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p-Y397-LYN
Stable Identifier
R-HSA-8942608
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G1-G1/S phases (Homo sapiens)
G1 Phase (Homo sapiens)
Cyclin D associated events in G1 (Homo sapiens)
Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes (Homo sapiens)
(p-Y342-PTK6,p-Y397-LYN,p-Y226,Y393-ABL1,p-Y419-SRC,p-5Y-JAK2) [cytosol] (Homo sapiens)
p-Y397-LYN [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07948 LYN
Gene Names
LYN, JTK8
Chain
initiator methionine:1, chain:2-512
Reference Genes
BioGPS Gene:4067 LYN
COSMIC (genes):LYN LYN
CTD Gene:4067 LYN
dbSNP Gene:4067 LYN
ENSEMBL:ENSG00000254087 LYN
HGNC:6735 LYN
KEGG Gene (Homo sapiens):hsa:4067 LYN
Monarch:4067 LYN
NCBI Gene:4067 LYN
OMIM:165120 LYN
UCSC:P07948 LYN
Reference Transcript
RefSeq:NM_002350.3 LYN
RefSeq:NM_001111097.2 LYN
RefSeq:XM_017013416.1 LYN
Other Identifiers
0003390019
11718084_a_at
11718085_s_at
11732514_s_at
1231
1402_at
17069063
1W1F
1WA7
2024_s_at
202625_at
202626_s_at
210754_s_at
3098979
3098997
3098998
3098999
3099000
3099001
3099002
3099005
3099006
3099007
3099010
3099011
3099024
3099026
3099028
3099029
3099030
3099050
32616_at
3A4O
4067
4492
54933_at
77231_at
8146500
A_14_P123503
A_23_P147431
CAB004492
CCDS47859
CCDS6162
ENSG00000254087
ENSP00000428424
ENSP00000428924
ENST00000519728
ENST00000520220
EntrezGene:4067
g187270_3p_a_at
g4505054_3p_a_at
GE57840
GO:0000166
GO:0001782
GO:0001817
GO:0001932
GO:0001933
GO:0001934
GO:0002223
GO:0002250
GO:0002376
GO:0002431
GO:0002513
GO:0002553
GO:0002576
GO:0002762
GO:0002768
GO:0002774
GO:0002902
GO:0004672
GO:0004713
GO:0004715
GO:0004716
GO:0005102
GO:0005161
GO:0005178
GO:0005515
GO:0005524
GO:0005634
GO:0005737
GO:0005758
GO:0005794
GO:0005829
GO:0005886
GO:0005913
GO:0006468
GO:0006954
GO:0006974
GO:0006991
GO:0007165
GO:0007169
GO:0007417
GO:0007596
GO:0008284
GO:0008285
GO:0009636
GO:0009725
GO:0009743
GO:0010976
GO:0014003
GO:0014069
GO:0014070
GO:0016020
GO:0016032
GO:0016301
GO:0016310
GO:0016740
GO:0017124
GO:0018108
GO:0019899
GO:0023014
GO:0030061
GO:0030097
GO:0030168
GO:0030218
GO:0030335
GO:0030889
GO:0031175
GO:0031234
GO:0031295
GO:0031625
GO:0031663
GO:0031668
GO:0031966
GO:0032403
GO:0032868
GO:0033003
GO:0033628
GO:0034136
GO:0034144
GO:0034605
GO:0034666
GO:0035556
GO:0038083
GO:0038095
GO:0038096
GO:0042327
GO:0042493
GO:0042531
GO:0042629
GO:0043015
GO:0043200
GO:0043208
GO:0043231
GO:0043304
GO:0043407
GO:0043434
GO:0043552
GO:0044325
GO:0045087
GO:0045121
GO:0045646
GO:0046777
GO:0046875
GO:0048013
GO:0048471
GO:0048678
GO:0050663
GO:0050707
GO:0050727
GO:0050731
GO:0050777
GO:0050853
GO:0050855
GO:0050861
GO:0050900
GO:0051219
GO:0051272
GO:0051279
GO:0060252
GO:0060369
GO:0060397
GO:0070062
GO:0070304
GO:0070372
GO:0070373
GO:0070447
GO:0070667
GO:0070668
GO:0071300
GO:0090025
GO:0090330
GO:0097028
GO:0140031
GO:1902532
GO:1902961
GO:2000670
HGNC:6735
HPA001231
Hs.80887.0.A2_3p_at
ILMN_1781155
LYN
LYN-202
LYN-204
M16038_at
MIM:165120
NM_001111097
NM_002350
NP_001104567
NP_002341
PF00017
PF00018
PF07714
PH_hs_0004647
PR00109
PR00401
PR00452
SM00219
SM00252
SM00326
TC08000383.hg
uc003xsk.5
uc003xsl.5
UPI000013DACD
UPI000016AC37
XM_011517529
XM_017013416
XP_011515831
XP_016868905
Participant Of
hasCandidate
(p-Y342-PTK6,p-Y397-LYN,p-Y226,Y393-ABL1,p-Y419-SRC,p-5Y-JAK2) [cytosol]
Other forms of this molecule
LYN [plasma membrane]
LYN [cytosol]
p-Y396-LYN [plasma membrane]
Inferred To
phospho-p-Y397-LYN [cytosol] (Bos taurus)
phospho-p-Y397-LYN [cytosol] (Danio rerio)
phospho-p-Y397-LYN [cytosol] (Mus musculus)
phospho-p-Y397-LYN [cytosol] (Rattus norvegicus)
phospho-p-Y397-LYN [cytosol] (Sus scrofa)
phospho-p-Y397-LYN [cytosol] (Xenopus tropicalis)
Homologues of p-Y397-LYN [cytosol] (Danio rerio)
Homologues of p-Y397-LYN [cytosol] (Xenopus tropicalis)
Modified Residues
Name
O4'-phospho-L-tyrosine at 397
Coordinate
397
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_002341.1
,
XP_016868905.1
,
NP_001104567.1
Brenda
2.7.10.2
ZINC - World Drugs
LYN_HUMAN
ZINC - FDA approved
LYN_HUMAN
GeneCards
P07948
ZINC - Substances
LYN_HUMAN
DOCK Blaster
3A4O
ZINC target
P07948
PRO
P07948
ZINC - Predictions - Purchasable
LYN_HUMAN
PDB
5XY1
,
1W1F
,
3A4O
,
1WA7
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
58
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.763
6
UniProt:P27958 Genome polyprotein
1
POLG [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HCV-8854138)
0.704
4
UniProt:Q9WMX2 POLG
0.667
3
UniProt:Q9NWQ8 PAG1
2
p-Y317-PAG1 [plasma membrane]
(R-HSA-180494)
PAG1 [plasma membrane]
(R-HSA-180500)
0.641
16
UniProt:Q9HCN6 GP6
1
GP6 [plasma membrane]
(R-HSA-114574)
0.641
5
UniProt:Q07666 KHDRBS1
3
p-Y435,Y440,Y443-KHDRBS1 [cytosol]
(R-HSA-8848995)
KHDRBS1 [nucleoplasm]
(R-HSA-8848941)
p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm]
(R-HSA-8848970)
0.609
2
UniProt:O92972 POLG
0.589
2
UniProt:Q05397 PTK2
10
p-5Y,S732-PTK2 [cytosol]
(R-HSA-5229006)
p-5Y-PTK2 [cytosol]
(R-HSA-5218711)
p-6Y,S732-PTK2 [cytosol]
(R-HSA-5218694)
PTK2(773-1052) [cytosol]
(R-HSA-202829)
PTK2(1-772) [cytosol]
(R-HSA-202827)
p-Y194,Y397,Y576,Y577-PTK2 [cytosol]
(R-HSA-8874613)
p-Y194,Y397-PTK2 [cytosol]
(R-HSA-8874600)
PTK2 [cytosol]
(R-HSA-201621)
p-Y397-PTK2 [cytosol]
(R-HSA-354068)
p-6Y-PTK2 [cytosol]
(R-HSA-354128)
0.573
2
UniProt:P12931 SRC
4
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.564
2
UniProt:P22575 TIP
0.558
3
UniProt:Q8R5G7
1
ARAP3 [cytosol]
(R-MMU-195185)
0.558
2
UniProt:P46527 CDKN1B
6
CDKN1B [cytosol]
(R-HSA-198622)
CDKN1B [nucleoplasm]
(R-HSA-182563)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
0.544
2
UniProt:Q9HCN6-1 GP6
0.524
2
UniProt:Q15642 TRIP10
1
TRIP10 [cytosol]
(R-HSA-195120)
0.508
2
UniProt:P33993 MCM7
1
MCM7 [nucleoplasm]
(R-HSA-68555)
0.499
4
UniProt:P25063 CD24
1
CD24(29-534) [plasma membrane]
(R-HSA-430062)
0.499
6
UniProt:P11049 CD37
0.499
5
UniProt:P14317 HCLS1
0.499
2
UniProt:Q08857 Cd36
6
CD36 [phagocytic vesicle]
(R-MMU-1236835)
4xPalmC-CD36 [endocytic vesicle membrane]
(R-MMU-2239449)
CD36 [platelet alpha granule membrane]
(R-MMU-114687)
4xPalmC-CD36 [specific granule membrane]
(R-MMU-6806151)
Platelet glycoprotein 4 [plasma membrane]
(R-MMU-2187219)
4xPalmC-CD36 [plasma membrane]
(R-MMU-51645)
0.499
2
UniProt:P16671 CD36
5
CD36 [phagocytic vesicle]
(R-HSA-1236835)
4xPalmC-CD36 [endocytic vesicle membrane]
(R-HSA-2239449)
CD36 [platelet alpha granule membrane]
(R-HSA-114687)
4xPalmC-CD36 [plasma membrane]
(R-HSA-51645)
4xPalmC-CD36 [specific granule membrane]
(R-HSA-6806151)
0.499
3
UniProt:P20273 CD22
3
CD22 [plasma membrane]
(R-HSA-197703)
NAc-CD22 [plasma membrane]
(R-HSA-5690736)
p-Y762,807,822-CD22 [plasma membrane]
(R-HSA-5690726)
0.499
2
UniProt:P61980
1
HNRNPK [nucleoplasm]
(R-RNO-71945)
0.469
2
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