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SKAP2 [cytosol]
Stable Identifier
R-HSA-390927
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Src kinase-associated phosphoprotein 2 (SCAP2), SKAP2_HUMAN
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Signal regulatory protein family interactions (Homo sapiens)
p-4Y-SIRPA:CD47 binds SKAP2 (Homo sapiens)
SKAP2 [cytosol] (Homo sapiens)
p-Y429,Y453,Y470,Y496-SIRPA:CD47:SKAP2 [plasma membrane] (Homo sapiens)
SKAP2 [cytosol] (Homo sapiens)
p-4Y-SIRPA:CD47:SKAP2 binds FYB (Homo sapiens)
p-Y429,Y453,Y470,Y496-SIRPA:CD47:SKAP2 [plasma membrane] (Homo sapiens)
SKAP2 [cytosol] (Homo sapiens)
p-Y429,Y453,Y470,Y496y-SIRPA:CD47:SKAP2:FYB [plasma membrane] (Homo sapiens)
p-Y429,Y453,Y470,Y496-SIRPA:CD47:SKAP2 [plasma membrane] (Homo sapiens)
SKAP2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75563 SKAP2
Gene Names
SKAP2, PRAP, RA70, SAPS, SCAP2, SKAP55R
Chain
chain:1-359
Reference Genes
BioGPS Gene:8935 SKAP2
COSMIC (genes):SKAP2 SKAP2
CTD Gene:8935 SKAP2
dbSNP Gene:8935 SKAP2
ENSEMBL:ENSG00000005020 SKAP2
ENSEMBL_homo_sapiens_GENE:ENSG00000005020.13 SKAP2
HGNC:15687 SKAP2
KEGG Gene (Homo sapiens):8935 SKAP2
Monarch:8935 SKAP2
NCBI Gene:8935 SKAP2
OMIM:605215 SKAP2
UCSC:O75563 SKAP2
Reference Transcript
RefSeq:NM_003930.4 SKAP2
RefSeq:NM_001303468.1 SKAP2
RefSeq:XM_017012771.1 SKAP2
Other Identifiers
11720044_at
11749275_a_at
11758114_x_at
17056072
204361_PM_s_at
204361_s_at
204362_PM_at
204362_at
216899_PM_s_at
216899_s_at
225639_PM_at
225639_at
3042629
3042630
3042631
3042632
3042634
3042642
3042644
3042649
3042650
3042653
3042656
3042657
3042668
3042673
3042676
3042677
3042678
36091_at
64467_at
8138689
8935
A_23_P157128
A_33_P3388312
GE54436
GO:0002376
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0007165
GO:0008285
GO:0023052
GO:0042113
GO:0043226
HMNXSV003011544
HMNXSV003014482
Hs.52644.1.S1_3p_a_at
Hs.5888.0.A1_3p_at
ILMN_1657129
ILMN_2125010
PH_hs_0030091
TC07001217.hg
g4506962_3p_at
g4506962_3p_x_at
Participates
as a component of
p-Y429,Y453,Y470,Y496-SIRPA:CD47:SKAP2 [plasma membrane] (Homo sapiens)
as an input of
p-4Y-SIRPA:CD47 binds SKAP2 (Homo sapiens)
Inferred To
SKAP2 [cytosol]
(Bos taurus)
SKAP2 [cytosol]
(Canis familiaris)
SKAP2 [cytosol]
(Gallus gallus)
SKAP2 [cytosol]
(Sus scrofa)
Skap2 [cytosol]
(Mus musculus)
Skap2 [cytosol]
(Rattus norvegicus)
Cross References
RefSeq
NP_001290397.1
,
NP_003921.2
,
XP_016868260.1
OpenTargets
ENSG00000005020
GeneCards
O75563
HPA
ENSG00000005020-SKAP2
Ensembl
ENSP00000005587
,
ENST00000345317
,
ENSG00000005020
PRO
O75563
Pharos - Targets
O75563
PDB
3OMH
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9Y2R2 PTPN22
1
PTPN22 [cytosol]
(R-HSA-8852205)
0.611
3
UniProt:P06241 FYN
6
p-S21,Y420-FYN [cytosol]
(R-HSA-5218745)
p-Y531-FYN [cytosol]
(R-HSA-391819)
MyrG2-PalmC3,6-FYN [plasma membrane]
(R-HSA-9606873)
p-Y420-FYN [cytosol]
(R-HSA-391821)
MyrG-p-Y420-FYN [plasma membrane]
(R-HSA-1810410)
FYN [cytosol]
(R-HSA-200917)
0.547
2
UniProt:Q8WTS1 ABHD5
2
ABHD5 [lipid droplet]
(R-HSA-163485)
ABHD5 [cytosol]
(R-HSA-163531)
0.527
2
UniProt:Q8N878 FRMD1
0.527
2
UniProt:P63162 SNRPN
1
Me2-R108,R112-SNRPN [nucleoplasm]
(R-HSA-8865931)
0.527
2
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.508
2
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