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MAP3K3 [cytosol]
Stable Identifier
R-HSA-507725
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
MEKK3, Mitogen-activated protein kinase kinase kinase 3, M3K3_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-1 family signaling (Homo sapiens)
Interleukin-1 signaling (Homo sapiens)
p62:MEKK3 binds to TRAF6 (Homo sapiens)
MAP3K3:SQSTM1 [cytosol] (Homo sapiens)
MAP3K3 [cytosol] (Homo sapiens)
MAP3K3:SQSTM1:TRAF6 [cytosol] (Homo sapiens)
MAP3K3:SQSTM1 [cytosol] (Homo sapiens)
MAP3K3 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99759 MAP3K3
Gene Names
MAP3K3, MAPKKK3, MEKK3
Chain
chain:1-626
Reference Genes
BioGPS Gene:4215 MAP3K3
COSMIC (genes):MAP3K3 MAP3K3
CTD Gene:4215 MAP3K3
dbSNP Gene:4215 MAP3K3
ENSEMBL:ENSG00000198909 MAP3K3
HGNC:6855 MAP3K3
KEGG Gene (Homo sapiens):4215 MAP3K3
Monarch:4215 MAP3K3
NCBI Gene:4215 MAP3K3
OMIM:602539 MAP3K3
UCSC:Q99759 MAP3K3
Reference Transcript
RefSeq:NM_002401.3 MAP3K3
RefSeq:NM_203351.1 MAP3K3
Other Identifiers
0001050601
0004150167
11720218_a_at
11720219_a_at
11737820_a_at
1330_at
16836985
203514_at
227131_at
3730807
3730808
3730809
3730810
3730811
3730813
3730826
3730828
3730831
3730836
3730846
3730848
3730851
3730853
3730854
3730856
3730857
3730858
3730859
3730860
3730861
3730862
3730863
3730865
4215
43929_at
44635_at
8009183
A_14_P101684
A_14_P122017
A_14_P125072
A_14_P200491
A_23_P207131
A_23_P207138
A_33_P3271430
GE61966
GO:0000165
GO:0000166
GO:0000186
GO:0001568
GO:0003674
GO:0004672
GO:0004674
GO:0004709
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0006464
GO:0006468
GO:0006950
GO:0007165
GO:0007568
GO:0008150
GO:0008283
GO:0016301
GO:0016310
GO:0016740
GO:0035556
GO:0040011
GO:0043123
GO:0043167
GO:0046777
GO:0046872
GO:0048646
GO:0048856
GO:0048870
GO:0070498
GO:0071864
GO:0090050
GO:1900745
GO:2000773
Hs.25227.0.A1_3p_at
Hs.29282.0.S2_3p_at
ILMN_1690398
ILMN_1779010
ILMN_2296697
PH_hs_0002542
TC17000770.hg
U78876_at
Participant Of
hasComponent
MAP3K3:SQSTM1 [cytosol]
Inferred To
Homologues of MAP3K3 [cytosol] (Dictyostelium discoideum)
egfr [cytosol] (Xenopus tropicalis)
map3k3 [cytosol] (Danio rerio)
sepA [cytosol] (Dictyostelium discoideum)
Map3k3 [cytosol] (Mus musculus)
Map3k3 [cytosol] (Rattus norvegicus)
MAP3K3 [cytosol] (Bos taurus)
MAP3K3 [cytosol] (Canis familiaris)
MAP3K3 [cytosol] (Dictyostelium discoideum)
MAP3K3 [cytosol] (Gallus gallus)
MAP3K3 [cytosol] (Sus scrofa)
Cross References
RefSeq
NP_976226.1
,
NP_002392.2
ZINC - World Drugs
M3K3_HUMAN
OpenTargets
ENSG00000198909
ZINC - FDA approved
M3K3_HUMAN
ZINC - Substances
M3K3_HUMAN
ZINC - Biogenic
M3K3_HUMAN
ZINC target
Q99759
PRO
Q99759
PDB
4YL6
,
2O2V
,
4Y5O
,
2JRH
,
2PPH
,
2C60
ZINC - Investigational
M3K3_HUMAN
IntEnz
2.7.11.25
HPA
ENSG00000198909-MAP3K3
GeneCards
Q99759
Ensembl
ENSP00000354485
,
ENSP00000354927
,
ENST00000579585
,
ENST00000361357
,
ENSG00000198909
,
ENSP00000461988
,
ENST00000361733
ZINC - Predictions - Purchasable
M3K3_HUMAN
HMDB Protein
HMDBP01142
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.669
3
UniProt:O15111 CHUK
3
CHUK [cytosol]
(R-HSA-168104)
p-S176,S180-CHUK [cytosol]
(R-HSA-177667)
p-T23-CHUK [cytosol]
(R-HSA-198615)
0.589
2
UniProt:Q13163 MAP2K5
1
MAP2K5 [cytosol]
(R-HSA-198722)
0.589
2
UniProt:P21333 FLNA
3
p-S2152-FLNA [cytosol]
(R-HSA-5669246)
FLNA [extracellular region]
(R-HSA-350712)
FLNA [cytosol]
(R-HSA-210019)
0.589
2
UniProt:P31946 YWHAB
1
YWHAB [cytosol]
(R-HSA-48888)
0.564
2
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.564
2
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.553
2
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