Reactome | IGFBP3(28-126) [extracellular region]

IGFBP3(28-126) [extracellular region]

Stable Identifier

R-HSA-381534

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

IGFBP-3 (28-126 fragment)

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P17936 IGFBP3

Gene Names

IGFBP3, IBP3

Chain

signal peptide:1-27, chain:28-291

Reference Genes

BioGPS Gene:3486 IGFBP3

COSMIC (genes):IGFBP3 IGFBP3

CTD Gene:3486 IGFBP3

dbSNP Gene:3486 IGFBP3

ENSEMBL:ENSG00000146674 IGFBP3

ENSEMBL_homo_sapiens_GENE:ENSG00000146674.16 IGFBP3

HGNC:5472 IGFBP3

KEGG Gene (Homo sapiens):3486 IGFBP3

Monarch:3486 IGFBP3

NCBI Gene:3486 IGFBP3

OMIM:146732 IGFBP3

UCSC:P17936 IGFBP3

Reference Transcript

Other Identifiers

11721135_s_at

11749912_x_at

1586_at

17057478

210095_PM_s_at

210095_s_at

212143_PM_s_at

212143_s_at

3049293

3049294

3049295

3049296

3049297

3049299

3049302

3049303

3049304

3049306

3049307

3049308

3049309

3049310

3049311

3486

37319_at

8139488

A_23_P215634

A_24_P320699

GE59912

GO:0000165

GO:0001558

GO:0001649

GO:0001933

GO:0001968

GO:0005515

GO:0005520

GO:0005576

GO:0005615

GO:0005634

GO:0005783

GO:0005788

GO:0005975

GO:0006468

GO:0006915

GO:0008160

GO:0008285

GO:0009968

GO:0010906

GO:0012501

GO:0014912

GO:0016942

GO:0019838

GO:0023052

GO:0030154

GO:0031994

GO:0031995

GO:0036211

GO:0040008

GO:0042567

GO:0043065

GO:0043226

GO:0043410

GO:0043567

GO:0043568

GO:0044342

GO:0045663

GO:0046872

GO:0048662

GO:0048856

GO:0048870

GO:0098772

HMNXSV003031537

Hs.77326.1.S2_3p_a_at

ILMN_1746085

ILMN_2396875

M35878_at

PH_hs_0036058

TC07001355.hg

g183115_3p_a_at

Participates

as an output of

Matrix metalloproteinase proteolyzes IGF:IGFBP3:ALS (Homo sapiens)

Other forms of this molecule

IGFBP3(188-291) [extracellular region]

IGFBP3(125-187) [extracellular region]

IGFBP3 [extracellular region]

IGFBP3(125-233) [extracellular region]

IGFBP3(28-124) [extracellular region]

IGFBP3(234-291) [extracellular region]

IGFBP3(127-291) [extracellular region]

IGFBP3(291-187) [extracellular region]

IGFBP3(28-186) [extracellular region]

IGFBP3 [endoplasmic reticulum lumen]

p-IGFBP3 [endoplasmic reticulum lumen]

IGFBP3(28-168) [extracellular region]

IGFBP3(227-291) [extracellular region]

IGFBP3(169-226) [extracellular region]

Inferred To

Igfbp3 [extracellular region] (Rattus norvegicus)

igfbp3 [extracellular region] (Danio rerio)

Cross References

RefSeq

NP_000589.2, NP_001013416.1, XP_016867641.1

OpenTargets

ENSG00000146674

GeneCards

P17936

ZINC - Substances

IBP3_HUMAN

HPA

ENSG00000146674-IGFBP3

Ensembl

ENST00000613132, ENSP00000370473, ENST00000381083, ENSP00000477772, ENSG00000146674

ZINC target

P17936

PRO

P17936

Pharos - Targets

P17936

ZINC - Predictions - Purchasable

IBP3_HUMAN

PDB

7WRQ

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q86XT9 TMEM219	1	TMEM219 [plasma membrane] (R-HSA-6800018)	0.66	8
hyaluronic acid [ChEBI:16336]	3	HUA [endocytic vesicle lumen] (R-ALL-2239419) HUA [extracellular region] (R-ALL-1297302) HUA [cytosol] (R-ALL-877209)	0.611	8
UniProt:Q8IVG9 MT-RNR2	1	MT-RNR2 [extracellular region] (R-HSA-444568)	0.602	7
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:Q8TAP4-4 LMO3			0.556	3
UniProt:Q15047-2 SETDB1			0.556	3
UniProt:P17252 PRKCA	8	PRKCA [nucleoplasm] (R-HSA-450530) PRKCA [photoreceptor disc membrane] (R-HSA-2648987) PRKCA [cytosol] (R-HSA-58196) pT497,T638,S657-PRKCA [plasma membrane] (R-HSA-4332340) p-T497,T638,S657-PRKCA [cytosol] (R-HSA-4332337) PRKCA [plasma membrane] (R-HSA-156469) p-T497-PRKCA [cytosol] (R-HSA-5218731) p-T497,T638,S657-PRKCA [nucleoplasm] (R-HSA-5223292)	0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.539	3
UniProt:P06429 VE7			0.488	2
UniProt:P03129 VE7			0.488	2

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