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PIM1 [nucleoplasm]
Stable Identifier
R-HSA-3215094
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Serine/threonine-protein kinase pim-1
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
FLT3 signaling in disease (Homo sapiens)
Signaling by FLT3 ITD and TKD mutants (Homo sapiens)
STAT5 activation downstream of FLT3 ITD mutants (Homo sapiens)
STAT5-dependent PIM1 gene expression downstream of FLT3 ITD and fusion mutants (Homo sapiens)
PIM1 [nucleoplasm] (Homo sapiens)
Signaling by FLT3 fusion proteins (Homo sapiens)
STAT5-dependent PIM1 gene expression downstream of FLT3 ITD and fusion mutants (Homo sapiens)
PIM1 [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-4 and Interleukin-13 signaling (Homo sapiens)
Expression of STAT3-upregulated nuclear proteins (Homo sapiens)
STAT3-upregulated nuclear proteins [nucleoplasm] (Homo sapiens)
PIM1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P11309 PIM1
Gene Names
PIM1
Chain
chain:1-313
Reference Genes
BioGPS Gene:5292 PIM1
COSMIC (genes):PIM1 PIM1
CTD Gene:5292 PIM1
dbSNP Gene:5292 PIM1
ENSEMBL:ENSG00000137193 PIM1
ENSEMBL_homo_sapiens_GENE:ENSG00000137193.14 PIM1
HGNC:8986 PIM1
KEGG Gene (Homo sapiens):5292 PIM1
Monarch:5292 PIM1
NCBI Gene:5292 PIM1
OMIM:164960 PIM1
UCSC:P11309 PIM1
Reference Transcript
RefSeq:NM_002648.3 PIM1
RefSeq:NM_001243186.1 PIM1
Other Identifiers
11717256_at
11717257_s_at
11717258_a_at
11746350_a_at
17008092
1779_s_at
209193_PM_at
209193_at
2905406
2905407
2905408
2905409
2905410
2905412
2905413
2905418
2905419
2905421
2905422
2905423
5292
8119161
883_s_at
A_14_P116737
A_23_P345118
GE57963
GO:0000166
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0006915
GO:0007049
GO:0008134
GO:0012501
GO:0016020
GO:0016301
GO:0016310
GO:0016740
GO:0022898
GO:0023052
GO:0030145
GO:0030154
GO:0036211
GO:0043024
GO:0043066
GO:0043226
GO:0043433
GO:0045893
GO:0046777
GO:0046872
GO:0048856
GO:0050821
GO:0055085
GO:0060045
GO:0070561
GO:0090336
GO:0098754
GO:0106310
GO:0140096
GO:1902033
GO:1905062
GO:1990748
HMNXSV003058113
ILMN_1815023
M16750_s_at
M54915_s_at
PH_hs_0004657
TC06000541.hg
g1066790_3p_at
Participates
as a member of
STAT3-upregulated nuclear proteins [nucleoplasm] (Homo sapiens)
as an output of
STAT5-dependent PIM1 gene expression downstream of FLT3 ITD and fusion mutants (Homo sapiens)
Cross References
RefSeq
NP_002639.1
,
NP_001230115.1
ZINC - World Drugs
PIM1_HUMAN
Guide to Pharmacology - Targets
2158
OpenTargets
ENSG00000137193
ZINC - FDA approved
PIM1_HUMAN
ZINC - Substances
PIM1_HUMAN
ZINC target
P11309
ZINC - Biogenic
PIM1_HUMAN
PRO
P11309
PDB
2XIX
,
5N4Y
,
5VUB
,
4K18
,
1YXT
,
5EOL
,
5N5L
,
4RC4
,
6PDP
,
3C4E
,
5KCX
,
2O3P
,
2BIK
,
5DWR
,
5DGZ
,
5KGE
,
6BSK
,
5N4U
,
2XJ1
,
3VBQ
,
4BZN
,
5DIA
,
6QXK
,
5V82
,
6MT0
,
6NO9
,
2C3I
,
5N4O
,
4LL5
,
4ALV
,
3A99
,
4N6Z
,
3R04
,
6L15
,
5O13
,
4AS0
,
5V80
,
2XJ2
,
7OOV
,
6KZI
,
7QFM
,
4N6Y
,
5N4Z
,
6VRV
,
3MA3
,
4MTA
,
5VUC
,
4K0Y
,
3VBW
,
6L11
,
5KGI
,
5N5M
,
6VRU
,
2OBJ
,
3VBT
,
6PDO
,
3UMW
,
3JPV
,
2XJ0
,
7XSV
,
8AFR
,
7ZUN
,
3BGQ
,
3DCV
,
1XR1
,
5TEL
,
5TOE
,
5NDT
,
4JX7
,
3JY0
,
3R01
,
3JYA
,
3UIX
,
3QF9
,
2BZI
,
7OOW
,
1XQZ
,
4RBL
,
1YI4
,
6PCW
,
2BZH
,
6NO8
,
2O65
,
4ENX
,
5N4N
,
6L14
,
3T9I
,
4K1B
,
2BZJ
,
3BGP
,
5O12
,
6L12
,
3BWF
,
5KGK
,
5C1Q
,
5N50
,
2BIL
,
4TY1
,
3CY2
,
5O11
,
2J2I
,
6PDN
,
2XIY
,
4DTK
,
3R00
,
2OI4
,
4WT6
,
4ALU
,
5TEX
,
7QB2
,
5IPJ
,
2BZK
,
6PDI
,
4JX3
,
3VC4
,
1YHS
,
3CY3
,
5N4R
,
2O64
,
4I41
,
4BZO
,
4RC3
,
7OOX
,
4MBL
,
1YI3
,
3VBX
,
5KZI
,
6L16
,
4N70
,
5N51
,
6L13
,
4IAA
,
4WRS
,
4MBI
,
1YXU
,
3WE8
,
4LM5
,
5N4X
,
5VUA
,
4WSY
,
5KGG
,
2XIZ
,
1YWV
,
4RPV
,
2O63
,
1YXX
,
5N4V
,
1YXV
,
5TUR
,
3F2A
,
3UMX
,
3VBV
,
3CXW
,
3VBY
,
6YKD
,
3R02
,
4RC2
,
5KGD
,
4GW8
,
3BGZ
,
4ENY
,
4XHK
,
5MZL
,
6L17
,
3JXW
,
1YXS
,
1XWS
,
5N52
,
4A7C
,
5IIS
,
5DHJ
,
4XH6
,
4LMU
,
6AYD
,
4ALW
ZINC - Investigational
PIM1_HUMAN
ZINC - Metabolites
PIM1_HUMAN
IntEnz
2.7.11.1
HPA
ENSG00000137193-PIM1
GeneCards
P11309
Ensembl
ENST00000373509
,
ENSG00000137193
,
ENSP00000362608
Pharos - Targets
P11309
ZINC - Predictions - Purchasable
PIM1_HUMAN
HMDB Protein
HMDBP01271
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P39019 RPS19
2
RPS19 [nucleoplasm]
(R-HSA-6798710)
RPS19 [cytosol]
(R-HSA-72343)
0.633
7
UniProt:P51116 FXR2
0.556
3
UniProt:Q8N7W2-2 BEND7
0.556
3
UniProt:Q96MH2 HEXI2
0.556
3
UniProt:P0C1Z6-2 TFPT
0.556
3
UniProt:Q9Y2K1 ZBTB1
0.556
3
UniProt:Q5T203 Q5T203
0.556
3
UniProt:P07954 FH
1
FH [mitochondrial matrix]
(R-HSA-70980)
0.556
3
UniProt:Q8N9N5 BANP
1
BANP [nucleoplasm]
(R-HSA-3221973)
0.556
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
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