The inframe deletion that removes histidine and glutamic acid residues at positions 450 and 451 in the iSH2 domain of PIK3R1 relieves inhibition of PI3K catalytic subunit, PIK3CA, and enables constitutive activity of PI3K complex that contains PIK3R1 H450_E451del mutant (Urick et al. 2011).
Urick, ME, Rudd, ML, Godwin, AK, Sgroi, D, Bell, DW, Merino, M
© 2023 Reactome