Reactome | MAP3K3 [cytosol]

MAP3K3 [cytosol]

Stable Identifier

R-HSA-507725

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

MEKK3, Mitogen-activated protein kinase kinase kinase 3, M3K3_HUMAN

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Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-1 family signaling (Homo sapiens)
      - Interleukin-1 signaling (Homo sapiens)
        
        p62:MEKK3 binds to TRAF6 (Homo sapiens)
        
        MAP3K3:SQSTM1 [cytosol] (Homo sapiens)
        
        MAP3K3 [cytosol] (Homo sapiens)
        
        MAP3K3:SQSTM1:TRAF6 [cytosol] (Homo sapiens)
        
        MAP3K3:SQSTM1 [cytosol] (Homo sapiens)
        
        MAP3K3 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q99759 MAP3K3

Gene Names

MAP3K3, MAPKKK3, MEKK3

Chain

chain:1-626

Reference Genes

BioGPS Gene:4215 MAP3K3

COSMIC (genes):MAP3K3 MAP3K3

CTD Gene:4215 MAP3K3

dbSNP Gene:4215 MAP3K3

ENSEMBL:ENSG00000198909 MAP3K3

HGNC:6855 MAP3K3

KEGG Gene (Homo sapiens):4215 MAP3K3

Monarch:4215 MAP3K3

NCBI Gene:4215 MAP3K3

OMIM:602539 MAP3K3

UCSC:Q99759 MAP3K3

Reference Transcript

Other Identifiers

0001050601

0004150167

11720218_a_at

11720219_a_at

11737820_a_at

1330_at

16836985

203514_at

227131_at

3730807

3730808

3730809

3730810

3730811

3730813

3730826

3730828

3730831

3730836

3730846

3730848

3730851

3730853

3730854

3730856

3730857

3730858

3730859

3730860

3730861

3730862

3730863

3730865

4215

43929_at

44635_at

8009183

A_14_P101684

A_14_P122017

A_14_P125072

A_14_P200491

A_23_P207131

A_23_P207138

A_33_P3271430

GE61966

GO:0000165

GO:0000166

GO:0000186

GO:0001568

GO:0003674

GO:0004672

GO:0004674

GO:0004709

GO:0005515

GO:0005524

GO:0005575

GO:0005622

GO:0005737

GO:0005829

GO:0006464

GO:0006468

GO:0006950

GO:0007165

GO:0007568

GO:0008150

GO:0008283

GO:0016301

GO:0016310

GO:0016740

GO:0035556

GO:0040011

GO:0043123

GO:0043167

GO:0046777

GO:0046872

GO:0048646

GO:0048856

GO:0048870

GO:0070498

GO:0071864

GO:0090050

GO:1900745

GO:2000773

Hs.25227.0.A1_3p_at

Hs.29282.0.S2_3p_at

ILMN_1690398

ILMN_1779010

ILMN_2296697

PH_hs_0002542

TC17000770.hg

U78876_at

Participant Of

hasComponent

MAP3K3:SQSTM1 [cytosol]

Inferred To

Homologues of MAP3K3 [cytosol] (Dictyostelium discoideum)

egfr [cytosol] (Xenopus tropicalis)

map3k3 [cytosol] (Danio rerio)

sepA [cytosol] (Dictyostelium discoideum)

Map3k3 [cytosol] (Mus musculus)

Map3k3 [cytosol] (Rattus norvegicus)

MAP3K3 [cytosol] (Bos taurus)

MAP3K3 [cytosol] (Canis familiaris)

MAP3K3 [cytosol] (Dictyostelium discoideum)

MAP3K3 [cytosol] (Gallus gallus)

MAP3K3 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_976226.1, NP_002392.2

ZINC - World Drugs

M3K3_HUMAN

OpenTargets

ENSG00000198909

ZINC - FDA approved

M3K3_HUMAN

ZINC - Substances

M3K3_HUMAN

ZINC - Biogenic

M3K3_HUMAN

ZINC target

Q99759

PRO

Q99759

PDB

4YL6, 2O2V, 4Y5O, 2JRH, 2PPH, 2C60

ZINC - Investigational

M3K3_HUMAN

IntEnz

2.7.11.25

HPA

ENSG00000198909-MAP3K3

GeneCards

Q99759

Ensembl

ENSP00000354485, ENSP00000354927, ENST00000579585, ENST00000361357, ENSG00000198909, ENSP00000461988, ENST00000361733

ZINC - Predictions - Purchasable

M3K3_HUMAN

HMDB Protein

HMDBP01142

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.669	3
UniProt:O15111 CHUK	3	CHUK [cytosol] (R-HSA-168104) p-S176,S180-CHUK [cytosol] (R-HSA-177667) p-T23-CHUK [cytosol] (R-HSA-198615)	0.589	2
UniProt:Q13163 MAP2K5	1	MAP2K5 [cytosol] (R-HSA-198722)	0.589	2
UniProt:P21333 FLNA	3	p-S2152-FLNA [cytosol] (R-HSA-5669246) FLNA [extracellular region] (R-HSA-350712) FLNA [cytosol] (R-HSA-210019)	0.589	2
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.564	2
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.564	2
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.553	2

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