Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
p-Y-GAB1 [cytosol]
Stable Identifier
R-HSA-8855306
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
GRB2-associated binding protein 1
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Erythropoietin (Homo sapiens)
Erythropoietin activates Phosphoinositide-3-kinase (PI3K) (Homo sapiens)
EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:phospho-GAB1 binds PI3K (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Homo sapiens)
p-Y-GAB1 [cytosol] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Homo sapiens)
p-Y-GAB1 [cytosol] (Homo sapiens)
EPOR-associated PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
PI3K bound to EPOR [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1:PI3K [plasma membrane] (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Homo sapiens)
p-Y-GAB1 [cytosol] (Homo sapiens)
JAK2 phosphorylates GAB1 in EPO:phospho-EPOR:phospho-JAK2:LYN:IRS2:GAB1 (Homo sapiens)
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Homo sapiens)
p-Y-GAB1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13480 GAB1
Gene Names
GAB1
Chain
initiator methionine:, chain:2-694
Reference Genes
COSMIC (genes):GAB1 GAB1
dbSNP Gene:2549 GAB1
ENSEMBL:ENSG00000109458 GAB1
Participates
as a component of
EPO:p-8Y-EPOR:p-12Y-JAK2:LYN:IRS2:p-Y-GAB1 [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-Y627,Y659-GAB1 [cytosol]
p-5Y-GAB1 [cytosol]
GAB1 [cytosol]
Inferred To
phospho-gab1 [cytosol]
(Xenopus tropicalis)
phospho-GAB1 [cytosol]
(Bos taurus)
phospho-GAB1 [cytosol]
(Canis familiaris)
phospho-GAB1 [cytosol]
(Sus scrofa)
phospho-Gab1 [cytosol]
(Mus musculus)
phospho-Gab1 [cytosol]
(Rattus norvegicus)
phospho-dos [cytosol]
(Drosophila melanogaster)
Modified Residues
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Interactors (13)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q06124 PTPN11
4
p-Y542,Y580-PTPN11 [cytosol]
(R-HSA-162573)
PTPN11 [cytosol]
(R-HSA-162563)
PTPN11 [nucleoplasm]
(R-HSA-8937745)
p-Y542-PTPN11 [cytosol]
(R-HSA-1369081)
0.957
42
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.927
13
UniProt:P27986 PIK3R1
16
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
0.796
33
UniProt:P46109 CRKL
2
CRKL [cytosol]
(R-HSA-354384)
p-CRKL [cytosol]
(R-HSA-9024730)
0.753
5
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.735
5
UniProt:O75791 GRAP2
1
GRAP2 [cytosol]
(R-HSA-202367)
0.702
4
UniProt:Q12913 PTPRJ
2
PTPRJ [specific granule membrane]
(R-HSA-6799570)
PTPRJ [plasma membrane]
(R-HSA-6785269)
0.609
2
UniProt:P20936 RASA1
1
RASA1 [cytosol]
(R-HSA-186833)
0.59
25
UniProt:Q9UNN4 TF2AY
0.556
3
UniProt:Q06124-2 PTPN11
0.544
2
UniProt:P50904
1
Rasa1 [cytosol]
(R-RNO-186833)
0.499
2
UniProt:P49023 PXN
4
p-Y-PXN [plasma membrane]
(R-HSA-9031680)
PXN [plasma membrane]
(R-HSA-180493)
PXN [cytosol]
(R-HSA-210014)
p-Y31,Y118-PXN [cytosol]
(R-HSA-5218693)
0.499
2
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.483
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text