Reactome | MDH1 [cytosol]

MDH1 [cytosol]

Stable Identifier

R-HSA-198471

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

malate dehydrogenase 1

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P40925 MDH1

Gene Names

MDH1, MDHA

Chain

initiator methionine:, chain:2-334

Reference Genes

BioGPS Gene:4190 MDH1

COSMIC (genes):MDH1 MDH1

CTD Gene:4190 MDH1

dbSNP Gene:4190 MDH1

ENSEMBL:ENSG00000014641 MDH1

HGNC:6970 MDH1

KEGG:hsa:4190 MDH1

Monarch:4190 MDH1

NCBI Gene:4190 MDH1

OMIM:154200 MDH1

UCSC:P40925 MDH1

Reference Transcript

Other Identifiers

11715372_a_at

11749961_a_at

16880596

200978_PM_at

200978_at

235374_PM_at

235374_at

2485183

2485184

2485185

2485186

2485187

2485188

2485189

2485190

2485191

2485192

2485193

2485194

2485198

2485199

2485200

2485201

2485202

2485203

2485204

2485205

2485206

2485208

2485209

2485210

2485211

2485213

2485214

2485215

2485216

2485217

2485218

36608_at

4190

59602_at

8042259

A_23_P101950

A_33_P3261818

D55654_at

GE57262

GO:0003824

GO:0004470

GO:0005515

GO:0005615

GO:0005737

GO:0005739

GO:0005813

GO:0005815

GO:0005829

GO:0006099

GO:0006107

GO:0006108

GO:0006734

GO:0006739

GO:0016491

GO:0016615

GO:0016616

GO:0019752

GO:0030060

GO:0043226

GO:0043490

GO:0047860

GO:0047995

GO:0055085

GO:0055086

GO:0070062

HMNXSV003022073

Hs.194603.0.A1_3p_at

ILMN_1656913

PH_hs_0004324

PH_hs_0035455

g5174538_3p_at

Participates

as a component of

MDH1 dimer [cytosol] (Homo sapiens)

Inferred To

MDH1 [cytosol] (Bos taurus)

MDH1 [cytosol] (Caenorhabditis elegans)

MDH1 [cytosol] (Canis familiaris)

MDH1 [cytosol] (Danio rerio)

MDH1 [cytosol] (Dictyostelium discoideum)

MDH1 [cytosol] (Drosophila melanogaster)

MDH1 [cytosol] (Gallus gallus)

MDH1 [cytosol] (Mus musculus)

MDH1 [cytosol] (Rattus norvegicus)

MDH1 [cytosol] (Sus scrofa)

MDH1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001186040.1, NP_001186041.1, NP_001303303.1, NP_005908.1

ENSEMBL

ENSP00000233114, ENST00000544381, ENSP00000446395, ENSP00000410073, ENST00000233114, ENST00000432309

OpenTargets

ENSG00000014641

HPA

ENSG00000014641-MDH1

ZINC - Substances

MDHC_HUMAN

ZINC target

P40925

PRO

P40925

Pharos - Targets

P40925

GlyGen

P40925

ZINC - Predictions - Purchasable

MDHC_HUMAN

HMDB Protein

HMDBP00860

PDB

7RM9, 7RRL

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P48163 ME1	2	p-S336-ME1 [cytosol] (R-HSA-9861606) ME1 [cytosol] (R-HSA-400119)	0.62	11
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2

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