Reactome | Polyglutamyl-TUBA4A [cytosol]

Polyglutamyl-TUBA4A [cytosol]

Stable Identifier

R-HSA-8867386

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

TUBA4A, Tubulin alpha-4A chain, alpha tubulin -1, Alpha-tubulin 1

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Carboxyterminal post-translational modifications of tubulin (Homo sapiens)
    - CCPs deglutamylate tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBA4A [cytosol] (Homo sapiens)
    - Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)
      - Alpha-polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Alpha-polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Alpha-polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBA4A [cytosol] (Homo sapiens)
    - TTLLs polyglutamylate tubulin (Homo sapiens)
      - Polyglutamylated microtubule [cytosol] (Homo sapiens)
        
        Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
        
        Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
        
        Polyglutamyl-TUBA4A [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P68366 TUBA4A

Gene Names

TUBA4A, TUBA1

Chain

chain:1-448

Reference Genes

BioGPS Gene:7277 TUBA4A

COSMIC (genes):TUBA4A TUBA4A

CTD Gene:7277 TUBA4A

dbSNP Gene:7277 TUBA4A

ENSEMBL:ENSG00000127824 TUBA4A

HGNC:12407 TUBA4A

KEGG Gene (Homo sapiens):7277 TUBA4A

Monarch:7277 TUBA4A

NCBI Gene:7277 TUBA4A

OMIM:191110 TUBA4A

UCSC:P68366 TUBA4A

Reference Transcript

Other Identifiers

0005720136

11716459_at

11716460_x_at

212242_at

2528412

2528417

2528418

2600069

2600070

2600073

2600075

2600076

2600080

2600081

330_s_at

36591_at

39247

43684

4621

5887

61786_at

63394

7277

8059177

A_23_P154065

A_23_P154070

AAH09238

AAP35377

AAW65371

AC068946

AC114803

AK054731

AK299958

AY895018

BAG51418

BAH13182

BC009238

BT006731

C9JDL2

C9JDS9

C9JEV8

C9JJQ8

C9JQ00

CAA30026

CAB004621

CAB005887

CCDS2438

CCDS63131

CH471063

EAW70718

EAW70719

ENSG00000127824

ENSP00000248437

ENSP00000375938

ENST00000248437

ENST00000248437.8

ENST00000392088

ENST00000392088.6

EntrezGene:7277

EntrezGene:TUBA4A

GE505003

GE86661

GO:0000086

GO:0000166

GO:0000226

GO:0000278

GO:0002576

GO:0003674

GO:0003924

GO:0005198

GO:0005200

GO:0005515

GO:0005525

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005737

GO:0005829

GO:0005856

GO:0005874

GO:0006810

GO:0007010

GO:0007017

GO:0007049

GO:0008150

GO:0010389

GO:0015630

GO:0016192

GO:0019899

GO:0019901

GO:0022607

GO:0043167

GO:0043226

GO:0070062

GO:0097711

HGNC:12407

HPA039247

HPA043684

HPA063394

Hs.75318.0.S1_3p_at

Hs.75318.0.S1_3p_x_at

ILMN_1784300

IPR000217

IPR002452

IPR003008

IPR008280

IPR017975

IPR018316

IPR023123

IPR036525

IPR037103

MIM:191110

MIM:616208

NM_001278552

NM_006000

NP_001265481

NP_005991

PF00091

PF03953

PH_hs_0028966

PH_hs_0031317

PR01161

PR01162

SM00864

SM00865

TC02002793.hg

TUBA4A

TUBA4A-201

TUBA4A-202

UPI0000004129

UPI000013CC44

X06956

X06956_at

Participant Of

hasCandidate

Polyglutamyl alpha tubulin [cytosol]

Other forms of this molecule

TUBA4A [cytosol]

TUBA4A [axonemal microtubule]

TUBA4A [extracellular region]

L-isoglutamyl polyglycyl-TUBA4A [cytosol]

TUBA4A unfolded [cytosol]

TUBA4A folding intermediate [cytosol]

Ac K40 TUBA4A [axonemal microtubule]

AcK-TUBA4A [cytosol]

Inferred To

nda2 [cytosol] (Schizosaccharomyces pombe)

TUB3 [cytosol] (Saccharomyces cerevisiae)

Homologues of Polyglutamyl-TUBA4A [cytosol] (Dictyostelium discoideum)

Homologues of Polyglutamyl-TUBA4A [cytosol] (Plasmodium falciparum)

Homologues of Polyglutamyl-TUBA4A [cytosol] (Saccharomyces cerevisiae)

Homologues of Polyglutamyl-TUBA4A [cytosol] (Schizosaccharomyces pombe)

tubA [cytosol] (Dictyostelium discoideum)

TUBA4A [cytosol] (Bos taurus)

TUBA4A [cytosol] (Canis familiaris)

Tuba4a [cytosol] (Mus musculus)

Tuba4a [cytosol] (Rattus norvegicus)

tub1 [cytosol] (Schizosaccharomyces pombe)

Polyglutamyl-TUBA4A [cytosol] (Dictyostelium discoideum)

Polyglutamyl-TUBA4A [cytosol] (Plasmodium falciparum)

Polyglutamyl-TUBA4A [cytosol] (Sus scrofa)

TUB1 [cytosol] (Saccharomyces cerevisiae)

Modified Residues

Name

L-isoglutamyl-polyglutamic acid at unknown position

PsiMod Name

L-isoglutamyl-polyglutamic acid

PsiMod Definition

A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl-polyglutamic acid, forming an isopeptide bond with a polyglutamic acid.

Cross References

RefSeq

NP_005991.1, NP_001265481.1

Target Pathogen

57c0987dbe737e1cc0a980a0, 57c0840cbe737e1cc0a94465, 5b354852be737e166372e783, 57c0987dbe737e1cc0a9809f, 57c09dd1be737e1cc0a98f68

OpenTargets

ENSG00000127824

GeneCards

P68366

HPA

ENSG00000127824-TUBA4A

Ensembl

ENSP00000375938, ENST00000392088, ENSG00000127824, ENSP00000248437, ENST00000248437

PRO

P68366

Orphanet

25006

HMDB Protein

HMDBP08598

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P30622 CLIP1	1	CLIP1 [cytosol] (R-HSA-377732)	0.618	3
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.527	2
UniProt:P36507 MAP2K2	5	MAP2K2 [cytosol] (R-HSA-59504) p-S222,S226-MAP2K2 [cytosol] (R-HSA-169292) p-S,T-MAP2K2 [cytosol] (R-HSA-109848) MAP2K2(11-400) [cytosol] (R-HSA-5211337) MAP2K2(1-10) [cytosol] (R-HSA-5211334)	0.527	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.527	5

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