complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane]

Stable Identifier
R-COV-9694343
Type
Protein [EntityWithAccessionedSequence]
Species
Severe acute respiratory syndrome coronavirus 2
Compartment
Synonyms
P0DTC2
Locations in the PathwayBrowser
General

SARS-CoV-2 mRNA2 open reading frame has a length of 3,822 nt and encodes the 1,273 aa spike preprotein (Wu et al, 2020).

Literature References
PubMed ID Title Journal Year
12775768 Mass spectrometric characterization of proteins from the SARS virus: a preliminary report

Plummer, F, Jones, S, Flick, R, Wilkins, J, Krokhin, O, Cheng, K, Perreault, H, Bastien, N, Ens, W, Feldmann, H, Li, Y, Standing, KG, Stroeher, U, Simonsen, JN, Andonov, A, Dasuri, KV

Mol. Cell Proteomics 2003
16122388 The SARS coronavirus S glycoprotein receptor binding domain: fine mapping and functional characterization

Xiao, X, Chakraborti, S, Prabakaran, P, Dimitrov, DS

Virol. J. 2005
20129637 Identification of N-linked carbohydrates from severe acute respiratory syndrome (SARS) spike glycoprotein

Feldmann, H, Feldmann, F, Rudd, PM, Stroeher, U, Royle, L, Harvey, DJ, Dwek, RA, Ritchie, G

Virology 2010
15253436 Proteomic analysis of SARS associated coronavirus using two-dimensional liquid chromatography mass spectrometry and one-dimensional sodium dodecyl sulfate-polyacrylamide gel electrophoresis followed by mass spectroemtric analysis

Zhou, H, Ruan, HQ, Wu, JR, Zeng, R, Sheng, QH, Xia, QC, Jiang, XS, Zhang, L, Tu, Q, Shi, L

J. Proteome Res. 2004
14760722 Proteomic analysis on structural proteins of Severe Acute Respiratory Syndrome coronavirus

Hao, Y, He, F, Li, X, Shi, R, Qin, E, Li, D, Li, W, Wei, H, Peng, W, Wan, P, Wu, S, Du, C, Ying, W, Wang, J, Cao, C, Cai, Y, Dai, J, Dai, S, Yu, M, Dong, F, Li, J, Guo, L, Liu, H, Zhang, Y, Qian, X, Wan, J, Zhang, X, Kuai, X, Zhu, Y, Wang, J, Wang, D, Chen, T, Wei, K, Sun, W, Chang, G, Zhu, Q

Proteomics 2004
17715238 Specific asparagine-linked glycosylation sites are critical for DC-SIGN- and L-SIGN-mediated severe acute respiratory syndrome coronavirus entry

Cho, MW, Han, DP, Lohani, M

J. Virol. 2007
External Reference Information
External Reference
Gene Names
S, 2
Chain
signal peptide:1-12, chain:13-1273, chain:13-685, chain:686-1273, chain:816-1273
Reference Transcript
Participates
Other forms of this molecule
Inferred From
Modified Residues
Name
palmitoylated-L-cysteine at unknown position
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-cysteine residue to a palmitoylated-L-cysteine, such as N-palmitoyl-L-cysteine or S-palmitoyl-L-cysteine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 1074
Coordinate
1074
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (high-mannose N-glycan-yl group) at 801
Coordinate
801
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 1098
Coordinate
1098
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 1134
Coordinate
1134
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (tri-antennary complex N-glycan group) at 1173
Coordinate
1173
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (sialylated complex N-glycan group) at 1158
Coordinate
1158
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Name
N4-(N-acetylamino)glucosyl-L-asparagine (sialylated complex N-glycan group) at 1194
Coordinate
1194
Modification
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-asparagine residue to N4-(N-acetylaminoglucosyl)-L-asparagine.
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
GlyGen
PDB
7FDI, 7DX5, 7E86, 6YLA, 7OAO, 6ZXN, 7KNI, 7CAB, 6VW1, 7V7N, 7L7K, 7D4G, 7KQB, 7L02, 7KML, 7M7B, 6M0J, 7BEM, 7MZG, 7MJN, 7LS9, 7LAB, 7V7J, 7K8X, 7CWN, 7KDK, 6YZ7, 7E23, 7DD8, 7KFV, 7V89, 7N1U, 7CHC, 6XEY, 7R6W, 7LC8, 7JVB, 7NXC, 7V80, 7LXZ, 7V78, 7DDD, 7CZR, 6YM0, 7EB5, 7LCN, 7NDA, 7MKB, 7M7W, 6VXX, 7FDK, 6ZGG, 7E88, 7N8I, 7MZH, 7KL9, 6ZP5, 7L06, 7E39, 7K8Y, 6WPT, 7LYP, 7DK3, 7LWS, 7C8V, 7N1V, 6XF5, 6XE1, 7V7Z, 7JMW, 7M71, 7MJJ, 7KDJ, 7L7F, 7KKK, 7ND8, 7E7Y, 7CZP, 7LRS, 7MZF, 6VSB, 7C8D, 7MJM, 7CHB, 7CZZ, 7LAA, 7D2Z, 7V7I, 7K8W, 6ZP1, 6WPS, 7JV4, 7C53, 7N1T, 7DD2, 7B3O, 7V87, 7B62, 7JVA, 7A98, 7FDH, 7NXB, 7DX4, 7LXY, 7KEC, 7KNH, 7OAN, 7V77, 7LWQ, 7A5S, 7DK0, 7D30, 7N6E, 7KKL, 7ND9, 6ZGE, 7EB4, 7N8H, 7CZQ, 6ZP2, 7BEL, 7LRT, 6ZWV, 7KMK, 7C8J, 7CWM, 7LYO, 7JV6, 7MJK, 6ZFO, 7CN9, 7V88, 7A91, 6YZ5, 7K4N, 7K8M, 6XC2, 7M53, 7NDC, 7DWX, 7KFY, 7JW0, 7K90, 7FG3, 7NT9, 7CZT, 6M1V, 7DX8, 7L2D, 7LWK, 7V7P, 6ZB4, 7KE4, 7EDG, 7N1X, 7CWS, 7S0C, 7DK5, 7BWJ, 6VYB, 7KMZ, 7N9B, 7KLH, 7LDJ, 7E3J, 7KRR, 7OAQ, 7R8L, 7L4Z, 7V7A, 7KLW, 7BNN, 7LY2, 7EAM, 6ZLR, 7MKM, 7V82, 7M8K, 7FG7, 7S0D, 7CAI, 7L2E, 7M6D, 7V7Q, 7LWL, 6ZH9, 7N0H, 7DK6, 7BYR, 7CZU, 7E8C, 6ZOW, 7V8B, 7MZJ, 7CHH, 7BH9, 7A92, 7OAU, 7E3K, 7KN3, 7MDW, 6XKQ, 7DEO, 7L56, 7LWU, 7V7D, 6X2A, 7LQ7, 7BEP, 7ORB, 7JWB, 7LSS, 7V79, 7OAP, 7OR9, 7F63, 7CAC, 7OLZ, 7V7O, 7LYQ, 7R7N, 7LWI, 7FG2, 7LD1, 7DX6, 7JVC, 6XKL, 7E3B, 7CWO, 7BEN, 7EDF, 7KQE, 7DK4, 6M17, 7KDL, 7KFW, 7F62, 6YOR, 7KLG, 6ZP7, 7R6X, 7LJR, 7KMS, 7K43, 7CHE, 7BNM, 7V81, 7LY0, 7L0N, 7NDB, 7MKL, 7CAH, 7C8W, 7M8J, 7KFX, 6ZGI, 7L3N, 7LOP, 7L2C, 7CZS, 7LWJ, 7DX7, 7DDN, 7V8A, 6XKP, 7K8Z, 7M42, 7MZI, 7L09, 7S0B, 7N9A, 7KRQ, 7LWT, 6X29, 7MJL, 7LO4, 7K45, 7BEO, 7LM8, 7E3C, 6XF6, 7CHF, 7N1W, 7N0G, 7ORA, 7JJC, 7RTD, 7LWN, 7A94, 7E5R, 7V84, 7RNJ, 7CHP, 7MZL, 7RKV, 7JZL, 7KJ2, 7MF1, 7KMB, 7K8T, 7V7S, 7KDG, 7NTC, 7M6F, 7L2F, 7LYK, 7ND4, 7E8M, 7V7F, 7MEJ, 7NX6, 7KSG, 7MM0, 7KN5, 7P78, 7N9E, 7M8T, 7DZX, 7LWW, 7D03, 7L57, 6ZBP, 7CWU, 7AKD, 7N1E, 7LQV, 7M6G, 6XC7, 7KZB, 7D0B, 7DX0, 7MMO, 7EJ4, 7KN6, 7JZM, 6X79, 7KJ3, 7EH5, 7N4J, 7CAN, 7M0J, 7EAZ, 7NX7, 7MZM, 7RAL, 6XM3, 7B14, 6ZOY, 7RR0, 7BEH, 7N9T, 6ZCZ, 7CYH, 7CZW, 7NEH, 7KXK, 7DEU, 7K9J, 7DZY, 7EY4, 6LXT, 7KE8, 7EDJ, 7RA8, 6LVN, 7MTD, 7R8O, 7L58, 7LWM, 7NDD, 7KM5, 7DWY, 7JWY, 7DMU, 6Z97, 7P77, 7E3O, 7CHO, 6XC3, 7RKU, 6ZB5, 7DPM, 7MZK, 7MLZ, 7S0E, 7N1A, 7M6E, 7K8S, 7BNO, 7V7R, 7DX9, 7S4S, 7KGJ, 6XLU, 7NTA, 7BZ5, 7N1Y, 7ND3, 7V8C, 7R8M, 7E3L, 6Z2M, 7K9H, 7KRS, 7OAY, 7D00, 7CWT, 7M8S, 7LWV, 7EDH, 7N9C, 7KE6, 6XC4, 7DWZ, 6X2C, 7LY3, 7EAN, 7JX3, 6X6P, 7V83, 7E5O, 7KXJ, 7N4I, 7NKT, 6XM0, 7KGK, 7CAK, 7N1B, 7DK7, 6ZOX, 7EY0, 7CZV, 6Z43, 7E8F, 7NEG, 7DET, 7R8N, 7K9I, 7KN4, 7ME7, 7A93, 7N3I, 6X2B, 7MTC, 7DZW, 7V7E, 7P3D, 7KE7, 7EDI, 6ZHD, 7KS9, 7LXW, 7M6I, 7LWO, 6XDG, 7MJI, 7DX2, 7FDG, 7DF4, 7A96, 7NX9, 7K8V, 7A29, 7AD1, 7A5R, 7CZY, 6XCN, 7V26, 7V7H, 7JZU, 7LYM, 7KMH, 6ZP0, 7MY3, 7BEJ, 7N1Q, 7CYV, 7V86, 7JMO, 7CJF, 7JV2, 7A4N, 6ZDH, 7A97, 7V76, 7V7V, 7E7X, 7LXX, 7KNE, 7DX3, 7LQW, 7D0D, 7LWP, 7KEB, 7C01, 7V2A, 7KDI, 6ZER, 7B18, 7N6D, 7MY8, 7EB3, 7NXA, 7CT5, 7P7B, 7N64, 7CN4, 7KMI, 7DHX, 7DJZ, 7CH5, 7ND7, 7LYN, 7CWL, 7KJ5, 7BEK, 7L7E, 7JMP, 7EZV, 7E7D, 7C2L, 7DCX, 7M6H, 7E5Y, 7V7T, 7MJG, 7CHS, 6XRA, 7A95, 7K9K, 7DX1, 7KN7, 7K8U, 7NX8, 7JJI, 6XM4, 7LYL, 7V7G, 6ZOZ, 6ZDG, 6W41, 7BEI, 6XCM, 7ND5, 7KMG, 7JZN, 6XR8, 7P79, 7DF3, 6LZG, 7RTR, 7MFU, 7M3I, 7KE9, 7CDI, 7EY5, 7M8U, 7CM4, 7D0C, 7EB0, 7V7U, 7RXD, 7N1F, 7EYA, 7RW2, 7MJH, 7EK6, 7KEA, 6XM5, 7A25, 7B17, 7KDH, 7CH4, 7JJJ, 7MZN, 7K9Z, 7KNB, 6XS6, 7CZX, 7MTE, 7R95, 7MY2, 7DCC, 7L5B, 7L7D, 7EJ5, 7KJ4, 7ND6, 7V85, 7E7B, 7CYP, 7N62, 7P7A, 7LX5, 7CDJ
Interactors (58)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:Q9BYF1 ACE2  5 0.997 224
 UniProt:P0DTC2 S  16 0.985 54
 UniProt:Q9NNX6 CD209  1 0.888 12
 UniProt:Q9H2X3 CLC4M      0.857 12
 UniProt:P09958 FURIN  4 0.854 5
 UniProt:P11021 HSPA5  6 0.746 8
 UniProt:Q9C0B5 ZDHHC5  1 0.725 5
 UniProt:Q7Z5G4 GOLGA7  3 0.725 5
 UniProt:Q8R0I0  1 0.688 4
 UniProt:Q8IUN9-2 CLEC10A      0.683 4
 UniProt:P35247-PRO_0000017465 SFTPD      0.683 11
 UniProt:Q96D42 HAVR1      0.667 7
 UniProt:Q96L92 SNX27      0.664 16
 UniProt:P30530 AXL  2 0.655 9
 UniProt:P35613 BSG  2 0.652 7
 IntAct:EBI-26657218 PEPTIDE      0.645 7
 ChEBI:17033 BILIVERDIN      0.642 9
 UniProt:Q58DD0 ACE2      0.641 3
 UniProt:O14786 NRP1  1 0.639 9
 maltose [ChEBI:17306]  2 0.623 3
 UniProt:Q8IUN9 CLEC10A  1 0.623 4
 ChEBI:28304 HEPARIN      0.623 5
 UniProt:Q96LC7 SIGLEC10  1 0.623 2
 UniProt:P07711 CTSL  8 0.623 3
 UniProt:P59665-PRO_0000006773 DEFA1      0.618 3
 UniProt:A5CKE2 A5CKE2      0.618 3
 UniProt:P31431 SDC4  20 0.599 17
 hemin [ChEBI:50385]  1 0.59 2
 UniProt:P14635 CCNB1  4 0.59 2
 IntAct:EBI-27090397 RC-101      0.558 2
 cholesterol [ChEBI:16113]  20 0.558 5
 N-acetylneuraminic acid [ChEBI:17012]  4 0.558 2
 UniProt:Q07021-PRO_0000018590 C1QBP      0.558 2
 UniProt:Q61830 Mrc1  4 0.558 2
 lipopolysaccharide [ChEBI:16412]  5 0.558 3
 UniProt:P35247 SFTPD  3 0.544 3
 UniProt:P01130 LDLR  4 0.537 4
 UniProt:P00533 EGFR  20 0.537 4
 IntAct:EBI-26657222 PEPTIDE      0.525 2
 IntAct:EBI-26657225 PEPTIDE      0.525 2
 IntAct:EBI-26997889 ACE2      0.524 2
 UniProt:A0A1S3APE5 A0A1S3APE5      0.524 2
 UniProt:Q5EGZ1  1 0.524 2
 UniProt:E2DHI3 E2DHI3      0.524 2
 UniProt:Q14416 GRM2  1 0.524 4
 linoleic acid [ChEBI:17351]  6 0.522 2
 UniProt:P35579 MYH9  3 0.518 7
 UniProt:P35606 COPB2  4 0.499 3
 UniProt:Q5EA32  1 0.499 3
 UniProt:Q9Y5S1 TRPV2  1 0.499 2
 UniProt:Q5MNZ6 WDR45B  1 0.499 4
 UniProt:Q15436 SEC23A  4 0.499 20
 UniProt:Q15005 SPCS2  1 0.499 2
 UniProt:P26038 MSN  4 0.499 20
 UniProt:P0DTD1-PRO_0000449625 REP      0.488 2
 UniProt:P0DTD1-PRO_0000449627 REP      0.488 2
 UniProt:P0DTD1-PRO_0000449628 REP      0.488 2
 UniProt:P15311 EZR  3 0.483 10
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