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XRN2 [nucleoplasm]
Stable Identifier
R-HSA-6791205
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
5'-3' exoribonuclease 2 ecNumber3.1.13.-/ecNumber, XRN2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
rRNA processing (Homo sapiens)
rRNA processing in the nucleus and cytosol (Homo sapiens)
Major pathway of rRNA processing in the nucleolus and cytosol (Homo sapiens)
45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA (Homo sapiens)
XRN2 [nucleoplasm] (Homo sapiens)
47S pre-rRNA is nucleolytically processed at A' (01,A1), site A0, and site 02 (site 6) to yield 45S pre-rRNA (Homo sapiens)
XRN2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H0D6 XRN2
Gene Names
XRN2
Chain
chain:1-950
Reference Genes
BioGPS Gene:22803 XRN2
COSMIC (genes):XRN2 XRN2
CTD Gene:22803 XRN2
dbSNP Gene:22803 XRN2
ENSEMBL:ENSG00000088930 XRN2
HGNC:12836 XRN2
Monarch:22803 XRN2
NCBI Gene:22803 XRN2
OMIM:608851 XRN2
UCSC:Q9H0D6 XRN2
Reference Transcript
RefSeq:NM_012255.4 XRN2
RefSeq:NM_001317960.1 XRN2
Other Identifiers
11743117_a_at
11743118_a_at
11743119_x_at
11746472_a_at
11753770_a_at
11753771_x_at
16911943
223002_PM_s_at
223002_s_at
22803
233878_PM_s_at
233878_s_at
3879475
3879476
3879479
3879480
3879482
3879483
3879484
3879485
3879486
3879487
3879488
3879489
3879490
3879491
3879492
3879495
3879497
3879498
3879499
3879503
3879504
3879506
3879507
3879508
3879509
3879510
3879512
3879517
3879518
3879521
3879527
3879532
3879533
3879541
3879542
3879543
45825_at
77664_at
80109_at
8061324
A_23_P166135
GE88812
GO:0000175
GO:0000956
GO:0001147
GO:0003676
GO:0003677
GO:0003723
GO:0003824
GO:0004518
GO:0004527
GO:0004534
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0006139
GO:0006353
GO:0006364
GO:0006369
GO:0006396
GO:0006397
GO:0006401
GO:0007283
GO:0008409
GO:0016020
GO:0016070
GO:0016071
GO:0016235
GO:0016787
GO:0021766
GO:0022414
GO:0030154
GO:0030182
GO:0042802
GO:0043226
GO:0046872
GO:0048856
GO:0060041
GO:0140098
HMNXSV003028227
Hs.268555.1.S1_3p_s_at
ILMN_1727617
ILMN_2196479
PH_hs_0013738
TC20000140.hg
g12053188_3p_s_at
This entity regulates
Positively
45S pre-rRNA is nucleolytically processed at site 2 (site 2b) to yield 30S pre-rRNA and 32S pre-rRNA
(Homo sapiens)
Other forms of this molecule
XRN2 [cytosol]
Inferred To
XRN2 [nucleoplasm]
(Bos taurus)
XRN2 [nucleoplasm]
(Canis familiaris)
XRN2 [nucleoplasm]
(Dictyostelium discoideum)
XRN2 [nucleoplasm]
(Gallus gallus)
XRN2 [nucleoplasm]
(Plasmodium falciparum)
XRN2 [nucleoplasm]
(Sus scrofa)
RAT1 [nucleoplasm]
(Saccharomyces cerevisiae)
exo2 [nucleoplasm]
(Schizosaccharomyces pombe)
XRN1 [nucleoplasm]
(Saccharomyces cerevisiae)
xrn2 [nucleoplasm]
(Dictyostelium discoideum)
Homologues of XRN2 [nucleoplasm]
(Dictyostelium discoideum)
Homologues of XRN2 [nucleoplasm]
(Plasmodium falciparum)
Homologues of XRN2 [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of XRN2 [nucleoplasm]
(Schizosaccharomyces pombe)
Xrn2 [nucleoplasm]
(Mus musculus)
Xrn2 [nucleoplasm]
(Rattus norvegicus)
xrn1 [nucleoplasm]
(Dictyostelium discoideum)
Rat1 [nucleoplasm]
(Drosophila melanogaster)
xrn-2 [nucleoplasm]
(Caenorhabditis elegans)
dhp1 [nucleoplasm]
(Schizosaccharomyces pombe)
Cross References
ENSEMBL
ENSP00000366396
,
ENST00000377191
OpenTargets
ENSG00000088930
HPA
ENSG00000088930-XRN2
PRO
Q9H0D6
Pharos - Targets
Q9H0D6
GlyGen
Q9H0D6
Interactors (14)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q96HQ2 C2AIL
0.744
4
UniProt:Q9NXV6 CARF
0.708
7
UniProt:Q9NRI5 DISC1
0.667
3
UniProt:Q13148 TADBP
0.666
7
UniProt:P80188 LCN2
2
LCN2 [extracellular region]
(R-HSA-5215934)
LCN2 [specific granule lumen]
(R-HSA-6799614)
0.556
3
UniProt:Q5W5X9-3 TTC23
0.556
3
UniProt:Q9H8W4 PKHF2
0.556
3
UniProt:Q9H0D6 XRN2
2
XRN2 [nucleoplasm]
(R-HSA-6791205)
XRN2 [cytosol]
(R-HSA-391297)
0.556
3
UniProt:Q49AN0 CRY2
4
p-S-CRY2 [cytosol]
(R-HSA-400305)
p-S-CRY2 [nucleoplasm]
(R-HSA-400328)
CRY2 [cytosol]
(R-HSA-400255)
Ub-p-S-CRY2 [nucleoplasm]
(R-HSA-517935)
0.556
3
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.553
2
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.527
5
UniProt:P52294 KPNA1
2
KPNA1 [cytosol]
(R-HSA-180612)
KPNA1 [nucleoplasm]
(R-HSA-188865)
0.527
2
UniProt:P61962 DCAF7
2
Unfolded DCAF7 [cytosol]
(R-HSA-6813821)
DCAF7 [nucleoplasm]
(R-HSA-8863312)
0.508
2
UniProt:P09651 HNRNPA1
2
HNRNPA1 [nucleoplasm]
(R-HSA-71927)
HNRNPA1 [cytosol]
(R-HSA-9727902)
0.483
2
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