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Polyglutamyl-TUBA4A [cytosol]
Stable Identifier
R-HSA-8867386
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
TUBA4A, Tubulin alpha-4A chain, alpha tubulin -1, Alpha-tubulin 1
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Carboxyterminal post-translational modifications of tubulin (Homo sapiens)
CCPs deglutamylate tubulin (Homo sapiens)
Polyglutamylated microtubule [cytosol] (Homo sapiens)
Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
Polyglutamyl-TUBA4A [cytosol] (Homo sapiens)
Polyglutamylase complex (TTLL1) polyglutamylates alpha subunits of tubulin (Homo sapiens)
Polyglutamylated microtubule [cytosol] (Homo sapiens)
Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
Polyglutamyl-TUBA4A [cytosol] (Homo sapiens)
TTLLs polyglutamylate tubulin (Homo sapiens)
Polyglutamylated microtubule [cytosol] (Homo sapiens)
Polyglutamyl microtubule protofilament [cytosol] (Homo sapiens)
Polyglutamyl alpha-beta tubulin dimer [cytosol] (Homo sapiens)
Polyglutamyl alpha tubulin:GTP [cytosol] (Homo sapiens)
Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
Polyglutamyl-TUBA4A [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P68366 TUBA4A
Gene Names
TUBA4A, TUBA1
Chain
chain:1-448
Reference Genes
BioGPS Gene:7277 TUBA4A
COSMIC (genes):TUBA4A TUBA4A
CTD Gene:7277 TUBA4A
dbSNP Gene:7277 TUBA4A
ENSEMBL:ENSG00000127824 TUBA4A
HGNC:12407 TUBA4A
KEGG Gene (Homo sapiens):7277 TUBA4A
Monarch:7277 TUBA4A
NCBI Gene:7277 TUBA4A
OMIM:191110 TUBA4A
UCSC:P68366 TUBA4A
Reference Transcript
RefSeq:NM_006000.2 TUBA4A
RefSeq:NM_001278552.1 TUBA4A
Other Identifiers
0005720136
11716459_at
11716460_x_at
212242_PM_at
212242_at
2528412
2528417
2528418
2600069
2600070
2600073
2600075
2600076
2600080
2600081
330_s_at
36591_at
61786_at
7277
8059177
A_23_P154065
A_23_P154070
GE505003
GE86661
GO:0000166
GO:0000226
GO:0000278
GO:0003674
GO:0003924
GO:0005198
GO:0005200
GO:0005515
GO:0005525
GO:0005575
GO:0005576
GO:0005615
GO:0005622
GO:0005737
GO:0005829
GO:0005856
GO:0005874
GO:0007010
GO:0007017
GO:0007049
GO:0008150
GO:0015630
GO:0019899
GO:0019901
GO:0043167
GO:0043226
GO:0070062
HMNXSV003013201
HMNXSV003042752
Hs.75318.0.S1_3p_at
Hs.75318.0.S1_3p_x_at
ILMN_1784300
PH_hs_0028966
PH_hs_0031317
TC02002793.hg
X06956_at
Participates
as a candidate of
Polyglutamyl alpha tubulin [cytosol] (Homo sapiens)
Other forms of this molecule
AcK-TUBA4A [cytosol]
Ac K40 TUBA4A [axonemal microtubule]
TUBA4A folding intermediate [cytosol]
TUBA4A unfolded [cytosol]
L-isoglutamyl polyglycyl-TUBA4A [cytosol]
TUBA4A [extracellular region]
TUBA4A [axonemal microtubule]
TUBA4A [cytosol]
Inferred To
nda2 [cytosol]
(Schizosaccharomyces pombe)
TUB3 [cytosol]
(Saccharomyces cerevisiae)
Homologues of Polyglutamyl-TUBA4A [cytosol]
(Dictyostelium discoideum)
Homologues of Polyglutamyl-TUBA4A [cytosol]
(Plasmodium falciparum)
Homologues of Polyglutamyl-TUBA4A [cytosol]
(Saccharomyces cerevisiae)
Homologues of Polyglutamyl-TUBA4A [cytosol]
(Schizosaccharomyces pombe)
Homologues of Polyglutamyl-TUBA4A [cytosol]
(Xenopus tropicalis)
tubA [cytosol]
(Dictyostelium discoideum)
TUBA4A [cytosol]
(Bos taurus)
TUBA4A [cytosol]
(Gallus gallus)
TUBA4A [cytosol]
(Sus scrofa)
Tuba4a [cytosol]
(Mus musculus)
Tuba4a [cytosol]
(Rattus norvegicus)
tub1 [cytosol]
(Schizosaccharomyces pombe)
tuba4b [cytosol]
(Xenopus tropicalis)
Polyglutamyl-TUBA4A [cytosol]
(Dictyostelium discoideum)
Polyglutamyl-TUBA4A [cytosol]
(Plasmodium falciparum)
TUB1 [cytosol]
(Saccharomyces cerevisiae)
tuba [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
L-isoglutamyl-polyglutamic acid at unknown position
PsiMod Name
L-isoglutamyl-polyglutamic acid
PsiMod Definition
A protein modification that effectively converts an L-glutamic acid residue to isoglutamyl-polyglutamic acid, forming an isopeptide bond with a polyglutamic acid.
Cross References
RefSeq
NP_001265481.1
,
NP_005991.1
Guide to Pharmacology - Targets
2639
OpenTargets
ENSG00000127824
HPA
ENSG00000127824-TUBA4A
GeneCards
P68366
Ensembl
ENSP00000375938
,
ENST00000392088
,
ENSP00000248437
,
ENST00000248437
,
ENSG00000127824
PRO
P68366
Pharos - Targets
P68366
Orphanet
25006
HMDB Protein
HMDBP08598
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P30622 CLIP1
1
CLIP1 [cytosol]
(R-HSA-377732)
0.618
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.527
5
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.527
2
UniProt:P36507 MAP2K2
12
MAP2K2(1-10) [cytosol]
(R-HSA-5211334)
MAP2K2(11-400) [cytosol]
(R-HSA-5211337)
MAP2K2 C125S [cytosol]
(R-HSA-9652070)
MAP2K2 P128Q [cytosol]
(R-HSA-9652082)
MAP2K2 V35M [cytosol]
(R-HSA-9652086)
MAP2K2 Y134C [cytosol]
(R-HSA-9652089)
p-S222,S226-MAP2K2 [cytosol]
(R-HSA-169292)
MAP2K2 [cytosol]
(R-HSA-59504)
p-S,T-MAP2K2 [cytosol]
(R-HSA-109848)
MAP2K2 N126D [cytosol]
(R-HSA-9652079)
MAP2K2 L46F [cytosol]
(R-HSA-9652076)
MAP2K2 F57C [cytosol]
(R-HSA-9652073)
0.527
3
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