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p-T14-CDK1
Stable Identifier
R-HSA-170064
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
phospho-Cdc-2(Thr 14)
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
G2/M DNA replication checkpoint (Homo sapiens)
Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Homo sapiens)
CCNB:p-T14-CDK1 [cytosol] (Homo sapiens)
p-T14-CDK1 [cytosol] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Cyclin A/B1/B2 associated events during G2/M transition (Homo sapiens)
Myt-1 mediated phosphorylation of Cyclin A:Cdc2 (Homo sapiens)
CCNA:p-T14-CDK1 [cytosol] (Homo sapiens)
p-T14-CDK1 [cytosol] (Homo sapiens)
Myt-1 mediated phosphorylation of Cyclin B:Cdc2 complexes (Homo sapiens)
CCNB:p-T14-CDK1 [cytosol] (Homo sapiens)
p-T14-CDK1 [cytosol] (Homo sapiens)
Translocation of Cyclin A:phospho-Cdc2 (Thr 14) to the nucleus (Homo sapiens)
CCNA:p-T14-CDK1 [cytosol] (Homo sapiens)
p-T14-CDK1 [cytosol] (Homo sapiens)
Translocation of Cyclin B1:phospho-Cdc2 complexes to the nucleus (Homo sapiens)
cytoplasmic Cyclin B1:Cdc2 complexes [cytosol] (Homo sapiens)
Cyclin B1:phospho-Cdc2 ( Thr 14) [cytosol] (Homo sapiens)
p-T14-CDK1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P06493 CDK1
Gene Names
CDK1, CDC2, CDC28A, CDKN1, P34CDC2
Chain
chain:1-297
Reference Genes
BioGPS Gene:983 CDK1
CTD Gene:983 CDK1
dbSNP Gene:983 CDK1
ENSEMBL:ENSG00000170312 CDK1
HGNC:1722 CDK1
KEGG Gene (Homo sapiens):CDK1 CDK1
KEGG Gene (Homo sapiens):hsa:983 CDK1
Monarch:983 CDK1
NCBI Gene:983 CDK1
OMIM:116940 CDK1
UCSC:P06493 CDK1
Reference Transcript
RefSeq:NM_001786.4 CDK1
RefSeq:XM_005270303.3 CDK1
RefSeq:NM_033379.4 CDK1
RefSeq:NM_001320918.1 CDK1
Other Identifiers
0001660059
0005360092
11726617_s_at
11745843_a_at
16705159
1803_at
1LC9
203213_at
203214_x_at
210559_s_at
33324_s_at
3387
3799
40915_r_at
4Y72
4YC3
4YC6
5HQ0
5LQF
7927710
91194_at
983
A0A024QZJ8
A0A024QZP7
A_23_P138507
AAH14563
AAM34793
AAP35650
AC022390
AF512554
AK291939
BAA26001
BAF84628
BC014563
BT007004
CAA28963
CAA68376
CAB003799
CCDS44408
CCDS7260
CDK1
CDK1-201
CDK1-202
CDK1-203
CH471083
D88357
EAW54204
EAW54206
EAW54207
ENSG00000170312
ENSP00000325970
ENSP00000362915
ENSP00000378699
ENST00000316629
ENST00000373809
ENST00000395284
EntrezGene:983
g3126638_3p_a_at
GE63002
GO:0000086
GO:0000166
GO:0000187
GO:0000226
GO:0000278
GO:0000307
GO:0000784
GO:0001618
GO:0003682
GO:0004672
GO:0004674
GO:0004693
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005759
GO:0005789
GO:0005813
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005876
GO:0006260
GO:0006281
GO:0006461
GO:0006468
GO:0006915
GO:0006977
GO:0007049
GO:0007077
GO:0007095
GO:0007098
GO:0007344
GO:0007569
GO:0008283
GO:0008353
GO:0009636
GO:0010243
GO:0010389
GO:0010468
GO:0010628
GO:0010971
GO:0014038
GO:0014070
GO:0014075
GO:0014823
GO:0016020
GO:0016301
GO:0016310
GO:0016477
GO:0016572
GO:0016579
GO:0016740
GO:0018105
GO:0018107
GO:0030261
GO:0030332
GO:0030496
GO:0030544
GO:0030855
GO:0031100
GO:0031145
GO:0033160
GO:0034501
GO:0035173
GO:0042493
GO:0042542
GO:0042787
GO:0043066
GO:0043161
GO:0044772
GO:0045471
GO:0045740
GO:0045931
GO:0045995
GO:0046686
GO:0046688
GO:0046718
GO:0048678
GO:0051301
GO:0051436
GO:0051437
GO:0051439
GO:0051445
GO:0055015
GO:0060045
GO:0070062
GO:0070301
GO:0072686
GO:0090166
GO:0097125
GO:0097472
GO:0097711
GO:1900182
GO:1905448
HGNC:1722
HPA003387
Hs.184572.0.S2_3p_at
ILMN_1710428
ILMN_1747911
IPR000719
IPR008271
IPR011009
IPR017441
MIM:116940
NM_001320918
NM_001786
NM_033379
NP_001307847
NP_001777
NP_203698
PF00069
PH_hs_0016443
SM00220
TC10000373.hg
uc001jld.3
uc001jlg.4
uc057tmn.1
UPI0000035BE1
UPI000013FE3C
X05360
X05360_at
XM_005270303
XP_005270360
Y00272
Participant Of
hasComponent
CCNA:p-T14-CDK1 [cytosol]
CCNB:p-T14-CDK1 [cytosol]
Cyclin B1:phospho-Cdc2 ( Thr 14) [cytosol]
Other forms of this molecule
CDK1 [endoplasmic reticulum membrane]
CDK1 [nucleoplasm]
CDK1 [cytosol]
p-T14-CDK1 [nucleoplasm]
p-T14,T161-CDK1 [nucleoplasm]
p-T14,Y15,T161-CDK1 [cytosol]
p-T161-CDK1 [nucleoplasm]
p-T14,Y15,T161-CDK1 [nucleoplasm]
p-T161-CDK1 [cytosol]
Inferred To
phospho-p-T14-CDK1 [cytosol] (Arabidopsis thaliana)
phospho-p-T14-CDK1 [cytosol] (Bos taurus)
phospho-p-T14-CDK1 [cytosol] (Caenorhabditis elegans)
phospho-p-T14-CDK1 [cytosol] (Canis familiaris)
phospho-p-T14-CDK1 [cytosol] (Danio rerio)
phospho-p-T14-CDK1 [cytosol] (Drosophila melanogaster)
phospho-p-T14-CDK1 [cytosol] (Gallus gallus)
phospho-p-T14-CDK1 [cytosol] (Mus musculus)
phospho-p-T14-CDK1 [cytosol] (Oryza sativa)
phospho-p-T14-CDK1 [cytosol] (Rattus norvegicus)
phospho-p-T14-CDK1 [cytosol] (Saccharomyces cerevisiae)
phospho-p-T14-CDK1 [cytosol] (Schizosaccharomyces pombe)
phospho-p-T14-CDK1 [cytosol] (Sus scrofa)
phospho-p-T14-CDK1 [cytosol] (Taeniopygia guttata)
phospho-p-T14-CDK1 [cytosol] (Xenopus tropicalis)
Homologues of p-T14-CDK1 [cytosol] (Canis familiaris)
Homologues of p-T14-CDK1 [cytosol] (Oryza sativa)
Homologues of p-T14-CDK1 [cytosol] (Sus scrofa)
Homologues of p-T14-CDK1 [cytosol] (Xenopus tropicalis)
Modified Residues
Name
O-phospho-L-threonine at 14
Coordinate
14
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001777.1
,
NP_001307847.1
,
XP_005270360.1
,
NP_203698.1
ZINC - World Drugs
CDK1_HUMAN
Brenda
2.7.11.22
,
2.7.11.23
ZINC - Substances
CDK1_HUMAN
ZINC target
P06493
ZINC - Biogenic
CDK1_HUMAN
PRO
P06493
PDB
4Y72
,
1LC9
,
5LQF
,
5HQ0
,
4YC6
,
4YC3
ZINC - Metabolites
CDK1_HUMAN
GeneCards
P06493
DOCK Blaster
4YC6
,
5HQ0
,
5LQF
,
4YC3
,
4Y72
ZINC - Predictions - Purchasable
CDK1_HUMAN
HMDB Protein
HMDBP01364
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14635 CCNB1
4
p-4S-CCNB1 [cytosol]
(R-HSA-170058)
CCNB1 [nucleoplasm]
(R-HSA-68901)
p-4S-CCNB1 [nucleoplasm]
(R-HSA-170049)
CCNB1 [cytosol]
(R-HSA-157451)
0.961
18
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.818
8
UniProt:Q99640 PKMYT1
3
PKMYT1 [cytosol]
(R-HSA-157457)
p-PKMYT1 [nucleoplasm]
(R-HSA-162650)
PKMYT1 [nucleoplasm]
(R-HSA-74386)
0.688
4
UniProt:P38936 CDKN1A
5
CDKN1A [cytosol]
(R-HSA-182512)
CDKN1A [nucleoplasm]
(R-HSA-182585)
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
0.659
3
UniProt:Q12778 FOXO1
4
p-T24,S256,S319-FOXO1 [cytosol]
(R-HSA-211158)
p-S215 FOXO1 [nucleoplasm]
(R-HSA-5692651)
p-T24,S256,S319-FOXO1 [nucleoplasm]
(R-HSA-199306)
FOXO1 [nucleoplasm]
(R-HSA-199300)
0.645
5
UniProt:P33552 CKS2
0.643
4
UniProt:P20248 CCNA2
3
CCNA2 [cytosol]
(R-HSA-157444)
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
CCNA2 [nucleoplasm]
(R-HSA-68905)
0.643
3
UniProt:O95067 CCNB2
1
CCNB2 [cytosol]
(R-HSA-68897)
0.643
5
UniProt:O95835 LATS1
2
LATS1 [cytosol]
(R-HSA-2028562)
p-S909,T1097-LATS1 [cytosol]
(R-HSA-2028551)
0.632
3
UniProt:Q16667 CDKN3
0.553
2
UniProt:P00533 EGFR
58
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.547
2
UniProt:P46527 CDKN1B
6
CDKN1B [cytosol]
(R-HSA-198622)
CDKN1B [nucleoplasm]
(R-HSA-182563)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
0.527
2
UniProt:Q99741 CDC6
4
p-CDC6 [cytosol]
(R-HSA-68583)
p-CDC6 [nucleoplasm]
(R-HSA-5661317)
CDC6 [cytosol]
(R-HSA-113566)
CDC6 [nucleoplasm]
(R-HSA-68542)
0.524
2
UniProt:O75618-1 DEDD
0.499
2
UniProt:P30307 CDC25C
8
p-S191-CDC25C [nucleoplasm]
(R-HSA-6802968)
p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol]
(R-HSA-8863654)
p-S198-CDC25C [nucleoplasm]
(R-HSA-156668)
p-S198-CDC25C [cytosol]
(R-HSA-8981697)
CDC25C [cytosol]
(R-HSA-157879)
CDC25C [nucleoplasm]
(R-HSA-69741)
p-S216-CDC25C [cytosol]
(R-HSA-75003)
p-S216-CDC25C [nucleoplasm]
(R-HSA-156496)
0.499
2
UniProt:P01732 CD8A
1
CD8A [plasma membrane]
(R-HSA-197601)
0.488
2
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.463
2
UniProt:Q96GD4 AURKB
3
AURKB [nucleoplasm]
(R-HSA-4655360)
SUMO2,3-K202-AURKB [cytosol]
(R-HSA-4655414)
AURKB [cytosol]
(R-HSA-174231)
0.463
5
UniProt:O15392 BIRC5
3
BIRC5 [nucleoplasm]
(R-HSA-4655344)
ub-BIRC5 [cytosol]
(R-HSA-8955933)
BIRC5 [cytosol]
(R-HSA-50851)
0.463
6
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