Reactome | p-Y342-PTK6 [nucleoplasm]

p-Y342-PTK6 [nucleoplasm]

Stable Identifier

R-HSA-8848937

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

p-Y342-BRK

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q13882 PTK6

Gene Names

PTK6, BRK

Chain

chain:1-451

Reference Genes

BioGPS Gene:5753 PTK6

COSMIC (genes):PTK6 PTK6

CTD Gene:5753 PTK6

dbSNP Gene:5753 PTK6

ENSEMBL:ENSG00000101213 PTK6

ENSEMBL_homo_sapiens_GENE:ENSG00000101213.7 PTK6

HGNC:9617 PTK6

KEGG Gene (Homo sapiens):5753 PTK6

Monarch:5753 PTK6

NCBI Gene:5753 PTK6

OMIM:602004 PTK6

UCSC:Q13882 PTK6

Reference Transcript

Other Identifiers

11748835_a_at

11755228_a_at

1208_at

1553114_3p_a_at

1553114_PM_a_at

1553114_a_at

16921268

206482_PM_at

206482_at

33559_at

3913927

3913928

3913929

3913931

3913932

3913933

3913936

3913937

3913938

3913939

3913941

3913942

5753

8067662

A_23_P56978

GE484877

GE80189

GO:0000166

GO:0001726

GO:0002376

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005102

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006260

GO:0006468

GO:0007169

GO:0007260

GO:0010976

GO:0016020

GO:0016301

GO:0016310

GO:0016477

GO:0016604

GO:0016740

GO:0023052

GO:0030154

GO:0031234

GO:0036211

GO:0038128

GO:0042531

GO:0042802

GO:0042995

GO:0043226

GO:0045087

GO:0045740

GO:0045742

GO:0045787

GO:0045926

GO:0046777

GO:0048856

GO:0048870

GO:0060575

GO:0061099

GO:0071300

GO:0098542

GO:0140096

HMNXSV003006584

Hs2.51133.1.S1_3p_x_at

ILMN_1764508

ILMN_2075800

PH_hs_0003525

TC20001033.hg

X78549_at

g5174646_3p_at

Participates

as an input of

PTK6 binds KHDRBS1 (Homo sapiens)

as an output of

as a component of

p-Y342-PTK6:KHDRBS1 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

p-Y342,Y447-PTK6 [cytosol]

p-Y351-PTK6 [cytosol]

PTK6 [cytosol]

p-Y342-PTK6 [cytosol]

Inferred To

Homologues of p-Y342-PTK6 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-Y342-PTK6 [nucleoplasm] (Bos taurus)

phospho-p-Y342-PTK6 [nucleoplasm] (Caenorhabditis elegans)

phospho-p-Y342-PTK6 [nucleoplasm] (Danio rerio)

phospho-p-Y342-PTK6 [nucleoplasm] (Mus musculus)

phospho-p-Y342-PTK6 [nucleoplasm] (Sus scrofa)

phospho-p-Y342-PTK6 [nucleoplasm] (Xenopus tropicalis)

phospho-Ptk6 [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

O4'-phospho-L-tyrosine at 342

Coordinate

342

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_005966.1, NP_001243287.1

ZINC - World Drugs

PTK6_HUMAN

Guide to Pharmacology - Targets

2182

OpenTargets

ENSG00000101213

ZINC - FDA approved

PTK6_HUMAN

ZINC - Substances

PTK6_HUMAN

ZINC target

Q13882

ZINC - Biogenic

PTK6_HUMAN

PRO

Q13882

PDB

1RJA, 5D7V, 2KGT, 5H2U, 6CZ4, 6CZ2, 5DA3, 6CZ3

ZINC - Investigational

PTK6_HUMAN

GeneCards

Q13882

HPA

ENSG00000101213-PTK6

Ensembl

ENSG00000101213, ENSP00000217185, ENST00000542869, ENSP00000442460, ENST00000217185

Pharos - Targets

Q13882

ZINC - Predictions - Purchasable

PTK6_HUMAN

HMDB Protein

HMDBP01216

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q5JST6 EFHC2			0.781	7
UniProt:O00471 EXOC5	2	EXOC5 [cytosol] (R-HSA-265045) EXOC5 [cytosol] (R-HSA-5623383)	0.718	6
UniProt:Q13882 PTK6	5	p-Y342-PTK6 [nucleoplasm] (R-HSA-8848937) p-Y342,Y447-PTK6 [cytosol] (R-HSA-8849103) p-Y351-PTK6 [cytosol] (R-HSA-8857570) PTK6 [cytosol] (R-HSA-8848000) p-Y342-PTK6 [cytosol] (R-HSA-8848007)	0.713	3
UniProt:Q5VWX1 KHDRBS2	2	KHDRBS2 [nucleoplasm] (R-HSA-8849028) p-Y-KHDRBS2 [nucleoplasm] (R-HSA-8849031)	0.666	4
UniProt:Q92841 DDX17	2	DDX17 [nucleoplasm] (R-HSA-3900090) monoSUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104)	0.666	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.666	4
UniProt:O14526 FCHO1	1	FCHO1 [cytosol] (R-HSA-8862257)	0.666	4
UniProt:P23246 SFPQ	3	SFPQ [cytosol] (R-HSA-9635505) p-Y-SFPQ [nucleoplasm] (R-HSA-8849461) SFPQ [nucleoplasm] (R-HSA-3900138)	0.632	5
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.628	4
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	3
UniProt:Q13064 MKRN3			0.556	3
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.556	3
UniProt:Q8TDC0 MYOZ3			0.556	3
UniProt:Q8N9I9 DTX3			0.556	3
UniProt:Q5T5P2-6 KIAA1217			0.556	3
UniProt:O14770-4 MEIS2			0.556	3
UniProt:Q9BYN7 ZN341			0.556	3
UniProt:Q9UKT9 IKZF3			0.556	3
UniProt:Q13191 CBLB	1	CBLB [cytosol] (R-HSA-976009)	0.556	3
UniProt:Q3KP44 ANR55			0.556	3
UniProt:O00401 WASL	4	N-WASP [cytosol] (R-HSA-201873) p-Y256-WASL [cytosol] (R-HSA-2197672) WASL [plasma membrane] (R-HSA-203010) WASL [endocytic vesicle membrane] (R-HSA-535012)	0.556	3
UniProt:Q13239-3 Q132393			0.556	3
UniProt:P78337 PITX1			0.556	3
UniProt:Q08043 ACTN3	1	ACTN3 [cytosol] (R-HSA-390565)	0.556	3
IntAct:EBI-10171584 80125			0.556	3
UniProt:Q9NQX0 PRDM6			0.556	3
UniProt:P49368 CCT3	1	CCT3 [cytosol] (R-HSA-390463)	0.527	3
UniProt:P50990 CCT8	5	CCT8 [secretory granule lumen] (R-HSA-6801035) CCT8 [ficolin-1-rich granule lumen] (R-HSA-6800894) CCT8 [extracellular region] (R-HSA-6806238) CCT8 [azurophil granule lumen] (R-HSA-6799369) CCT8 [cytosol] (R-HSA-390449)	0.527	3
UniProt:P50991 CCT4	1	CCT4 [cytosol] (R-HSA-390458)	0.527	3
UniProt:P17987 TCP1	1	TCP1 [cytosol] (R-HSA-390448)	0.527	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.499	4

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