Reactome | PPP5C [cytosol]

PPP5C [cytosol]

Stable Identifier

R-HSA-5675402

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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External Reference Information

External Reference

UniProt:P53041 PPP5C

Gene Names

PPP5C, PPP5

Chain

initiator methionine:1, chain:2-499

Reference Genes

BioGPS Gene:5536 PPP5C

COSMIC (genes):PPP5C PPP5C

CTD Gene:5536 PPP5C

dbSNP Gene:5536 PPP5C

ENSEMBL:ENSG00000011485 PPP5C

HGNC:9322 PPP5C

KEGG Gene (Homo sapiens):5536 PPP5C

Monarch:5536 PPP5C

NCBI Gene:5536 PPP5C

OMIM:600658 PPP5C

UCSC:P53041 PPP5C

Reference Transcript

RefSeq:NM_006247.3 PPP5C

Other Identifiers

0002470707

11718622_x_at

11745533_x_at

16863460

201979_s_at

3836763

3836764

3836772

3836774

3836779

3836781

3836784

3836786

3836787

3836789

3836790

3836791

3836794

3836795

3836796

3836797

3836798

3836799

3866044

391_at

392_g_at

5536

8029814

A_14_P136374

A_23_P153583

GE60120

GO:0000165

GO:0000278

GO:0001933

GO:0001965

GO:0003674

GO:0003723

GO:0004721

GO:0004722

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006259

GO:0006281

GO:0006351

GO:0006464

GO:0006470

GO:0006950

GO:0006974

GO:0007049

GO:0007165

GO:0008017

GO:0008092

GO:0008150

GO:0008219

GO:0008289

GO:0009058

GO:0010288

GO:0016020

GO:0016576

GO:0016787

GO:0016791

GO:0031072

GO:0032991

GO:0034641

GO:0035970

GO:0042802

GO:0043005

GO:0043025

GO:0043123

GO:0043167

GO:0043204

GO:0043226

GO:0043231

GO:0043278

GO:0043531

GO:0044877

GO:0046872

GO:0048156

GO:0051276

GO:0051879

GO:0060548

GO:0070262

GO:0070301

GO:0071276

GO:0071944

GO:0101031

GO:0106306

GO:0106307

GO:1901215

GO:1904550

GO:1990635

GO:2000324

HMNXSV003006202

ILMN_1745332

PH_hs_0025229

TC19000663.hg

X89416_at

g5453957_3p_at

g5453957_3p_x_at

Other forms of this molecule

PPP5C [nucleoplasm]

Inferred To

PpD3 [cytosol] (Drosophila melanogaster)

PPP5C [cytosol] (Bos taurus)

PPP5C [cytosol] (Canis familiaris)

PPP5C [cytosol] (Dictyostelium discoideum)

PPP5C [cytosol] (Sus scrofa)

Ppp5c [cytosol] (Mus musculus)

Ppp5c [cytosol] (Rattus norvegicus)

pph-5 [cytosol] (Caenorhabditis elegans)

ppp5c [cytosol] (Danio rerio)

Cross References

RefSeq

NP_006238.1

OpenTargets

ENSG00000011485

IntEnz

3.1.3.16

GeneCards

P53041

HPA

ENSG00000011485-PPP5C

Ensembl

ENSP00000012443, ENST00000012443, ENSG00000011485

ZINC target

P53041

PRO

P53041

HMDB Protein

HMDBP08687

PDB

5HPE, 5UI1, 3H66, 3H60, 1S95, 3H67, 4ZX2, 1WAO, 3H63, 2BUG, 3H68, 4ZVZ, 3H62, 3H64, 3H69, 3H61, 1A17, 5WG8

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.827	7
UniProt:P07900 HSP90AA1	8	HSP90AA1 [ficolin-1-rich granule lumen] (R-HSA-6801470) HSP90AA1 [endocytic vesicle lumen] (R-HSA-3221912) HSP90AA1 [extracellular region] (R-HSA-3221946) HSP90AA1 [secretory granule lumen] (R-HSA-6801515) HSP90AA1 [plasma membrane] (R-HSA-534996) HSP90AA1 [nucleoplasm] (R-HSA-5082401) HSP90AA1 [cytosol] (R-HSA-192864) HSP90AA1 [lysosomal lumen] (R-HSA-9622850)	0.786	11
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.708	5
UniProt:P03372 ESR1	8	SUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210) PalmS-ESR1 [cytosol] (R-HSA-9020974) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) Me260-ESR1 [cytosol] (R-HSA-9632177) ESR1 [nucleoplasm] (R-HSA-446168) ESR1 [cytosol] (R-HSA-9020968)	0.625	4
UniProt:P31948 STIP1	1	STIP1 [cytosol] (R-HSA-443857)	0.623	4
UniProt:O14654 IRS4	2	IRS4 [plasma membrane] (R-HSA-2424297) p-Y-IRS4 [plasma membrane] (R-HSA-2424302)	0.569	3
UniProt:Q9NRI5 DISC1			0.553	2
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.553	2
UniProt:Q9UHD1 CHRD1			0.547	2
UniProt:P50750 CDK9	1	CDK9 [nucleoplasm] (R-HSA-51801)	0.539	3
UniProt:Q15185 PTGES3	2	PTGES3 [cytosol] (R-HSA-265269) PTGES3 [nucleoplasm] (R-HSA-5082403)	0.527	2
UniProt:P30153 PPP2R1A	2	PPP2R1A [nucleoplasm] (R-HSA-165968) PPP2R1A [cytosol] (R-HSA-165982)	0.524	3
UniProt:Q92731 ESR2	5	PalmS-ESR2 [plasma membrane] (R-HSA-9021059) PalmS-ESR2 [cytosol] (R-HSA-9020979) Me-PalmS-ESR2 [plasma membrane] (R-HSA-9637787) ESR2 [nucleoplasm] (R-HSA-446165) ESR2 [cytosol] (R-HSA-9020970)	0.508	4
UniProt:Q9UL18 AGO1	2	EIF2C1 [cytosol] (R-HSA-210616) EIF2C1 [nucleoplasm] (R-HSA-5578686)	0.499	2
UniProt:Q9H9G7 AGO3	1	EIF2C3 [cytosol] (R-HSA-210615)	0.499	2
UniProt:P53041 PPP5C	2	PPP5C [cytosol] (R-HSA-5675402) PPP5C [nucleoplasm] (R-HSA-5683410)	0.499	2
UniProt:Q5SY16 NOL9	1	NOL9 [nucleoplasm] (R-HSA-6791216)	0.499	2
UniProt:Q49AN0 CRY2	4	p-S-CRY2 [nucleoplasm] (R-HSA-400328) p-S-CRY2 [cytosol] (R-HSA-400305) CRY2 [cytosol] (R-HSA-400255) Ub-p-S-CRY2 [nucleoplasm] (R-HSA-517935)	0.499	3

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