Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
PIK3C2B [cytosol]
Stable Identifier
R-HSA-1604619
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Homo sapiens)
PIK3(2) [cytosol] (Homo sapiens)
PIK3C2B:Ca2+/Mg2+/Mn2+ [cytosol] (Homo sapiens)
PIK3C2B [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00750 PIK3C2B
Gene Names
PIK3C2B
Chain
chain:1-1634
Reference Genes
BioGPS Gene:5287 PIK3C2B
COSMIC (genes):PIK3C2B PIK3C2B
CTD Gene:5287 PIK3C2B
dbSNP Gene:5287 PIK3C2B
ENSEMBL:ENSG00000133056 PIK3C2B
HGNC:8972 PIK3C2B
KEGG Gene (Homo sapiens):5287 PIK3C2B
Monarch:5287 PIK3C2B
NCBI Gene:5287 PIK3C2B
OMIM:602838 PIK3C2B
UCSC:O00750 PIK3C2B
Reference Transcript
RefSeq:XM_011509630.2 PIK3C2B
RefSeq:XM_011509631.2 PIK3C2B
RefSeq:XM_017001473.1 PIK3C2B
RefSeq:XM_017001474.1 PIK3C2B
RefSeq:NM_002646.3 PIK3C2B
RefSeq:XM_005245257.2 PIK3C2B
Other Identifiers
0000430037
11751880_x_at
16698356
204484_at
2452070
2452071
2452072
2452073
2452074
2452075
2452076
2452077
2452078
2452079
2452081
2452083
2452085
2452086
2452087
2452088
2452089
2452090
2452091
2452092
2452093
2452094
2452095
2452096
2452097
2452098
2452099
2452104
2452105
2452107
2452109
2452110
2452111
2452112
2452113
2452114
2452115
2452121
2452122
2452129
2452130
41715_at
5287
7923662
A_23_P200710
GE60286
GO:0000166
GO:0001727
GO:0003674
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005654
GO:0005737
GO:0005783
GO:0005829
GO:0005886
GO:0005942
GO:0006629
GO:0006661
GO:0006914
GO:0006950
GO:0007165
GO:0008150
GO:0008289
GO:0009056
GO:0009058
GO:0009267
GO:0014065
GO:0016020
GO:0016236
GO:0016301
GO:0016303
GO:0016310
GO:0016477
GO:0016740
GO:0030139
GO:0031410
GO:0032991
GO:0035005
GO:0035091
GO:0036092
GO:0040011
GO:0043167
GO:0043226
GO:0043231
GO:0043491
GO:0046854
GO:0048015
GO:0048870
GO:0052742
GO:1905037
ILMN_1678537
ILMN_2117323
PH_hs_0023888
TC01003733.hg
g11136637_3p_at
Participant Of
hasComponent
PIK3C2B:Ca2+/Mg2+/Mn2+ [cytosol]
Inferred To
pikB [cytosol] (Dictyostelium discoideum)
pikC [cytosol] (Dictyostelium discoideum)
Homologues of PIK3C2B [cytosol] (Dictyostelium discoideum)
piki-1 [cytosol] (Caenorhabditis elegans)
pik3c2b [cytosol] (Danio rerio)
pikA [cytosol] (Dictyostelium discoideum)
Pi3K68D [cytosol] (Drosophila melanogaster)
PIK3C2B [cytosol] (Bos taurus)
PIK3C2B [cytosol] (Canis familiaris)
PIK3C2B [cytosol] (Dictyostelium discoideum)
PIK3C2B [cytosol] (Gallus gallus)
PIK3C2B [cytosol] (Sus scrofa)
Pik3c2b [cytosol] (Mus musculus)
Pik3c2b [cytosol] (Rattus norvegicus)
Cross References
RefSeq
XP_005245314.1
,
XP_011507933.1
,
XP_016856963.1
,
XP_011507932.1
,
XP_016856962.1
,
NP_002637.3
ZINC - World Drugs
P3C2B_HUMAN
OpenTargets
ENSG00000133056
ZINC - FDA approved
P3C2B_HUMAN
ZINC - Substances
P3C2B_HUMAN
ZINC target
O00750
PRO
O00750
ZINC - Investigational
P3C2B_HUMAN
IntEnz
2.7.1.154
HPA
ENSG00000133056-PIK3C2B
GeneCards
O00750
Ensembl
ENSG00000133056
,
ENSP00000356155
,
ENST00000367187
ZINC - Predictions - Purchasable
P3C2B_HUMAN
HMDB Protein
HMDBP01252
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.811
10
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.744
5
UniProt:P14373 TRIM27
2
TRIM27 [cytosol]
(R-HSA-8851002)
TRIM27 [nucleoplasm]
(R-HSA-2997690)
0.602
5
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.564
2
UniProt:P04626 ERBB2
117
ERBB2 G309A [plasma membrane]
(R-HSA-9665349)
ERBB2 G309E [plasma membrane]
(R-HSA-9665342)
ERBB2 S310F [plasma membrane]
(R-HSA-9665350)
ERBB2 S310Y [plasma membrane]
(R-HSA-9665344)
p-6Y-ERBB2 G309A [plasma membrane]
(R-HSA-9665381)
p-6Y-ERBB2 G309E [plasma membrane]
(R-HSA-9665382)
p-6Y-ERBB2 S310F [plasma membrane]
(R-HSA-9665379)
p-6Y-ERBB2 S310Y [plasma membrane]
(R-HSA-9665385)
p-Y-ERBB2 L755P [plasma membrane]
(R-HSA-9654268)
p-Y-ERBB2 I767M [plasma membrane]
(R-HSA-9654303)
p-Y-ERBB2 A775_G776insYVMA [plasma membrane]
(R-HSA-9665656)
p-Y-ERBB2 T798I [plasma membrane]
(R-HSA-9654618)
p-Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654695)
p-Y-ERBB2 T798M [plasma membrane]
(R-HSA-9654615)
p-Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9654833)
p-Y-ERBB2 V777L [plasma membrane]
(R-HSA-9654401)
p-Y-ERBB2 L755S [plasma membrane]
(R-HSA-9654194)
p-Y-ERBB2 V777E [plasma membrane]
(R-HSA-9654397)
p-Y-ERBB2 V777M [plasma membrane]
(R-HSA-9654398)
p-Y-ERBB2 L755M [plasma membrane]
(R-HSA-9654191)
p-Y-ERBB2 A771_Y772insYVMA [plasma membrane]
(R-HSA-9665652)
p-Y-ERBB2 L755W [plasma membrane]
(R-HSA-9654193)
p-Y-ERBB2 T733I [plasma membrane]
(R-HSA-9654610)
p-Y-ERBB2 H878R [plasma membrane]
(R-HSA-9654835)
p-Y-ERBB2 L869R [plasma membrane]
(R-HSA-9654730)
p-Y-ERBB2 G776S [plasma membrane]
(R-HSA-9664608)
p-Y-ERBB2 L869Q [plasma membrane]
(R-HSA-9654732)
p-Y-ERBB2 G776L [plasma membrane]
(R-HSA-9664600)
p-Y-ERBB2 G776V [plasma membrane]
(R-HSA-9664602)
p-Y-ERBB2 G776C [plasma membrane]
(R-HSA-9664611)
ERBB2 D769Y [plasma membrane]
(R-HSA-9646620)
ERBB2 L755P [plasma membrane]
(R-HSA-9646494)
ERBB2 V842I [plasma membrane]
(R-HSA-9646703)
ERBB2 H878Y [plasma membrane]
(R-HSA-9646824)
ERBB2 T798M [plasma membrane]
(R-HSA-9646825)
ERBB2 D769H [plasma membrane]
(R-HSA-9646617)
ERBB2 T862A [plasma membrane]
(R-HSA-9649434)
ERBB2 A775_G776insYVMA [plasma membrane]
(R-HSA-9665621)
ERBB2 L755S [plasma membrane]
(R-HSA-9646423)
ERBB2 I767M [plasma membrane]
(R-HSA-9646737)
ERBB2 V777L [plasma membrane]
(R-HSA-9646579)
ERBB2 D769N [plasma membrane]
(R-HSA-9646636)
ERBB2 T733I [plasma membrane]
(R-HSA-9646765)
ERBB2 V777M [plasma membrane]
(R-HSA-9646591)
ERBB2 V777E [plasma membrane]
(R-HSA-9646586)
ERBB2 L755W [plasma membrane]
(R-HSA-9646516)
ERBB2 L755M [plasma membrane]
(R-HSA-9646517)
ERBB2 A771_Y772insYVMA [plasma membrane]
(R-HSA-9665622)
ERBB2 H878R [plasma membrane]
(R-HSA-9646822)
ERBB2 V842E [plasma membrane]
(R-HSA-9646710)
ERBB2 T798I [plasma membrane]
(R-HSA-9646823)
ERBB2 R896C [plasma membrane]
(R-HSA-9646714)
ERBB2 P780_Y781insGSP [plasma membrane]
(R-HSA-9646667)
ERBB2 R896H [plasma membrane]
(R-HSA-9646728)
ERBB2 G778_P780insGSP [plasma membrane]
(R-HSA-9665625)
ERBB2 G776S [plasma membrane]
(R-HSA-9664463)
ERBB2 L869R [plasma membrane]
(R-HSA-9646827)
ERBB2 L869Q [plasma membrane]
(R-HSA-9646828)
ERBB2 G776C [plasma membrane]
(R-HSA-9664457)
ERBB2 G776L [plasma membrane]
(R-HSA-9664454)
ERBB2 G776V [plasma membrane]
(R-HSA-9664450)
p-6Y-ERBB2 V777L [plasma membrane]
(R-HSA-9647214)
p-6Y-ERBB2 H878Y [plasma membrane]
(R-HSA-9647215)
ERBB2 L755_T759del [plasma membrane]
(R-HSA-9663599)
p-6Y-ERBB2 R896C [plasma membrane]
(R-HSA-9647208)
p-6Y-ERBB2 V842I [plasma membrane]
(R-HSA-9647209)
p-6Y-ERBB2 I767M [plasma membrane]
(R-HSA-9647211)
p-6Y-ERBB2 T862A [plasma membrane]
(R-HSA-9654692)
p-6Y-ERBB2 D769H [plasma membrane]
(R-HSA-9647200)
p-6Y-ERBB2 T798I [plasma membrane]
(R-HSA-9647202)
p-6Y-ERBB2 L755P [plasma membrane]
(R-HSA-9647196)
p-6Y-ERBB2 P780_Y781insGSP [plasma membrane]
(R-HSA-9647198)
p-6Y-ERBB2 L755S [plasma membrane]
(R-HSA-9647216)
p-6Y-ERBB2 A775_G776insYVMA [plasma membrane]
(R-HSA-9665650)
p-6Y-ERBB2 T798M [plasma membrane]
(R-HSA-9647218)
p-6Y-ERBB2 A771_Y772insYVMA [plasma membrane]
(R-HSA-9665644)
p-6Y-ERBB2 D769Y [plasma membrane]
(R-HSA-9647199)
p-6Y-ERBB2 V777E [plasma membrane]
(R-HSA-9647210)
p-6Y-ERBB2 T733I [plasma membrane]
(R-HSA-9647195)
p-6Y-ERBB2 L755M [plasma membrane]
(R-HSA-9647204)
p-6Y-ERBB2 V777M [plasma membrane]
(R-HSA-9647205)
p-6Y-ERBB2 V842E [plasma membrane]
(R-HSA-9647206)
p-6Y-ERBB2 D769N [plasma membrane]
(R-HSA-9647207)
p-6Y-ERBB2 R896H [plasma membrane]
(R-HSA-9647217)
p-6Y-ERBB2 L755W [plasma membrane]
(R-HSA-9647201)
p-6Y-ERBB2 G778_P780insGSP [plasma membrane]
(R-HSA-9665634)
p-6Y-ERBB2 H878R [plasma membrane]
(R-HSA-9647203)
p-6Y-ERBB2 E693K [plasma membrane]
(R-HSA-9665871)
p-6Y-ERBB2 R677L [plasma membrane]
(R-HSA-9665864)
p-6Y-ERBB2 Q709L [plasma membrane]
(R-HSA-9665865)
p-6Y-ERBB2 G660D [plasma membrane]
(R-HSA-9665866)
p-6Y-ERBB2 G660R [plasma membrane]
(R-HSA-9665878)
p-6Y-ERBB2 V659K [plasma membrane]
(R-HSA-9665863)
p-6Y-ERBB2 V659E [plasma membrane]
(R-HSA-9665874)
ERBB2 R678Q [plasma membrane]
(R-HSA-9665756)
ERBB2 S653C [plasma membrane]
(R-HSA-9665754)
ERBB2 R677L [plasma membrane]
(R-HSA-9665759)
ERBB2 G660R [plasma membrane]
(R-HSA-9665768)
ERBB2 V659E [plasma membrane]
(R-HSA-9665752)
ERBB2 G660D [plasma membrane]
(R-HSA-9665753)
ERBB2 V659K [plasma membrane]
(R-HSA-9665769)
ERBB2 Q709L [plasma membrane]
(R-HSA-9665770)
ERBB2 E693K [plasma membrane]
(R-HSA-9665761)
p-6Y-ERBB2 R678Q [plasma membrane]
(R-HSA-9665876)
p-6Y-ERBB2 S653C [plasma membrane]
(R-HSA-9665875)
p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8863841)
p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8863836)
p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8864084)
p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8864090)
p-Y877-ERBB2 [plasma membrane]
(R-HSA-1810438)
ERBB2 [plasma membrane]
(R-HSA-372889)
p-6Y-ERBB2 [plasma membrane]
(R-HSA-1963569)
p-6Y,Y1112-ERBB2 [plasma membrane]
(R-HSA-8864081)
p-Y-ERBB2 [plasma membrane]
(R-HSA-1678589)
p-Y,Y877-ERBB2 [plasma membrane]
(R-HSA-1810446)
p-7Y,Y1112-ERBB2 [plasma membrane]
(R-HSA-8864079)
p-7Y-ERBB2 [plasma membrane]
(R-HSA-1248698)
0.525
2
© 2021
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text