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IGFBP3(28-186) [extracellular region]
Stable Identifier
R-HSA-381454
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
IGFBP-3 (28-186 fragment)
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) (Homo sapiens)
Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
IGFBP3(28-186) [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P17936 IGFBP3
Gene Names
IGFBP3, IBP3
Chain
signal peptide:1-27, chain:28-291
Reference Genes
BioGPS Gene:3486 IGFBP3
COSMIC (genes):IGFBP3 IGFBP3
CTD Gene:3486 IGFBP3
dbSNP Gene:3486 IGFBP3
ENSEMBL:ENSG00000146674.16 IGFBP3
HGNC:5472 IGFBP3
KEGG Gene (Homo sapiens):3486 IGFBP3
Monarch:3486 IGFBP3
NCBI Gene:3486 IGFBP3
OMIM:146732 IGFBP3
UCSC:P17936 IGFBP3
Reference Transcript
RefSeq:NM_001013398.1 IGFBP3
RefSeq:NM_000598.4 IGFBP3
RefSeq:XM_017012152.1 IGFBP3
Other Identifiers
0006450411
11721135_s_at
11749912_x_at
1586_at
17057478
210095_PM_s_at
210095_s_at
212143_PM_s_at
212143_s_at
3049293
3049294
3049295
3049296
3049297
3049299
3049302
3049303
3049304
3049306
3049307
3049308
3049309
3049310
3049311
3486
37319_at
8139488
A_23_P215634
A_24_P320699
GE59912
GO:0000165
GO:0001558
GO:0001649
GO:0001933
GO:0001968
GO:0005515
GO:0005520
GO:0005576
GO:0005615
GO:0005622
GO:0005634
GO:0005737
GO:0005783
GO:0005788
GO:0005975
GO:0006468
GO:0006915
GO:0008160
GO:0008285
GO:0009968
GO:0010906
GO:0012501
GO:0014912
GO:0016942
GO:0019838
GO:0023052
GO:0030154
GO:0031994
GO:0031995
GO:0032991
GO:0036211
GO:0040008
GO:0042567
GO:0043065
GO:0043226
GO:0043410
GO:0043567
GO:0043568
GO:0044342
GO:0045663
GO:0046872
GO:0048662
GO:0048856
GO:0048870
GO:0050790
GO:0098772
HMNXSV003031537
Hs.77326.1.S2_3p_a_at
ILMN_1746085
ILMN_2396875
M35878_at
PH_hs_0036058
TC07001355.hg
g183115_3p_a_at
Participates
as an output of
Prostate-specific Antigen proteolyzes IGF:IGFBP3:ALS (Homo sapiens)
Other forms of this molecule
IGFBP3 [extracellular region]
IGFBP3(125-233) [extracellular region]
IGFBP3(28-124) [extracellular region]
IGFBP3(234-291) [extracellular region]
IGFBP3 [endoplasmic reticulum lumen]
p-IGFBP3 [endoplasmic reticulum lumen]
IGFBP3(125-187) [extracellular region]
IGFBP3(188-291) [extracellular region]
IGFBP3(28-168) [extracellular region]
IGFBP3(227-291) [extracellular region]
IGFBP3(169-226) [extracellular region]
IGFBP3(127-291) [extracellular region]
IGFBP3(28-126) [extracellular region]
IGFBP3(291-187) [extracellular region]
Inferred To
Igfbp3 [extracellular region]
(Rattus norvegicus)
IGFBP3(28-186) [extracellular region]
(Danio rerio)
Cross References
RefSeq
NP_001013416.1
,
XP_016867641.1
,
NP_000589.2
OpenTargets
ENSG00000146674
HPA
ENSG00000146674-IGFBP3
ZINC - Substances
IBP3_HUMAN
GeneCards
P17936
ZINC target
P17936
Ensembl
ENST00000613132
,
ENSP00000370473
,
ENST00000381083
,
ENSG00000146674
,
ENSP00000477772
PRO
P17936
Pharos - Targets
P17936
ZINC - Predictions - Purchasable
IBP3_HUMAN
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q86XT9 TMEM219
1
TMEM219 [plasma membrane]
(R-HSA-6800018)
0.66
8
hyaluronic acid [ChEBI:16336]
3
HUA [endocytic vesicle lumen]
(R-ALL-2239419)
HUA [extracellular region]
(R-ALL-1297302)
HUA [cytosol]
(R-ALL-877209)
0.611
8
UniProt:Q8IVG9 MT-RNR2
1
MT-RNR2 [extracellular region]
(R-HSA-444568)
0.602
7
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.556
3
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.556
3
UniProt:P17252 PRKCA
8
PRKCA [cytosol]
(R-HSA-58196)
pT497,T638,S657-PRKCA [plasma membrane]
(R-HSA-4332340)
p-T497,T638,S657-PRKCA [cytosol]
(R-HSA-4332337)
PRKCA [plasma membrane]
(R-HSA-156469)
p-T497-PRKCA [cytosol]
(R-HSA-5218731)
p-T497,T638,S657-PRKCA [nucleoplasm]
(R-HSA-5223292)
PRKCA [photoreceptor disc membrane]
(R-HSA-2648987)
PRKCA [nucleoplasm]
(R-HSA-450530)
0.556
3
UniProt:Q8TAP4-4 LMO3
0.556
3
UniProt:Q15047-2 SETDB1
0.556
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.539
3
UniProt:P06429 VE7
0.488
2
UniProt:P03129 VE7
0.488
2
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