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ISG15-K-BECN1 [cytosol]
Stable Identifier
R-HSA-9853030
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Beclin-1, BECN1_HUMAN, ISG15:BECN1
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Respiratory Syncytial Virus Infection Pathway (Homo sapiens)
RSV-host interactions (Homo sapiens)
ISGylation of BECN1 (Homo sapiens)
ISG15:BECN1 [cytosol] (Homo sapiens)
ISG15-K-BECN1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q14457 BECN1
Gene Names
BECN1, GT197
Chain
chain:1-450, chain:134-450, chain:150-450
Reference Genes
BioGPS Gene:8678 BECN1
COSMIC (genes):BECN1 BECN1
CTD Gene:8678 BECN1
dbSNP Gene:8678 BECN1
ENSEMBL:ENSG00000126581 BECN1
ENSEMBL_homo_sapiens_GENE:ENSG00000126581.13 BECN1
HGNC:1034 BECN1
KEGG Gene (Homo sapiens):8678 BECN1
Monarch:8678 BECN1
NCBI Gene:8678 BECN1
OMIM:604378 BECN1
UCSC:Q14457 BECN1
Reference Transcript
RefSeq:NM_001313999.1 BECN1
RefSeq:NM_003766.4 BECN1
RefSeq:NM_001313998.1 BECN1
RefSeq:NM_001314000.1 BECN1
Other Identifiers
11743587_a_at
11743588_x_at
11745483_s_at
11746790_a_at
11746791_s_at
11746792_x_at
16845263
208945_PM_s_at
208945_s_at
208946_PM_s_at
208946_s_at
3758158
3758159
3758160
3758161
3758164
3758169
3758172
3758175
3758176
3758177
3758180
3758185
3758188
3758190
3758191
39378_at
8015715
8678
A_23_P433071
A_23_P89410
A_24_P313597
GE79828
GO:0000045
GO:0000278
GO:0000407
GO:0000423
GO:0000910
GO:0001666
GO:0002376
GO:0002753
GO:0003012
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005768
GO:0005773
GO:0005776
GO:0005783
GO:0005789
GO:0005794
GO:0005802
GO:0005829
GO:0006622
GO:0006629
GO:0006886
GO:0006897
GO:0006914
GO:0006915
GO:0006968
GO:0006995
GO:0007005
GO:0007040
GO:0007049
GO:0007059
GO:0007080
GO:0007254
GO:0008285
GO:0009410
GO:0010008
GO:0010040
GO:0010288
GO:0010506
GO:0010507
GO:0010508
GO:0010613
GO:0012501
GO:0016020
GO:0016192
GO:0016236
GO:0016241
GO:0016604
GO:0019901
GO:0023052
GO:0030154
GO:0030425
GO:0030674
GO:0031410
GO:0031625
GO:0031667
GO:0031966
GO:0032465
GO:0032473
GO:0032801
GO:0032991
GO:0033197
GO:0034198
GO:0034271
GO:0034272
GO:0035032
GO:0036092
GO:0038066
GO:0039521
GO:0042149
GO:0042802
GO:0043066
GO:0043069
GO:0043226
GO:0043548
GO:0043652
GO:0045022
GO:0045324
GO:0045335
GO:0048666
GO:0048856
GO:0050435
GO:0051020
GO:0051301
GO:0051607
GO:0051707
GO:0051897
GO:0060090
GO:0060395
GO:0061024
GO:0065003
GO:0070301
GO:0071275
GO:0071280
GO:0071364
GO:0090650
GO:0097352
GO:0098542
GO:0098780
GO:0140014
GO:1902425
GO:1902902
GO:1905672
GO:2000378
GO:2000786
GO:2001244
HMNXSV003004505
Hs.12272.0.S1_3p_a_at
ILMN_1744822
L38932_at
PH_hs_0001156
TC17001545.hg
g4680380_3p_a_at
Participates
as a component of
ISG15:BECN1 [cytosol] (Homo sapiens)
Other forms of this molecule
K63polyUb-BECN1 [cytosol]
p-S15-BECN1 [cytosol]
BECN1 [cytosol]
Modified Residues
Name
crosslinked L-lysine residue at unknown position
PsiMod Name
crosslinked L-lysine residue
PsiMod Definition
A protein modification that contains an L-lysine residue crosslinked to one or more amino acid residues.
Name
crosslinked L-lysine residue at unknown position
PsiMod Name
crosslinked L-lysine residue
PsiMod Definition
A protein modification that contains an L-lysine residue crosslinked to one or more amino acid residues.
Cross References
RefSeq
NP_001300928.1
,
NP_001300929.1
,
NP_003757.1
,
NP_001300927.1
OpenTargets
ENSG00000126581
HPA
ENSG00000126581-BECN1
GeneCards
Q14457
Ensembl
ENST00000361523
,
ENSG00000126581
,
ENSP00000355231
,
ENST00000590099
,
ENSP00000465364
PRO
Q14457
Pharos - Targets
Q14457
PDB
5VAX
,
8SRQ
,
4MI8
,
8SOR
,
5VAU
,
2PON
,
6HOK
,
3DVU
,
6DCO
,
6HOJ
,
6DCN
,
5HHE
,
6HOI
,
5EFM
,
4DDP
,
2P1L
,
5VAY
,
7BL1
Interactors (76)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q6ZNE5 ATG14
3
ATG14 [phagophore assembly site membrane]
(R-HSA-5682389)
ATG14 [endoplasmic reticulum membrane]
(R-HSA-5679263)
ATG14 [cytosol]
(R-HSA-5668893)
0.979
51
UniProt:Q9P2Y5 UVRAG
2
UVRAG [cytosol]
(R-HSA-5668884)
UVRAG [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9730510)
0.971
47
UniProt:Q8NEB9 PIK3C3
2
PIK3C3 [phagocytic vesicle membrane]
(R-HSA-6798182)
PIK3C3 [cytosol]
(R-HSA-188011)
0.97
43
UniProt:P10415 BCL2
1
BCL2 [mitochondrial outer membrane]
(R-HSA-50757)
0.951
18
UniProt:Q92622 RUBIC
0.922
16
UniProt:Q99570 PIK3R4
2
PIK3R4 [phagocytic vesicle membrane]
(R-HSA-6798171)
PIK3R4 [cytosol]
(R-HSA-188010)
0.875
10
UniProt:Q9C0C7 AMBRA1
2
p-AMBRA1 [cytosol]
(R-HSA-1632854)
AMBRA1 [cytosol]
(R-HSA-1632831)
0.868
9
UniProt:Q96F24 NRBF2
0.855
10
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.766
15
UniProt:O95229 ZWINT
1
ZWINT [cytosol]
(R-HSA-376254)
0.75
6
UniProt:P89884 ARBH
0.75
4
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.709
8
UniProt:Q07817-1 BCL2L1
0.704
5
UniProt:Q96ES7 SGF29
1
SGF29 [nucleoplasm]
(R-HSA-3662279)
0.666
4
UniProt:Q8N5C8 TAB3
3
TAB3 [plasma membrane]
(R-HSA-446879)
TAB3 [endosome membrane]
(R-HSA-450247)
TAB3 [cytosol]
(R-HSA-450264)
0.655
9
UniProt:Q9NYJ8 TAB2
4
TAB2 [cytosol]
(R-HSA-168117)
TAB2 [endosome membrane]
(R-HSA-450279)
TAB2 [plasma membrane]
(R-HSA-168116)
TAB2 [nucleoplasm]
(R-HSA-1253323)
0.655
11
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.643
3
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.643
3
UniProt:P54252-1 ATXN3
0.632
10
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.628
7
UniProt:Q8IYI6 EXOC8
2
EXOC8 [plasma membrane]
(R-HSA-264948)
EXOC8 [cytosol]
(R-HSA-5623388)
0.599
4
UniProt:Q2GJL5 Q2GJL5
0.593
4
UniProt:P53355 DAPK1
1
DAPK1 [cytosol]
(R-HSA-418262)
0.591
4
UniProt:Q91ZQ0 VMP1
0.571
6
UniProt:Q9Y371 SHLB1
0.564
2
UniProt:Q07817 BCL2L1
2
BCL2L1 [cytosol]
(R-HSA-50771)
BCL2L1 [mitochondrial outer membrane]
(R-HSA-114236)
0.564
2
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:P14679-2 P146792
0.556
3
UniProt:Q9UBU9 NXF1
2
NXF1 [cytosol]
(R-HSA-156481)
NXF1 [nucleoplasm]
(R-HSA-111690)
0.556
3
UniProt:P38398-6 BRCA1
0.556
3
UniProt:Q9Y3C5 RNF11
0.556
3
UniProt:P01100 FOS
2
FOS [nucleoplasm]
(R-HSA-450216)
p-T325,T331,S362,S374-FOS [nucleoplasm]
(R-HSA-450283)
0.556
3
UniProt:P04792 HSBP1
3
HSPB1 [cytosol]
(R-HSA-450563)
p-S15,S78,S82-HSP27 [cytosol]
(R-HSA-5218697)
p-S78,S82 HSPB1 [cytosol]
(R-HSA-5687009)
0.556
3
UniProt:P31930 UQCRC1
1
UQCRC1 [mitochondrial inner membrane]
(R-HSA-164284)
0.556
3
UniProt:P42261 GRIA1
6
GRIA1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-5689811)
GRIA1 [ER to Golgi transport vesicle membrane]
(R-HSA-5689810)
GRIA1 [endoplasmic reticulum membrane]
(R-HSA-5689460)
GRIA1 [endocytic vesicle membrane]
(R-HSA-3004479)
p-S849-GRIA1 [plasma membrane]
(R-HSA-9620488)
GRIA1 [plasma membrane]
(R-HSA-3004495)
0.556
3
UniProt:P50440 GATM
1
GATM [mitochondrial intermembrane space]
(R-HSA-71267)
0.556
3
UniProt:P46379-2 BAG6
0.556
3
UniProt:P48643 CCT5
1
CCT5 [cytosol]
(R-HSA-390447)
0.556
3
UniProt:O14645 IDLC
0.556
3
UniProt:Q8N2W9 PIAS4
2
PIAS4 [nucleoplasm]
(R-HSA-2993789)
monoSUMO1-K35-PIAS4 [nucleoplasm]
(R-HSA-3968415)
0.556
3
UniProt:P17752 TPH1
1
TPH1 [cytosol]
(R-HSA-976250)
0.556
3
UniProt:P14678-2 SNRPB
0.556
3
UniProt:P14927 UQCRB
1
UQCRB [mitochondrial inner membrane]
(R-HSA-164287)
0.556
3
UniProt:P21333-2 FLNA
0.556
3
UniProt:O60333-2 KIF1B
0.556
3
UniProt:P61758 VBP1
1
VBP1 [cytosol]
(R-HSA-379543)
0.556
3
UniProt:P54253 ATX1
0.556
6
UniProt:P60891 PRPS1
1
PRPS1 [cytosol]
(R-HSA-73483)
0.556
3
UniProt:P63000 RAC1
6
RAC1 [ficolin-1-rich granule membrane]
(R-HSA-6804802)
RAC1 [secretory granule membrane]
(R-HSA-6804770)
GGC-PalmC-RAC1 [plasma membrane]
(R-HSA-2316446)
RAC1 [endoplasmic reticulum membrane]
(R-HSA-5672076)
RAC1 [cytosol]
(R-HSA-442615)
RAC1 [plasma membrane]
(R-HSA-351141)
0.556
3
UniProt:P12931 SRC
6
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
SRC [cytosol]
(R-HSA-9628701)
p-Y419-SRC [cytosol]
(R-HSA-8964276)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.556
3
UniProt:P28799 GRN
2
GRN [azurophil granule lumen]
(R-HSA-6799168)
GRN [extracellular region]
(R-HSA-6806217)
0.556
3
UniProt:Q13449 LSAMP
2
cleaved GPI-LSAMP [extracellular region]
(R-HSA-8941032)
GPI-LSAMP [plasma membrane]
(R-HSA-8940809)
0.556
3
UniProt:P10276-2 RARA
0.556
3
UniProt:Q96A83-2 Q96A832
0.556
3
UniProt:O14901 KLF11
0.556
3
UniProt:O75190-2 DNAJB6
0.556
3
IntAct:EBI-25865403 EHD27213144
0.556
3
UniProt:Q16512 PKN1
3
p-T774-PKN1 [nucleoplasm]
(R-HSA-5625721)
p-T774-PKN1 [cytosol]
(R-HSA-5623651)
PKN1 [cytosol]
(R-HSA-5623613)
0.556
3
UniProt:Q13885 TUBB2A
6
TUBB2A folding intermediate [cytosol]
(R-HSA-392802)
TUBB2A unfolded [cytosol]
(R-HSA-392776)
Polyglycyl-TUBB2A [cytosol]
(R-HSA-8867466)
Polyglutamyl-TUBB2A [cytosol]
(R-HSA-8867392)
TUBB2A [axonemal microtubule]
(R-HSA-5610431)
TUBB2A [cytosol]
(R-HSA-191699)
0.556
3
UniProt:P15311 EZR
3
p-Y146,Y354-EZR [cytosol]
(R-HSA-374572)
p-T567-EZR [cytosol]
(R-HSA-374559)
EZR [cytosol]
(R-HSA-9020826)
0.556
3
UniProt:Q9H714 PACER
0.527
4
UniProt:Q14457 BECN1
4
K63polyUb-BECN1 [cytosol]
(R-HSA-6782989)
ISG15-K-BECN1 [cytosol]
(R-HSA-9853030)
p-S15-BECN1 [cytosol]
(R-HSA-5682391)
BECN1 [cytosol]
(R-HSA-1632841)
0.527
4
UniProt:O15392 BIRC5
3
ub-BIRC5 [cytosol]
(R-HSA-8955933)
BIRC5 [nucleoplasm]
(R-HSA-4655344)
BIRC5 [cytosol]
(R-HSA-50851)
0.524
3
IntAct:EBI-14080447 ISOLATED POLYQ STRETCH
0.524
4
UniProt:Q14964 RAB39A
4
RAB39A [Golgi membrane]
(R-HSA-8849601)
GGC-RAB39A [Golgi membrane]
(R-HSA-8877794)
GGC-RAB39A [cytosol]
(R-HSA-8874001)
RAB39A [cytosol]
(R-HSA-8873700)
0.524
2
UniProt:P05783 KRT18
1
KRT18 [cytosol]
(R-HSA-201582)
0.499
2
UniProt:Q96GC9 VMP1
0.499
3
UniProt:Q9H714-3 RUBCNL
0.499
3
UniProt:Q9QUM4 SLAF1
0.499
8
UniProt:P08670 VIM
11
VIM(2-85) [cytosol]
(R-HSA-350264)
VIM(86-466) [cytosol]
(R-HSA-350294)
VIM(430-466) [cytosol]
(R-HSA-350316)
VIM(2-429) [cytosol]
(R-HSA-350317)
VIM(260-466) [cytosol]
(R-HSA-350314)
VIM(2-259) [cytosol]
(R-HSA-350323)
VIM [cytosol]
(R-HSA-201600)
Vimentin [late endosome lumen]
(R-HSA-9660019)
Vimentin [microtubule organizing center]
(R-HSA-9657898)
Vimentin [cytosol]
(R-HSA-9646687)
Vimentin [lysosomal lumen]
(R-HSA-9659977)
0.499
3
UniProt:P07947 YES1
2
MyrG-p-Y426-YES1 [plasma membrane]
(R-HSA-1810411)
YES1 [cytosol]
(R-HSA-373640)
0.488
2
UniProt:Q9Y4W6 AFG3L2
1
AFG3L2 [mitochondrial inner membrane]
(R-HSA-8949650)
0.483
3
UniProt:A8K0Z3 WASH1
0.463
3
UniProt:O54921
2
Exoc2 [cytosol]
(R-RNO-5623376)
Exoc2 [plasma membrane]
(R-RNO-264887)
0.463
2
UniProt:Q8UZC1 Q8UZC1
0.463
2
UniProt:P0DTC8 8
2
8 [extracellular region]
(R-COV-9755410)
8 [endoplasmic reticulum lumen]
(R-COV-9727283)
0.463
2
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