Reactome | MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm]

MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm]

Stable Identifier

R-HSA-6785318

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Locations in the PathwayBrowser

Expand all

DNA Repair (Homo sapiens)

- Fanconi Anemia Pathway (Homo sapiens)
  - DNA nucleases bind monoubiquitinated ID2 complex (Homo sapiens)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI [nucleoplasm] (Homo sapiens)
        
        MonoUb:K561,p-T691,S717-FANCD2 [nucleoplasm] (Homo sapiens)
        
        MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (Homo sapiens)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Homo sapiens)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
        
        MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI [nucleoplasm] (Homo sapiens)
        
        MonoUb:K561,p-T691,S717-FANCD2 [nucleoplasm] (Homo sapiens)
        
        MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (Homo sapiens)
  - DNA nucleases unhook the interstrand crosslink (ICL) (Homo sapiens)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA:Unhooking nucleases [nucleoplasm] (Homo sapiens)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
        
        MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI [nucleoplasm] (Homo sapiens)
        
        MonoUb:K561,p-T691,S717-FANCD2 [nucleoplasm] (Homo sapiens)
        
        MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (Homo sapiens)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI [nucleoplasm] (Homo sapiens)
        
        MonoUb:K561,p-T691,S717-FANCD2 [nucleoplasm] (Homo sapiens)
        
        MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (Homo sapiens)
  - FANCD2 deubiquitination by USP1:WDR48 (Homo sapiens)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI [nucleoplasm] (Homo sapiens)
        
        MonoUb:K561,p-T691,S717-FANCD2 [nucleoplasm] (Homo sapiens)
        
        MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (Homo sapiens)
  - Monoubiquitination of FANCD2:FANCI (Homo sapiens)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:ICL-DNA [nucleoplasm] (Homo sapiens)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI [nucleoplasm] (Homo sapiens)
        
        MonoUb:K561,p-T691,S717-FANCD2 [nucleoplasm] (Homo sapiens)
        
        MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (Homo sapiens)
  - POLN binds ICL-DNA (Homo sapiens)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI [nucleoplasm] (Homo sapiens)
        
        MonoUb:K561,p-T691,S717-FANCD2 [nucleoplasm] (Homo sapiens)
        
        MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (Homo sapiens)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Homo sapiens)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
        
        MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI [nucleoplasm] (Homo sapiens)
        
        MonoUb:K561,p-T691,S717-FANCD2 [nucleoplasm] (Homo sapiens)
        
        MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (Homo sapiens)
  - Translesion synthesis across unhooked ICL by POLN (Homo sapiens)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI [nucleoplasm] (Homo sapiens)
      - MonoUb:K561,p-T691,S717-FANCD2 [nucleoplasm] (Homo sapiens)
        
        MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (Homo sapiens)
    - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA:POLN [nucleoplasm] (Homo sapiens)
      - MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI:FA Core Complex:Unhooked ICL-DNA [nucleoplasm] (Homo sapiens)
        
        MonoUb:K561,p-T691,S717-FANCD2:MonoUb:K523,p-4S-FANCI [nucleoplasm] (Homo sapiens)
        
        MonoUb:K561,p-T691,S717-FANCD2 [nucleoplasm] (Homo sapiens)
        
        MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BXW9 FANCD2

Gene Names

FANCD2, FACD

Chain

chain:1-1451

Reference Genes

BioGPS Gene:2177 FANCD2

COSMIC (genes):FANCD2 FANCD2

CTD Gene:2177 FANCD2

dbSNP Gene:2177 FANCD2

ENSEMBL:ENSG00000144554 FANCD2

ENSEMBL_homo_sapiens_GENE:ENSG00000144554.13 FANCD2

HGNC:3585 FANCD2

KEGG Gene (Homo sapiens):2177 FANCD2

Monarch:2177 FANCD2

NCBI Gene:2177 FANCD2

OMIM:613984 FANCD2

UCSC:Q9BXW9 FANCD2

Reference Transcript

Other Identifiers

11732535_a_at

11736546_at

11736547_a_at

11736548_s_at

11756910_x_at

11761656_at

1568889_PM_at

1568889_at

1568891_3p_x_at

1568891_PM_x_at

1568891_x_at

16937505

17123142

2177

223545_PM_at

223545_at

242560_PM_at

242560_at

2610206

2610210

2610211

2610242

2610243

2610245

2610246

2610247

2610248

2610250

2610251

2610252

2610254

2610255

2610256

2610257

2610258

2610259

2610260

2610261

2610262

2610263

2610264

2610265

2610266

2610267

2610268

2610269

2610271

2610272

2610273

2610274

2610275

2610277

2610278

2610280

2610281

2610283

2610284

2610285

2610286

2610287

2610288

2610289

2610290

2610291

2610292

2610293

2610294

2610296

2610297

2610298

2610299

2610301

2610303

2610304

2610305

2610307

2610308

2610309

2610310

2610311

2610312

2610313

2610314

2610927

2610928

2610929

2610933

2610934

2610935

2610936

2610937

2610939

2610940

2610941

53423_i_at

53426_r_at

65277_at

8077731

87453_s_at

87455_at

A_23_P143994

A_23_P345678

A_32_P24165

GE83604

GO:0000278

GO:0000785

GO:0000793

GO:0002376

GO:0005515

GO:0005634

GO:0005654

GO:0005694

GO:0005730

GO:0005829

GO:0006281

GO:0006310

GO:0006954

GO:0006974

GO:0007049

GO:0007059

GO:0007129

GO:0007276

GO:0010332

GO:0016604

GO:0022414

GO:0023052

GO:0030154

GO:0031573

GO:0034599

GO:0036297

GO:0043226

GO:0045589

GO:0048854

GO:0048856

GO:0050727

GO:0070182

GO:0097150

GO:0140013

GO:1990391

GO:1990918

GO:2000348

HMNXSV003019165

HMNXSV003036583

Hs.278187.0.A1_3p_at

Hs2.423134.1.S1_3p_s_at

Hs2.423134.1.S1_3p_x_at

ILMN_1657634

ILMN_1712122

ILMN_2235137

PH_hs_0023045

PH_hs_0041048

TC03000051.hg

g13183880_3p_at

Participates

as a component of

MonoUb:K561,p-T691,S717-FANCD2 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-T691,S717-FANCD2 [nucleoplasm]

FANCD2 [nucleoplasm]

Inferred To

phospho-MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (Gallus gallus)

phospho-FANCD2 [nucleoplasm] (Bos taurus)

phospho-FANCD2 [nucleoplasm] (Canis familiaris)

phospho-FANCD2 [nucleoplasm] (Sus scrofa)

phospho-Fancd2 [nucleoplasm] (Mus musculus)

phospho-Fancd2 [nucleoplasm] (Rattus norvegicus)

Ghost homologue of MonoUb-K561,p-T691,S717-FANCD2 [nucleoplasm] (Xenopus tropicalis)

Modified Residues

Name

O-phospho-L-serine at 717

Coordinate

717

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-threonine at 691

Coordinate

691

PsiMod Name

O-phospho-L-threonine [MOD:00047]

PsiMod Definition

A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.

Name

ubiquitinylated lysine at 561

Coordinate

561

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_149075.2, NP_001018125.1, NP_001306913.1

OpenTargets

ENSG00000144554

GeneCards

Q9BXW9

HPA

ENSG00000144554-FANCD2

Ensembl

ENSP00000398754, ENSG00000144554, ENST00000431693, ENST00000419585, ENST00000675286, ENSP00000399354, ENSP00000287647, ENST00000287647, ENSP00000502379

PRO

Q9BXW9

Pharos - Targets

Q9BXW9

Orphanet

16023

PDB

7KZQ, 6VAE, 7KZR, 7ZF1, 8A9K, 7KZV, 6VAD, 7KZS, 8A9J, 7KZT, 6VAF, 6VAA, 7AY1

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P51587 BRCA2	20	BRCA2 D2983Ffs34 [cytosol] (R-HSA-9709538) BRCA2 K2555 [cytosol] (R-HSA-9711337) BRCA2 N2553Tfs95 [cytosol] (R-HSA-9712872) BRCA2 T2685Hfs9 [cytosol] (R-HSA-9712879) BRCA2 K2674Rfs2 [cytosol] (R-HSA-9712610) BRCA2 S3231 [cytosol] (R-HSA-9711458) BRCA2 I2675Dfs6 [cytosol] (R-HSA-9712869) BRCA2 R2625 [cytosol] (R-HSA-9711482) BRCA2 E3071* [cytosol] (R-HSA-9711354) BRCA2 V2716Wfs17 [cytosol] (R-HSA-9712761) BRCA2 W2586 [cytosol] (R-HSA-9711487) BRCA2 P2767Lfs10 [cytosol] (R-HSA-9712509) BRCA2 K3032 [cytosol] (R-HSA-9711485) BRCA2 S2835* [cytosol] (R-HSA-9711345) BRCA2 Y3006* [cytosol] (R-HSA-9711222) BRCA2 L2926* [cytosol] (R-HSA-9711348) BRCA2 R3128* [cytosol] (R-HSA-9711177) BRCA2 E2599* [cytosol] (R-HSA-9711304) BRCA2 E2571* [cytosol] (R-HSA-9711560) BRCA2 Y2977* [cytosol] (R-HSA-9711182)	0.688	16
UniProt:Q16658 FSCN1	1	FSCN1 [cytosol] (R-HSA-6789835)	0.649	6
UniProt:P49959 MRE11	2	MRE11A [nucleoplasm] (R-HSA-59544) MRE11A [cytosol] (R-HSA-3204309)	0.646	6
UniProt:O60934 NBN	3	p-S343-NBN [nucleoplasm] (R-HSA-75237) NBN [cytosol] (R-HSA-5684005) NBN [nucleoplasm] (R-HSA-75163)	0.626	6
UniProt:Q9HB96 FANCE	2	FANCE [cytosol] (R-HSA-420786) FANCE [nucleoplasm] (R-HSA-419543)	0.616	4
UniProt:P49716 CEBPD	1	CEBPD [nucleoplasm] (R-HSA-381280)	0.612	8
UniProt:Q9NVI1 FANCI	3	MonoUb-K523,p-4S-FANCI [nucleoplasm] (R-HSA-6785321) p-4S-FANCI [nucleoplasm] (R-HSA-6788480) FANCI [nucleoplasm] (R-HSA-419529)	0.589	2
UniProt:P38398 BRCA1	20	polySUMO2,3-BRCA1 [nucleoplasm] (R-HSA-2997624) monoSUMO1-K109-BRCA1 [nucleoplasm] (R-HSA-2997644) BRCA1 M1411T [nucleoplasm] (R-HSA-9702140) BRCA1 M1400V [nucleoplasm] (R-HSA-9701202) BRCA1 L1407P [nucleoplasm] (R-HSA-9702135) BRCA1 Y777* [nucleoplasm] (R-HSA-9702765) BRCA1 S1009* [nucleoplasm] (R-HSA-9702755) BRCA1 P724Lfs12 [nucleoplasm] (R-HSA-9703778) BRCA1 S451 [nucleoplasm] (R-HSA-9702754) BRCA1 S864* [nucleoplasm] (R-HSA-9702752) BRCA1 P897Kfs5 [nucleoplasm] (R-HSA-9703782) BRCA1 N555Kfs17 [nucleoplasm] (R-HSA-9703781) BRCA1 Y1127Sfs6 [nucleoplasm] (R-HSA-9703780) BRCA1 S886Cfs16 [nucleoplasm] (R-HSA-9703802) BRCA1 V83Cfs2 [nucleoplasm] (R-HSA-9703800) BRCA1 T464Pfs11 [nucleoplasm] (R-HSA-9703807) BRCA1 G813Dfs2 [nucleoplasm] (R-HSA-9703549) BRCA1 V340Gfs6 [nucleoplasm] (R-HSA-9703804) BRCA1 Y655* [nucleoplasm] (R-HSA-9702769) BRCA1 W372* [nucleoplasm] (R-HSA-9702768)	0.583	3
UniProt:Q92878 RAD50	1	RAD50 [nucleoplasm] (R-HSA-75160)	0.578	4
UniProt:P56180-2 TPTE			0.569	3
UniProt:O00255 MEN1	4	MEN1 [cytosol] (R-HSA-5672315) p-MEN1 [endoplasmic reticulum lumen] (R-HSA-8956901) MEN1 [endoplasmic reticulum lumen] (R-HSA-8956785) MEN1 [nucleoplasm] (R-HSA-2186626)	0.524	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.499	2
UniProt:Q14676 MDC1	6	monoSUMO1-K1840-MDC1 [nucleoplasm] (R-HSA-4570546) polySUMO2,3-K1840-MDC1 [nucleoplasm] (R-HSA-4570473) K48PolyUb,SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684074) SUMO2-K1840,p-5T-MDC1 [nucleoplasm] (R-HSA-5684061) p-5T-MDC1 [nucleoplasm] (R-HSA-75236) MDC1 [nucleoplasm] (R-HSA-75231)	0.483	2