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p-Y546-PTPN11
Stable Identifier
R-HSA-1369081
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
p(Y)-SHP2, Tyrosine-protein phosphatase non-receptor type 11, PTN11_HUMAN, PTPN11
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Prolactin receptor signaling (Homo sapiens)
SHP2 is phosphorylated (Homo sapiens)
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-SHP2 [plasma membrane] (Homo sapiens)
p-Y546-PTPN11 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q06124 PTPN11
Gene Names
PTPN11, PTP2C, SHPTP2
Chain
initiator methionine:1, chain:2-597
Reference Genes
BioGPS Gene:5781 PTPN11
COSMIC (genes):PTPN11 PTPN11
CTD Gene:5781 PTPN11
dbSNP Gene:5781 PTPN11
ENSEMBL:ENSG00000179295 PTPN11
HGNC:9644 PTPN11
KEGG Gene (Homo sapiens):hsa:5781 PTPN11
Monarch:5781 PTPN11
NCBI Gene:5781 PTPN11
OMIM:176876 PTPN11
UCSC:Q06124 PTPN11
Reference Transcript
RefSeq:NM_002834.4 PTPN11
RefSeq:NM_001330437.1 PTPN11
RefSeq:NM_080601.2 PTPN11
Other Identifiers
0000940170
11729206_at
11729207_s_at
11729208_x_at
11761200_at
1552637_at
16757255
1870_at
1871_g_at
205867_at
205868_s_at
209895_at
209896_s_at
212610_at
2687514
2775657
2851175
2976271
2SHP
3136729
3136745
3432340
3432342
3432343
3432344
3432345
3432350
3432351
3432352
3432353
3432354
3432357
3432358
3432359
3432360
3432365
3432367
3432368
3432369
3432370
3432371
3432372
3432373
3432374
3432375
38443_at
3B7O
3MOW
3O5X
3TKZ
3TL0
3ZM0
3ZM1
3ZM2
3ZM3
4DGP
4DGX
4GWF
4H1O
4H34
4JE4
4JEG
4JMG
4NWF
4NWG
4OHD
4OHE
4OHH
4OHI
4OHL
4PVG
4QSY
4RDD
5377
5781
5DF6
5EHP
5EHR
5I6V
5IBM
5IBS
7958846
A_14_P201950
A_23_P105436
A_23_P204090
A_23_P99027
A_32_P61757
CAB005377
CCDS58280
CCDS81741
CCDS9163
D13540_at
ENSG00000179295
ENSP00000340944
ENSP00000376376
ENSP00000489597
ENST00000351677
ENST00000392597
ENST00000635625
EntrezGene:5781
g13430845_3p_at
g292406_3p_a_at
g7770146_RC_3p_at
GE59447
GE79583
GO:0000077
GO:0000187
GO:0004721
GO:0004725
GO:0004726
GO:0005070
GO:0005158
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0006470
GO:0006629
GO:0006641
GO:0007173
GO:0007229
GO:0007409
GO:0007411
GO:0007420
GO:0007507
GO:0008543
GO:0009755
GO:0009967
GO:0014066
GO:0016303
GO:0016311
GO:0016787
GO:0016791
GO:0019904
GO:0021697
GO:0030168
GO:0030220
GO:0030971
GO:0031295
GO:0031748
GO:0032528
GO:0033277
GO:0033628
GO:0033629
GO:0035264
GO:0035265
GO:0035335
GO:0035855
GO:0036092
GO:0036302
GO:0038111
GO:0038127
GO:0040014
GO:0042445
GO:0042593
GO:0043234
GO:0043254
GO:0043274
GO:0043560
GO:0045931
GO:0046676
GO:0046825
GO:0046854
GO:0046887
GO:0046888
GO:0046934
GO:0048008
GO:0048011
GO:0048013
GO:0048015
GO:0048609
GO:0048806
GO:0048839
GO:0048873
GO:0050839
GO:0050900
GO:0051428
GO:0051463
GO:0060020
GO:0060125
GO:0060325
GO:0060338
GO:0061582
GO:0070374
GO:0071260
GO:0071364
GO:1990782
GO:2001275
HGNC:9644
Hs.506852
Hs.83572.0.S1_3p_at
Hs2.22868.1.S1_3p_at
ILMN_1778236
LRG_614
LRG_614t1
MIM:151100
MIM:156250
MIM:163950
MIM:176876
MIM:607785
NM_001330437
NM_002834
NM_080601
NP_001317366
NP_002825
NP_542168
PF00017
PF00102
PH_hs_0027176
PR00401
PR00700
PTPN11
PTPN11-201
PTPN11-202
PTPN11-205
SM00194
SM00252
SM00404
TC12000881.hg
TC12002571.hg
U79291_at
uc001ttw.2
uc001ttx.4
uc284ngq.1
UPI000006F711
UPI000013296E
UPI000041C017
XM_006719526
XM_011538613
XM_017019722
XP_006719589
XP_011536915
XP_016875211
Participant Of
hasComponent
PRLR ligands:p-Y611-PRLR:p-Y1007-JAK2 dimer:p-SHP2 [plasma membrane]
Other forms of this molecule
PTPN11 [nucleoplasm]
PTPN11 [cytosol]
p-Y546,Y584-PTPN11 [cytosol]
Modified Residues
Name
O4'-phospho-L-tyrosine at 546
Coordinate
546
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001317366.1
,
NP_002825.3
,
NP_542168.1
Brenda
3.1.3.48
ZINC - World Drugs
PTN11_HUMAN
ZINC - Substances
PTN11_HUMAN
ZINC - Biogenic
PTN11_HUMAN
ZINC target
Q06124
PRO
Q06124
PDB
4NWF
,
4NWG
,
6BMW
,
6BMX
,
4OHD
,
4OHE
,
6BMY
,
6BN5
,
2SHP
,
3B7O
,
4OHH
,
4OHI
,
4GWF
,
4H1O
,
5X7B
,
5X94
,
4H34
,
4JE4
,
5XZR
,
6BMR
,
4JEG
,
4JMG
,
6BMU
,
6BMV
,
5DF6
,
5EHP
,
3ZM2
,
3ZM3
,
3ZM1
,
3ZM0
,
4RDD
,
4QSY
,
3TL0
,
3TKZ
,
4PVG
,
4OHL
,
3O5X
,
3MOW
,
5IBS
,
5IBM
,
4DGX
,
4DGP
,
5I6V
,
5EHR
ZINC - Metabolites
PTN11_HUMAN
GeneCards
Q06124
DOCK Blaster
4H1O
,
4JEG
,
4DGX
,
4JE4
,
5I6V
,
5IBM
,
4DGP
,
4RDD
,
5DF6
,
4PVG
,
4JMG
,
2SHP
,
3MOW
,
4QSY
,
5EHP
,
5EHR
,
4NWF
,
4NWG
,
3TL0
,
5IBS
,
3O5X
,
3TKZ
,
3ZM3
,
3ZM2
,
3ZM1
,
3ZM0
,
3B7O
,
4H34
,
4OHD
,
4OHL
,
4OHI
,
4OHH
,
4GWF
,
4OHE
ZINC - Predictions - Purchasable
PTN11_HUMAN
Orphanet
15170
HMDB Protein
HMDBP08926
Interactors (35)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q13480 GAB1
3
p-5Y-GAB1 [cytosol]
(R-HSA-180344)
p-Y627,Y659-GAB1 [cytosol]
(R-HSA-180496)
GAB1 [cytosol]
(R-HSA-179795)
0.95
39
UniProt:P09619 PDGFRB
3
PDGFRB [plasma membrane]
(R-HSA-186767)
p-11Y-PDGFRB [plasma membrane]
(R-HSA-8864039)
p-12Y-PDGFRB [plasma membrane]
(R-HSA-186803)
0.909
8
UniProt:P80200 CGA1
0.77
8
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.744
6
UniProt:P16284 PECAM1
4
p-Y663,Y686-PECAM1(27-?) [plasma membrane]
(R-HSA-210007)
PECAM1 [platelet alpha granule membrane]
(R-HSA-61489)
PECAM1 [secretory granule membrane]
(R-HSA-6804778)
PECAM1 [plasma membrane]
(R-HSA-114686)
0.69
7
UniProt:P20138 CD33
3
CD33 [plasma membrane]
(R-HSA-197719)
CD33 [specific granule membrane]
(R-HSA-6799615)
CD33 [tertiary granule membrane]
(R-HSA-6800959)
0.677
5
UniProt:P49247 RPIA
2
RPIA [cytosol]
(R-HSA-71304)
RPIA A61V [cytosol]
(R-HSA-5660009)
0.666
4
UniProt:P35570 Irs1
2
p-Y-Irs1 [cytosol]
(R-RNO-112362)
Irs1 [cytosol]
(R-RNO-1168867)
0.656
3
UniProt:Q9UQC2 GAB2
4
p-Y-GAB2 [cytosol]
(R-HSA-912529)
p-5Y-GAB2 [cytosol]
(R-HSA-8855574)
GAB2 [cytosol]
(R-HSA-508239)
p-Y452,Y476,Y584-GAB2 [cytosol]
(R-HSA-2685615)
0.643
4
UniProt:P49023 PXN
4
PXN [plasma membrane]
(R-HSA-180493)
p-Y-PXN [plasma membrane]
(R-HSA-9031680)
PXN [cytosol]
(R-HSA-210014)
p-Y31,Y118-PXN [cytosol]
(R-HSA-5218693)
0.641
3
UniProt:P32239 CCKBR
1
CCKBR [plasma membrane]
(R-HSA-388515)
0.623
5
UniProt:P08069 IGF1R
3
IGF1R(31-736) [plasma membrane]
(R-HSA-2404169)
IGF1R(741-1367) [plasma membrane]
(R-HSA-2404180)
p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane]
(R-HSA-2404172)
0.621
3
UniProt:P08581 MET
7
p-Y1349,Y1356-MET [plasma membrane]
(R-HSA-6807032)
p-Y1234,Y1235,Y1356-MET [plasma membrane]
(R-HSA-6807014)
MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-8875181)
MonoUb-K,p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8875180)
p-Y1003,4Y-MET [plasma membrane]
(R-HSA-8874689)
MET [plasma membrane]
(R-HSA-419603)
p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]
(R-HSA-6806973)
0.609
13
UniProt:P00533 EGFR
58
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.609
4
UniProt:Q15116 PDCD1
2
PDCD1 [plasma membrane]
(R-HSA-197604)
p-Y223,Y248-PDCD1 [plasma membrane]
(R-HSA-389736)
0.602
3
UniProt:Q08345 DDR1
1
DDR1 [plasma membrane]
(R-HSA-2327723)
0.576
4
UniProt:P06213 INSR
6
INSR(763-1382) [endosome membrane]
(R-HSA-141722)
p-6Y-INSR(763-1382) [endosome membrane]
(R-HSA-141719)
INSR(28-758) [endosome membrane]
(R-HSA-141718)
INSR(763-1382) [plasma membrane]
(R-HSA-74669)
p-6Y-INSR(763-1382) [plasma membrane]
(R-HSA-74670)
INSR(28-758) [plasma membrane]
(R-HSA-74668)
0.564
2
UniProt:O95297 MPZL1
0.564
4
UniProt:P97710 Sirpa
9
Sirpa_Rat [plasma membrane]
(R-RNO-548921)
pSirpa_Rat [plasma membrane]
(R-RNO-548918)
phospho-p-Y428,Y452,Y469,Y495-SIRPA [plasma membrane]
(R-RNO-391102-3)
SIRPG [plasma membrane]
(R-RNO-197571-3)
SIRPA [ficolin-1-rich granule membrane]
(R-RNO-6803321-3)
SIRPB1 [secretory granule membrane]
(R-RNO-6804801-3)
SIRPA [plasma membrane]
(R-RNO-3209922-3)
SIRPA [tertiary granule membrane]
(R-RNO-6803288-3)
SIRPB1 [plasma membrane]
(R-RNO-197568-3)
0.564
3
UniProt:Q13049 TRIM32
1
TRIM32 [cytosol]
(R-HSA-976030)
0.556
3
UniProt:P04040 CAT
5
CAT [secretory granule lumen]
(R-HSA-6801311)
CAT [cytosol]
(R-HSA-9033141)
CAT [extracellular region]
(R-HSA-6806458)
CAT [ficolin-1-rich granule lumen]
(R-HSA-6801279)
CAT [peroxisomal matrix]
(R-HSA-51417)
0.544
3
UniProt:P68105 EEF1A1
1
reEF1A [cytosol]
(R-OCU-159543)
0.544
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P48357 LEPR
0.527
2
UniProt:P32927 CSF2RB
6
CSF2RB [plasma membrane]
(R-HSA-879960)
p-Y593,Y628-CSF2RB [plasma membrane]
(R-HSA-912312)
p-S585-CSF2RB [plasma membrane]
(R-HSA-914170)
p-Y593-CSF2RB [plasma membrane]
(R-HSA-914092)
CSF2RB R211Efs*54 [plasma membrane]
(R-HSA-5688863)
CSF2RB S271L [plasma membrane]
(R-HSA-5688879)
0.527
2
UniProt:Q9BZW8 CD244
1
CD244 [plasma membrane]
(R-HSA-197846)
0.525
5
UniProt:Q03135 CAV1
5
CAV1 [early endosome membrane]
(R-HSA-5368451)
CAV1 [plasma membrane]
(R-HSA-534994)
CAV1 [lipid droplet]
(R-HSA-163510)
CAV1 [endocytic vesicle membrane]
(R-HSA-535009)
CAV1 [Golgi membrane]
(R-HSA-204504)
0.499
2
UniProt:O75496 GMNN
2
GMNN [cytosol]
(R-HSA-68534)
GMNN [nucleoplasm]
(R-HSA-113554)
0.488
4
UniProt:Q9UKI8 TLK1
0.488
2
UniProt:P43626 KIR2DL1
1
KIR2DL1 [plasma membrane]
(R-HSA-199538)
0.488
2
UniProt:P43628 KIR2DL3
1
KIR2DL3 [plasma membrane]
(R-HSA-3006532)
0.462
4
UniProt:Q13291 SLAF1
0.462
2
UniProt:Q9Y3P8 SIT1
0.462
2
UniProt:P36888 FLT3
1
FLT3 [plasma membrane]
(R-HSA-6786756)
0.462
2
UniProt:Q8WU20 FRS2
7
FRS2 [cytosol]
(R-HSA-190244)
p-Y-FRS2 [cytosol]
(R-HSA-162551)
FRS2 [endosome]
(R-HSA-190054)
p-6Y-FRS2 [endosome]
(R-HSA-190062)
p-8T-FRS2 [plasma membrane]
(R-HSA-1270462)
p-6Y-FRS2 [plasma membrane]
(R-HSA-170959)
FRS2 [plasma membrane]
(R-HSA-170963)
0.462
2
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