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PPP5C
Stable Identifier
R-HSA-5675402
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
Negative regulation of MAPK pathway (Homo sapiens)
PP5 dephosphorylates RAF1 S338 (Homo sapiens)
PPP5C [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P53041 PPP5C
Gene Names
PPP5C, PPP5
Chain
initiator methionine:1, chain:2-499
Reference Genes
BioGPS Gene:5536 PPP5C
COSMIC (genes):PPP5C PPP5C
CTD Gene:5536 PPP5C
dbSNP Gene:5536 PPP5C
ENSEMBL:ENSG00000011485 PPP5C
HGNC:9322 PPP5C
KEGG Gene (Homo sapiens):hsa:5536 PPP5C
Monarch:5536 PPP5C
NCBI Gene:5536 PPP5C
OMIM:600658 PPP5C
UCSC:P53041 PPP5C
Reference Transcript
RefSeq:NM_006247.3 PPP5C
Other Identifiers
0002470707
04660+3.1.3.16
11718622_x_at
11745533_x_at
16863460
1A17
1S95
1WAO
201979_s_at
22641
29065
2BUG
3836762
3836763
3836764
3836772
3836774
3836779
3836781
3836784
3836786
3836787
3836789
3836790
3836791
3836794
3836795
3836796
3836797
3836798
3866044
391_at
392_g_at
3H60
3H61
3H62
3H63
3H64
3H66
3H67
3H68
3H69
4ZVZ
4ZX2
5536
56933
5HPE
8029814
A0A024R0Q7
A_23_P153583
CAB022641
CCDS12684
ENSG00000011485
ENSP00000012443
ENST00000012443
EntrezGene:5536
g5453957_3p_at
g5453957_3p_x_at
GE60120
GO:0000165
GO:0000278
GO:0001933
GO:0001965
GO:0003723
GO:0004721
GO:0004722
GO:0004871
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005886
GO:0006281
GO:0006351
GO:0006470
GO:0006974
GO:0008017
GO:0008289
GO:0010288
GO:0016020
GO:0016576
GO:0016787
GO:0031072
GO:0042802
GO:0043005
GO:0043025
GO:0043123
GO:0043204
GO:0043231
GO:0043234
GO:0043278
GO:0043531
GO:0046872
GO:0051259
GO:0051291
GO:0051879
GO:0060548
GO:0070301
GO:0071276
GO:0071944
GO:1901215
GO:1990635
GO:2000324
HGNC:9322
HPA029065
HPA056933
Hs.654604
ILMN_1745332
MIM:600658
NM_001204284
NM_006247
NP_001191213
NP_006238
PF00149
PF00515
PF08321
PH_hs_0025229
PPP5C
PPP5C-201
PR00114
SM00028
SM00156
TC19000663.hg
uc002pem.4
UPI0000041859
X89416_at
XM_017026935
XP_016882424
Other forms of this molecule
PPP5C [nucleoplasm]
Inferred To
PPP5C [cytosol] (Bos taurus)
PPP5C [cytosol] (Caenorhabditis elegans)
PPP5C [cytosol] (Canis familiaris)
PPP5C [cytosol] (Danio rerio)
PPP5C [cytosol] (Dictyostelium discoideum)
PPP5C [cytosol] (Drosophila melanogaster)
PPP5C [cytosol] (Mus musculus)
PPP5C [cytosol] (Plasmodium falciparum)
PPP5C [cytosol] (Rattus norvegicus)
PPP5C [cytosol] (Sus scrofa)
PPP5C [cytosol] (Xenopus tropicalis)
Homologues of PPP5C [cytosol] (Danio rerio)
Cross References
RefSeq
NP_006238.1
Brenda
3.1.3.16
GeneCards
P53041
DOCK Blaster
3H61
,
3H69
,
4ZVZ
,
5HPE
,
1S95
,
1WAO
,
3H68
,
3H67
,
3H66
,
3H64
,
3H63
,
3H60
,
3H62
,
4ZX2
,
1A17
ZINC target
P53041
PRO
P53041
HMDB Protein
HMDBP08687
PDB
3H63
,
3H69
,
1WAO
,
5UI1
,
3H68
,
3H62
,
1S95
,
3H67
,
5HPE
,
3H61
,
1A17
,
3H66
,
4ZX2
,
3H60
,
4ZVZ
,
3H64
,
2BUG
Interactors (19)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P08238 HSP90AB1
5
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
0.832
7
UniProt:P07900 HSP90AA1
7
HSP90AA1 [secretory granule lumen]
(R-HSA-6801515)
HSP90AA1 [endocytic vesicle lumen]
(R-HSA-3221912)
HSP90AA1 [extracellular region]
(R-HSA-3221946)
HSP90AA1 [ficolin-1-rich granule lumen]
(R-HSA-6801470)
HSP90AA1 [plasma membrane]
(R-HSA-534996)
HSP90AA1 [nucleoplasm]
(R-HSA-5082401)
HSP90AA1 [cytosol]
(R-HSA-192864)
0.794
11
UniProt:Q16543 CDC37
1
CDC37 [cytosol]
(R-HSA-1221609)
0.708
5
UniProt:P03372 ESR1
3
ESR1 [nucleoplasm]
(R-HSA-446168)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
ESR1 [cytosol]
(R-HSA-9020968)
0.625
4
UniProt:P31948 STIP1
1
STIP1 [cytosol]
(R-HSA-443857)
0.623
4
UniProt:O14654 IRS4
2
IRS4 [plasma membrane]
(R-HSA-2424297)
p-Y-IRS4 [plasma membrane]
(R-HSA-2424302)
0.597
3
UniProt:P50750 CDK9
1
CDK9 [nucleoplasm]
(R-HSA-51801)
0.558
3
UniProt:Q9UHD1 CHRD1
0.547
2
UniProt:Q15185 PTGES3
2
PTGES3 [nucleoplasm]
(R-HSA-5082403)
PTGES3 [cytosol]
(R-HSA-265269)
0.527
2
UniProt:P30153 PPP2R1A
2
PPP2R1A [cytosol]
(R-HSA-165982)
PPP2R1A [nucleoplasm]
(R-HSA-165968)
0.524
3
UniProt:Q92731 ESR2
2
ESR2 [cytosol]
(R-HSA-9020970)
ESR2 [nucleoplasm]
(R-HSA-446165)
0.508
4
UniProt:Q5SY16 NOL9
1
NOL9 [nucleoplasm]
(R-HSA-6791216)
0.499
2
UniProt:Q9UL18 AGO1
2
EIF2C1 [cytosol]
(R-HSA-210616)
EIF2C1 [nucleoplasm]
(R-HSA-5578686)
0.499
2
UniProt:Q9H9G7 AGO3
1
EIF2C3 [cytosol]
(R-HSA-210615)
0.499
2
UniProt:P53041 PPP5C
2
PPP5C [nucleoplasm]
(R-HSA-5683410)
PPP5C [cytosol]
(R-HSA-5675402)
0.499
2
UniProt:Q49AN0 CRY2
4
p-S-CRY2 [nucleoplasm]
(R-HSA-400328)
p-S-CRY2 [cytosol]
(R-HSA-400305)
CRY2 [cytosol]
(R-HSA-400255)
Ub-p-S-CRY2 [nucleoplasm]
(R-HSA-517935)
0.499
3
UniProt:Q58FG0 HS905
0.462
2
UniProt:P27708 CAD
1
CAD [cytosol]
(R-HSA-73452)
0.462
2
UniProt:Q9Y266 NUDC
3
NUDC [nucleoplasm]
(R-HSA-156716)
p-S274,S326-NUDC [nucleoplasm]
(R-HSA-156702)
NUDC [cytosol]
(R-HSA-377731)
0.462
2
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