Reactome | GPNMB [plasma membrane]

GPNMB [plasma membrane]

Stable Identifier

R-HSA-8857550

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Transmembrane glycoprotein NMB, Transmembrane glycoprotein HGFIN, NMB, HGFIN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q14956 GPNMB

Gene Names

GPNMB, HGFIN, NMB, UNQ1725/PRO9925

Chain

signal peptide:1-22, chain:23-572

Reference Genes

BioGPS Gene:10457 GPNMB

COSMIC (genes):GPNMB GPNMB

CTD Gene:10457 GPNMB

dbSNP Gene:10457 GPNMB

ENSEMBL:ENSG00000136235 GPNMB

HGNC:4462 GPNMB

KEGG Gene (Homo sapiens):10457 GPNMB

Monarch:10457 GPNMB

NCBI Gene:10457 GPNMB

OMIM:604368 GPNMB

UCSC:Q14956 GPNMB

Reference Transcript

Other Identifiers

0005690180

10457

11724463_a_at

11748750_a_at

11748751_a_at

11752544_a_at

17044253

201141_at

2992815

2992816

2992825

2992826

2992827

2992828

2992831

2992832

2992833

2992839

2992840

2992841

2992842

2992845

2992847

2992848

2992849

2992850

38379_at

8131844

A_14_P100953

A_23_P134426

GE60022

GO:0000278

GO:0001818

GO:0001934

GO:0002376

GO:0003674

GO:0005178

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005768

GO:0005886

GO:0005887

GO:0006464

GO:0007049

GO:0007155

GO:0007165

GO:0007267

GO:0008150

GO:0008201

GO:0008219

GO:0008283

GO:0008285

GO:0016020

GO:0016021

GO:0030335

GO:0031410

GO:0031901

GO:0031954

GO:0033162

GO:0034103

GO:0040011

GO:0042056

GO:0042130

GO:0043167

GO:0043226

GO:0045545

GO:0045765

GO:0048018

GO:0048646

GO:0048856

GO:0048870

GO:0050868

GO:0050918

GO:0070374

GO:1901215

GO:2000134

HMNXSV003036421

ILMN_1801205

ILMN_2407389

PH_hs_0033092

TC07000144.hg

X76534_at

g4505404_3p_at

Participates

as an input of

HBEGF-bound EGFR forms a heterodimer with GPNMB (Homo sapiens)

as a component of

HBEGF:EGFR:GPNMB [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-Y525-GPNMB [plasma membrane]

Inferred To

GPNMB [plasma membrane] (Canis familiaris)

gpnmb [plasma membrane] (Danio rerio)

Gpnmb [plasma membrane] (Mus musculus)

Gpnmb [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001005340.1, NP_002501.1

OpenTargets

ENSG00000136235

GeneCards

Q14956

HPA

ENSG00000136235-GPNMB

Ensembl

ENSG00000136235, ENST00000381990, ENSP00000258733, ENSP00000371420, ENST00000258733

PRO

Q14956

Orphanet

27022

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.524	3

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