Reactome | p-PNPLA2 [endoplasmic reticulum lumen]

p-PNPLA2 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-8956923

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

PNPLA2, Patatin-like phospholipase domain-containing protein 2 ecNumber3.1.1.3/ecNumber, PLPL2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q96AD5 PNPLA2

Gene Names

PNPLA2, ATGL, FP17548

Chain

chain:1-504

Reference Genes

BioGPS Gene:57104 PNPLA2

COSMIC (genes):PNPLA2 PNPLA2

CTD Gene:57104 PNPLA2

dbSNP Gene:57104 PNPLA2

ENSEMBL:ENSG00000177666.17 PNPLA2

HGNC:30802 PNPLA2

KEGG Gene (Homo sapiens):57104 PNPLA2

Monarch:57104 PNPLA2

NCBI Gene:57104 PNPLA2

OMIM:609059 PNPLA2

UCSC:Q96AD5 PNPLA2

Reference Transcript

Other Identifiers

0106370014

11730221_at

11730222_x_at

11730223_a_at

16720353

212705_PM_x_at

212705_x_at

3316288

3316289

3316290

3316291

3316294

3316295

3316297

3316299

3316301

3316303

3316304

3316305

3316306

3316307

3316308

3316309

3316310

3316312

39854_3p_r_at

39854_PM_r_at

39854_r_at

4919656_3p_s_at

57104

7937485

A_14_P130284

A_23_P10077

GO:0003824

GO:0004465

GO:0004623

GO:0004806

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005788

GO:0005789

GO:0005811

GO:0005829

GO:0005886

GO:0006629

GO:0006651

GO:0010891

GO:0010898

GO:0016020

GO:0016021

GO:0016042

GO:0016411

GO:0016740

GO:0016787

GO:0019433

GO:0019915

GO:0034389

GO:0036155

GO:0042572

GO:0043226

GO:0044242

GO:0050253

GO:0051264

GO:0051265

GO:0055088

GO:1905691

HMNXSV003002929

Hs.118463.0.S1_3p_s_at

ILMN_1787923

PH_hs_0006526

TC11000032.hg

Participates

as a member of

FAM20C products [endoplasmic reticulum lumen] (Homo sapiens)

Other forms of this molecule

PNPLA2 [endoplasmic reticulum lumen]

PNPLA2 [endoplasmic reticulum membrane]

Inferred To

phospho-atgl-1 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

phospho-bmm [endoplasmic reticulum lumen] (Drosophila melanogaster)

phospho-p-PNPLA2 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

phospho-p-PNPLA2 [endoplasmic reticulum lumen] (Canis familiaris)

phospho-p-PNPLA2 [endoplasmic reticulum lumen] (Danio rerio)

phospho-pnpla2 [endoplasmic reticulum lumen] (Xenopus tropicalis)

phospho-PNPLA2 [endoplasmic reticulum lumen] (Bos taurus)

phospho-PNPLA2 [endoplasmic reticulum lumen] (Gallus gallus)

phospho-PNPLA2 [endoplasmic reticulum lumen] (Sus scrofa)

phospho-Pnpla2 [endoplasmic reticulum lumen] (Mus musculus)

phospho-Pnpla2 [endoplasmic reticulum lumen] (Rattus norvegicus)

Homologues of p-PNPLA2 [endoplasmic reticulum lumen] (Caenorhabditis elegans)

Homologues of p-PNPLA2 [endoplasmic reticulum lumen] (Drosophila melanogaster)

phospho-dob [endoplasmic reticulum lumen] (Drosophila melanogaster)

Modified Residues

Name

phosphorylated residue at unknown position

PsiMod Name

phosphorylated residue [MOD:00696]

PsiMod Definition

A protein modification that effectively replaces a hydrogen atom with a phosphate group.

Cross References

RefSeq

XP_016873517.1, NP_065109.1

OpenTargets

ENSG00000177666

IntEnz

3.1.1.3

GeneCards

Q96AD5

HPA

ENSG00000177666-PNPLA2

Ensembl

ENST00000336615, ENSG00000177666, ENSP00000337701

PRO

Q96AD5

Pharos - Targets

Q96AD5

Orphanet

16794

HMDB Protein

HMDBP07347

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2

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