Reactome | Ub-SH3KBP1 [cytosol]

Ub-SH3KBP1 [cytosol]

Stable Identifier

R-HSA-182926

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

monoUb-CIN85, CIN85 ubiquitinated

Locations in the PathwayBrowser

Expand all

Signal Transduction (Homo sapiens)

- Signaling by Receptor Tyrosine Kinases (Homo sapiens)
  - Signaling by EGFR (Homo sapiens)
    - EGFR downregulation (Homo sapiens)
      - CBL-mediated ubiquitination of CIN85 (Homo sapiens)
        
        EGF-like ligands:p-6Y-EGFR:p-Y371-CBL:Ub-CIN85:Endophilin:Epsin:Eps15L1:Eps15 [plasma membrane] (Homo sapiens)
        
        Ub-CIN85:endophilin [cytosol] (Homo sapiens)
        
        Ub-CIN85 [cytosol] (Homo sapiens)
        
        Ub-SH3KBP1 [cytosol] (Homo sapiens)

Literature References

PubMed ID	Title	Journal	Year
12218189	Cbl-directed monoubiquitination of CIN85 is involved in regulation of ligand-induced degradation of EGF receptors Shimokawa, N, Szymkiewicz, I, Dikic, I, Haglund, K	Proc Natl Acad Sci U S A	2002

External Reference Information

External Reference

UniProt:Q96B97 SH3KBP1

Gene Names

SH3KBP1, CIN85

Chain

chain:1-665

Reference Genes

BioGPS Gene:30011 SH3KBP1

COSMIC (genes):SH3KBP1 SH3KBP1

CTD Gene:30011 SH3KBP1

dbSNP Gene:30011 SH3KBP1

ENSEMBL:ENSG00000147010 SH3KBP1

ENSEMBL_homo_sapiens_GENE:ENSG00000147010.19 SH3KBP1

HGNC:13867 SH3KBP1

KEGG Gene (Homo sapiens):30011 SH3KBP1

Monarch:30011 SH3KBP1

NCBI Gene:30011 SH3KBP1

OMIM:300374 SH3KBP1

UCSC:Q96B97 SH3KBP1

Reference Transcript

Other Identifiers

11724816_a_at

11724817_a_at

11724818_a_at

11724819_a_at

1554168_PM_a_at

1554168_a_at

17109612

223082_PM_at

223082_at

235692_PM_at

235692_at

30011

4001865

4001866

4001867

4001868

4001869

4001871

4001873

4001878

4001880

4001884

4001896

4001898

4001900

4001905

4001909

4001913

4001920

4001928

4001936

4001941

4001954

4001965

4001966

4001978

4001979

4001980

4001994

4001995

4001996

45889_at

8171684

83386_at

A_23_P374782

A_24_P289139

A_33_P3387145

GE54993

GO:0002376

GO:0003824

GO:0005515

GO:0005737

GO:0005829

GO:0005856

GO:0005886

GO:0005911

GO:0005925

GO:0006897

GO:0006915

GO:0007010

GO:0007015

GO:0007267

GO:0008360

GO:0012501

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016477

GO:0016740

GO:0017124

GO:0023052

GO:0030139

GO:0030659

GO:0031410

GO:0031625

GO:0043005

GO:0043226

GO:0045202

GO:0048856

GO:0048870

GO:0050871

GO:0070161

HMNXSV003018719

Hs.31922.0.A1_3p_at

Hs2.153260.2.S1_3p_s_at

ILMN_1652650

ILMN_1808501

ILMN_1810782

PH_hs_0009216

TC0X000903.hg

g7188748_3p_at

Participates

as a component of

Ub-CIN85 [cytosol] (Homo sapiens)

Other forms of this molecule

SH3KBP1 [plasma membrane]

SH3KBP1 [cytosol]

Inferred To

cdap-2 [cytosol] (Caenorhabditis elegans)

SH3KBP1 [cytosol] (Bos taurus)

SH3KBP1 [cytosol] (Canis familiaris)

SH3KBP1 [cytosol] (Sus scrofa)

cindr [cytosol] (Drosophila melanogaster)

Sh3kbp1 [cytosol] (Mus musculus)

Sh3kbp1 [cytosol] (Rattus norvegicus)

Ub-SH3KBP1 [cytosol] (Gallus gallus)

Modified Residues

Name

ubiquitinylated lysine at unknown position

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001171889.1, NP_114098.1, XP_016884958.1, NP_001019837.1

OpenTargets

ENSG00000147010

HPA

ENSG00000147010-SH3KBP1

GeneCards

Q96B97

Ensembl

ENST00000699723, ENSP00000369039, ENST00000397821, ENSP00000514545, ENSP00000380921, ENST00000379716, ENSG00000147010, ENSP00000369020, ENST00000379698

PRO

Q96B97

Pharos - Targets

Q96B97

PDB

2BZ8, 2YDL, 2K9G, 2O2O, 2K6D, 5ABS, 2N64

Interactors (63)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.974	28
UniProt:Q13191 CBLB	1	CBLB [cytosol] (R-HSA-976009)	0.939	25
UniProt:Q9ULH1 ASAP1	1	ASAP1 [cytosol] (R-HSA-5620905)	0.848	13
UniProt:Q99962 SH3GL2	4	SH3GL2 [cytosol] (R-HSA-182958) SH3GL2 [plasma membrane] (R-HSA-177495) SH3GL2 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130629) SH3GL2 [Golgi membrane] (R-HSA-351189)	0.788	5
UniProt:P52907 CAPZA1	2	CAPZA1(265-276) [extracellular region] (R-HSA-879421) CAPZA1 [cytosol] (R-HSA-879363)	0.773	7
UniProt:Q9ULZ2 STAP1			0.752	7
UniProt:Q9Y5K6 CD2AP	1	CD2AP [cytosol] (R-HSA-373620)	0.738	6
UniProt:P47755 CAPZA2	2	CAPZA2 [cytosol] (R-HSA-879448) CAPZA2(265-276) [extracellular region] (R-HSA-879417)	0.725	7
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.695	4
UniProt:Q99963 SH3GL3	1	SH3GL3 [cytosol] (R-HSA-8867734)	0.691	4
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.683	6
UniProt:O15056 SYNJ2	1	SYNJ2 [cytosol] (R-HSA-1806193)	0.669	6
UniProt:O43150 ASAP2			0.669	4
UniProt:P98078	3	Dab2 [cytosol] (R-MMU-8862456) Dab2 [lysosomal membrane] (R-MMU-2980807) Dab2 [plasma membrane] (R-MMU-2980808)	0.669	9
UniProt:Q8IZC4 RTKN2			0.643	5
UniProt:Q96P48 ARAP1	2	ARAP1 [cytosol] (R-HSA-3211582) p-Y231-ARAP1 [cytosol] (R-HSA-8848869)	0.643	5
UniProt:Q9Y3L3 SH3BP1	1	SH3BP1 [cytosol] (R-HSA-3006458)	0.643	5
UniProt:A6NNY8 UBP27			0.643	4
UniProt:Q8N3F8 MILK1			0.643	5
UniProt:Q68EM7 ARHGAP17	1	ARHGAP17 [cytosol] (R-HSA-427895)	0.643	5
UniProt:P47756 CAPZB	1	CAPZB [cytosol] (R-HSA-879409)	0.643	5
UniProt:P78314 3BP2			0.639	8
UniProt:P06729 CD2	1	CD2 [plasma membrane] (R-HSA-197795)	0.618	3
UniProt:O94850 DEND			0.616	5
UniProt:Q99961 SH3GL1	1	SH3GL1 [cytosol] (R-HSA-8867732)	0.593	3
UniProt:Q8WUM4 PDCD6IP	1	PDCD6IP [cytosol] (R-HSA-917717)	0.591	5
UniProt:Q9Y6R4 M3K4			0.591	5
UniProt:Q8WWN8 ARAP3	1	ARAP3 [cytosol] (R-HSA-195185)	0.564	4
UniProt:Q9JLQ0 Cd2ap	1	CD2AP_MOUSE [cytosol] (R-MMU-451711)	0.564	2
UniProt:Q3LI67 KRTAP6-3	1	KRTAP6-3 [cytosol] (R-HSA-6810281)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q9Y3C5 RNF11			0.556	3
UniProt:Q5T749 KPRP	1	KPRP [cytosol] (R-HSA-9839614)	0.556	5
UniProt:Q6PI77 GASP3			0.556	5
UniProt:Q86UU5 GGN			0.556	3
UniProt:Q05BL1 Q05BL1			0.556	3
UniProt:Q9ULE3-2 DENND2A			0.556	3
UniProt:Q7Z783 Q7Z783			0.556	3
IntAct:EBI-22317115 CCSB ORF ID			0.556	3
UniProt:A8MQ03 CRTP1			0.556	3
UniProt:Q2TAC2-2 CCDC57			0.556	3
UniProt:A6NC98 CC88B			0.556	3
UniProt:Q49AR9 Q49AR9			0.556	3
UniProt:O60333-2 KIF1B			0.556	3
UniProt:O15156-2 ZBTB7B			0.556	3
UniProt:Q9BRK4 LZTS2			0.556	3
UniProt:P07237 P4HB	3	P4HB [endoplasmic reticulum lumen] (R-HSA-174692) p-P4HB [endoplasmic reticulum lumen] (R-HSA-8956902) HC53,56-P4HB [endoplasmic reticulum lumen] (R-HSA-3341287)	0.556	3
UniProt:Q9H3P2 NELFA	1	NELFA [nucleoplasm] (R-HSA-112426)	0.556	3
UniProt:P53803 POLR2K	2	POLR2K [nucleoplasm] (R-HSA-63537) POLR2K [cytosol] (R-HSA-1964445)	0.556	3
UniProt:P39052 Dnm2	5	DNM2 [Golgi membrane] (R-RNO-2980842) DNM2 [endocytic vesicle membrane] (R-RNO-2029000) Dnm2 [cytosol] (R-RNO-9619847) DNM2 [lysosomal membrane] (R-RNO-2980840) Dynamin-2 [plasma membrane] (R-RNO-941852)	0.544	4
UniProt:P52815 MRPL12	2	MRPL12 [mitochondrial matrix] (R-HSA-9839674) MRPL12 [mitochondrial inner membrane] (R-HSA-5368256)	0.527	2
UniProt:Q96H86 ZNF764	1	ZNF764 [nucleoplasm] (R-HSA-3343766)	0.527	2
UniProt:Q9NZZ3 CHMP5	1	CHMP5 [cytosol] (R-HSA-917694)	0.527	2
UniProt:Q8TDR4 TCP1L			0.527	3
UniProt:Q9NVF7 FBX28			0.527	4
UniProt:P30260 CDC27	2	CDC27 [nucleoplasm] (R-HSA-174175) CDC27 [cytosol] (R-HSA-174073)	0.527	2
UniProt:Q17R89 ARHGAP44	1	ARHGAP44 [cytosol] (R-HSA-195160)	0.527	2
UniProt:Q9H3D4 TP63	1	TP63 [nucleoplasm] (R-HSA-2997585)	0.527	2
UniProt:Q9H0B6 KLC2	1	KLC2 [cytosol] (R-HSA-983191)	0.527	2
UniProt:Q13501 SQSTM1	7	SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.524	4
UniProt:Q8CHC4	1	Synj1 [cytosol] (R-MMU-1604634)	0.524	6
UniProt:P50570 DNM2	5	DNM2 [Golgi membrane] (R-HSA-2980842) DNM2 [endocytic vesicle membrane] (R-HSA-2029000) DNM2 [cytosol] (R-HSA-2213180) DNM2 [lysosomal membrane] (R-HSA-2980840) DNM2 [plasma membrane] (R-HSA-2984201)	0.524	5
UniProt:O43597 SPRY2	8	p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-1295629) p-S111,S120-SPRY2 [cytosol] (R-HSA-1295590) p-Y55-SPRY2 [cytosol] (R-HSA-182950) SPRY2 [plasma membrane] (R-HSA-182924) SPRY2 [cytosol] (R-HSA-182949) p-S112,S115-SPRY2 [cytosol] (R-HSA-1295619) p-Y55,Y227-SPRY2 [plasma membrane] (R-HSA-934555) p-S112,S121-SPRY2 [plasma membrane] (R-HSA-934595)	0.499	2

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