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GPNMB [plasma membrane]
Stable Identifier
R-HSA-8857550
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Transmembrane glycoprotein NMB, Transmembrane glycoprotein HGFIN, NMB, HGFIN
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 promotes HIF1A stabilization (Homo sapiens)
EGFR phosphorylates GPNMB (Homo sapiens)
HBEGF:EGFR:GPNMB [plasma membrane] (Homo sapiens)
GPNMB [plasma membrane] (Homo sapiens)
HBEGF-bound EGFR forms a heterodimer with GPNMB (Homo sapiens)
GPNMB [plasma membrane] (Homo sapiens)
HBEGF:EGFR:GPNMB [plasma membrane] (Homo sapiens)
GPNMB [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14956 GPNMB
Gene Names
GPNMB, HGFIN, NMB, UNQ1725/PRO9925
Chain
signal peptide:1-22, chain:23-572
Reference Genes
BioGPS Gene:10457 GPNMB
COSMIC (genes):GPNMB GPNMB
CTD Gene:10457 GPNMB
dbSNP Gene:10457 GPNMB
ENSEMBL:ENSG00000136235 GPNMB
ENSEMBL:ENSG00000136235.17 GPNMB
HGNC:4462 GPNMB
KEGG Gene (Homo sapiens):10457 GPNMB
Monarch:10457 GPNMB
NCBI Gene:10457 GPNMB
OMIM:604368 GPNMB
UCSC:Q14956 GPNMB
Reference Transcript
RefSeq:NM_002510.2 GPNMB
RefSeq:NM_001005340.1 GPNMB
Other Identifiers
10457
11724463_a_at
11748750_a_at
11748751_a_at
11752544_a_at
17044253
201141_PM_at
201141_at
2992815
2992816
2992825
2992826
2992827
2992828
2992831
2992832
2992833
2992839
2992840
2992841
2992842
2992845
2992847
2992848
2992849
2992850
38379_at
8131844
A_14_P100953
A_23_P134426
GE60022
GO:0000278
GO:0001818
GO:0001934
GO:0002376
GO:0005178
GO:0005515
GO:0005768
GO:0005886
GO:0007155
GO:0007165
GO:0007267
GO:0008201
GO:0008285
GO:0016020
GO:0023052
GO:0030335
GO:0031410
GO:0031901
GO:0031954
GO:0032720
GO:0033162
GO:0034103
GO:0036211
GO:0042056
GO:0042130
GO:0043226
GO:0045545
GO:0045765
GO:0048018
GO:0048856
GO:0048870
GO:0050868
GO:0050918
GO:0070374
GO:0098772
GO:1901215
GO:2000134
HMNXSV003036421
ILMN_1801205
ILMN_2407389
PH_hs_0033092
TC07000144.hg
X76534_at
g4505404_3p_at
Participates
as an input of
HBEGF-bound EGFR forms a heterodimer with GPNMB (Homo sapiens)
as a component of
HBEGF:EGFR:GPNMB [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-Y525-GPNMB [plasma membrane]
Inferred To
GPNMB [plasma membrane]
(Bos taurus)
GPNMB [plasma membrane]
(Canis familiaris)
GPNMB [plasma membrane]
(Danio rerio)
GPNMB [plasma membrane]
(Gallus gallus)
GPNMB [plasma membrane]
(Sus scrofa)
gpnmb [plasma membrane]
(Xenopus tropicalis)
Gpnmb [plasma membrane]
(Mus musculus)
Gpnmb [plasma membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001005340.1
,
NP_002501.1
OpenTargets
ENSG00000136235
HPA
ENSG00000136235-GPNMB
GeneCards
Q14956
Ensembl
ENST00000258733
,
ENST00000381990
,
ENSG00000136235
,
ENSP00000371420
,
ENSP00000258733
PRO
Q14956
Pharos - Targets
Q14956
Orphanet
27022
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.524
3
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