Reactome | ITGB2 [specific granule membrane]

ITGB2 [specific granule membrane]

Stable Identifier

R-HSA-6803284

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

specific granule membrane

Synonyms

Integrin beta-2, ITB2_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P05107 ITGB2

Gene Names

ITGB2, CD18, MFI7

Chain

signal peptide:1-22, chain:23-769

Reference Genes

BioGPS Gene:3689 ITGB2

COSMIC (genes):ITGB2 ITGB2

CTD Gene:3689 ITGB2

dbSNP Gene:3689 ITGB2

ENSEMBL:ENSG00000160255 ITGB2

HGNC:6155 ITGB2

KEGG:hsa:3689 ITGB2

Monarch:3689 ITGB2

NCBI Gene:3689 ITGB2

OMIM:600065 ITGB2

UCSC:P05107 ITGB2

Reference Transcript

Other Identifiers

11717337_a_at

1555349_PM_a_at

1555349_a_at

16926460

202803_PM_s_at

202803_s_at

236988_3p_x_at

236988_PM_x_at

236988_x_at

3689

37918_at

3934730

3934731

3934732

3934734

3934736

3934737

3934738

3934739

3934740

3934741

3934743

3934744

3934745

3934746

3934747

3934748

3934749

3934753

3934755

3934756

3934757

3934758

3934759

3934760

3934761

3934762

3934763

3934764

3934769

3934772

3934773

3934774

3934775

3934776

3934777

3934780

58602_at

8070826

A_23_P329573

A_23_P430411

A_33_P3398143

GE62084

GO:0001540

GO:0001774

GO:0001851

GO:0002376

GO:0002523

GO:0005178

GO:0005515

GO:0005886

GO:0005925

GO:0006898

GO:0006909

GO:0006911

GO:0006915

GO:0006954

GO:0007155

GO:0007159

GO:0007160

GO:0007229

GO:0007267

GO:0008305

GO:0008360

GO:0009897

GO:0009986

GO:0012501

GO:0016020

GO:0016192

GO:0019901

GO:0023052

GO:0030154

GO:0030369

GO:0030593

GO:0031072

GO:0031623

GO:0032930

GO:0034113

GO:0034687

GO:0034688

GO:0034689

GO:0035579

GO:0035987

GO:0038024

GO:0043113

GO:0043226

GO:0043235

GO:0043315

GO:0043542

GO:0044853

GO:0044877

GO:0045121

GO:0045123

GO:0045429

GO:0045766

GO:0045963

GO:0046872

GO:0048870

GO:0050730

GO:0050839

GO:0060089

GO:0061024

GO:0070062

GO:0070821

GO:0071404

GO:0090314

GO:0097242

GO:0098609

GO:0098742

GO:0101003

GO:1903561

GO:1904996

GO:1990266

GO:2000363

HMNXSV003010714

HMNXSV003020990

HMNXSV003025531

Hs.323138.0.A1_3p_at

Hs.323138.0.A1_3p_s_at

Hs2.83968.2.S1_3p_s_at

ILMN_2175912

M15395_at

PH_hs_0018273

X64072_s_at

Participates

as a member of

Specific granule membrane proteins [specific granule membrane] (Homo sapiens)

Other forms of this molecule

ITGB2 [plasma membrane]

ITGB2 [ficolin-1-rich granule membrane]

ITGB2 [tertiary granule membrane]

Inferred To

ITGB2 [specific granule membrane] (Bos taurus)

ITGB2 [specific granule membrane] (Caenorhabditis elegans)

ITGB2 [specific granule membrane] (Canis familiaris)

ITGB2 [specific granule membrane] (Gallus gallus)

ITGB2 [specific granule membrane] (Mus musculus)

ITGB2 [specific granule membrane] (Sus scrofa)

mys [specific granule membrane] (Drosophila melanogaster)

Itgbn [specific granule membrane] (Drosophila melanogaster)

pat-3 [specific granule membrane] (Caenorhabditis elegans)

Itgb2 [specific granule membrane] (Rattus norvegicus)

Homologues of ITGB2 [specific granule membrane] (Caenorhabditis elegans)

Homologues of ITGB2 [specific granule membrane] (Drosophila melanogaster)

Cross References

RefSeq

NP_000202.3, NP_001290167.1, NP_001120963.2

Guide to Pharmacology - Targets

2456

OpenTargets

ENSG00000160255

ENSEMBL

ENST00000397850, ENST00000397852, ENSP00000380955, ENST00000397857, ENST00000652462, ENST00000355153, ENSP00000380950, ENSP00000347279, ENSP00000498780, ENSP00000380948

HPA

ENSG00000160255-ITGB2

PRO

P05107

Pharos - Targets

P05107

Orphanet

ITGB2

GlyGen

P05107

HMDB Protein

HMDBP02085

PDB

3K71, 5XR1, 4NEN, 5E6V, 1L3Y, 2V7D, 5ES4, 7USL, 5E6W, 2JF1, 2P28, 2P26, 5E6U, 3K6S, 1YUK, 5ZAZ, 4NEH, 7P2D, 7USM, 5E6R, 3K72, 5E6S, 5E6X

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q7Z3S9 NOTCH2NLA	3	NOTCH2NLA [extracellular region] (R-HSA-9908935) NOTCH2NLA(1-?) [extracellular region] (R-HSA-9911493) NOTCH2NLA(?-236) [extracellular region] (R-HSA-9911490)	0.781	7
UniProt:Q96S59 RANBP9	1	RANBP9 [cytosol] (R-HSA-374586)	0.611	4
UniProt:Q9H2K0 MTIF3	1	MTIF3 [mitochondrial matrix] (R-HSA-5368284)	0.556	3
UniProt:P0DPK4 NOTCH2NLC	1	NOTCH2NLC [extracellular region] (R-HSA-9908932)	0.556	3
UniProt:Q14145 KEAP1	3	KEAP1 [cytosol] (R-HSA-976038) ub-KEAP1 [cytosol] (R-HSA-9766647) Ub-KEAP1 [cytosol] (R-HSA-6782766)	0.556	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P00519 ABL1	6	p-S456-ABL1 [nucleoplasm] (R-HSA-5686576) ABL1 [nucleoplasm] (R-HSA-5686579) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) p-Y393-ABL1 [cytosol] (R-HSA-9865161)	0.524	4
UniProt:P04578 env	7	ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Surface protein gp120 (P04578) [cytosol] (R-HIV-189269)	0.462	2

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