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MPL [plasma membrane]
Stable Identifier
R-HSA-443938
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Thrombopoietin receptor, TPOR_HUMAN
Locations in the PathwayBrowser
Expand all
Hemostasis (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
Platelet Aggregation (Plug Formation) (Homo sapiens)
Thrombopoietin binds the thrombopoietin receptor (Homo sapiens)
MPL [plasma membrane] (Homo sapiens)
TPO:Thrombopoietin receptor [plasma membrane] (Homo sapiens)
MPL [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P40238 MPL
Gene Names
MPL, TPOR
Chain
signal peptide:1-25, chain:26-635
Reference Genes
BioGPS Gene:4352 MPL
COSMIC (genes):MPL MPL
CTD Gene:4352 MPL
dbSNP Gene:4352 MPL
ENSEMBL:ENSG00000117400 MPL
HGNC:7217 MPL
Monarch:4352 MPL
NCBI Gene:4352 MPL
OMIM:159530 MPL
UCSC:P40238 MPL
Reference Transcript
RefSeq:NM_005373.2 MPL
Other Identifiers
11740944_at
11752643_a_at
16663498
207550_PM_at
207550_at
211903_PM_s_at
211903_s_at
216825_PM_s_at
216825_s_at
2333108
2333109
2333110
2333111
2333112
2333113
2333114
2333115
2333116
2333117
2333118
2333120
2333122
2333123
2333124
2333125
2333126
2333127
2333128
2333129
2333130
2333131
2333134
34004_at
4352
7900683
A_23_P137806
A_24_P156769
A_33_P3325897
GE60541
GO:0001780
GO:0002376
GO:0004896
GO:0005515
GO:0005794
GO:0005886
GO:0007166
GO:0009897
GO:0009986
GO:0016020
GO:0016064
GO:0019221
GO:0031965
GO:0035702
GO:0038163
GO:0038164
GO:0043025
GO:0043226
GO:0050671
GO:0060089
GO:0071456
GO:1905221
GO:1990959
GO:1990960
HMNXSV003014378
Hs.307129.0.S1_3p_s_at
ILMN_1776640
PH_hs_0004791
TC01000544.hg
U68162_cds1_s_at
g184262_3p_at
g184262_3p_x_at
g4885490_3p_at
Participates
as a component of
TPO:TPOR [plasma membrane] (Homo sapiens)
TPO:Thrombopoietin receptor [plasma membrane] (Homo sapiens)
as an input of
Thrombopoietin binds the thrombopoietin receptor (Homo sapiens)
Thrombopoietin binds the thrombopoietin receptor (Homo sapiens)
Cross References
ZINC - World Drugs
TPOR_HUMAN
Guide to Pharmacology - Targets
1722
ENSEMBL
ENST00000372470
,
ENSP00000361548
OpenTargets
ENSG00000117400
ZINC - FDA approved
TPOR_HUMAN
ZINC - Substances
TPOR_HUMAN
ZINC target
P40238
PRO
P40238
PDB
8G04
HPA
ENSG00000117400-MPL
Pharos - Targets
P40238
Orphanet
MPL
ZINC - Predictions - Purchasable
TPOR_HUMAN
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O60674 JAK2
8
JAK2 [cytosol]
(R-HSA-210620)
p-Y1007-JAK2 [cytosol]
(R-HSA-873799)
p-12Y-JAK2 [cytosol]
(R-HSA-2586516)
JAK2 [endosome lumen]
(R-HSA-2002372)
JAK2 V617F [nucleoplasm]
(R-HSA-5211269)
p-Y813-JAK2 [cytosol]
(R-HSA-997248)
p-JAK2 [cytosol]
(R-HSA-210621)
p-Y1007,Y1008-JAK2 [cytosol]
(R-HSA-9005327)
0.518
6
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