Reactome | TGFA precursor [endoplasmic reticulum-Golgi intermediate compartment membrane]

TGFA precursor [endoplasmic reticulum-Golgi intermediate compartment membrane]

Stable Identifier

R-HSA-5689841

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum-Golgi intermediate compartment membrane

Synonyms

Protransforming growth factor alpha, TGFA(24-160)

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - ER to Golgi Anterograde Transport (Homo sapiens)
        
        COPII-mediated vesicle transport (Homo sapiens)
        
        BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        CNIH1:TFGA,AREG precursors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        TFGA, AREG precursors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        TGFA precursor [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)

Vesicle-mediated transport (Homo sapiens)

- Membrane Trafficking (Homo sapiens)
  - ER to Golgi Anterograde Transport (Homo sapiens)
    - COPII-mediated vesicle transport (Homo sapiens)
      - BET1:GOSR2:STX5 bind v-SNARES on tethered vesicle (Homo sapiens)
        
        COPII cargo:receptors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        CNIH1:TFGA,AREG precursors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        TFGA, AREG precursors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)
        
        TGFA precursor [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P01135 TGFA

Gene Names

TGFA

Chain

signal peptide:1-23, chain:24-160, propeptide:24-39, chain:40-89, propeptide:90-160

Reference Genes

BioGPS Gene:7039 TGFA

COSMIC (genes):TGFA TGFA

CTD Gene:7039 TGFA

dbSNP Gene:7039 TGFA

ENSEMBL:ENSG00000163235 TGFA

ENSEMBL_homo_sapiens_GENE:ENSG00000163235.16 TGFA

HGNC:11765 TGFA

KEGG Gene (Homo sapiens):7039 TGFA

Monarch:7039 TGFA

NCBI Gene:7039 TGFA

OMIM:190170 TGFA

UCSC:P01135 TGFA

Reference Transcript

Other Identifiers

11728302_at

11728303_at

11745159_a_at

11745160_s_at

160025_at

16898788

205015_PM_s_at

205015_s_at

205016_PM_at

205016_at

211258_PM_s_at

211258_s_at

2558640

2558641

2558642

2558643

2558644

2558645

2558646

2558647

2558648

2558649

2558650

2558654

2558660

2558669

2558695

2558709

2558710

383_at

7039

8052872

A_23_P377291

A_33_P3408203

GE59968

GO:0000278

GO:0001525

GO:0005102

GO:0005154

GO:0005515

GO:0005576

GO:0005615

GO:0005783

GO:0005789

GO:0005886

GO:0007173

GO:0008083

GO:0008284

GO:0009986

GO:0012507

GO:0016020

GO:0016323

GO:0023052

GO:0030297

GO:0030669

GO:0031410

GO:0033116

GO:0035556

GO:0036211

GO:0038134

GO:0043226

GO:0043410

GO:0045840

GO:0048018

GO:0048471

GO:0048856

GO:0050679

GO:0050731

GO:0051781

GO:0060749

GO:0072574

GO:0098772

GO:0140014

HMNXSV003001777

ILMN_1805175

ILMN_2083946

PH_hs_0010146

TC02001963.hg

X70340_at

g339537_3p_a_at

g4507460_3p_at

g6175597_3p_a_at

Participates

as a member of

TFGA, AREG precursors [endoplasmic reticulum-Golgi intermediate compartment membrane] (Homo sapiens)

Other forms of this molecule

TGFA(24-98) [clathrin-coated endocytic vesicle membrane]

TGFA precursor [ER to Golgi transport vesicle membrane]

TGFA(24-98) [extracellular region]

TGFA precursor [endoplasmic reticulum membrane]

Inferred To

TGFA [endoplasmic reticulum-Golgi intermediate compartment membrane] (Bos taurus)

TGFA [endoplasmic reticulum-Golgi intermediate compartment membrane] (Canis familiaris)

TGFA [endoplasmic reticulum-Golgi intermediate compartment membrane] (Sus scrofa)

Tgfa [endoplasmic reticulum-Golgi intermediate compartment membrane] (Mus musculus)

Tgfa [endoplasmic reticulum-Golgi intermediate compartment membrane] (Rattus norvegicus)

TGFA precursor [endoplasmic reticulum-Golgi intermediate compartment membrane] (Gallus gallus)

Cross References

RefSeq

NP_001295088.1, NP_001093161.1, NP_003227.1, NP_001295087.1

OpenTargets

ENSG00000163235

GeneCards

P01135

HPA

ENSG00000163235-TGFA

Ensembl

ENST00000295400, ENSP00000295400, ENST00000418333, ENST00000445399, ENSG00000163235, ENSP00000404099, ENSP00000387493

PRO

P01135

Pharos - Targets

P01135

Orphanet

17254

HMDB Protein

HMDBP12416

PDB

7SZ7, 1YUG, 2TGF, 1GK5, 3E50, 4TGF, 5KN5, 7SZ5, 1YUF, 3TGF, 1MOX

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.779	4
UniProt:Q969F2 NKD2			0.573	3
UniProt:O43765 SGTA	1	SGTA [cytosol] (R-HSA-5423595)	0.556	3
UniProt:Q9EQJ9 MAGI3			0.543	4

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