Reactome | GPNMB [plasma membrane]

GPNMB [plasma membrane]

Stable Identifier

R-HSA-8857550

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Transmembrane glycoprotein NMB, Transmembrane glycoprotein HGFIN, NMB, HGFIN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q14956 GPNMB

Gene Names

GPNMB, HGFIN, NMB, UNQ1725/PRO9925

Chain

signal peptide:1-22, chain:23-572

Reference Genes

BioGPS Gene:10457 GPNMB

COSMIC (genes):GPNMB GPNMB

COSMIC (genes):NMB NMB

CTD Gene:10457 GPNMB

dbSNP Gene:10457 GPNMB

ENSEMBL:ENSG00000136235 GPNMB

HGNC:4462 GPNMB

KEGG:hsa:10457 GPNMB

Monarch:10457 GPNMB

NCBI Gene:10457 GPNMB

OMIM:604368 GPNMB

UCSC:Q14956 GPNMB

Reference Transcript

Participates

as a component of

HBEGF:EGFR:GPNMB [plasma membrane] (Homo sapiens)

as an input of

HBEGF-bound EGFR forms a heterodimer with GPNMB (Homo sapiens)

Other forms of this molecule

p-Y525-GPNMB [plasma membrane]

Inferred To

GPNMB [plasma membrane] (Bos taurus)

GPNMB [plasma membrane] (Gallus gallus)

GPNMB [plasma membrane] (Sus scrofa)

gpnmb [plasma membrane] (Xenopus tropicalis)

Gpnmb [plasma membrane] (Mus musculus)

Gpnmb [plasma membrane] (Rattus norvegicus)

Cross References

RefSeq

NP_001005340.1, XP_047275732.1, NP_002501.1

ENSEMBL

ENST00000381990, ENSP00000258733, ENSP00000371420, ENST00000258733, ENSG00000136235

OpenTargets

ENSG00000136235

GeneCards

GPNMB

HPA

ENSG00000136235-GPNMB

PRO

Q14956

Pharos - Targets

Q14956

GlyGen

Q14956

Orphanet

GPNMB

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.524	3

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