Reactome | p-Y546-PTPN11 [cytosol]

p-Y546-PTPN11

Stable Identifier

R-HSA-1369081

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p(Y)-SHP2, Tyrosine-protein phosphatase non-receptor type 11, PTN11_HUMAN, PTPN11

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q06124 PTPN11

Gene Names

PTPN11, PTP2C, SHPTP2

Chain

initiator methionine:1, chain:2-597

Reference Genes

BioGPS Gene:5781 PTPN11

COSMIC (genes):PTPN11 PTPN11

CTD Gene:5781 PTPN11

dbSNP Gene:5781 PTPN11

ENSEMBL:ENSG00000179295 PTPN11

HGNC:9644 PTPN11

KEGG Gene (Homo sapiens):hsa:5781 PTPN11

Monarch:5781 PTPN11

NCBI Gene:5781 PTPN11

OMIM:176876 PTPN11

UCSC:Q06124 PTPN11

Reference Transcript

Other Identifiers

0000940170

11729206_at

11729207_s_at

11729208_x_at

11761200_at

1552637_at

16757255

1870_at

1871_g_at

205867_at

205868_s_at

209895_at

209896_s_at

212610_at

2687514

2775657

2851175

2976271

2SHP

3136729

3136745

3432340

3432342

3432343

3432344

3432345

3432350

3432351

3432352

3432353

3432354

3432357

3432358

3432359

3432360

3432365

3432367

3432368

3432369

3432370

3432371

3432372

3432373

3432374

3432375

38443_at

3B7O

3MOW

3O5X

3TKZ

3TL0

3ZM0

3ZM1

3ZM2

3ZM3

4DGP

4DGX

4GWF

4H1O

4H34

4JE4

4JEG

4JMG

4NWF

4NWG

4OHD

4OHE

4OHH

4OHI

4OHL

4PVG

4QSY

4RDD

5377

5781

5DF6

5EHP

5EHR

5I6V

5IBM

5IBS

5X7B

5X94

5XZR

6BMR

6BMU

6BMV

6BMW

6BMX

6BMY

6BN5

7958846

A0A0U1RRI0

A0A1W2PPU4

A_14_P201950

A_23_P105436

A_23_P204090

A_23_P99027

A_32_P61757

AAA17022

AAA36611

AAH08692

AAP35770

AK289854

BAA02740

BAF82543

BC008692

BT007106

CAA50045

CAB005377

CCDS58280

CCDS81741

CCDS9163

CH471054

D13540

D13540_at

EAW98012

ENSG00000179295

ENSP00000340944

ENSP00000376376

ENSP00000489597

ENST00000351677

ENST00000392597

ENST00000635625

EntrezGene:5781

g13430845_3p_at

g292406_3p_a_at

g7770146_RC_3p_at

GE59447

GE79583

GO:0000003

GO:0000077

GO:0000187

GO:0000278

GO:0000902

GO:0001784

GO:0002376

GO:0003674

GO:0004721

GO:0004725

GO:0004726

GO:0005070

GO:0005158

GO:0005515

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005829

GO:0006464

GO:0006470

GO:0006629

GO:0006641

GO:0006810

GO:0006913

GO:0006950

GO:0007049

GO:0007155

GO:0007165

GO:0007173

GO:0007229

GO:0007267

GO:0007409

GO:0007411

GO:0007420

GO:0007507

GO:0008150

GO:0008543

GO:0009058

GO:0009755

GO:0009967

GO:0016301

GO:0016303

GO:0016311

GO:0016787

GO:0016791

GO:0019221

GO:0019899

GO:0019904

GO:0021697

GO:0022607

GO:0030154

GO:0030168

GO:0030220

GO:0030674

GO:0030971

GO:0031295

GO:0031748

GO:0032528

GO:0032991

GO:0033277

GO:0033628

GO:0033629

GO:0035264

GO:0035265

GO:0035335

GO:0035855

GO:0036092

GO:0036302

GO:0038127

GO:0040007

GO:0040011

GO:0040014

GO:0042445

GO:0042592

GO:0042593

GO:0043226

GO:0043254

GO:0043274

GO:0043560

GO:0045931

GO:0046676

GO:0046825

GO:0046854

GO:0046887

GO:0046888

GO:0046934

GO:0048008

GO:0048011

GO:0048013

GO:0048609

GO:0048646

GO:0048806

GO:0048839

GO:0048856

GO:0048870

GO:0048873

GO:0050839

GO:0050900

GO:0051428

GO:0051463

GO:0051897

GO:0055085

GO:0060020

GO:0060125

GO:0060325

GO:0060338

GO:0061582

GO:0065003

GO:0070102

GO:0070374

GO:0071260

GO:0071345

GO:0071364

GO:1990782

GO:2001275

HGNC:9644

Hs.83572.0.S1_3p_at

Hs2.22868.1.S1_3p_at

ILMN_1778236

IPR000242

IPR000387

IPR000980

IPR003595

IPR012152

IPR016130

IPR029021

IPR036860

L03535

L07527

L08807

LRG_614

LRG_614t1

MIM:151100

MIM:156250

MIM:163950

MIM:176876

MIM:607785

NM_001330437

NM_002834

NM_080601

NP_001317366

NP_002825

NP_542168

PF00017

PF00102

PH_hs_0027176

PR00401

PR00700

PTPN11

PTPN11-201

PTPN11-202

PTPN11-205

SM00194

SM00252

SM00404

TC12000881.hg

TC12002571.hg

U79291_at

uc001ttw.2

uc001ttx.4

uc284ngq.1

UPI000006F711

UPI000013296E

UPI000041C017

X70766

XM_006719526

XM_011538613

XM_017019722

XP_006719589

XP_011536915

XP_016875211

Participant Of

hasComponent

PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-SHP2 [plasma membrane]

Other forms of this molecule

PTPN11 [nucleoplasm]

p-Y546,Y584-PTPN11 [cytosol]

PTPN11 [cytosol]

Modified Residues

Name

O4'-phospho-L-tyrosine at 546

Coordinate

546

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001317366.1, NP_002825.3, NP_542168.1

ZINC - World Drugs

PTN11_HUMAN

ZINC - Substances

PTN11_HUMAN

ZINC - Biogenic

PTN11_HUMAN

ZINC target

Q06124

PRO

Q06124

PDB

4DGX, 3MOW, 5IBS, 3B7O, 4NWG, 4OHE, 2SHP, 6BMW, 4JE4, 5EHP, 4H34, 3O5X, 4RDD, 4OHH, 5EHR, 3TL0, 3TKZ, 3ZM1, 6BMX, 6BMY, 4H1O, 5XZR, 4OHI, 6BMR, 5DF6, 4GWF, 6BN5, 3ZM0, 4PVG, 4DGP, 3ZM2, 4JEG, 5IBM, 4QSY, 4JMG, 6BMU, 4NWF, 4OHL, 5X7B, 6BMV, 5I6V, 3ZM3, 5X94, 4OHD

ZINC - Metabolites

PTN11_HUMAN

GeneCards

Q06124

BRENDA (Homo sapiens)

3.1.3.48

Orphanet

15170

ZINC - Predictions - Purchasable

PTN11_HUMAN

HMDB Protein

HMDBP08926

Interactors (33)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13480 GAB1	4	p-Y627,Y659-GAB1 [cytosol] (R-HSA-180496) p-Y-GAB1 [cytosol] (R-HSA-8855306) p-5Y-GAB1 [cytosol] (R-HSA-180344) GAB1 [cytosol] (R-HSA-179795)	0.95	39
UniProt:P09619 PDGFRB	3	PDGFRB [plasma membrane] (R-HSA-186767) p-11Y-PDGFRB [plasma membrane] (R-HSA-8864039) p-12Y-PDGFRB [plasma membrane] (R-HSA-186803)	0.909	8
UniProt:P80200 CGA1			0.77	8
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.744	6
UniProt:P16284 PECAM1	4	PECAM1 [secretory granule membrane] (R-HSA-6804778) PECAM1 [platelet alpha granule membrane] (R-HSA-61489) p-Y663,Y686-PECAM1(27-?) [plasma membrane] (R-HSA-210007) PECAM1 [plasma membrane] (R-HSA-114686)	0.69	7
UniProt:P20138 CD33	3	CD33 [plasma membrane] (R-HSA-197719) CD33 [specific granule membrane] (R-HSA-6799615) CD33 [tertiary granule membrane] (R-HSA-6800959)	0.677	5
UniProt:P49247 RPIA	2	RPIA [cytosol] (R-HSA-71304) RPIA A61V [cytosol] (R-HSA-5660009)	0.666	4
UniProt:P35570 Irs1	2	p-Y-Irs1 [cytosol] (R-RNO-112362) Irs1 [cytosol] (R-RNO-1168867)	0.656	3
UniProt:Q9UQC2 GAB2	4	p-Y452,Y476,Y584-GAB2 [cytosol] (R-HSA-2685615) p-5Y-GAB2 [cytosol] (R-HSA-8855574) GAB2 [cytosol] (R-HSA-508239) p-Y-GAB2 [cytosol] (R-HSA-912529)	0.643	4
UniProt:P49023 PXN	4	PXN [plasma membrane] (R-HSA-180493) p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.641	3
UniProt:P32239 CCKBR	1	CCKBR [plasma membrane] (R-HSA-388515)	0.623	5
UniProt:P08069 IGF1R	3	IGF1R(31-736) [plasma membrane] (R-HSA-2404169) IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.621	3
UniProt:P00533 EGFR	58	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.609	4
UniProt:P08581 MET	7	p-Y1349,Y1356-MET [plasma membrane] (R-HSA-6807032) p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-HSA-6807014) MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-8875181) MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-HSA-8875180) p-Y1003,4Y-MET [plasma membrane] (R-HSA-8874689) MET [plasma membrane] (R-HSA-419603) p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-6806973)	0.609	13
UniProt:Q15116 PDCD1	2	PDCD1 [plasma membrane] (R-HSA-197604) p-Y223,Y248-PDCD1 [plasma membrane] (R-HSA-389736)	0.602	3
UniProt:Q08345 DDR1	1	DDR1 [plasma membrane] (R-HSA-2327723)	0.576	4
UniProt:P06213 INSR	6	INSR(763-1382) [endosome membrane] (R-HSA-141722) p-6Y-INSR(763-1382) [endosome membrane] (R-HSA-141719) INSR(28-758) [endosome membrane] (R-HSA-141718) INSR(763-1382) [plasma membrane] (R-HSA-74669) p-6Y-INSR(763-1382) [plasma membrane] (R-HSA-74670) INSR(28-758) [plasma membrane] (R-HSA-74668)	0.564	2
UniProt:O95297 MPZL1			0.564	4
UniProt:P97710 Sirpa	9	Sirpa_Rat [plasma membrane] (R-RNO-548921) pSirpa_Rat [plasma membrane] (R-RNO-548918) phospho-p-Y428,Y452,Y469,Y495-SIRPA [plasma membrane] (R-RNO-391102) SIRPA [tertiary granule membrane] (R-RNO-6803288) SIRPA [ficolin-1-rich granule membrane] (R-RNO-6803321) SIRPB1 [secretory granule membrane] (R-RNO-6804801-3) SIRPB1 [plasma membrane] (R-RNO-197568-3) SIRPA [plasma membrane] (R-RNO-3209922) SIRPG [plasma membrane] (R-RNO-197571-6)	0.564	3
UniProt:Q13049 TRIM32	1	TRIM32 [cytosol] (R-HSA-976030)	0.556	3
UniProt:P04040 CAT	5	CAT [ficolin-1-rich granule lumen] (R-HSA-6801279) CAT [cytosol] (R-HSA-9033141) CAT [extracellular region] (R-HSA-6806458) CAT [secretory granule lumen] (R-HSA-6801311) CAT [peroxisomal matrix] (R-HSA-51417)	0.544	3
UniProt:P68105 EEF1A1	1	reEF1A [cytosol] (R-OCU-159543)	0.544	2
UniProt:P48357 LEPR			0.527	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P32927 CSF2RB	6	CSF2RB [plasma membrane] (R-HSA-879960) p-Y593,Y628-CSF2RB [plasma membrane] (R-HSA-912312) p-S585-CSF2RB [plasma membrane] (R-HSA-914170) p-Y593-CSF2RB [plasma membrane] (R-HSA-914092) CSF2RB R211Efs*54 [plasma membrane] (R-HSA-5688863) CSF2RB S271L [plasma membrane] (R-HSA-5688879)	0.527	2
UniProt:Q9BZW8 CD244	1	CD244 [plasma membrane] (R-HSA-197846)	0.525	5
UniProt:Q03135 CAV1	5	CAV1 [early endosome membrane] (R-HSA-5368451) CAV1 [plasma membrane] (R-HSA-534994) CAV1 [Golgi membrane] (R-HSA-204504) CAV1 [lipid droplet] (R-HSA-163510) CAV1 [endocytic vesicle membrane] (R-HSA-535009)	0.499	2
UniProt:P43626 KIR2DL1	1	KIR2DL1 [plasma membrane] (R-HSA-199538)	0.488	2
UniProt:P43628 KIR2DL3	1	KIR2DL3 [plasma membrane] (R-HSA-3006532)	0.462	4
UniProt:Q13291 SLAF1			0.462	2
UniProt:Q9Y3P8 SIT1			0.462	2
UniProt:Q8WU20 FRS2	6	p-6Y-FRS2 [cytosol] (R-HSA-190355) p-Y-FRS2 [cytosol] (R-HSA-162551) FRS2 [cytosol] (R-HSA-190244) p-8T-FRS2 [plasma membrane] (R-HSA-1270462) FRS2 [plasma membrane] (R-HSA-170963) p-6Y-FRS2 [plasma membrane] (R-HSA-170959)	0.462	2
UniProt:P36888 FLT3	2	Autophosphorylated FLT3 [plasma membrane] (R-HSA-9604780) FLT3 [plasma membrane] (R-HSA-6786756)	0.462	2