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SYK [cytosol]
Stable Identifier
R-HSA-58268
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Tyrosine-protein kinase SYK , Spleen tyrosine kinase
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Parasitic Infection Pathways (Homo sapiens)
Leishmania infection (Homo sapiens)
Leishmania parasite growth and survival (Homo sapiens)
Anti-inflammatory response favouring Leishmania parasite infection (Homo sapiens)
FCGR3A-mediated IL10 synthesis (Homo sapiens)
SYK binds IgG:Lma antigens:FCGR3A:p-CD3 dimers (Homo sapiens)
IgG:Lma antigens:FCGR3A:p-CD3 dimers:SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK (Homo sapiens)
IgG:Lma antigens:FCGR3A:p-CD3 dimers:SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
Parasite infection (Homo sapiens)
Leishmania phagocytosis (Homo sapiens)
FCGR3A-mediated phagocytosis (Homo sapiens)
SYK binds IgG:Lma antigens:FCGR3A:p-CD3 dimers (Homo sapiens)
IgG:Lma antigens:FCGR3A:p-CD3 dimers:SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
Src phosphorylate SYK in IgG:Leishmania surface:p-FCGR3A:SYK (Homo sapiens)
IgG:Lma antigens:FCGR3A:p-CD3 dimers:SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
Binding of Syk tyrosine kinase (Homo sapiens)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
GPVI stimulates PI3K beta, gamma (Homo sapiens)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
PLC gamma 2-mediated PIP2 hydrolysis (Homo sapiens)
p-Y7-CLEC1B dimer:PDPN:SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
SYK autophosphorylates (Homo sapiens)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
p-Y7-CLEC1B dimer:PDPN binds SYK (Homo sapiens)
SYK [cytosol] (Homo sapiens)
p-Y7-CLEC1B dimer:PDPN:SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Integrin signaling (Homo sapiens)
SYK activation by SRC (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
SYK binds to integrin alphaIIb beta3 (Homo sapiens)
SYK [cytosol] (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
SYK autophosphorylates at the activated BCR (Homo sapiens)
Antigen:p-BCR:SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
SYK binds the activated BCR (Homo sapiens)
Antigen:p-BCR:SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
FLT3 signaling through SRC family kinases (Homo sapiens)
Active FLT3 binds to SYK (Homo sapiens)
SYK [cytosol] (Homo sapiens)
active FLT3:SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
Signaling by CSF3 (G-CSF) (Homo sapiens)
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK (Homo sapiens)
SYK [cytosol] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin-2 signaling (Homo sapiens)
SYK binds IL2RB (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
SYK is a substrate for JAK1 (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
Regulation of signaling by CBL (Homo sapiens)
CBL is tyrosine phosphorylated (Homo sapiens)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
FYN-like kinases [cytosol] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
FYN-like kinases [cytosol] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
CBL ubiquitinates PI3K (Homo sapiens)
FYN-like kinases:p(Y731)-CBL:GRB2:Ubiquitinated p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
FYN-like kinases [cytosol] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
FYN-like kinases:p(Y731)-CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
FYN-like kinases [cytosol] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
CBL, GRB2, FYN and PI3K p85 subunit are constitutively associated (Homo sapiens)
FYN-like kinases [cytosol] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
FYN-like kinases:CBL:GRB2:p85-containing Class 1A PI3Ks [cytosol] (Homo sapiens)
FYN-like kinases [cytosol] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
1,3-beta-D-glucan:p-Y15-CLEC7A:SYK phosphorylates PLCG (Homo sapiens)
1,3-beta-D-glucan:p-Y15-CLEC7A:SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan (Homo sapiens)
1,3-beta-D-glucan:p-Y15-CLEC7A:SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
Dectin-2 family (Homo sapiens)
SYK autophosphorylates (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
SYK binds to p-Y65,Y76-FCER1G (Homo sapiens)
SYK [cytosol] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
DAP12 interactions (Homo sapiens)
DAP12 signaling (Homo sapiens)
Phosphorylation of SYK (Homo sapiens)
DAP12 receptors:p-DAP12:SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
Recruitment of SYK to p-DAP12 (Homo sapiens)
DAP12 receptors:p-DAP12:SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
Fc epsilon receptor (FCERI) signaling (Homo sapiens)
Phosphorylation of SYK (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
Recruitment of SYK to p-FCERI gamma subunit (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
Fcgamma receptor (FCGR) dependent phagocytosis (Homo sapiens)
FCGR activation (Homo sapiens)
Phosphorylation of SYK by Src kinases (Homo sapiens)
clustered IgG-Ag:p-FCGRs:SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
Recruitment of SYK to phosphorylated ITAMs (Homo sapiens)
SYK [cytosol] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Integrin signaling (Homo sapiens)
SYK activation by SRC (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
SYK binds to integrin alphaIIb beta3 (Homo sapiens)
SYK [cytosol] (Homo sapiens)
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
SYK [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P43405 SYK
Gene Names
SYK
Chain
chain:1-635
Reference Genes
BioGPS Gene:6850 P434052
COSMIC (genes):SYK SYK
CTD Gene:6850 SYK
dbSNP Gene:6850 SYK
ENSEMBL:ENSG00000165025 SYK
HGNC:11491 P434052
KEGG:hsa:6850 P434052
Monarch:6850 P434052
NCBI Gene:6850 P434052
OMIM:600085 P434052
UCSC:P43405 P434052
Reference Transcript
RefSeq:XM_005252147.5 P434052
RefSeq:XM_047423810.1 P434052
RefSeq:XM_054363653.1 P434052
RefSeq:NM_001174168.3 P434052
RefSeq:NM_001135052.4 P434052
RefSeq:XM_011518946.4 P434052
RefSeq:XM_054363654.1 P434052
RefSeq:XM_047423809.1 P434052
RefSeq:NM_003177.6 P434052
RefSeq:NM_001174167.3 P434052
RefSeq:XM_054363652.1 P434052
Participates
as an input of
CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1 binds and activates JAK2, TYK2, SYK, and HCK (Homo sapiens)
p-Y7-CLEC1B dimer:PDPN binds SYK (Homo sapiens)
SYK binds to integrin alphaIIb beta3 (Homo sapiens)
Active FLT3 binds to SYK (Homo sapiens)
SYK binds IL2RB (Homo sapiens)
SYK binds to p-Y65,Y76-FCER1G (Homo sapiens)
SYK binds p-Y15-Clec7a:1,3-beta-D-glucan (Homo sapiens)
SYK binds p-Y15-CLEC7A:1,3-beta-D-glucan (Homo sapiens)
Recruitment of SYK to p-FCERI gamma subunit (Homo sapiens)
Recruitment of SYK to phosphorylated ITAMs (Homo sapiens)
Recruitment of SYK to p-DAP12 (Homo sapiens)
SYK binds the activated BCR (Homo sapiens)
SYK binds IgG:Lma antigens:FCGR3A:p-CD3 dimers (Homo sapiens)
Binding of Syk tyrosine kinase (Homo sapiens)
as a component of
Talin:RIAM:ECM ligands:2X (Integrin alphaIIb beta3:Active (p-Y419)-SRC):SYK [plasma membrane] (Homo sapiens)
active FLT3:SYK [plasma membrane] (Homo sapiens)
IL2:IL2R trimer:p-JAK1:JAK3:SYK [plasma membrane] (Homo sapiens)
pathogens:CLEC6A,CLEC4E:p-Y65,Y76-FCER1G dimer:SYK [plasma membrane] (Homo sapiens)
p-Y15-Clec7a:SYK [plasma membrane] (Homo sapiens)
1,3-beta-D-glucan:p-Y15-CLEC7A:SYK [plasma membrane] (Homo sapiens)
clustered IgG-Ag:p-FCGRs:SYK [plasma membrane] (Homo sapiens)
Clustered p:LYN:p-FCERI:IgE:allergen:SYK [plasma membrane] (Homo sapiens)
DAP12 receptors:p-DAP12:SYK [plasma membrane] (Homo sapiens)
Antigen:p-BCR:SYK [plasma membrane] (Homo sapiens)
IgG:Lma antigens:FCGR3A:p-CD3 dimers:SYK [plasma membrane] (Homo sapiens)
GPVI:phosphorylated Fc Epsilon R1 gamma:FYN:LYN:Collagen type I:SYK [plasma membrane] (Homo sapiens)
p-Y7-CLEC1B dimer:PDPN:SYK [plasma membrane] (Homo sapiens)
as a candidate of
FYN-like kinases [cytosol] (Homo sapiens)
Other forms of this molecule
p-Y348-SYK [cytosol]
p-6Y-SYK [cytosol]
SYK [plasma membrane]
p-Y-SYK [plasma membrane]
p-Y-SYK [cytosol]
Inferred To
SYK [cytosol]
(Bos taurus)
SYK [cytosol]
(Caenorhabditis elegans)
SYK [cytosol]
(Canis familiaris)
SYK [cytosol]
(Gallus gallus)
SYK [cytosol]
(Sus scrofa)
syk [cytosol]
(Xenopus tropicalis)
Syk [cytosol]
(Mus musculus)
Syk [cytosol]
(Rattus norvegicus)
Wsck [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001128524.1
,
NP_001167638.1
,
NP_001167639.1
,
NP_003168.2
,
XP_054219629.1
,
XP_054219627.1
,
XP_011517248.1
,
XP_054219628.1
,
XP_047279766.1
,
XP_047279765.1
,
XP_005252204.1
ZINC - World Drugs
KSYK_HUMAN
Guide to Pharmacology - Targets
2230
OpenTargets
ENSG00000165025
ENSEMBL
ENST00000375747
,
ENST00000375746
,
ENSP00000364898
,
ENSP00000364899
,
ENSP00000364904
,
ENST00000375754
,
ENSP00000364907
,
ENST00000375751
,
ENSG00000165025
ZINC - FDA approved
KSYK_HUMAN
ZINC - Substances
KSYK_HUMAN
ZINC - Biogenic
KSYK_HUMAN
ZINC target
P43405
PRO
P43405
GlyGen
P43405
PDB
4I0R
,
4PV0
,
4F4P
,
4YJS
,
4DFL
,
4XG9
,
7Q5T
,
8WYW
,
5CXZ
,
5TIU
,
4RX8
,
4XG2
,
4XG8
,
5TR6
,
6HM7
,
3FQH
,
3SRV
,
3TUC
,
4XG6
,
4YJQ
,
1XBC
,
6ZCQ
,
4RX7
,
6ZC0
,
3FQS
,
4XG7
,
6ZCY
,
5LMB
,
8BI2
,
4YJT
,
5Y5U
,
5LMA
,
1CSY
,
4XG4
,
4I0T
,
6ZCP
,
1XBB
,
6ZCX
,
5CY3
,
4I0S
,
5TT7
,
4PUZ
,
1A81
,
4FYN
,
4YJR
,
3VF9
,
4FZ7
,
6ZCU
,
7Q63
,
4FL1
,
4FZ6
,
4RSS
,
4WNM
,
4YJV
,
6ZCS
,
6VOV
,
3VF8
,
4YJO
,
4RX9
,
8X5K
,
4YJU
,
5C26
,
3FQE
,
6ZCR
,
3TUB
,
6HM6
,
4YJP
,
6SSB
,
8RRQ
,
4GFG
,
7Q5U
,
3BUW
,
7SA7
,
5Y5T
,
3EMG
,
1CSZ
,
5CXH
,
3TUD
,
1XBA
,
4PX6
,
5C27
,
7Q5W
,
8RRZ
,
4FL2
,
4FYO
,
4XG3
,
5T68
,
4DFN
,
4FL3
,
5GHV
ZINC - Investigational
KSYK_HUMAN
ZINC - Metabolites
KSYK_HUMAN
IntEnz
2.7.10.2
GeneCards
SYK
HPA
ENSG00000165025-SYK
Pharos - Targets
P43405
ZINC - Predictions - Purchasable
KSYK_HUMAN
HMDB Protein
HMDBP01458
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P40763 STAT3
12
p-Y705-STAT3 [nucleoplasm]
(R-HSA-1112554)
p-Y705-STAT3 [cytosol]
(R-HSA-914048)
STAT3 [cytosol]
(R-HSA-539044)
p-Y705,S727-STAT3 [cytosol]
(R-HSA-539048)
p-Y705-STAT3 [cytosol]
(R-HSA-8983130)
p-S727-STAT3 [cytosol]
(R-HSA-198705)
p-Y705-STAT3 [nucleoplasm]
(R-HSA-9027589)
p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701429)
AcK685- p-Y705,S727-STAT3 [nucleoplasm]
(R-HSA-9701435)
p-STAT3 [cytosol]
(R-HSA-8982823)
p-STAT3 [nucleoplasm]
(R-HSA-8983188)
Unfolded STAT3 [cytosol]
(R-HSA-6813811)
0.873
10
UniProt:Q9UHP3 USP25
1
USP25 [cytosol]
(R-HSA-5696900)
0.831
8
UniProt:P06239 LCK
4
LCK [cytosol]
(R-HSA-167609)
p-Y394-LCK [cytosol]
(R-HSA-202308)
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
0.748
8
UniProt:P22681 CBL
20
PolyUb,p-Y-CBL [cytosol]
(R-HSA-9763893)
CBL R420G [cytosol]
(R-HSA-9706203)
CBL R420Q [cytosol]
(R-HSA-9706186)
CBL Y371H [cytosol]
(R-HSA-9706680)
CBL H398Y [cytosol]
(R-HSA-9706639)
CBL P417A [cytosol]
(R-HSA-9706636)
CBL S376F [cytosol]
(R-HSA-9706643)
CBL E366_Q409del [cytosol]
(R-HSA-9706179)
CBL del366-477 [cytosol]
(R-HSA-9706176)
CBL R499L [cytosol]
(R-HSA-9706678)
CBL L380P [cytosol]
(R-HSA-9706630)
CBL L287R [cytosol]
(R-HSA-9706693)
CBL L380R [cytosol]
(R-HSA-9706635)
CBL G375P [cytosol]
(R-HSA-9706219)
CBL P417L [cytosol]
(R-HSA-9706634)
CBL H398Q [cytosol]
(R-HSA-9706633)
CBL P417R [cytosol]
(R-HSA-9706632)
CBL [cytosol]
(R-HSA-112199)
p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-912656)
PolyUb,p-Y700,Y731,Y774-CBL [cytosol]
(R-HSA-8848826)
0.743
7
UniProt:P36888 FLT3
20
FLT3 F691I [plasma membrane]
(R-HSA-9702900)
FLT3 N676D [plasma membrane]
(R-HSA-9702895)
FLT3 R834Q [plasma membrane]
(R-HSA-9691899)
FLT3 Y572C [plasma membrane]
(R-HSA-9691902)
FLT3 A848P [plasma membrane]
(R-HSA-9702909)
FLT3 A627P [plasma membrane]
(R-HSA-9699448)
FLT3 F621L [plasma membrane]
(R-HSA-9699426)
p-Y768,Y969 FLT3 [plasma membrane]
(R-HSA-9698405)
Ub-pY FLT3 [endosome membrane]
(R-HSA-9706174)
Ub-pY FLT3 [plasma membrane]
(R-HSA-9706171)
FLT3 V592G [plasma membrane]
(R-HSA-9691071)
FLT3 F590_F605dup [plasma membrane]
(R-HSA-9697939)
FLT3 F590G Y591D [plasma membrane]
(R-HSA-9691062)
FLT3 F594L [plasma membrane]
(R-HSA-9691058)
FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE [plasma membrane]
(R-HSA-9699433)
FLT3 V579A [plasma membrane]
(R-HSA-9691051)
FLT3 Y599_D600insGLYVDFREYEY [plasma membrane]
(R-HSA-9696044)
FLT3 Y591_V592insVDFREDREHH [plasma membrane]
(R-HSA-9696043)
FLT3 D600_L601insMGMGGECNPGRQ [plasma membrane]
(R-HSA-9690076)
FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE [plasma membrane]
(R-HSA-9696033)
0.737
22
UniProt:P20273 CD22
3
p-Y762,807,822-CD22 [plasma membrane]
(R-HSA-5690726)
CD22 [plasma membrane]
(R-HSA-197703)
NAc-CD22 [plasma membrane]
(R-HSA-5690736)
0.623
4
UniProt:P07766 CD3E
2
p-Y188,Y199-CD3E [plasma membrane]
(R-HSA-202228)
CD3E [plasma membrane]
(R-HSA-197906)
0.597
6
UniProt:Q9ULZ3 PYCARD
4
PYCARD [cytosol]
(R-HSA-561191)
PYCARD [secretory granule lumen]
(R-HSA-6800957)
PYCARD [extracellular region]
(R-HSA-6806196)
PYCARD [azurophil granule lumen]
(R-HSA-6798768)
0.591
4
UniProt:P27986 PIK3R1
16
PIK3R1 [plasma membrane]
(R-HSA-198365)
PIK3R1 [cytosol]
(R-HSA-74789)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
0.581
5
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.571
7
UniProt:Q96IP4 TET5A
0.57
3
UniProt:P30273 FCER1G
5
FCER1G [ficolin-1-rich granule membrane]
(R-HSA-6801016)
FCER1G [tertiary granule membrane]
(R-HSA-6800183)
p-Y65-FCER1G [plasma membrane]
(R-HSA-2454244)
FCER1G [plasma membrane]
(R-HSA-54715)
p-Y65,Y76-FCER1G [plasma membrane]
(R-HSA-141096)
0.564
2
UniProt:Q9NP31 SH2D2A
1
SH2D2A [cytosol]
(R-HSA-4420125)
0.556
3
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:Q8TF42 UBS3B
0.544
2
UniProt:P54274 TERF1
1
TERF1 [nucleoplasm]
(R-HSA-164618)
0.508
2
ChEBI:49375 DASATINIB
0.499
2
UniProt:P11049 CD37
0.499
3
ChEBI:39112 BOSUTINIB
0.499
2
UniProt:Q8TDQ0 HAVCR2
1
HAVCR2 [plasma membrane]
(R-HSA-5340408)
0.462
3
UniProt:P19174 PLCG1
6
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
0.462
4
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