cytosol] (R-HSA-976008)	0.556	3
UniProt:O15205 UBD	1	UBD [cytosol] (R-HSA-8956123)	0.556	3
UniProt:Q6GQQ9-2 Q6GQQ92			0.556	3
UniProt:Q8TDB4 HUMMR			0.556	3
UniProt:P62158 CALM			0.556	3
UniProt:Q9BR01-2 Q9BR012			0.556	3
UniProt:O75886 STAM2	2	Ub-STAM2 [cytosol] (R-HSA-6782781) STAM2 [cytosol] (R-HSA-182965)	0.556	3
UniProt:O00746 NME4	1	NME4 [mitochondrial inner membrane] (R-HSA-60026)	0.556	3
UniProt:Q02156 PRKCE	2	PRKCE [cytosol] (R-HSA-58202) p-T566,T710,S729-PRKCE [plasma membrane] (R-HSA-198260)	0.556	3
UniProt:Q13569 TDG	3	polySUMO2,3-K330-TDG [nucleoplasm] (R-HSA-4551628) monoSUMO1-K330-TDG [nucleoplasm] (R-HSA-4551718) TDG [nucleoplasm] (R-HSA-65812)	0.556	3
UniProt:A8K878 A8K878			0.556	3
UniProt:Q8N6T3-3 ARFGAP1			0.556	3
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.556	3
UniProt:O75530-2 EED			0.556	3
UniProt:P09017 HOXC4	1	HOXC4 [nucleoplasm] (R-HSA-5617871)	0.556	3
UniProt:Q8N988-2 ZNF557			0.556	3
UniProt:Q8N448 LNX2			0.556	3
UniProt:Q96NC0 ZMAT2	1	ZMAT2 [nucleoplasm] (R-HSA-9770248)	0.556	3
UniProt:A0AVK6 E2F8	1	E2F8 [nucleoplasm] (R-HSA-8952990)	0.556	3
UniProt:P07948 LYN	7	MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) LYN [plasma membrane] (R-HSA-197943) p-Y397-LYN [cytosol] (R-HSA-8942608) p-Y397-LYN [plasma membrane] (R-HSA-2454229) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875) LYN [cytosol] (R-HSA-354251)	0.556	3
UniProt:Q9BYZ2 LDHAL6B	1	LDHAL6B [mitochondrial matrix] (R-HSA-6807613)	0.556	3
UniProt:P17252 PRKCA	8	PRKCA [nucleoplasm] (R-HSA-450530) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [cytosol] (R-HSA-58196) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) PRKCA [plasma membrane] (R-HSA-156469) p-T497-PRKCA [cytosol] (R-HSA-5218731) p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292)	0.556	3
UniProt:P18847 ATF3	1	ATF3 [nucleoplasm] (R-HSA-535543)	0.556	3
UniProt:P17980 PSMC3	5	PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [cytosol] (R-HSA-68774)	0.556	6
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:Q5QJC9	1	Bag5 [cytosol] (R-RNO-5255453)	0.548	3
UniProt:P49841 GSK3B	4	GSK3B del304-316 [cytosol] (R-HSA-5339682) GSK3B [nucleoplasm] (R-HSA-2022823) p-S9-GSK3B [cytosol] (R-HSA-3149577) GSK3B [cytosol] (R-HSA-2997551)	0.544	2
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.543	4
UniProt:Q01959 SLC6A3	5	SLC6A3 [plasma membrane] (R-HSA-379482) SLC6A3 L368Q [plasma membrane] (R-HSA-5660710) SLC6A3 L224P [plasma membrane] (R-HSA-5660718) SLC6A3 P395L [plasma membrane] (R-HSA-5660716) SLC6A3 R521W [plasma membrane] (R-HSA-5660729)	0.539	3
UniProt:Q9WV55	4	Vapa [cytosol] (R-MMU-9609920) Vapa [plasma membrane] (R-MMU-6806269) Vapa [azurophil granule membrane] (R-MMU-6799364) Vapa [endoplasmic reticulum membrane] (R-MMU-429677)	0.527	2
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.524	2
UniProt:Q9Y6H5-2 SNCAIP	1	SNCAIP-1A [cytosol] (R-HSA-5667110)	0.524	2
UniProt:Q61327	1	SLC6A3 [plasma membrane] (R-MMU-379482)	0.518	5
UniProt:O88507	1	Cntfr [plasma membrane] (R-MMU-5696438)	0.512	4
UniProt:P00414 MT-CO3	1	MT-CO3 [mitochondrial inner membrane] (R-HSA-164312)	0.508	3
UniProt:Q16623 STX1A	5	STX1A [plasma membrane] (R-HSA-449128) STX1A(?-288) [plasma membrane] (R-HSA-5246518) STX1A(1-?) [cytosol] (R-HSA-3065964) STX1A [cytosol] (R-HSA-9609866) STX1A [endoplasmic reticulum membrane] (R-HSA-9609878)	0.499	2
UniProt:P60880-2 SNAP25			0.499	3
UniProt:P00520 Abl1	7	Abl1 [cytosol] (R-MMU-449189) phospho-p-Y393-ABL1 [cytosol] (R-MMU-9865161) p-Y226,Y393-ABL1 [nucleoplasm] (R-MMU-8985251) ABL1 [cytosol] (R-MMU-375987) p-Y226,Y393-ABL1 [cytosol] (R-MMU-8942610) ABL1 [nucleoplasm] (R-MMU-5686579) phospho-p-S456-ABL1 [nucleoplasm] (R-MMU-5686576)	0.463	2
UniProt:P00519-2 ABL1			0.463	5
UniProt:Q08406	1	Cntfr [plasma membrane] (R-RNO-5696438)	0.462	2
UniProt:P54253 ATX1			0.462	3

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