Reactome | p-Y1349,Y1356-MET [plasma membrane]

p-Y1349,Y1356-MET [plasma membrane]

Stable Identifier

R-HSA-6807032

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

p-2Y-MET

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Locations in the PathwayBrowser

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Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by MET (Homo sapiens)
    - Negative regulation of MET activity (Homo sapiens)
      - PTPN1 and PTPN2 dephosphorylate MET (Homo sapiens)
        
        HGF:p-Y,1349,Y1356-MET dimer [plasma membrane] (Homo sapiens)
        
        HGF dimer:p-Y1349,Y1356-MET [plasma membrane] (Homo sapiens)
        
        p-Y1349,Y1356-MET [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P08581 MET

Gene Names

MET

Chain

signal peptide:1-24, chain:25-1390

Reference Genes

BioGPS Gene:4233 MET

COSMIC (genes):MET MET

CTD Gene:4233 MET

dbSNP Gene:4233 MET

ENSEMBL:ENSG00000105976 MET

ENSEMBL_homo_sapiens_GENE:ENSG00000105976.16 MET

HGNC:7029 MET

KEGG Gene (Homo sapiens):4233 MET

Monarch:4233 MET

NCBI Gene:4233 MET

OMIM:164860 MET

UCSC:P08581 MET

Reference Transcript

Other Identifiers

11716407_a_at

11716408_a_at

11735116_a_at

11751246_a_at

11752248_a_at

11754144_a_at

1609_g_at

17050591

1812_s_at

203510_PM_at

203510_at

211599_PM_x_at

211599_x_at

213807_PM_x_at

213807_x_at

213816_PM_s_at

213816_s_at

3020342

3020344

3020348

3020349

3020350

3020363

3020365

3020366

3020367

3020374

3020377

3020378

3020379

3020380

3020381

3020382

3020384

3020385

3020387

3020390

3020391

3020392

3020393

3020395

3020396

3020397

3020399

3020401

3020402

3020403

3020404

3020405

3020406

3020407

3020408

3020409

3020410

3020411

3020412

3020420

35684_at

4233

46302_at

8135601

A_14_P102324

A_14_P113351

A_14_P119122

A_14_P137799

A_23_P145844

A_23_P145846

A_23_P359245

GE57468

GO:0000166

GO:0001886

GO:0001889

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0005008

GO:0005515

GO:0005524

GO:0005576

GO:0005886

GO:0006351

GO:0006355

GO:0006468

GO:0006909

GO:0006914

GO:0007010

GO:0007165

GO:0007166

GO:0007169

GO:0007399

GO:0009925

GO:0009986

GO:0010507

GO:0012501

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016477

GO:0016740

GO:0017154

GO:0019903

GO:0023052

GO:0030154

GO:0030182

GO:0031016

GO:0031116

GO:0035024

GO:0036211

GO:0042802

GO:0043235

GO:0045944

GO:0048012

GO:0048754

GO:0048856

GO:0048870

GO:0050896

GO:0050918

GO:0051497

GO:0060089

GO:0061436

GO:0065003

GO:0070495

GO:0071526

GO:0098772

GO:0140096

GO:0140677

GO:1901299

GO:1905098

GO:2001028

HMNXSV003052945

Hs.285754.0.S2_3p_at

Hs.285754.1.S1_3p_a_at

ILMN_1715175

PH_hs_0025104

TC07000722.hg

g625085_3p_s_at

Participates

as a component of

HGF dimer:p-Y1349,Y1356-MET [plasma membrane] (Homo sapiens)

Other forms of this molecule

p-Y1234,Y1235,Y1356-MET [plasma membrane]

MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]

MonoUb-K,p-Y1003,4Y-MET [plasma membrane]

p-Y1003,4Y-MET [plasma membrane]

MET [plasma membrane]

p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane]

Inferred To

Homologues of p-Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)

phospho-p-Y1349,Y1356-MET [plasma membrane] (Bos taurus)

phospho-p-Y1349,Y1356-MET [plasma membrane] (Caenorhabditis elegans)

phospho-p-Y1349,Y1356-MET [plasma membrane] (Canis familiaris)

phospho-p-Y1349,Y1356-MET [plasma membrane] (Gallus gallus)

phospho-p-Y1349,Y1356-MET [plasma membrane] (Mus musculus)

phospho-p-Y1349,Y1356-MET [plasma membrane] (Rattus norvegicus)

phospho-p-Y1349,Y1356-MET [plasma membrane] (Sus scrofa)

phospho-p-Y1349,Y1356-MET [plasma membrane] (Xenopus tropicalis)

Modified Residues

Name

O4'-phospho-L-tyrosine at 1349

Coordinate

1349

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 1356

Coordinate

1356

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001120972.1, NP_000236.2

ZINC - World Drugs

MET_HUMAN

Guide to Pharmacology - Targets

1815

OpenTargets

ENSG00000105976

ZINC - FDA approved

MET_HUMAN

ZINC - Substances

MET_HUMAN

ZINC target

P08581

ZINC - Biogenic

MET_HUMAN

PRO

P08581

PDB

3DKF, 3C1X, 7B42, 1FYR, 8AU5, 3F66, 3R7O, 6I04, 3CCN, 7V3S, 7B44, 7B3T, 4R1V, 8OWG, 4DEH, 3VW8, 4K3J, 8OUV, 6SDE, 3BUX, 5LSP, 1R0P, 7B3W, 5HTI, 3RHK, 2UZY, 5HOA, 2WKM, 7B41, 8AW1, 2RFN, 3EFK, 3ZXZ, 3ZC5, 3CD8, 4XMO, 5DG5, 6UBW, 4AP7, 3U6I, 6SD9, 7Y4T, 5HOR, 7MOA, 3U6H, 3LQ8, 7V3R, 5HLW, 8GVJ, 1SSL, 1SHY, 4KNB, 5EOB, 4IWD, 4GG7, 3ZCL, 4MXC, 3Q6W, 8AN8, 8AU3, 5UAB, 5UAD, 3ZZE, 3I5N, 7MO9, 3CTH, 1R1W, 5T3Q, 3DKC, 7B43, 4O3U, 8OUU, 5HNI, 5EYC, 4GG5, 4DEI, 6SDD, 8OW3, 6GCU, 5HO6, 4R1Y, 3A4P, 7B3Z, 4AOI, 7B40, 4EEV, 3DKG, 2UZX, 8OV7, 4O3T, 7Y4U, 4XYF, 3L8V, 7B3Q, 8ANS, 3QTI, 3EFJ, 4DEG, 6SDC, 7MOB, 5EYD, 7B3V, 7MO7, 3CE3, 8OVZ, 3Q6U, 2G15, 2RFS, 5YA5, 3ZBX, 3CTJ, 6WVZ, 2WGJ, 2WD1, 7MO8, 3F82

ZINC - Investigational

MET_HUMAN

ZINC - Metabolites

MET_HUMAN

GeneCards

P08581

HPA

ENSG00000105976-MET

Ensembl

ENSP00000380860, ENST00000436117, ENSP00000410980, ENST00000318493, ENST00000397752, ENSP00000317272, ENSG00000105976

Pharos - Targets

P08581

ZINC - Predictions - Purchasable

MET_HUMAN

Orphanet

16392

HMDB Protein

HMDBP09447

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.863	17
UniProt:P14210 HGF	5	HGF(32-494) [platelet alpha granule lumen] (R-HSA-139866) HGF(495-728) [platelet alpha granule lumen] (R-HSA-141764) pro-HGF [extracellular region] (R-HSA-6800218) HGF(495-728) [extracellular region] (R-HSA-141767) HGF(32-494) [extracellular region] (R-HSA-56497)	0.851	7
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.8	8
UniProt:P12931 SRC	6	p-Y419-SRC [nucleoplasm] (R-HSA-8937690) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.787	7
UniProt:O43157 PLXNB1	2	PLXNB1 [plasma membrane] (R-HSA-3008951) p-Y-PLXNB1 [plasma membrane] (R-HSA-419609)	0.775	9
UniProt:Q12913 PTPRJ	2	PTPRJ [plasma membrane] (R-HSA-6785269) PTPRJ [specific granule membrane] (R-HSA-6799570)	0.733	5
UniProt:P18031 PTPN1	2	PTPN1 [cytosol] (R-HSA-210625) PTPN1 [endosome membrane] (R-HSA-9815895)	0.713	3
UniProt:P14210-6 HGF			0.676	3
UniProt:Q96EY1 DNJA3			0.636	4
UniProt:P0DQD2 inlB	1	InlB [peptidoglycan-based cell wall] (R-LMO-9637760)	0.618	4
UniProt:P08581 MET	7	p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-HSA-6807014) p-Y1349,Y1356-MET [plasma membrane] (R-HSA-6807032) MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-8875181) MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-HSA-8875180) p-Y1003,4Y-MET [plasma membrane] (R-HSA-8874689) MET [plasma membrane] (R-HSA-419603) p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-6806973)	0.609	2
UniProt:Q06124 PTPN11	4	p-Y542-PTPN11 [cytosol] (R-HSA-1369081) PTPN11 [nucleoplasm] (R-HSA-8937745) PTPN11 [cytosol] (R-HSA-162563) p-Y542,Y580-PTPN11 [cytosol] (R-HSA-162573)	0.609	13
UniProt:Q00944	11	phospho-pY-PTK2 [cytosol] (R-GGA-9632393) phospho-p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-GGA-8874613) phospho-p-Y194,Y397-PTK2 [cytosol] (R-GGA-8874600) phospho-p-5Y-PTK2 [cytosol] (R-GGA-5218711) phospho-p-5Y,S732-PTK2 [cytosol] (R-GGA-5229006) phospho-p-6Y,S732-PTK2 [cytosol] (R-GGA-5218694) PTK2(773-1052) [cytosol] (R-GGA-202829) PTK2(1-772) [cytosol] (R-GGA-202827) PTK2 [cytosol] (R-GGA-201621) phospho-p-Y397-PTK2 [cytosol] (R-GGA-354068) phospho-p-6Y-PTK2 [cytosol] (R-GGA-354128)	0.602	5
UniProt:Q96S59 RANBP9	1	RANBP9 [cytosol] (R-HSA-374586)	0.593	3
UniProt:Q16827 PTPRO	1	PTPRO [plasma membrane] (R-HSA-9603761)	0.59	2
UniProt:P35918 Kdr	5	p-Y799,Y1052,Y1172-Kdr [plasma membrane] (R-MMU-9860469) Kdr [plasma membrane] (R-MMU-9860502) Mouse Vegfr2-Human CSF1R fusion protein [plasma membrane] (R-MMU-5218738) VEGFR2 [plasma membrane] (R-MMU-195382) phospho-p-6Y-VEGFR2 [plasma membrane] (R-MMU-4420103)	0.563	3
UniProt:Q08048 Hgf	6	Hgf beta [extracellular region] (R-MMU-1264804) Hgf [platelet alpha granule lumen] (R-MMU-139866) Hgf [platelet alpha granule lumen] (R-MMU-141764) Hgf [extracellular region] (R-MMU-6800218) Hgf [extracellular region] (R-MMU-141767) Hgf [extracellular region] (R-MMU-56497)	0.558	3
UniProt:P41218 MNDA	3	MNDA [ficolin-1-rich granule lumen] (R-HSA-6800897) MNDA [extracellular region] (R-HSA-6806244) MNDA [azurophil granule lumen] (R-HSA-6799237)	0.556	3
UniProt:O95968 SG1D1			0.527	2
UniProt:Q15365 PCBP1	1	PCBP1 [nucleoplasm] (R-HSA-71919)	0.527	2
UniProt:O15031 PLXB2			0.524	2
UniProt:Q9ULL4 PLXNB3	1	PLXNB3 [plasma membrane] (R-HSA-416675)	0.524	2
UniProt:Q8TCU6 PREX1	1	PREX1 [cytosol] (R-HSA-8863083)	0.524	2
UniProt:Q96EY1-2 DNAJA3			0.524	2
UniProt:Q16288 NTRK3	6	NTRK3(32-495) [plasma membrane] (R-HSA-9603541) NTRK3(642-839) [cytosol] (R-HSA-9603540) NTRK3(496-641) [mitochondrial outer membrane] (R-HSA-9603557) NTRK3(496-641) [cytosol] (R-HSA-9603542) NTRK3 [plasma membrane] (R-HSA-6798240) p-5Y-NTRK3 [plasma membrane] (R-HSA-9034718)	0.499	2
UniProt:Q86VI4 LAP4B			0.463	3

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