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p-Y525-GPNMB [plasma membrane]
Stable Identifier
R-HSA-8857558
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Non-Receptor Tyrosine Kinases (Homo sapiens)
Signaling by PTK6 (Homo sapiens)
PTK6 promotes HIF1A stabilization (Homo sapiens)
EGFR phosphorylates GPNMB (Homo sapiens)
HBEGF:EGFR:p-Y525-GPNMB [plasma membrane] (Homo sapiens)
p-Y525-GPNMB [plasma membrane] (Homo sapiens)
LINC01139 facilitates PTK6 autophosphorylation (Homo sapiens)
HBEGF:EGFR:p-Y525-GPNMB:LINC01139:PTK6:LRRK2 [plasma membrane] (Homo sapiens)
HBEGF:EGFR:p-Y525-GPNMB [plasma membrane] (Homo sapiens)
p-Y525-GPNMB [plasma membrane] (Homo sapiens)
HBEGF:EGFR:p-Y525-GPNMB:LINC01139:p-Y351-PTK6:LRRK2 [plasma membrane] (Homo sapiens)
HBEGF:EGFR:p-Y525-GPNMB [plasma membrane] (Homo sapiens)
p-Y525-GPNMB [plasma membrane] (Homo sapiens)
LINC01139 promotes phosphorylation of HIF1A by LRRK2 (Homo sapiens)
HBEGF:EGFR:p-Y525-GPNMB:LINC01139:p-Y351-PTK6:LRRK2 [plasma membrane] (Homo sapiens)
HBEGF:EGFR:p-Y525-GPNMB [plasma membrane] (Homo sapiens)
p-Y525-GPNMB [plasma membrane] (Homo sapiens)
LINC01139 promotes phosphorylation of HIF1A by PTK6 (Homo sapiens)
HBEGF:EGFR:p-Y525-GPNMB:LINC01139:p-Y351-PTK6:LRRK2 [plasma membrane] (Homo sapiens)
HBEGF:EGFR:p-Y525-GPNMB [plasma membrane] (Homo sapiens)
p-Y525-GPNMB [plasma membrane] (Homo sapiens)
Phosphorylated GPNMB recruits PTK6 and LRRK2 in the presence of LINC01139 (Homo sapiens)
HBEGF:EGFR:p-Y525-GPNMB [plasma membrane] (Homo sapiens)
p-Y525-GPNMB [plasma membrane] (Homo sapiens)
HBEGF:EGFR:p-Y525-GPNMB:LINC01139:PTK6:LRRK2 [plasma membrane] (Homo sapiens)
HBEGF:EGFR:p-Y525-GPNMB [plasma membrane] (Homo sapiens)
p-Y525-GPNMB [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14956 GPNMB
Gene Names
GPNMB, HGFIN, NMB, UNQ1725/PRO9925
Chain
signal peptide:1-22, chain:23-572
Reference Genes
BioGPS Gene:10457 GPNMB
COSMIC (genes):GPNMB GPNMB
COSMIC (genes):NMB NMB
CTD Gene:10457 GPNMB
dbSNP Gene:10457 GPNMB
ENSEMBL:ENSG00000136235 GPNMB
HGNC:4462 GPNMB
KEGG:hsa:10457 GPNMB
Monarch:10457 GPNMB
NCBI Gene:10457 GPNMB
OMIM:604368 GPNMB
UCSC:Q14956 GPNMB
Reference Transcript
RefSeq:XM_047419776.1 GPNMB
RefSeq:NM_002510.3 GPNMB
RefSeq:NM_001005340.2 GPNMB
Participates
as a component of
HBEGF:EGFR:p-Y525-GPNMB [plasma membrane] (Homo sapiens)
Other forms of this molecule
GPNMB [plasma membrane]
Inferred To
phospho-Gpnmb [plasma membrane]
(Mus musculus)
phospho-Gpnmb [plasma membrane]
(Rattus norvegicus)
phospho-GPNMB [plasma membrane]
(Bos taurus)
phospho-GPNMB [plasma membrane]
(Sus scrofa)
phospho-gpnmb [plasma membrane]
(Xenopus tropicalis)
phospho-p-Y525-GPNMB [plasma membrane]
(Gallus gallus)
Modified Residues
Name
O4'-phospho-L-tyrosine at 525
Coordinate
525
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_001005340.1
,
XP_047275732.1
,
NP_002501.1
ENSEMBL
ENST00000381990
,
ENSP00000258733
,
ENSP00000371420
,
ENST00000258733
,
ENSG00000136235
OpenTargets
ENSG00000136235
GeneCards
GPNMB
HPA
ENSG00000136235-GPNMB
PRO
Q14956
Pharos - Targets
Q14956
GlyGen
Q14956
Orphanet
GPNMB
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.524
3
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