Reactome | p-Y GRB10 [cytosol]

p-Y GRB10 [cytosol]

Stable Identifier

R-HSA-9706168

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Growth factor receptor-bound protein 10, GRB10 adaptor protein, Insulin receptor binding protein GRB-IR

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13322 GRB10

Gene Names

GRB10, GRBIR, KIAA0207

Chain

chain:1-594

Reference Genes

BioGPS Gene:2887 GRB10

COSMIC (genes):GRB10 GRB10

CTD Gene:2887 GRB10

dbSNP Gene:2887 GRB10

ENSEMBL:ENSG00000106070 GRB10

HGNC:4564 GRB10

KEGG Gene (Homo sapiens):2887 GRB10

Monarch:2887 GRB10

NCBI Gene:2887 GRB10

OMIM:601523 GRB10

UCSC:Q13322 GRB10

Reference Transcript

Other Identifiers

0000130215

11722160_a_at

11734495_a_at

11741924_a_at

209409_at

209410_s_at

210999_s_at

2887

3050461

3050463

3050464

3050465

3050471

3050476

3050478

3050480

3050481

3050485

3050487

3050488

3050489

3050491

3050492

3050498

3050507

3050514

3050528

3050529

3050532

3050533

3050546

3050548

3050549

3050552

3050562

3050566

3050567

3050568

3050570

37615_at

8139656

A_24_P235266

A_33_P3312147

D86962_at

GE57367

GO:0000902

GO:0003674

GO:0005070

GO:0005158

GO:0005515

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0005886

GO:0006810

GO:0007165

GO:0007267

GO:0007411

GO:0008150

GO:0008286

GO:0030154

GO:0030178

GO:0030674

GO:0030949

GO:0032991

GO:0040011

GO:0042592

GO:0046325

GO:0046627

GO:0048856

GO:0055085

GO:0120162

ILMN_1652662

ILMN_1667771

ILMN_1669617

ILMN_2340919

PH_hs_0031701

g1503997_3p_at

g2130616_3p_a_at

Participant Of

hasComponent

Other forms of this molecule

GRB10 [cytosol]

Inferred To

phospho-grb10 [cytosol] (Xenopus tropicalis)

phospho-grb10b [cytosol] (Danio rerio)

phospho-Grb10 [cytosol] (Mus musculus)

phospho-Grb10 [cytosol] (Rattus norvegicus)

phospho-GRB10 [cytosol] (Canis familiaris)

phospho-p-Y GRB10 [cytosol] (Bos taurus)

phospho-p-Y GRB10 [cytosol] (Gallus gallus)

phospho-p-Y GRB10 [cytosol] (Sus scrofa)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_011513606.1, XP_016867556.1, XP_016867557.1, NP_001001549.1, XP_011513614.1, XP_016867534.1, XP_016867535.1, XP_011513618.1, XP_016867554.1, NP_005302.3, XP_016867555.1, XP_016867552.1, XP_016867553.1, NP_001001550.1, NP_001001555.1

OpenTargets

ENSG00000106070

HPA

ENSG00000106070-GRB10

GeneCards

Q13322

Ensembl

ENSP00000496245, ENSG00000106070, ENSP00000385046, ENSP00000385189, ENST00000402497, ENST00000407526, ENST00000643299, ENST00000335866, ENSP00000385366, ENSP00000338543, ENSP00000495341, ENSP00000385544, ENST00000398812, ENSP00000385748, ENSP00000381790, ENST00000398810, ENSP00000385770, ENST00000401949, ENST00000403097, ENST00000406641, ENSP00000381793, ENST00000645075, ENSP00000349818, ENST00000402578, ENST00000357271

PRO

Q13322

PDB

1NRV, 3HK0

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.729	4
UniProt:P36888 FLT3	144	FLT3 N676D [plasma membrane] (R-HSA-9702895) FLT3 F691I [plasma membrane] (R-HSA-9702900) FLT3 R834Q [plasma membrane] (R-HSA-9691899) FLT3 Y572C [plasma membrane] (R-HSA-9691902) FLT3 A848P [plasma membrane] (R-HSA-9702909) FLT3 A627P [plasma membrane] (R-HSA-9699448) FLT3 F621L [plasma membrane] (R-HSA-9699426) p-Y768,Y969 FLT3 [plasma membrane] (R-HSA-9698405) Ub-pY FLT3 [endosome membrane] (R-HSA-9706174) Ub-pY FLT3 [plasma membrane] (R-HSA-9706171) FLT3 V592G [plasma membrane] (R-HSA-9691071) FLT3 Y589_F590insFYVDFREYEYDLKWEF [plasma membrane] (R-HSA-9697939) FLT3 F590G Y591D [plasma membrane] (R-HSA-9691062) FLT3 F594L [plasma membrane] (R-HSA-9691058) FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE [plasma membrane] (R-HSA-9699433) FLT3 V579A [plasma membrane] (R-HSA-9691051) FLT3 Y599_D600insGLYVDFREYEY [plasma membrane] (R-HSA-9696044) FLT3 Y591_V592insVDFREDREHH [plasma membrane] (R-HSA-9696043) FLT3 D600_L601insMGMGGECNPGRQ [plasma membrane] (R-HSA-9690076) FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE [plasma membrane] (R-HSA-9696033) FLT3 Y591_V592insVDFREYEYDH [plasma membrane] (R-HSA-9691903) FLT3 F612_G613insGYVDFREYEYDLKWEFRPRENLF [plasma membrane] (R-HSA-9696038) FLT3 Y599_F600insFYVDFREYEYDLKWEF [plasma membrane] (R-HSA-9690084) FLT3 E598_Y599insYDLKWEFRRENLEFG [plasma membrane] (R-HSA-9696037) FLT3 N609_L610insSSDNEYFYVDFREYEYDLKW [plasma membrane] (R-HSA-9690086) FLT3 F594_R595insREYEYDL [plasma membrane] (R-HSA-9696032) FLT3 L601_K602insREYEYDL [plasma membrane] (R-HSA-9696048) FLT3 N609_L610insSSDNEYFYVDFREYEYDLKWEFPREN [plasma membrane] (R-HSA-9690074) FLT3 E596_Y597insRTDFRE [plasma membrane] (R-HSA-9699428) FLT3 D586_E587insEYFYVDFREY [plasma membrane] (R-HSA-9690083) FLT3 E598_Y599insFYVDFREY [plasma membrane] (R-HSA-9699437) FLT3 V592A [plasma membrane] (R-HSA-9691070) FLT3 L610_E611insCSSDNEYFYVDFREYEYDLKWEFPRENL [plasma membrane] (R-HSA-9696042) FLT3 E598_Y599insVDFREYE [plasma membrane] (R-HSA-9699445) FLT3 E598_Y599insFDFREYE [plasma membrane] (R-HSA-9696041) FLT3 K602_W603insYEYDLK [plasma membrane] (R-HSA-9683381) FLT3 L610_E611insLKWEFPRENL [plasma membrane] (R-HSA-9699438) FLT3 V579L [plasma membrane] (R-HSA-9691073) FLT3 F594V [plasma membrane] (R-HSA-9691061) FLT3 F594I [plasma membrane] (R-HSA-9691068) FLT3 V579E [plasma membrane] (R-HSA-9691057) FLT3 V592D [plasma membrane] (R-HSA-9691069) FLT3 V579I [plasma membrane] (R-HSA-9691056) FLT3 F594S [plasma membrane] (R-HSA-9691067) FLT3 D835del [plasma membrane] (R-HSA-9695715) FLT3 K663Q [plasma membrane] (R-HSA-9691908) FLT3 I836del [plasma membrane] (R-HSA-9695714) FLT3 D835N [plasma membrane] (R-HSA-9682321) FLT3 D835V [plasma membrane] (R-HSA-9682323) FLT3 Y842C [plasma membrane] (R-HSA-9699435) FLT3 D835H [plasma membrane] (R-HSA-9682304) FLT3 A627E_T628insYEYDLKWEFPRENLEFGKVLGSGAFGKVMNA [plasma membrane] (R-HSA-9691894) FLT3 I836LInsD [plasma membrane] (R-HSA-9682360) FLT3 D835E [plasma membrane] (R-HSA-9682297) FLT3 D835A [plasma membrane] (R-HSA-9682290) FLT3 D835Y [plasma membrane] (R-HSA-9682353) FLT3 N676K [plasma membrane] (R-HSA-9695721) FLT3 N841I [plasma membrane] (R-HSA-9691895) FLT3 F691L [plasma membrane] (R-HSA-9695722) FLT3 D839G [plasma membrane] (R-HSA-9695718) FLT3 K633N [plasma membrane] (R-HSA-9691906) FLT3 D839N [plasma membrane] (R-HSA-9695720) FLT3 N841Y [plasma membrane] (R-HSA-9691909) FLT3 D835G [plasma membrane] (R-HSA-9682301) FLT3 K633R [plasma membrane] (R-HSA-9691898) FLT3 N841T [plasma membrane] (R-HSA-9691896) FLT3 D835F [plasma membrane] (R-HSA-9682313) FLT3 N676T [plasma membrane] (R-HSA-9695719) FLT3 N676S [plasma membrane] (R-HSA-9695717) FLT3 N841K [plasma membrane] (R-HSA-9691907) FLT3 D839H [plasma membrane] (R-HSA-9695713) FLT3 F691V [plasma membrane] (R-HSA-9695716) FLT3 N841H [plasma membrane] (R-HSA-9691900) FLT3 D839E [plasma membrane] (R-HSA-9695712) FLT3 Y842H [plasma membrane] (R-HSA-9699443) FLT3 S451F [plasma membrane] (R-HSA-9691901) p-6Y FLT3 N676K [plasma membrane] (R-HSA-9695738) p-6Y FLT3 D839G [plasma membrane] (R-HSA-9695737) p-6Y FLT3 D835A [plasma membrane] (R-HSA-9682391) p-6Y FLT3 I836del [plasma membrane] (R-HSA-9695742) p-6Y FLT3 D835H [plasma membrane] (R-HSA-9682372) p-6Y FLT3 D835del [plasma membrane] (R-HSA-9695736) p-6Y FLT3 D835Y [plasma membrane] (R-HSA-9682387) p-6Y FLT3 D835V [plasma membrane] (R-HSA-9682373) p-6Y FLT3 D835N [plasma membrane] (R-HSA-9682378) p-6Y FLT3 N841I [plasma membrane] (R-HSA-9691926) p-6Y FLT3 K663Q [plasma membrane] (R-HSA-9691942) p-6Y FLT3 F691L [plasma membrane] (R-HSA-9695734) p-6Y FLT3 Y842C [plasma membrane] (R-HSA-9699420) p-6Y FLT3 D835E [plasma membrane] (R-HSA-9682395) p-6Y FLT3 D839H [plasma membrane] (R-HSA-9695739) p-6Y FLT3 N841T [plasma membrane] (R-HSA-9691939) p-6Y FLT3 D839N [plasma membrane] (R-HSA-9695744) p-6Y FLT3 N676T [plasma membrane] (R-HSA-9695743) p-6Y FLT3 K633N [plasma membrane] (R-HSA-9691928) p-6Y FLT3 Y842H [plasma membrane] (R-HSA-9699449) p-6Y FLT3 N841K [plasma membrane] (R-HSA-9691925) p-6Y FLT3 D835F [plasma membrane] (R-HSA-9682376) p-6Y FLT3 N841H [plasma membrane] (R-HSA-9691932) p-6Y FLT3 K633R [plasma membrane] (R-HSA-9691940) p-6Y FLT3 D835G [plasma membrane] (R-HSA-9682389) p-6Y FLT3 F691V [plasma membrane] (R-HSA-9695741) p-6Y FLT3 N676S [plasma membrane] (R-HSA-9695745) p-6Y FLT3 N841Y [plasma membrane] (R-HSA-9691927) p-6Y FLT3 D839E [plasma membrane] (R-HSA-9695740) p-6Y FLT3 S451F [plasma membrane] (R-HSA-9691933) p-6Y FLT3 F590G Y591D [plasma membrane] (R-HSA-9691065) p-6Y FLT3 E596_Y597insRTDFRE [plasma membrane] (R-HSA-9699436) p-6Y FLT3 F594L [plasma membrane] (R-HSA-9691052) p-6Y FLT3 V592A [plasma membrane] (R-HSA-9691053) p-6Y FLT3 V579A [plasma membrane] (R-HSA-9691066) p-6Y FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE [plasma membrane] (R-HSA-9699446) p-6Y FLT3 V592G [plasma membrane] (R-HSA-9691060) p-6Y FLT3 F594S [plasma membrane] (R-HSA-9691072) p-6Y FLT3 V579L [plasma membrane] (R-HSA-9691064) p-6Y FLT3 F594I [plasma membrane] (R-HSA-9691059) p-6Y FLT3 V579I [plasma membrane] (R-HSA-9691055) p-6Y FLT3 V592D [plasma membrane] (R-HSA-9691050) p-6Y FLT3 F594V [plasma membrane] (R-HSA-9691049) p-6Y FLT3 V579E [plasma membrane] (R-HSA-9691054) p-6Y FLT3 E598_Y599insVDFREYE [plasma membrane] (R-HSA-9699429) p-6Y FLT3 F594_R595insREYEYDL [plasma membrane] (R-HSA-9696035) p-6Y FLT3 E598_Y599insFYVDFREY [plasma membrane] (R-HSA-9699451) p-6Y FLT3 L601_K602insREYEYDL [plasma membrane] (R-HSA-9696049) p-6Y FLT3 L610_E611insLKWEFPRENL [plasma membrane] (R-HSA-9699417) p-6Y FLT3 A627E_T628insYEYDLKWEFPRENLEFGKVLGSGAFGKVMNA [plasma membrane] (R-HSA-9691924) p-6Y FLT3 N609_L610insSSDNEYFYVDFREYEYDLKW [plasma membrane] (R-HSA-9691931) p-6Y FLT3 N609_L610insSSDNEYFYVDFREYEYDLKWEFPREN [plasma membrane] (R-HSA-9691941) p-6Y FLT3 K602_W603insYEYDLK [plasma membrane] (R-HSA-9691930) p-6Y FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE [plasma membrane] (R-HSA-9696046) p-6Y FLT3 Y589_F590insFYVDFREYEYDLKWEF [plasma membrane] (R-HSA-9697935) p-6Y FLT3 E598_Y599insFDFREYE [plasma membrane] (R-HSA-9696031) p-6Y FLT3 E598_Y599insYDLKWEFRRENLEFG [plasma membrane] (R-HSA-9696039) p-6Y FLT3 D600_L601insMGMGGECNPGRQ [plasma membrane] (R-HSA-9691943) p-6Y FLT3 Y600_D601insGLYVDFREYEY [plasma membrane] (R-HSA-9696034) p-6Y FLT3 Y599_F600insFYVDFREYEYDLKWEF [plasma membrane] (R-HSA-9691944) p-6Y FLT3 L610_E611insCSSDNEYFYVDFREYEYDLKWEFPRENL [plasma membrane] (R-HSA-9696047) p-6Y FLT3 Y591_V592insVDFREDREHH [plasma membrane] (R-HSA-9696045) p-6Y FLT3 F612_G613insGYVDFREYEYDLKWEFRPRENLF [plasma membrane] (R-HSA-9696036) p-6Y FLT3 D586_E587insEYFYVDFREY [plasma membrane] (R-HSA-9691936) p-6Y FLT3 Y591_V592insVDFREYEYDH [plasma membrane] (R-HSA-9691937) p-6Y FLT3 I836LInsD [plasma membrane] (R-HSA-9682380) Autophosphorylated FLT3 [plasma membrane] (R-HSA-9604780) FLT3 [plasma membrane] (R-HSA-6786756)	0.591	6
UniProt:P06213 INSR	6	INSR(763-1382) [endosome membrane] (R-HSA-141722) p-6Y-INSR(763-1382) [endosome membrane] (R-HSA-141719) INSR(28-758) [endosome membrane] (R-HSA-141718) INSR(763-1382) [plasma membrane] (R-HSA-74669) p-6Y-INSR(763-1382) [plasma membrane] (R-HSA-74670) INSR(28-758) [plasma membrane] (R-HSA-74668)	0.581	4
UniProt:Q9UKA8 RCAN3			0.57	3
UniProt:P08069 IGF1R	3	IGF1R(31-736) [plasma membrane] (R-HSA-2404169) IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.527	2
UniProt:P54762 EPHB1	6	EPHB1 (?-984) [cytosol] (R-HSA-3928438) EPHB1 (?-?) [plasma membrane] (R-HSA-3928449) EPHB1 (?-984) [plasma membrane] (R-HSA-3928402) EPHB1 (18-?) [extracellular region] (R-HSA-3928393) EPHB1 [plasma membrane] (R-HSA-2682340) p-Y594,Y600-EPHB1 [plasma membrane] (R-HSA-3928347)	0.499	2
UniProt:Q9UQB8-6 BAIAP2			0.488	2

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