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AP2S1 [clathrin-coated endocytic vesicle membrane]
Stable Identifier
R-HSA-2130707
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
clathrin-coated endocytic vesicle membrane
Synonyms
AP-2 complex subunit sigma, Adaptor protein complex AP-2 subunit sigma, Plasma membrane adapto AP-2 17 kDa protein
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
WNT5A-dependent internalization of FZD4 (Homo sapiens)
WNT5A:FZD4 is endocytosed (Homo sapiens)
WNT5A:FZD4:p-DVL2:AP-2:clathrin [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
clathrin:AP-2 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP-2 Complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
AP2S1 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P53680 AP2S1
Gene Names
AP2S1, AP17, CLAPS2
Chain
chain:1-142
Reference Genes
BioGPS Gene:1175 AP2S1
COSMIC (genes):AP2S1 AP2S1
CTD Gene:1175 AP2S1
dbSNP Gene:1175 AP2S1
ENSEMBL:ENSG00000042753 AP2S1
ENSEMBL_homo_sapiens_GENE:ENSG00000042753.12 AP2S1
HGNC:565 AP2S1
KEGG Gene (Homo sapiens):1175 AP2S1
Monarch:1175 AP2S1
NCBI Gene:1175 AP2S1
OMIM:602242 AP2S1
UCSC:P53680 AP2S1
Reference Transcript
RefSeq:NM_004069.4 AP2S1
RefSeq:NM_001301081.1 AP2S1
RefSeq:NM_001301078.1 AP2S1
RefSeq:NM_001301076.1 AP2S1
RefSeq:NM_021575.3 AP2S1
Other Identifiers
11716610_a_at
11716611_x_at
1175
11755456_a_at
16873647
202120_PM_x_at
202120_x_at
208074_PM_s_at
208074_s_at
211047_PM_x_at
211047_x_at
2483096
3866303
3866304
3866305
3866306
3866307
3866310
3866315
3866316
39347_at
8037847
A_33_P3346663
GE82612
GE86174
GO:0005515
GO:0005764
GO:0005768
GO:0005773
GO:0005829
GO:0005886
GO:0005905
GO:0006886
GO:0006897
GO:0009898
GO:0015031
GO:0016020
GO:0016192
GO:0030100
GO:0030117
GO:0030122
GO:0030666
GO:0030669
GO:0031410
GO:0035615
GO:0036020
GO:0043226
GO:0043231
GO:0045202
GO:0045334
GO:0048268
GO:0048488
GO:0060090
GO:0065003
GO:0071944
GO:0072583
GO:0098793
GO:0098794
GO:0098884
HMNXSV003057421
ILMN_1662426
ILMN_1809957
PH_hs_0035544
TC19001658.hg
X97074_at
g11038642_3p_s_at
g13623468_3p_s_at
Participates
as a component of
AP-2 Complex [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Other forms of this molecule
AP2S1 [cytosol]
AP2S1 [plasma membrane]
AP2S1 [endolysosome membrane]
Inferred To
AP-2sigma [clathrin-coated endocytic vesicle membrane]
(Drosophila melanogaster)
ap2s1 [clathrin-coated endocytic vesicle membrane]
(Xenopus tropicalis)
AP2S1 [clathrin-coated endocytic vesicle membrane]
(Bos taurus)
AP2S1 [clathrin-coated endocytic vesicle membrane]
(Canis familiaris)
AP2S1 [clathrin-coated endocytic vesicle membrane]
(Sus scrofa)
aps-2 [clathrin-coated endocytic vesicle membrane]
(Caenorhabditis elegans)
Ap2s1 [clathrin-coated endocytic vesicle membrane]
(Mus musculus)
Ap2s1 [clathrin-coated endocytic vesicle membrane]
(Rattus norvegicus)
Cross References
RefSeq
NP_001288007.1
,
NP_001288005.1
,
NP_067586.1
,
NP_001288010.1
,
NP_004060.2
OpenTargets
ENSG00000042753
GeneCards
P53680
HPA
ENSG00000042753-AP2S1
Ensembl
ENSP00000263270
,
ENST00000601649
,
ENST00000263270
,
ENSP00000470898
,
ENSG00000042753
PRO
P53680
Pharos - Targets
P53680
Orphanet
21725
PDB
6URI
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P42566 EPS15
2
p-Y849 EPS15 [cytosol]
(R-HSA-8867028)
EPS15 [cytosol]
(R-HSA-182920)
0.725
6
UniProt:Q9UBC2 EPS15L1
2
EPS15L1 [plasma membrane]
(R-HSA-182937)
EPS15L1 [cytosol]
(R-HSA-8935900)
0.643
4
UniProt:Q96CW1 AP2M1
6
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.643
5
UniProt:Q2M2I8 AAK1
1
AAK1 [cytosol]
(R-HSA-8854795)
0.643
4
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.569
3
UniProt:Q15811 ITSN1
1
ITSN1 [cytosol]
(R-HSA-3006481)
0.527
3
UniProt:P0CG47 UBB
20
UBB(77-152) [endocytic vesicle membrane]
(R-HSA-939253)
UBB(1-76) [endocytic vesicle membrane]
(R-HSA-939231)
UBB(153-228) [endocytic vesicle membrane]
(R-HSA-939171)
Ub-33-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783023)
Ub-109-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783008)
Ub-185-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783046)
Ub-215-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783002)
Ub-63-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783148)
Ub-139-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783012)
Ub-158-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783162)
Ub-6-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783014)
Ub-82-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783015)
Ub-163-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783025)
Ub-87-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6782998)
Ub-11-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783109)
Ub-124-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783131)
Ub-200-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783100)
Ub-48-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783165)
Ub-181-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783160)
Ub-29-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783070)
0.527
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P03372 ESR1
10
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.527
3
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