Reactome | p-Y GRB10 [cytosol]

p-Y GRB10 [cytosol]

Stable Identifier

R-HSA-9706168

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Growth factor receptor-bound protein 10, GRB10 adaptor protein, Insulin receptor binding protein GRB-IR

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13322 GRB10

Gene Names

GRB10, GRBIR, KIAA0207

Chain

chain:1-594

Reference Genes

BioGPS Gene:2887 GRB10

COSMIC (genes):GRB10 GRB10

CTD Gene:2887 GRB10

dbSNP Gene:2887 GRB10

ENSEMBL:ENSG00000106070 GRB10

HGNC:4564 GRB10

KEGG:hsa:2887 GRB10

Monarch:2887 GRB10

NCBI Gene:2887 GRB10

OMIM:601523 GRB10

UCSC:Q13322 GRB10

Reference Transcript

Participates

as a component of

Other forms of this molecule

GRB10 [cytosol]

Inferred To

phospho-grb10 [cytosol] (Xenopus tropicalis)

phospho-Grb10 [cytosol] (Mus musculus)

phospho-Grb10 [cytosol] (Rattus norvegicus)

phospho-Grb10 [cytosol] (Sus scrofa)

phospho-GRB10 [cytosol] (Bos taurus)

phospho-GRB10 [cytosol] (Canis familiaris)

phospho-GRB10 [cytosol] (Gallus gallus)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001337745.2, NP_001337743.1, XP_047276211.1, XP_011513618.1, NP_001001555.1, NP_001357937.1, NP_001001550.1, XP_054213954.1, XP_011513614.1, XP_047276200.1, XP_047276208.1, XP_011513606.1, XP_047276209.1, XP_047276210.1, NP_001001549.1, XP_016867553.1, XP_016867552.1, XP_016867534.1, NP_005302.3, XP_016867557.1, XP_054213942.1, XP_054213941.1, XP_054213939.1, XP_016867535.1, XP_016867554.1, XP_016867556.1, XP_047276199.1, XP_016867555.1, XP_054213938.1, XP_054213955.1, XP_047276197.1, XP_054213956.1

OpenTargets

ENSG00000106070

ENSEMBL

ENST00000406641, ENST00000403097, ENSP00000385748, ENSG00000106070, ENSP00000496245, ENST00000335866, ENST00000357271, ENSP00000385189, ENST00000401949, ENSP00000385366, ENSP00000385046, ENSP00000385544, ENST00000645075, ENSP00000381793, ENST00000643299, ENST00000402497, ENST00000407526, ENST00000402578, ENSP00000338543, ENSP00000385770, ENSP00000349818, ENSP00000495341, ENSP00000381790, ENST00000398812, ENST00000398810

GeneCards

GRB10

HPA

ENSG00000106070-GRB10

PRO

Q13322

Pharos - Targets

Q13322

GlyGen

Q13322

PDB

3HK0, 1NRV

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.729	4
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.643	4
UniProt:Q04917 YWHAH	1	YWHAH [cytosol] (R-HSA-1445107)	0.643	4
UniProt:P36888 FLT3	20	FLT3 F691I [plasma membrane] (R-HSA-9702900) FLT3 N676D [plasma membrane] (R-HSA-9702895) FLT3 R834Q [plasma membrane] (R-HSA-9691899) FLT3 Y572C [plasma membrane] (R-HSA-9691902) FLT3 A848P [plasma membrane] (R-HSA-9702909) FLT3 A627P [plasma membrane] (R-HSA-9699448) FLT3 F621L [plasma membrane] (R-HSA-9699426) p-Y768,Y969 FLT3 [plasma membrane] (R-HSA-9698405) Ub-pY FLT3 [endosome membrane] (R-HSA-9706174) Ub-pY FLT3 [plasma membrane] (R-HSA-9706171) FLT3 V592G [plasma membrane] (R-HSA-9691071) FLT3 F590_F605dup [plasma membrane] (R-HSA-9697939) FLT3 F590G Y591D [plasma membrane] (R-HSA-9691062) FLT3 F594L [plasma membrane] (R-HSA-9691058) FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE [plasma membrane] (R-HSA-9699433) FLT3 V579A [plasma membrane] (R-HSA-9691051) FLT3 Y599_D600insGLYVDFREYEY [plasma membrane] (R-HSA-9696044) FLT3 Y591_V592insVDFREDREHH [plasma membrane] (R-HSA-9696043) FLT3 D600_L601insMGMGGECNPGRQ [plasma membrane] (R-HSA-9690076) FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE [plasma membrane] (R-HSA-9696033)	0.591	6
UniProt:P06213 INSR	6	INSR(28-758) [plasma membrane] (R-HSA-74668) p-6Y-INSR(763-1382) [plasma membrane] (R-HSA-74670) INSR(763-1382) [plasma membrane] (R-HSA-74669) INSR(28-758) [endosome membrane] (R-HSA-141718) INSR(763-1382) [endosome membrane] (R-HSA-141722) p-6Y-INSR(763-1382) [endosome membrane] (R-HSA-141719)	0.581	4
UniProt:Q9UKA8 RCAN3	1	RCAN3 [cytosol] (R-HSA-9728800)	0.57	3
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.564	3
UniProt:P31947 SFN	1	SFN [cytosol] (R-HSA-1445105)	0.564	2
UniProt:Q66LE6 PPP2R2D	1	PPP2R2D [nucleoplasm] (R-HSA-2160962)	0.527	3
UniProt:P08069 IGF1R	3	IGF1R(741-1367) [plasma membrane] (R-HSA-2404180) IGF1R(31-736) [plasma membrane] (R-HSA-2404169) p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane] (R-HSA-2404172)	0.527	2
UniProt:P54762 EPHB1	6	p-Y594,Y600-EPHB1 [plasma membrane] (R-HSA-3928347) EPHB1 [plasma membrane] (R-HSA-2682340) EPHB1 (18-?) [extracellular region] (R-HSA-3928393) EPHB1 (?-984) [plasma membrane] (R-HSA-3928402) EPHB1 (?-984) [cytosol] (R-HSA-3928438) EPHB1 (?-?) [plasma membrane] (R-HSA-3928449)	0.499	2
UniProt:Q9UQB8-6 BAIAP2			0.488	2