Reactome | TACC3 [cytosol]

TACC3 [cytosol]

Stable Identifier

R-HSA-2160956

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Transforming acidic coiled-coil-containing protein 3, ERIC1

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9Y6A5 TACC3

Gene Names

TACC3, ERIC1

Chain

initiator methionine:, chain:2-838

Reference Genes

BioGPS Gene:10460 TACC3

COSMIC (genes):TACC3 TACC3

CTD Gene:10460 TACC3

dbSNP Gene:10460 TACC3

ENSEMBL:ENSG00000013810 TACC3

ENSEMBL_homo_sapiens_GENE:ENSG00000013810.21 TACC3

HGNC:11524 TACC3

KEGG Gene (Homo sapiens):10460 TACC3

Monarch:10460 TACC3

NCBI Gene:10460 TACC3

OMIM:605303 TACC3

UCSC:Q9Y6A5 TACC3

Reference Transcript

Other Identifiers

10460

11718297_a_at

11746461_a_at

11763455_a_at

11763456_x_at

16964000

218308_PM_at

218308_at

2714956

2714957

2714958

2714961

2714962

2714969

2714971

2714972

2714973

2714974

2714975

2714977

2714979

2714983

2714985

2714987

2714992

2714994

2714997

2714998

2714999

52238_s_at

8093500

A_14_P128134

A_23_P212844

GE58400

GO:0000226

GO:0000278

GO:0000922

GO:0005515

GO:0005737

GO:0005813

GO:0005815

GO:0005819

GO:0005829

GO:0005856

GO:0007010

GO:0007049

GO:0007052

GO:0007059

GO:0007091

GO:0008283

GO:0021987

GO:0034451

GO:0043226

GO:0043231

GO:0048856

GO:0051301

GO:0060236

GO:0072686

GO:1902850

HMNXSV003007489

ILMN_1724407

PH_hs_0005773

TC04000028.hg

g5454101_3p_at

Participates

as a component of

as an input of

Cross References

RefSeq

NP_006333.1, XP_016863142.1

OpenTargets

ENSG00000013810

HPA

ENSG00000013810-TACC3

GeneCards

Q9Y6A5

Ensembl

ENST00000651472, ENSG00000013810, ENSP00000326550, ENSP00000498361, ENST00000313288

PRO

Q9Y6A5

Pharos - Targets

Q9Y6A5

PDB

5ODS, 5LXO, 5ODT, 5LXN

Interactors (36)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14008 CKAP5	1	CKAP5 [cytosol] (R-HSA-377729)	0.819	10
UniProt:Q9NU19 TB22B			0.781	7
UniProt:Q2M2Z5 KIZ			0.718	6
UniProt:Q96Q77 CIB3			0.718	9
UniProt:Q9P270 SLAI2			0.643	4
UniProt:Q53EZ4 CEP55			0.621	3
UniProt:Q2WGJ6 KLH38			0.601	4
UniProt:A2AGT5	1	Ckap5 [cytosol] (R-MMU-377729)	0.564	2
UniProt:Q5VTR2 RNF20	2	RNF20 [cytosol] (R-HSA-9715141) RNF20 [nucleoplasm] (R-HSA-5689011)	0.556	3
UniProt:Q7Z614 SNX20			0.556	3
UniProt:Q8TD31-3 CCHCR1			0.556	3
UniProt:Q96DY2-2 Q96DY22			0.556	3
UniProt:Q7Z3B4 NUP54	2	NUP54 [cytosol] (R-HSA-9634221) NUP54 [nuclear envelope] (R-HSA-157724)	0.556	3
UniProt:Q86Y33-5 CDC20B			0.556	3
UniProt:Q9GZM8 NDEL1	1	NDEL1 [cytosol] (R-HSA-376258)	0.556	3
UniProt:Q99819 ARHGDIG	1	ARHGDIG [cytosol] (R-HSA-195087)	0.556	3
UniProt:Q53TS8 CTSRT			0.556	3
UniProt:Q8TC71 MIEAP			0.556	3
UniProt:Q9BZE9 ASPSCR1	1	ASPSCR1 [cytoplasmic vesicle membrane] (R-HSA-1449582)	0.556	3
UniProt:Q99988 GDF15			0.556	3
UniProt:A5D8V6 VPS37C	1	VPS37C [endosome membrane] (R-HSA-184438)	0.556	3
UniProt:Q07866-2 KLC1			0.556	3
UniProt:Q9BXY8 BEX2			0.556	3
UniProt:Q00994 BEX3	1	NGFRAP1 [cytosol] (R-HSA-194333)	0.556	3
UniProt:O95721 SNAP29	3	SNAP29 [azurophil granule membrane] (R-HSA-6799359) SNAP29 [plasma membrane] (R-HSA-2029020) SNAP29 [Golgi membrane] (R-HSA-6810997)	0.527	2
UniProt:Q96GS4 BORC6			0.527	3
UniProt:P50552 VASP	1	VASP [cytosol] (R-HSA-446323)	0.527	2
UniProt:P11142 HSPA8	10	Me3K561-HSPA8 [nucleoplasm] (R-HSA-8932217) HSPA8 [secretory granule lumen] (R-HSA-6801530) HSPA8 [extracellular region] (R-HSA-6805936) HSPA8 [ficolin-1-rich granule lumen] (R-HSA-6801494) HSPA8 [nucleoplasm] (R-HSA-5082380) HSPA8 [plasma membrane] (R-HSA-936508) HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-888599) HSPA8 [late endosome lumen] (R-HSA-9631104) HSPA8 [lysosomal lumen] (R-HSA-9625182) HSPA8 [cytosol] (R-HSA-264476)	0.527	2
UniProt:Q03426 MVK	1	MVK [cytosol] (R-HSA-191375)	0.527	2
UniProt:Q8N8S7 ENAH	1	ENAH [cytosol] (R-HSA-426406)	0.527	2
UniProt:O43482 OIP5	1	OIP5 [nucleoplasm] (R-HSA-606286)	0.527	2
UniProt:P16562 CRIS2			0.527	2
UniProt:O14965 AURKA	6	SUMO1-K258-AURKA [cytosol] (R-HSA-4655367) p-T288-AURKA [nucleoplasm] (R-HSA-6805089) AURKA [nucleoplasm] (R-HSA-4655443) PolyUb-AURKA [cytosol] (R-HSA-8854040) AURKA [cytosol] (R-HSA-174254) p-T288-AURKA [cytosol] (R-HSA-2574832)	0.527	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.508	3
UniProt:P09496 CLTA	6	CLTA [plasma membrane] (R-HSA-2980611) CLTA [lysosomal membrane] (R-HSA-2980595) CLTA [clathrin-coated endocytic vesicle membrane] (R-HSA-5138427) CLTA [endolysosome membrane] (R-HSA-8870825) CLTA [trans-Golgi network membrane] (R-HSA-5333758) CLTA [cytosol] (R-HSA-8856817)	0.499	3
UniProt:Q9Y6A5 TACC3	1	TACC3 [cytosol] (R-HSA-2160956)	0.488	2

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