Reactome | GABRA2 [plasma membrane]

GABRA2 [plasma membrane]

Stable Identifier

R-HSA-975254

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Gamma-aminobutyric acid receptor subunit alpha-2, GBRA2_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P47869 GABRA2

Gene Names

GABRA2

Chain

signal peptide:1-28, chain:29-451

Reference Genes

BioGPS Gene:2555 GABRA2

COSMIC (genes):GABRA2 GABRA2

CTD Gene:2555 GABRA2

dbSNP Gene:2555 GABRA2

ENSEMBL:ENSG00000151834.16 GABRA2

HGNC:4076 GABRA2

KEGG Gene (Homo sapiens):2555 GABRA2

Monarch:2555 GABRA2

NCBI Gene:2555 GABRA2

OMIM:137140 GABRA2

UCSC:P47869 GABRA2

Reference Transcript

Other Identifiers

11731933_a_at

1564841_PM_at

1564841_at

1679_at

16975607

207014_PM_at

207014_at

216039_PM_at

216039_at

237250_PM_at

237250_at

2555

2767965

2767967

2767969

2767971

2767973

2767974

2767975

2767981

2767988

2767989

2767992

2767995

2768002

2768006

2768008

2768009

2768010

2768011

2768012

37062_at

4026100

60578_at

8100109

A_32_P226200

D38503_at

GE61556

GE752657

GO:0001505

GO:0004888

GO:0004890

GO:0005215

GO:0005216

GO:0005230

GO:0005231

GO:0005237

GO:0005254

GO:0005515

GO:0005886

GO:0006811

GO:0006821

GO:0006836

GO:0007165

GO:0007214

GO:0007268

GO:0008503

GO:0016020

GO:0016021

GO:0022851

GO:0023052

GO:0030424

GO:0030425

GO:0030594

GO:0030659

GO:0030672

GO:0031410

GO:0032590

GO:0034220

GO:0034330

GO:0034707

GO:0042391

GO:0042995

GO:0043005

GO:0043025

GO:0043226

GO:0045202

GO:0045211

GO:0048856

GO:0050877

GO:0051932

GO:0055085

GO:0060077

GO:0060078

GO:0060079

GO:0060089

GO:0097060

GO:0098794

GO:0098982

GO:0099505

GO:0099507

GO:0099634

GO:1902476

GO:1902711

GO:1904315

GO:1904862

HMNXSV003006017

HMNXSV003008462

HMNXSV003032905

Hs.180121.0.A1_3p_at

Hs.48372.0.S1_3p_at

Hs2.383795.1.S1_3p_at

ILMN_1659678

ILMN_1870893

PH_hs_0003391

PH_hs_0005075

S62907_s_at

TC04002535.hg

TC04002536.hg

g4557600_3p_at

p12295

Participates

as a member of

GABRAs [plasma membrane] (Homo sapiens)

as a component of

GABRA2:ARHGEF9 [plasma membrane] (Homo sapiens)

Inferred To

gabra2 [plasma membrane] (Xenopus tropicalis)

Gabra2 [plasma membrane] (Mus musculus)

Gabra2 [plasma membrane] (Rattus norvegicus)

Lcch-14A [plasma membrane] (Drosophila melanogaster)

Grd [plasma membrane] (Drosophila melanogaster)

lgc-36 [plasma membrane] (Caenorhabditis elegans)

GABRA2 [plasma membrane] (Bos taurus)

GABRA2 [plasma membrane] (Canis familiaris)

GABRA2 [plasma membrane] (Danio rerio)

GABRA2 [plasma membrane] (Gallus gallus)

GABRA2 [plasma membrane] (Sus scrofa)

Homologues of GABRA2 [plasma membrane] (Caenorhabditis elegans)

Homologues of GABRA2 [plasma membrane] (Drosophila melanogaster)

lgc-37 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001317619.1, NP_000798.2, NP_001273756.1, NP_001107647.1, XP_016863471.1, XP_016863472.1

ZINC - World Drugs

GBRA2_HUMAN

Guide to Pharmacology - Targets

405

OpenTargets

ENSG00000151834

ZINC - FDA approved

GBRA2_HUMAN

ZINC - Substances

GBRA2_HUMAN

ZINC target

P47869

PRO

P47869

GeneCards

P47869

HPA

ENSG00000151834-GABRA2

Ensembl

ENST00000356504, ENSP00000348897, ENST00000381620, ENSG00000151834, ENSP00000371033, ENST00000510861, ENST00000514090, ENSP00000421300, ENSP00000421828

Pharos - Targets

P47869

ZINC - Predictions - Purchasable

GBRA2_HUMAN

Orphanet

28459

HMDB Protein

HMDBP08199

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.499	2