Reactome | RAPGEF1 [endosome]

RAPGEF1 [endosome]

Stable Identifier

R-HSA-3008667

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome

Synonyms

Rap guanine nucleotide exchange factor 1, RPGF1_HUMAN

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by NTRKs (Homo sapiens)
    - Signaling by NTRK1 (TRKA) (Homo sapiens)
      - Signalling to ERKs (Homo sapiens)
        
        Prolonged ERK activation events (Homo sapiens)
        
        Frs2-mediated activation (Homo sapiens)
        
        (Frs2)C3G stimulates nucleotide exchange on Rap1 (Homo sapiens)
        
        RAPGEF1 [endosome] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13905 RAPGEF1

Gene Names

RAPGEF1, GRF2

Chain

chain:1-1077

Reference Genes

BioGPS Gene:2889 RAPGEF1

COSMIC (genes):RAPGEF1 RAPGEF1

CTD Gene:2889 RAPGEF1

dbSNP Gene:2889 RAPGEF1

ENSEMBL:ENSG00000107263 RAPGEF1

ENSEMBL_homo_sapiens_GENE:ENSG00000107263.19 RAPGEF1

HGNC:4568 RAPGEF1

KEGG Gene (Homo sapiens):2889 RAPGEF1

Monarch:2889 RAPGEF1

NCBI Gene:2889 RAPGEF1

OMIM:600303 RAPGEF1

UCSC:Q13905 RAPGEF1

Reference Transcript

Other Identifiers

11716435_a_at

11742023_a_at

11748479_a_at

11756422_s_at

1570089_3p_at

1570089_PM_at

1570089_at

17099208

204543_PM_at

204543_at

225738_PM_at

225738_at

226389_PM_s_at

226389_s_at

2889

3227689

3227690

3227691

3227692

3227693

3227694

3227695

3227697

3227698

3227702

3227704

3227706

3227708

3227710

3227711

3227712

3227713

3227714

3227722

3227732

3227735

3227738

3227757

3227761

3227762

3227763

3227764

3227765

3227766

3227767

3227772

3227773

3227778

3227780

3227802

3227803

3227813

3227814

3227815

36240_at

51157_at

65978_at

78805_at

8164665

A_23_P304237

A_23_P391764

D21239_at

GE543837

GE57112

GE79218

GE84667

GO:0005085

GO:0005515

GO:0005737

GO:0005768

GO:0005769

GO:0005829

GO:0005886

GO:0007165

GO:0007169

GO:0007264

GO:0007265

GO:0007399

GO:0010976

GO:0017124

GO:0023052

GO:0030154

GO:0031410

GO:0032486

GO:0034330

GO:0038180

GO:0043226

GO:0043231

GO:0043547

GO:0048856

GO:0061028

GO:0071320

GO:0098772

GO:1901888

GO:1990090

HMNXSV003001706

Hs.9195.0.S1_3p_a_at

Hs.9195.1.S1_3p_x_at

Hs2.385815.1.S1_3p_at

Hs2.385815.1.S1_3p_x_at

ILMN_1678799

ILMN_1769412

PH_hs_0022453

TC09001668.hg

g4885356_3p_at

Other forms of this molecule

RAPGEF1 [cytosol]

Cross References

RefSeq

NP_001291204.1, NP_005303.2, NP_941372.1

OpenTargets

ENSG00000107263

HPA

ENSG00000107263-RAPGEF1

GeneCards

Q13905

Ensembl

ENST00000372190, ENST00000372189, ENSP00000361264, ENSG00000107263, ENSP00000361263, ENST00000372195, ENSP00000361269

PRO

Q13905

Pharos - Targets

Q13905

PDB

5L23

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.813	7
UniProt:P46109 CRKL	2	CRKL [cytosol] (R-HSA-354384) p-CRKL [cytosol] (R-HSA-9024730)	0.723	4
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.658	3
UniProt:P00519 ABL1	6	p-Y393-ABL1 [cytosol] (R-HSA-9865161) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) ABL1 [nucleoplasm] (R-HSA-5686579) p-S456-ABL1 [nucleoplasm] (R-HSA-5686576)	0.656	4
UniProt:P46108-1 CRK			0.564	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2

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