Reactome | SPCS2 [endoplasmic reticulum membrane]

SPCS2 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-264996

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q15005 SPCS2

Gene Names

SPCS2, KIAA0102, SPC25

Chain

initiator methionine:, chain:2-226

Reference Genes

BioGPS Gene:9789 SPCS2

COSMIC (genes):SPC25 SPC25

COSMIC (genes):SPCS2 SPCS2

CTD Gene:9789 SPCS2

dbSNP Gene:9789 SPCS2

ENSEMBL:ENSG00000118363 SPCS2

HGNC:28962 SPCS2

KEGG:hsa:9789 SPCS2

Monarch:9789 SPCS2

NCBI Gene:9789 SPCS2

OMIM:619411 SPCS2

UCSC:Q15005 SPCS2

Reference Transcript

RefSeq:NM_014752.2 SPCS2

Other Identifiers

11731969_at

11753772_s_at

11753773_x_at

11758173_s_at

201239_PM_s_at

201239_s_at

201240_PM_s_at

201240_s_at

2403426

2403428

2403430

2403432

243570_PM_at

243570_at

3340383

3340384

3340385

3340389

3340390

3340391

3340392

3340394

3340395

3340396

3340397

3340401

3340402

3340403

3340405

3591282

3591283

37359_at

48277_at

7914180

7942553

9789

A_23_P2143

D14658_at

GE81955

GO:0003824

GO:0005515

GO:0005783

GO:0005787

GO:0005789

GO:0006465

GO:0008233

GO:0016020

GO:0016787

GO:0043226

GO:0045047

GO:0051604

GO:0140096

HMNXSV003006598

Hs.77665.0.S1_3p_a_at

Hs.87095.0.A1_3p_at

ILMN_1720819

ILMN_1809488

ILMN_2213247

ILMN_2408645

PH_hs_0029024

PH_hs_0031389

PH_hs_0039154

TC01005360.hg

TC11000795.hg

TC11002784.hg

TC11002785.hg

g7661907_3p_a_at

Participates

as a component of

Inferred To

Spcs2 [endoplasmic reticulum membrane] (Mus musculus)

Spcs2 [endoplasmic reticulum membrane] (Rattus norvegicus)

spcs2 [endoplasmic reticulum membrane] (Danio rerio)

SPCS2 [endoplasmic reticulum membrane] (Bos taurus)

SPCS2 [endoplasmic reticulum membrane] (Sus scrofa)

Ghost homologue of SPCS2 [endoplasmic reticulum membrane] (Gallus gallus)

SPCS2_CANFA [endoplasmic reticulum membrane] (Canis familiaris)

Cross References

RefSeq

NP_055567.2

ENSEMBL

ENSP00000263672, ENSG00000118363, ENST00000263672

OpenTargets

ENSG00000118363

GeneCards

SPCS2

HPA

ENSG00000118363-SPCS2

PRO

Q15005

Pharos - Targets

Q15005

GlyGen

Q15005

PDB

7P2Q, 7P2P

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P0DTC3 3a	9	O-glycosyl 3a [virion membrane] (R-COV-9694395) O-glycosyl 3a [endocytic vesicle membrane] (R-COV-9694729) O-glycosyl 3a [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9694386) GalNAc-O-3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694658) 3a [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9694716) 3a [endoplasmic reticulum lumen] (R-COV-9694584) O-glycosyl 3a [endolysosome membrane] (R-COV-9754541) O-glycosyl 3a [plasma membrane] (R-COV-9694433) O-glycosyl 3a [extracellular region] (R-COV-9694387)	0.527	2
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) complex N-glycan-PALM-Spike S1 Fragment [virion membrane] (R-COV-9694638) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) fully glycosylated Spike [virion membrane] (R-COV-9698327) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997)	0.499	2
UniProt:P27824 CANX	2	CANX [endoplasmic reticulum lumen] (R-HSA-195906) CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091)	0.483	2

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