Reactome | p-Y397-LYN [cytosol]

p-Y397-LYN [cytosol]

Stable Identifier

R-HSA-8942608

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

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External Reference Information

External Reference

UniProt:P07948 LYN

Gene Names

LYN, JTK8

Chain

initiator methionine:1, chain:2-512

Reference Genes

BioGPS Gene:4067 LYN

COSMIC (genes):LYN LYN

CTD Gene:4067 LYN

dbSNP Gene:4067 LYN

ENSEMBL:ENSG00000254087 LYN

HGNC:6735 LYN

KEGG Gene (Homo sapiens):4067 LYN

Monarch:4067 LYN

NCBI Gene:4067 LYN

OMIM:165120 LYN

UCSC:P07948 LYN

Reference Transcript

Other Identifiers

0003390019

04660+2.7.10.2

11718084_a_at

11718085_s_at

11732514_s_at

1231

1402_at

17069063

1W1F

1WA7

2024_s_at

202625_at

202626_s_at

210754_s_at

3098978

3098979

3098997

3098998

3098999

3099000

3099001

3099002

3099005

3099006

3099007

3099010

3099011

3099024

3099026

3099028

3099029

3099030

3099050

32616_at

3A4O

4067

4492

54933_at

5XY1

6NMW

77231_at

8146500

A_14_P123503

A_23_P147431

AAA59540

AAB50019

AAH75001

AAH75002

AAI26457

AAI26459

BC075001

BC075002

BC126456

BC126458

CAB004492

CCDS47859

CCDS6162

E5RJ37

ENSG00000254087

ENSP00000428424

ENSP00000428924

ENST00000519728

ENST00000519728.5

ENST00000520220

ENST00000520220.6

EntrezGene:4067

EntrezGene:LYN

g187270_3p_a_at

g4505054_3p_a_at

GE57840

GO:0000166

GO:0001782

GO:0001817

GO:0001932

GO:0001933

GO:0001934

GO:0002223

GO:0002250

GO:0002376

GO:0002431

GO:0002513

GO:0002553

GO:0002576

GO:0002762

GO:0002768

GO:0002774

GO:0002902

GO:0003674

GO:0004672

GO:0004713

GO:0004715

GO:0005102

GO:0005161

GO:0005178

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005634

GO:0005737

GO:0005739

GO:0005758

GO:0005764

GO:0005773

GO:0005794

GO:0005829

GO:0005886

GO:0005913

GO:0006464

GO:0006468

GO:0006629

GO:0006810

GO:0006950

GO:0006954

GO:0006974

GO:0006991

GO:0007155

GO:0007165

GO:0007169

GO:0007267

GO:0007596

GO:0008092

GO:0008150

GO:0008219

GO:0008283

GO:0008284

GO:0008285

GO:0008289

GO:0009636

GO:0009725

GO:0009743

GO:0010976

GO:0014003

GO:0014068

GO:0014069

GO:0014070

GO:0015031

GO:0016020

GO:0016032

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0017124

GO:0018108

GO:0019899

GO:0030061

GO:0030097

GO:0030154

GO:0030168

GO:0030218

GO:0030335

GO:0030889

GO:0031175

GO:0031234

GO:0031295

GO:0031625

GO:0031663

GO:0031668

GO:0031966

GO:0032868

GO:0032991

GO:0033003

GO:0033628

GO:0034136

GO:0034142

GO:0034144

GO:0034605

GO:0034666

GO:0035556

GO:0038083

GO:0038095

GO:0038096

GO:0040011

GO:0042127

GO:0042327

GO:0042493

GO:0042531

GO:0042592

GO:0042629

GO:0043015

GO:0043167

GO:0043200

GO:0043208

GO:0043226

GO:0043231

GO:0043304

GO:0043407

GO:0043434

GO:0043552

GO:0044325

GO:0044403

GO:0044877

GO:0045087

GO:0045121

GO:0045646

GO:0046579

GO:0046777

GO:0046875

GO:0048013

GO:0048471

GO:0048678

GO:0048856

GO:0048870

GO:0050663

GO:0050707

GO:0050727

GO:0050777

GO:0050853

GO:0050855

GO:0050900

GO:0051219

GO:0051272

GO:0051279

GO:0055085

GO:0060252

GO:0060369

GO:0060397

GO:0070062

GO:0070304

GO:0070372

GO:0070373

GO:0070447

GO:0070667

GO:0070668

GO:0071300

GO:0090025

GO:0090330

GO:0097028

GO:0098978

GO:0099091

GO:0140031

GO:1902532

GO:1902961

GO:2000670

HGNC:6735

HPA001231

Hs.80887.0.A2_3p_at

ILMN_1781155

IPR000719

IPR000980

IPR001245

IPR001452

IPR008266

IPR011009

IPR017441

IPR020635

IPR035748

IPR035852

IPR036028

IPR036860

LYN

LYN-202

LYN-204

M16038

M16038_at

M79321

MIM:165120

NM_001111097

NM_002350

NP_001104567

NP_002341

PF00017

PF00018

PF07714

PH_hs_0004647

PR00109

PR00401

PR00452

SM00219

SM00252

SM00326

TC08000383.hg

UPI000013DACD

UPI000016AC37

XM_011517529

XM_017013416

XP_011515831

XP_016868905

Participant Of

hasCandidate

(p-Y342-PTK6,p-Y397-LYN,p-Y226,Y393-ABL1,p-Y419-SRC,p-5Y-JAK2) [cytosol]

Other forms of this molecule

LYN [cytosol]

p-Y396-LYN [plasma membrane]

MyrG2-PalmC3-LYN [plasma membrane]

LYN [plasma membrane]

Inferred To

phospho-LYN [cytosol] (Bos taurus)

phospho-p-Y397-LYN [cytosol] (Xenopus tropicalis)

phospho-Lyn [cytosol] (Mus musculus)

phospho-Lyn [cytosol] (Rattus norvegicus)

Modified Residues

Name

O4'-phospho-L-tyrosine at 397

Coordinate

397

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_016868905.1, NP_001104567.1, NP_002341.1

ZINC - World Drugs

LYN_HUMAN

OpenTargets

ENSG00000254087

ZINC - FDA approved

LYN_HUMAN

ZINC - Substances

LYN_HUMAN

ZINC target

P07948

ZINC - Biogenic

LYN_HUMAN

PRO

P07948

PDB

3A4O, 1WA7, 5XY1, 6NMW, 1W1F

ZINC - Investigational

LYN_HUMAN

HPA

ENSG00000254087-LYN

GeneCards

P07948

Ensembl

ENSP00000428424, ENST00000520220, ENSP00000428924, ENST00000519728, ENSG00000254087

ZINC - Predictions - Purchasable

LYN_HUMAN

Interactors (26)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.82	7
UniProt:P27958 Genome polyprotein	1	POLG [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HCV-8854138)	0.704	4
UniProt:Q9WMX2 POLG			0.667	3
UniProt:Q9HCN6 GP6	1	GP6 [plasma membrane] (R-HSA-114574)	0.641	5
UniProt:Q9NWQ8 PAG1	2	p-Y317-PAG1 [plasma membrane] (R-HSA-180494) PAG1 [plasma membrane] (R-HSA-180500)	0.641	16
UniProt:Q13444 ADAM15	1	ADAM15 [plasma membrane] (R-HSA-708329)	0.609	2
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.609	2
UniProt:O92972 POLG			0.589	2
UniProt:Q05397 PTK2	11	p-Y194,Y397-PTK2 [cytosol] (R-HSA-8874600) p-Y194,Y397,Y576,Y577-PTK2 [cytosol] (R-HSA-8874613) pY-PTK2 [cytosol] (R-HSA-9632393) PTK2(773-1052) [cytosol] (R-HSA-202829) PTK2(1-772) [cytosol] (R-HSA-202827) p-5Y-PTK2 [cytosol] (R-HSA-5218711) p-5Y,S732-PTK2 [cytosol] (R-HSA-5229006) p-6Y,S732-PTK2 [cytosol] (R-HSA-5218694) PTK2 [cytosol] (R-HSA-201621) p-Y397-PTK2 [cytosol] (R-HSA-354068) p-6Y-PTK2 [cytosol] (R-HSA-354128)	0.573	2
UniProt:P08238 HSP90AB1	6	HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	2
UniProt:P12931 SRC	6	p-Y416-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.564	2
UniProt:P22575 TIP			0.558	3
UniProt:Q8R5G7	1	Arap3 [cytosol] (R-MMU-195185)	0.558	2
UniProt:O43184 ADAM12	1	ADAM12 [plasma membrane] (R-HSA-179792)	0.558	2
UniProt:P46527 CDKN1B	8	CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.544	2
UniProt:Q9HCN6-1 GP6			0.524	2
UniProt:Q15642 TRIP10	1	TRIP10 [cytosol] (R-HSA-195120)	0.508	2
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.499	4
UniProt:Q6UWF3 SCIMP			0.499	3
UniProt:P11049 CD37			0.499	5
UniProt:P14317 HCLS1			0.499	2
UniProt:P20273 CD22	3	CD22 [plasma membrane] (R-HSA-197703) NAc-CD22 [plasma membrane] (R-HSA-5690736) p-Y762,807,822-CD22 [plasma membrane] (R-HSA-5690726)	0.499	2
UniProt:P16671 CD36	5	CD36 [platelet alpha granule membrane] (R-HSA-114687) 4xPalmC-CD36 [endocytic vesicle membrane] (R-HSA-2239449) CD36 [phagocytic vesicle] (R-HSA-1236835) 4xPalmC-CD36 [specific granule membrane] (R-HSA-6806151) 4xPalmC-CD36 [plasma membrane] (R-HSA-51645)	0.499	3
UniProt:Q08857 Cd36	6	Cd36 [platelet alpha granule membrane] (R-MMU-114687) Cd36 [endocytic vesicle membrane] (R-MMU-2239449) Cd36 [phagocytic vesicle] (R-MMU-1236835) Platelet glycoprotein 4 [plasma membrane] (R-MMU-2187219) Cd36 [plasma membrane] (R-MMU-51645) Cd36 [specific granule membrane] (R-MMU-6806151)	0.499	2
UniProt:P25063 CD24	1	CD24(29-534) [plasma membrane] (R-HSA-430062)	0.499	6
UniProt:P61980	2	Hnrnpk [nucleoplasm] (R-RNO-71945) Hnrnpk [nucleoplasm] (R-RNO-4570532)	0.469	2

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