Reactome | XRN2 [nucleoplasm]

XRN2 [nucleoplasm]

Stable Identifier

R-HSA-6791205

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

5'-3' exoribonuclease 2 ecNumber3.1.13.-/ecNumber, XRN2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q9H0D6 XRN2

Gene Names

XRN2

Chain

chain:1-950

Reference Genes

BioGPS Gene:22803 XRN2

COSMIC (genes):XRN2 XRN2

CTD Gene:22803 XRN2

dbSNP Gene:22803 XRN2

ENSEMBL:ENSG00000088930 XRN2

HGNC:12836 XRN2

KEGG Gene (Homo sapiens):22803 XRN2

Monarch:22803 XRN2

NCBI Gene:22803 XRN2

OMIM:608851 XRN2

UCSC:Q9H0D6 XRN2

Reference Transcript

Other Identifiers

0002190129

11743117_a_at

11743118_a_at

11743119_x_at

11746472_a_at

11753770_a_at

11753771_x_at

16911943

223002_PM_s_at

223002_s_at

22803

233878_PM_s_at

233878_s_at

3879475

3879476

3879479

3879480

3879482

3879483

3879484

3879485

3879486

3879487

3879488

3879489

3879490

3879491

3879492

3879495

3879497

3879498

3879499

3879503

3879504

3879506

3879507

3879508

3879509

3879510

3879512

3879517

3879518

3879521

3879527

3879532

3879533

3879541

3879542

3879543

45825_at

77664_at

80109_at

8061324

A_23_P166135

GE88812

GO:0000003

GO:0000175

GO:0000738

GO:0000956

GO:0001147

GO:0003674

GO:0003676

GO:0003677

GO:0003723

GO:0004518

GO:0004527

GO:0004534

GO:0005515

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005730

GO:0006139

GO:0006259

GO:0006353

GO:0006364

GO:0006396

GO:0006397

GO:0006401

GO:0007283

GO:0008150

GO:0008409

GO:0009056

GO:0009058

GO:0016020

GO:0016070

GO:0016235

GO:0016787

GO:0021766

GO:0030154

GO:0030182

GO:0034641

GO:0034655

GO:0042254

GO:0042802

GO:0043167

GO:0043226

GO:0046872

GO:0048856

GO:0060041

GO:0090503

HMNXSV003028227

Hs.268555.1.S1_3p_s_at

ILMN_1727617

ILMN_2196479

PH_hs_0013738

TC20000140.hg

g12053188_3p_s_at

This entity regulates

Positively

45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA (Homo sapiens)

Other forms of this molecule

XRN2 [cytosol]

Inferred To

XRN2 [nucleoplasm] (Bos taurus)

XRN2 [nucleoplasm] (Canis familiaris)

XRN2 [nucleoplasm] (Dictyostelium discoideum)

XRN2 [nucleoplasm] (Gallus gallus)

XRN2 [nucleoplasm] (Plasmodium falciparum)

XRN2 [nucleoplasm] (Sus scrofa)

RAT1 [nucleoplasm] (Saccharomyces cerevisiae)

xrn2 [nucleoplasm] (Danio rerio)

xrn2 [nucleoplasm] (Xenopus tropicalis)

Xrn2 [nucleoplasm] (Mus musculus)

Xrn2 [nucleoplasm] (Rattus norvegicus)

Rat1 [nucleoplasm] (Drosophila melanogaster)

xrn-2 [nucleoplasm] (Caenorhabditis elegans)

dhp1 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_036387.2, NP_001304889.1

OpenTargets

ENSG00000088930

GeneCards

Q9H0D6

HPA

ENSG00000088930-XRN2

Ensembl

ENST00000377191, ENSP00000366396, ENSG00000088930

PRO

Q9H0D6

Pharos - Targets

Q9H0D6

Interactors (10)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9NRI5 DISC1			0.667	3
UniProt:Q13148 TADBP			0.666	7
UniProt:Q96HQ2 C2AIL			0.564	2
UniProt:Q9H0D6 XRN2	2	XRN2 [nucleoplasm] (R-HSA-6791205) XRN2 [cytosol] (R-HSA-391297)	0.556	3
UniProt:Q49AN0 CRY2	4	p-S-CRY2 [cytosol] (R-HSA-400305) p-S-CRY2 [nucleoplasm] (R-HSA-400328) CRY2 [cytosol] (R-HSA-400255) Ub-p-S-CRY2 [nucleoplasm] (R-HSA-517935)	0.556	3
UniProt:P80188 LCN2	2	LCN2 [specific granule lumen] (R-HSA-6799614) LCN2 [extracellular region] (R-HSA-5215934)	0.556	3
UniProt:Q5W5X9-3 TTC23			0.556	3
UniProt:Q9H8W4 PKHF2			0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.527	5
UniProt:P61962 DCAF7	2	Unfolded DCAF7 [cytosol] (R-HSA-6813821) DCAF7 [nucleoplasm] (R-HSA-8863312)	0.508	2

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