Reactome | PIK3C2B [cytosol]

PIK3C2B [cytosol]

Stable Identifier

R-HSA-1604619

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O00750 PIK3C2B

Gene Names

PIK3C2B

Chain

chain:1-1634

Reference Genes

BioGPS Gene:5287 PIK3C2B

COSMIC (genes):PIK3C2B PIK3C2B

CTD Gene:5287 PIK3C2B

dbSNP Gene:5287 PIK3C2B

ENSEMBL:ENSG00000133056 PIK3C2B

HGNC:8972 PIK3C2B

KEGG Gene (Homo sapiens):5287 PIK3C2B

Monarch:5287 PIK3C2B

NCBI Gene:5287 PIK3C2B

OMIM:602838 PIK3C2B

UCSC:O00750 PIK3C2B

Reference Transcript

Other Identifiers

0000430037

00562+2.7.1.154

04070+2.7.1.154

11751880_x_at

16698356

204484_at

2452070

2452071

2452072

2452073

2452074

2452075

2452076

2452077

2452078

2452079

2452081

2452083

2452085

2452086

2452087

2452088

2452089

2452090

2452091

2452092

2452093

2452094

2452095

2452096

2452097

2452098

2452099

2452104

2452105

2452107

2452109

2452110

2452111

2452112

2452113

2452114

2452115

2452121

2452122

2452129

2452130

30515

41715_at

50360

5287

7923662

A2RUF7

A_23_P200710

AAI32877

AAI36646

ABY87552

AGC09602

AL606489

BC132876

BC136645

CAA72168

CAA74194

CCDS1446

CH471067

EAW91514

ENSG00000133056

ENSP00000356155

ENST00000367187

ENST00000367187.7

EntrezGene:5287

EntrezGene:PIK3C2B

EU332863

F5GWN5

g11136637_3p_at

GE60286

GO:0000166

GO:0001727

GO:0003674

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005623

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005829

GO:0005886

GO:0005942

GO:0006629

GO:0006661

GO:0006914

GO:0006950

GO:0007165

GO:0008150

GO:0008289

GO:0009056

GO:0009058

GO:0009267

GO:0014065

GO:0016020

GO:0016236

GO:0016301

GO:0016303

GO:0016310

GO:0016740

GO:0030139

GO:0031410

GO:0032991

GO:0035005

GO:0035091

GO:0036092

GO:0043167

GO:0043226

GO:0043231

GO:0043491

GO:0046854

GO:0048015

GO:1905037

HGNC:8972

HPA030515

HPA050360

ILMN_1678537

ILMN_2117323

IPR000008

IPR000341

IPR000403

IPR001263

IPR001683

IPR002420

IPR011009

IPR015433

IPR016024

IPR018936

IPR029071

IPR035892

IPR036871

IPR036940

IPR042134

IPR042236

JX512455

MIM:602838

NM_002646

NP_002637

PF00168

PF00454

PF00613

PF00787

PF00792

PF00794

PH_hs_0023888

PIK3C2B

PIK3C2B-202

Q5SW97

Q5SW98

Q5SWA0

SM00142

SM00144

SM00145

SM00146

SM00239

SM00312

TC01003733.hg

UPI00002056D1

XM_005245257

XM_011509630

XM_011509631

XM_017001473

XM_017001474

XM_017001475

XP_005245314

XP_011507932

XP_011507933

XP_016856962

XP_016856963

XP_016856964

XR_241085

XR_241086

Y11312

Y13892

Participant Of

hasComponent

PIK3C2B:Ca2+/Mg2+/Mn2+ [cytosol]

Inferred To

Homologues of PIK3C2B [cytosol] (Dictyostelium discoideum)

PIK3C2B [cytosol] (Bos taurus)

PIK3C2B [cytosol] (Caenorhabditis elegans)

PIK3C2B [cytosol] (Canis familiaris)

PIK3C2B [cytosol] (Danio rerio)

PIK3C2B [cytosol] (Dictyostelium discoideum)

PIK3C2B [cytosol] (Drosophila melanogaster)

PIK3C2B [cytosol] (Gallus gallus)

PIK3C2B [cytosol] (Mus musculus)

PIK3C2B [cytosol] (Rattus norvegicus)

PIK3C2B [cytosol] (Sus scrofa)

Cross References

ZINC - Investigational

P3C2B_HUMAN

RefSeq

XP_005245314.1, XP_016856962.1, XP_016856963.1, NP_002637.3, XP_011507932.1, XP_011507933.1

ZINC - World Drugs

P3C2B_HUMAN

OpenTargets

ENSG00000133056

ZINC - FDA approved

P3C2B_HUMAN

IntEnz

2.7.1.154

GeneCards

O00750

ZINC - Substances

P3C2B_HUMAN

ZINC target

O00750

PRO

O00750

ZINC - Predictions - Purchasable

P3C2B_HUMAN

HMDB Protein

HMDBP01252

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.755	9
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.669	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.602	5
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.564	2
UniProt:P04626 ERBB2	91	p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191) p-Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 L755W [plasma membrane] (R-HSA-9654193) p-Y-ERBB2 T733I [plasma membrane] (R-HSA-9654610) p-Y-ERBB2 H878R [plasma membrane] (R-HSA-9654835) p-Y-ERBB2 L869R [plasma membrane] (R-HSA-9654730) p-Y-ERBB2 G776S [plasma membrane] (R-HSA-9664608) p-Y-ERBB2 L869Q [plasma membrane] (R-HSA-9654732) p-Y-ERBB2 G776L [plasma membrane] (R-HSA-9664600) p-Y-ERBB2 G776V [plasma membrane] (R-HSA-9664602) p-Y-ERBB2 G776C [plasma membrane] (R-HSA-9664611) ERBB2 D769Y [plasma membrane] (R-HSA-9646620) ERBB2 L755P [plasma membrane] (R-HSA-9646494) ERBB2 V842I [plasma membrane] (R-HSA-9646703) ERBB2 H878Y [plasma membrane] (R-HSA-9646824) ERBB2 T798M [plasma membrane] (R-HSA-9646825) ERBB2 D769H [plasma membrane] (R-HSA-9646617) ERBB2 T862A [plasma membrane] (R-HSA-9649434) ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665621) ERBB2 L755S [plasma membrane] (R-HSA-9646423) ERBB2 I767M [plasma membrane] (R-HSA-9646737) ERBB2 V777L [plasma membrane] (R-HSA-9646579) ERBB2 D769N [plasma membrane] (R-HSA-9646636) ERBB2 T733I [plasma membrane] (R-HSA-9646765) ERBB2 V777M [plasma membrane] (R-HSA-9646591) ERBB2 V777E [plasma membrane] (R-HSA-9646586) ERBB2 L755W [plasma membrane] (R-HSA-9646516) ERBB2 L755M [plasma membrane] (R-HSA-9646517) ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665622) ERBB2 H878R [plasma membrane] (R-HSA-9646822) ERBB2 V842E [plasma membrane] (R-HSA-9646710) ERBB2 T798I [plasma membrane] (R-HSA-9646823) ERBB2 R896C [plasma membrane] (R-HSA-9646714) ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9646667) ERBB2 R896H [plasma membrane] (R-HSA-9646728) ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665625) ERBB2 G776S [plasma membrane] (R-HSA-9664463) ERBB2 L869R [plasma membrane] (R-HSA-9646827) ERBB2 L869Q [plasma membrane] (R-HSA-9646828) ERBB2 G776C [plasma membrane] (R-HSA-9664457) ERBB2 G776L [plasma membrane] (R-HSA-9664454) ERBB2 G776V [plasma membrane] (R-HSA-9664450) p-6Y-ERBB2 V777L [plasma membrane] (R-HSA-9647214) p-6Y-ERBB2 H878Y [plasma membrane] (R-HSA-9647215) ERBB2 L755_T759del [plasma membrane] (R-HSA-9663599) p-6Y-ERBB2 R896C [plasma membrane] (R-HSA-9647208) p-6Y-ERBB2 V842I [plasma membrane] (R-HSA-9647209) p-6Y-ERBB2 I767M [plasma membrane] (R-HSA-9647211) p-6Y-ERBB2 T862A [plasma membrane] (R-HSA-9654692) p-6Y-ERBB2 D769H [plasma membrane] (R-HSA-9647200) p-6Y-ERBB2 T798I [plasma membrane] (R-HSA-9647202) p-6Y-ERBB2 L755P [plasma membrane] (R-HSA-9647196) p-6Y-ERBB2 P780_Y781insGSP [plasma membrane] (R-HSA-9647198) p-6Y-ERBB2 L755S [plasma membrane] (R-HSA-9647216) p-6Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665650) p-6Y-ERBB2 T798M [plasma membrane] (R-HSA-9647218) p-6Y-ERBB2 A771_Y772insYVMA [plasma membrane] (R-HSA-9665644) p-6Y-ERBB2 D769Y [plasma membrane] (R-HSA-9647199) p-6Y-ERBB2 V777E [plasma membrane] (R-HSA-9647210) p-6Y-ERBB2 T733I [plasma membrane] (R-HSA-9647195) p-6Y-ERBB2 L755M [plasma membrane] (R-HSA-9647204) p-6Y-ERBB2 V777M [plasma membrane] (R-HSA-9647205) p-6Y-ERBB2 V842E [plasma membrane] (R-HSA-9647206) p-6Y-ERBB2 D769N [plasma membrane] (R-HSA-9647207) p-6Y-ERBB2 R896H [plasma membrane] (R-HSA-9647217) p-6Y-ERBB2 L755W [plasma membrane] (R-HSA-9647201) p-6Y-ERBB2 G778_P780insGSP [plasma membrane] (R-HSA-9665634) p-6Y-ERBB2 H878R [plasma membrane] (R-HSA-9647203) p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863841) p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8863836) p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864084) p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane] (R-HSA-8864090) ERBB2 [plasma membrane] (R-HSA-372889) p-Y877-ERBB2 [plasma membrane] (R-HSA-1810438) p-6Y-ERBB2 [plasma membrane] (R-HSA-1963569) p-6Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864081) p-Y-ERBB2 [plasma membrane] (R-HSA-1678589) p-Y,Y877-ERBB2 [plasma membrane] (R-HSA-1810446) p-7Y,Y1112-ERBB2 [plasma membrane] (R-HSA-8864079) p-7Y-ERBB2 [plasma membrane] (R-HSA-1248698)	0.525	2