Reactome | PIK3C2B [cytosol]

PIK3C2B [cytosol]

Stable Identifier

R-HSA-1604619

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O00750 PIK3C2B

Gene Names

PIK3C2B

Chain

chain:1-1634

Reference Genes

BioGPS Gene:5287 PIK3C2B

COSMIC (genes):PIK3C2B PIK3C2B

CTD Gene:5287 PIK3C2B

dbSNP Gene:5287 PIK3C2B

ENSEMBL:ENSG00000133056 PIK3C2B

HGNC:8972 PIK3C2B

KEGG Gene (Homo sapiens):5287 PIK3C2B

Monarch:5287 PIK3C2B

NCBI Gene:5287 PIK3C2B

OMIM:602838 PIK3C2B

UCSC:O00750 PIK3C2B

Reference Transcript

Other Identifiers

0000430037

11751880_x_at

16698356

204484_at

2452070

2452071

2452072

2452073

2452074

2452075

2452076

2452077

2452078

2452079

2452081

2452083

2452085

2452086

2452087

2452088

2452089

2452090

2452091

2452092

2452093

2452094

2452095

2452096

2452097

2452098

2452099

2452104

2452105

2452107

2452109

2452110

2452111

2452112

2452113

2452114

2452115

2452121

2452122

2452129

2452130

41715_at

5287

7923662

A_23_P200710

GE60286

GO:0000166

GO:0003674

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005829

GO:0005886

GO:0005942

GO:0006629

GO:0006661

GO:0007165

GO:0008150

GO:0008289

GO:0009058

GO:0014065

GO:0016020

GO:0016301

GO:0016303

GO:0016310

GO:0016477

GO:0016740

GO:0032991

GO:0035005

GO:0035091

GO:0036092

GO:0040011

GO:0043167

GO:0043226

GO:0043231

GO:0046854

GO:0048015

GO:0048870

GO:0052742

HMNXSV003013126

HMNXSV003031134

ILMN_1678537

ILMN_2117323

PH_hs_0023888

TC01003733.hg

g11136637_3p_at

Participates

as a component of

PIK3C2B:Ca2+/Mg2+/Mn2+ [cytosol] (Homo sapiens)

Inferred To

pikB [cytosol] (Dictyostelium discoideum)

pikC [cytosol] (Dictyostelium discoideum)

Homologues of PIK3C2B [cytosol] (Dictyostelium discoideum)

piki-1 [cytosol] (Caenorhabditis elegans)

pik3c2b [cytosol] (Danio rerio)

pikA [cytosol] (Dictyostelium discoideum)

Pi3K68D [cytosol] (Drosophila melanogaster)

PIK3C2B [cytosol] (Bos taurus)

PIK3C2B [cytosol] (Canis familiaris)

PIK3C2B [cytosol] (Dictyostelium discoideum)

PIK3C2B [cytosol] (Gallus gallus)

PIK3C2B [cytosol] (Sus scrofa)

Pik3c2b [cytosol] (Mus musculus)

Pik3c2b [cytosol] (Rattus norvegicus)

Cross References

RefSeq

XP_005245314.1, XP_011507932.1, XP_016856962.1, XP_016856963.1, NP_002637.3, XP_011507933.1

ZINC - World Drugs

P3C2B_HUMAN

Guide to Pharmacology - Targets

2151

OpenTargets

ENSG00000133056

ZINC - FDA approved

P3C2B_HUMAN

ZINC - Substances

P3C2B_HUMAN

ZINC target

O00750

PRO

O00750

ZINC - Investigational

P3C2B_HUMAN

IntEnz

2.7.1.154

HPA

ENSG00000133056-PIK3C2B

GeneCards

O00750

Ensembl

ENSG00000133056, ENST00000367187, ENSP00000356155

Pharos - Targets

O00750

ZINC - Predictions - Purchasable

P3C2B_HUMAN

HMDB Protein

HMDBP01252

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211)	0.811	10
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.744	5
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.602	5
UniProt:P63104 YWHAZ	2	YWHAZ [nucleoplasm] (R-HSA-450469) YWHAZ [cytosol] (R-HSA-206099)	0.564	2
UniProt:P04626 ERBB2	20	p-Y-ERBB2 A775_G776insYVMA [plasma membrane] (R-HSA-9665656) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191) ERBB2 G309E [plasma membrane] (R-HSA-9665342) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) ERBB2 G309A [plasma membrane] (R-HSA-9665349)	0.525	2

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