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PIK3C2B [cytosol]
Stable Identifier
R-HSA-1604619
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of lipids (Homo sapiens)
Phospholipid metabolism (Homo sapiens)
PI Metabolism (Homo sapiens)
Synthesis of PIPs at the plasma membrane (Homo sapiens)
PI4P is phosphorylated to PI(3,4)P2 by PI3K3C[2] at the plasma membrane (Homo sapiens)
PIK3(2) [cytosol] (Homo sapiens)
PIK3C2B:Ca2+/Mg2+/Mn2+ [cytosol] (Homo sapiens)
PIK3C2B [cytosol] (Homo sapiens)
PIK3C2B [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O00750 PIK3C2B
Gene Names
PIK3C2B
Chain
chain:1-1634
Reference Genes
BioGPS Gene:5287 PIK3C2B
COSMIC (genes):PIK3C2B PIK3C2B
CTD Gene:5287 PIK3C2B
dbSNP Gene:5287 PIK3C2B
ENSEMBL:ENSG00000133056 PIK3C2B
ENSEMBL_homo_sapiens_GENE:ENSG00000133056 PIK3C2B
HGNC:8972 PIK3C2B
KEGG Gene (Homo sapiens):5287 PIK3C2B
Monarch:5287 PIK3C2B
NCBI Gene:5287 PIK3C2B
OMIM:602838 PIK3C2B
UCSC:O00750 PIK3C2B
Reference Transcript
RefSeq:XM_011509630.2 PIK3C2B
RefSeq:XM_017001474.1 PIK3C2B
RefSeq:XM_011509631.2 PIK3C2B
RefSeq:NM_002646.3 PIK3C2B
RefSeq:XM_017001473.1 PIK3C2B
RefSeq:XM_005245257.2 PIK3C2B
Other Identifiers
0000430037
11751880_x_at
16698356
204484_at
2452070
2452071
2452072
2452073
2452074
2452075
2452076
2452077
2452078
2452079
2452081
2452083
2452085
2452086
2452087
2452088
2452089
2452090
2452091
2452092
2452093
2452094
2452095
2452096
2452097
2452098
2452099
2452104
2452105
2452107
2452109
2452110
2452111
2452112
2452113
2452114
2452115
2452121
2452122
2452129
2452130
30515
41715_at
50360
5287
7923662
A_23_P200710
AL606489
CAA72168
CAA74194
CCDS1446
ENSG00000133056
ENSP00000356155
ENST00000367187
EntrezGene:5287
g11136637_3p_at
GE60286
GO:0000166
GO:0001727
GO:0003674
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005623
GO:0005634
GO:0005654
GO:0005737
GO:0005783
GO:0005829
GO:0005886
GO:0005942
GO:0006629
GO:0006914
GO:0006950
GO:0007165
GO:0008150
GO:0008289
GO:0009056
GO:0009058
GO:0009267
GO:0014065
GO:0016020
GO:0016236
GO:0016301
GO:0016303
GO:0016310
GO:0016477
GO:0016740
GO:0030139
GO:0031410
GO:0032991
GO:0035005
GO:0035091
GO:0036092
GO:0040011
GO:0043167
GO:0043226
GO:0043231
GO:0043491
GO:0046854
GO:0048015
GO:0048870
GO:1905037
HGNC:8972
HPA030515
HPA050360
ILMN_1678537
ILMN_2117323
IPR000008
IPR000341
IPR000403
IPR001263
IPR001683
IPR002420
IPR011009
IPR015433
IPR016024
IPR018936
IPR029071
IPR035892
IPR036871
IPR036940
MIM:602838
NM_002646
NP_002637
PF00168
PF00454
PF00613
PF00787
PF00792
PF00794
PH_hs_0023888
PIK3C2B
PIK3C2B-202
Q5SW97
Q5SW98
Q5SWA0
SM00142
SM00144
SM00145
SM00146
SM00239
SM00312
TC01003733.hg
uc001haw.4
UPI00002056D1
XM_005245257
XM_011509630
XM_011509631
XM_017001473
XM_017001474
XM_017001475
XP_005245314
XP_011507932
XP_011507933
XP_016856962
XP_016856963
XP_016856964
XR_241085
XR_241086
Y11312
Y13892
Participant Of
hasComponent
PIK3C2B:Ca2+/Mg2+/Mn2+ [cytosol]
Inferred To
Homologues of PIK3C2B [cytosol] (Bos taurus)
Homologues of PIK3C2B [cytosol] (Drosophila melanogaster)
Homologues of PIK3C2B [cytosol] (Mus musculus)
Homologues of PIK3C2B [cytosol] (Oryza sativa)
Homologues of PIK3C2B [cytosol] (Rattus norvegicus)
Homologues of PIK3C2B [cytosol] (Sus scrofa)
PIK3C2B [cytosol] (Bos taurus)
PIK3C2B [cytosol] (Caenorhabditis elegans)
PIK3C2B [cytosol] (Canis familiaris)
PIK3C2B [cytosol] (Danio rerio)
PIK3C2B [cytosol] (Dictyostelium discoideum)
PIK3C2B [cytosol] (Drosophila melanogaster)
PIK3C2B [cytosol] (Gallus gallus)
PIK3C2B [cytosol] (Mus musculus)
PIK3C2B [cytosol] (Oryza sativa)
PIK3C2B [cytosol] (Rattus norvegicus)
PIK3C2B [cytosol] (Saccharomyces cerevisiae)
PIK3C2B [cytosol] (Sus scrofa)
PIK3C2B [cytosol] (Taeniopygia guttata)
Cross References
RefSeq
XP_011507933.1
,
XP_005245314.1
,
XP_016856962.1
,
XP_011507932.1
,
NP_002637.3
,
XP_016856963.1
ZINC - World Drugs
P3C2B_HUMAN
OpenTargets
ENSG00000133056
ZINC - FDA approved
P3C2B_HUMAN
GeneCards
O00750
ZINC - Substances
P3C2B_HUMAN
ZINC target
O00750
PRO
O00750
BRENDA (Homo sapiens)
2.7.1.154
ZINC - Predictions - Purchasable
P3C2B_HUMAN
HMDB Protein
HMDBP01252
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
58
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.755
9
UniProt:P14373 TRIM27
2
TRIM27 [nucleoplasm]
(R-HSA-2997690)
TRIM27 [cytosol]
(R-HSA-8851002)
0.602
5
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.564
2
UniProt:P04626 ERBB2
12
p-Y877,Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8863836)
p-Y1023,Y1139,Y1196,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8863841)
p-Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8864084)
p-Y877,Y1023,Y1139,Y1221,Y1222-ERBB2 [plasma membrane]
(R-HSA-8864090)
p-Y877-ERBB2 [plasma membrane]
(R-HSA-1810438)
ERBB2 [plasma membrane]
(R-HSA-372889)
p-6Y-ERBB2 [plasma membrane]
(R-HSA-1963569)
p-6Y,Y1112-ERBB2 [plasma membrane]
(R-HSA-8864081)
p-Y-ERBB2 [plasma membrane]
(R-HSA-1678589)
p-Y,Y877-ERBB2 [plasma membrane]
(R-HSA-1810446)
p-7Y,Y1112-ERBB2 [plasma membrane]
(R-HSA-8864079)
p-7Y-ERBB2 [plasma membrane]
(R-HSA-1248698)
0.525
2
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