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PTPN6 [cytosol]
Stable Identifier
R-HSA-197938
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SHP1, SHP-1, Src homology phosphatase-1, Protein-tyrosine phosphatase, non-receptor type 6, PTN6_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Cell-Cell communication (Homo sapiens)
Signal regulatory protein family interactions (Homo sapiens)
p-4Y-SIRPA:CD47 binds PTPN6,PTPN11 (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
p-Y429,Y453,Y470,Y496-SIRPA:PTPN6,PTPN11 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
Disease (Homo sapiens)
Diseases of signal transduction by growth factor receptors and second messengers (Homo sapiens)
Signaling by ALK in cancer (Homo sapiens)
Signaling by ALK fusions and activated point mutants (Homo sapiens)
Nuclear events stimulated by ALK signaling in cancer (Homo sapiens)
DNMT1-dependent PTPN6 gene silencing (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 activates/modulates innate and adaptive immune responses (Homo sapiens)
Phosphorylation of STAT1 (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
Hemostasis (Homo sapiens)
Cell surface interactions at the vascular wall (Homo sapiens)
PECAM1 interactions (Homo sapiens)
Interaction of PECAM-1 and SHP-1 (Homo sapiens)
PECAM-1:SHP-1 complex [plasma membrane] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
Platelet activation, signaling and aggregation (Homo sapiens)
GPVI-mediated activation cascade (Homo sapiens)
G6B binds PTPN6,PTPN11 (Homo sapiens)
G6B:PTPN6,PTPN11 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
SYK autophosphorylates (Homo sapiens)
G6B:PTPN6,PTPN11 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
p-Y7-CLEC1B dimer:PDPN binds SYK (Homo sapiens)
G6B:PTPN6,PTPN11 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
Platelet homeostasis (Homo sapiens)
Platelet sensitization by LDL (Homo sapiens)
Interaction of PECAM-1 and SHP-1 (Homo sapiens)
PECAM-1:SHP-1 complex [plasma membrane] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Costimulation by the CD28 family (Homo sapiens)
PD-1 signaling (Homo sapiens)
Dephosphorylation of CD3-zeta by PD-1 bound phosphatases (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
Interaction of SHP-1 or SHP-2 with phospho PD-1 (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
PTPN6,PTPN11:p-Y223,248-PDCD1:B7-DC,B7-H1 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
SHP-1 and SHP-2 bind pBTLA (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
SHP-1/SHP-2:pBTLA:HVEM [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
Signaling by the B Cell Receptor (BCR) (Homo sapiens)
Antigen activates B Cell Receptor (BCR) leading to generation of second messengers (Homo sapiens)
LYN, FYN, BLK phosphorylate ITAMs of Ig-alpha (CD79A) and Ig-beta (CD79B) (Homo sapiens)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
SYK autophosphorylates at the activated BCR (Homo sapiens)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
CD22 mediated BCR regulation (Homo sapiens)
SHP1 binds p-CD22 (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Growth hormone receptor signaling (Homo sapiens)
SHP1 (PTPN6) binds JAK2 in the receptor complex (Homo sapiens)
Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP1 [plasma membrane] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
SHP1 (PTPN6) dephosphorylates JAK2 (Homo sapiens)
Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-JAK2 dimer:SHP1 [plasma membrane] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP1 [plasma membrane] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
Interferon Signaling (Homo sapiens)
Interferon alpha/beta signaling (Homo sapiens)
Phosphorylation of STAT1 (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
Regulation of IFNA/IFNB signaling (Homo sapiens)
Dephosphorylation of JAK1 by SHP1 (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
Interferon gamma signaling (Homo sapiens)
Regulation of IFNG signaling (Homo sapiens)
Dephosphorylation of JAKs by PTPs (Homo sapiens)
PTPs-SHP1/2/PTP1B [cytosol] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
Transphosphorylation of JAK1 (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
The SHC1:SHIP1 complex is stabilized by GRB2 (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
Interleukin-3, Interleukin-5 and GM-CSF signaling (Homo sapiens)
Interleukin receptor SHC signaling (Homo sapiens)
The SHC1:SHIP1 complex is stabilized by GRB2 (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP:GRB2 [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
SHP1 and SHP2 bind the common beta chain (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
SHP1 and SHP2 dephosphorylate Y628 of IL3RB (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
High affinity binding complex dimers of cytokine receptors using Bc, inactive JAK2,p(Y593,628)-Bc:SHP1, SHP2 [plasma membrane] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ALK (Homo sapiens)
PTPN6 dephosphorylates JAK3 (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
Signaling by SCF-KIT (Homo sapiens)
Regulation of KIT signaling (Homo sapiens)
Interaction of SHP1 and KIT (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
PTPN6:p-c-Kit complex [plasma membrane] (Homo sapiens)
PTPN6 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P29350 PTPN6
Gene Names
PTPN6, HCP, PTP1C
Chain
chain:1-595
Reference Genes
BioGPS Gene:5777 PTPN6
COSMIC (genes):PTPN6 PTPN6
CTD Gene:5777 PTPN6
dbSNP Gene:5777 PTPN6
ENSEMBL:ENSG00000111679 PTPN6
ENSEMBL_homo_sapiens_GENE:ENSG00000111679.17 PTPN6
HGNC:9658 PTPN6
KEGG Gene (Homo sapiens):5777 PTPN6
Monarch:5777 PTPN6
NCBI Gene:5777 PTPN6
OMIM:176883 PTPN6
UCSC:P29350 PTPN6
Reference Transcript
RefSeq:NM_002831.5 PTPN6
RefSeq:NM_080548.4 PTPN6
RefSeq:NM_080549.3 PTPN6
RefSeq:XM_011520988.1 PTPN6
Other Identifiers
11726034_a_at
11739054_a_at
11739055_x_at
16747623
206687_PM_s_at
206687_s_at
3403093
3403095
3403096
3403097
3403099
3403102
3403106
3403107
3403108
3403109
3403110
3403111
3403113
3403114
3403117
3403118
3403119
3403120
3403121
3403122
3403123
5777
794_at
7953569
A_23_P162486
GE59877
GO:0000165
GO:0000278
GO:0001784
GO:0002244
GO:0002376
GO:0002924
GO:0003824
GO:0004721
GO:0004725
GO:0004726
GO:0005001
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0005886
GO:0005911
GO:0006470
GO:0006954
GO:0007155
GO:0007186
GO:0008284
GO:0008285
GO:0012501
GO:0016020
GO:0016311
GO:0016787
GO:0016791
GO:0017124
GO:0018108
GO:0019221
GO:0019901
GO:0023052
GO:0030154
GO:0030220
GO:0031295
GO:0031410
GO:0032715
GO:0032720
GO:0032991
GO:0033007
GO:0033630
GO:0035335
GO:0035556
GO:0035580
GO:0035855
GO:0036211
GO:0042060
GO:0042098
GO:0042105
GO:0042130
GO:0042169
GO:0042267
GO:0042981
GO:0043226
GO:0043409
GO:0045577
GO:0048856
GO:0050732
GO:0050839
GO:0050852
GO:0050853
GO:0050860
GO:0051279
GO:0051897
GO:0055065
GO:0055085
GO:0060089
GO:0060338
GO:0070062
GO:0070372
GO:0070527
GO:0071310
GO:0098542
GO:0106015
GO:0140031
GO:0140096
GO:1904724
GO:1905867
GO:2000045
HMNXSV003044817
ILMN_1664122
ILMN_1716578
ILMN_1738675
PH_hs_0003980
TC12000101.hg
X62055_at
g4506296_3p_a_at
Participates
as a component of
Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-JAK2 dimer:SHP1 [plasma membrane] (Homo sapiens)
Growth Hormone: Tyrosine phosphorylated Growth Hormone Receptor-p(Y1007)-JAK2 dimer:SHP1 [plasma membrane] (Homo sapiens)
PECAM-1:SHP-1 complex [plasma membrane] (Homo sapiens)
PTPN6:p-c-Kit complex [plasma membrane] (Homo sapiens)
Interleukin receptor complexes with activated SHC1:SHIP1 [plasma membrane] (Homo sapiens)
PTPN6:p-Y762,807,822-CD22:Antigen:p-BCR [plasma membrane] (Homo sapiens)
as an input of
SHP1 (PTPN6) binds JAK2 in the receptor complex (Homo sapiens)
Interaction of PECAM-1 and SHP-1 (Homo sapiens)
Interaction of SHP1 and KIT (Homo sapiens)
SHP1 binds p-CD22 (Homo sapiens)
as an output of
DNMT1-dependent PTPN6 gene silencing (Homo sapiens)
as a member of
PTPs-SHP1/2/PTP1B [cytosol] (Homo sapiens)
PTPN6,PTPN11 [cytosol] (Homo sapiens)
This entity regulates
Negatively
Transphosphorylation of JAK1
(Homo sapiens)
Other forms of this molecule
PTPN6 [specific granule lumen]
PTPN6 [extracellular region]
PTPN6 [tertiary granule lumen]
PTPN6 [nucleoplasm]
Inferred To
ptp-2 [cytosol]
(Caenorhabditis elegans)
PTPN6 [cytosol]
(Bos taurus)
PTPN6 [cytosol]
(Canis familiaris)
PTPN6 [cytosol]
(Drosophila melanogaster)
PTPN6 [cytosol]
(Gallus gallus)
PTPN6 [cytosol]
(Mus musculus)
PTPN6 [cytosol]
(Rattus norvegicus)
PTPN6 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_002822.2
,
NP_536858.1
,
XP_011519290.1
,
NP_536859.1
OpenTargets
ENSG00000111679
ZINC - Substances
PTN6_HUMAN
ZINC target
P29350
ZINC - Biogenic
PTN6_HUMAN
PRO
P29350
PDB
6SM5
,
4GRZ
,
2YU7
,
8YHI
,
4GRY
,
4GS0
,
4HJQ
,
1FPR
,
3PS5
,
2RMX
,
1X6C
,
1GWZ
,
4HJP
,
2B3O
IntEnz
3.1.3.48
GeneCards
P29350
HPA
ENSG00000111679-PTPN6
Ensembl
ENST00000399448
,
ENST00000456013
,
ENSP00000391592
,
ENST00000318974
,
ENSG00000111679
,
ENSP00000326010
,
ENSP00000382376
Pharos - Targets
P29350
ZINC - Predictions - Purchasable
PTN6_HUMAN
HMDB Protein
HMDBP02499
Interactors (29)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P43628 KIR2DL3
1
KIR2DL3 [plasma membrane]
(R-HSA-3006532)
0.824
13
UniProt:P20138 CD33
3
CD33 [tertiary granule membrane]
(R-HSA-6800959)
CD33 [plasma membrane]
(R-HSA-197719)
CD33 [specific granule membrane]
(R-HSA-6799615)
0.824
10
UniProt:P19235 EPOR
2
EPOR [plasma membrane]
(R-HSA-1168347)
p-8Y-EPOR [plasma membrane]
(R-HSA-9006274)
0.8
11
UniProt:P31994 FCGR2B
1
FCGR2B [plasma membrane]
(R-HSA-197854)
0.669
3
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.646
3
UniProt:P08922 ROS1
0.642
4
UniProt:P06239 LCK
4
p-Y394-LCK [plasma membrane]
(R-HSA-8857940)
p-Y505-LCK [plasma membrane]
(R-HSA-202159)
p-Y394-LCK [cytosol]
(R-HSA-202308)
LCK [cytosol]
(R-HSA-167609)
0.623
5
UniProt:Q6GTX8 LAIR1
3
LAIR1 [specific granule membrane]
(R-HSA-6799644)
LAIR1 [plasma membrane]
(R-HSA-5686426)
LAIR1 [tertiary granule membrane]
(R-HSA-6800947)
0.613
5
UniProt:O94916-1 NFAT5
0.602
4
UniProt:Q9UKJ1 PILRA
1
PILRA [plasma membrane]
(R-HSA-3008978)
0.581
5
UniProt:P35968 KDR
5
p-11Y-VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) [plasma membrane]
(R-HSA-9673636)
VEGFR2(20-662)insVAGTWTSGLMSL-PDGFRA(471-1089) fusion [plasma membrane]
(R-HSA-9673613)
p-Y801,Y1054,Y1175-KDR [plasma membrane]
(R-HSA-9860484)
VEGFR2 [plasma membrane]
(R-HSA-195382)
p-6Y-VEGFR2 [plasma membrane]
(R-HSA-4420103)
0.573
2
UniProt:B7UM99 TIR
0.571
4
UniProt:Q05209 PTPN12
2
PTPN12 [cytosol]
(R-HSA-432933)
PTPN12 [nucleoplasm]
(R-HSA-9008905)
0.564
3
UniProt:Q9BZW8 CD244
1
CD244 [plasma membrane]
(R-HSA-197846)
0.564
2
UniProt:Q13643 FHL3
0.556
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.547
2
UniProt:P24394 IL4R
2
IL4R [plasma membrane]
(R-HSA-449670)
p-Y-IL4R [plasma membrane]
(R-HSA-6786087)
0.527
2
UniProt:Q14790 CASP8
8
CASP8(1-374) [cytosol]
(R-HSA-3465404)
CASP8(217-374) [mitochondrial outer membrane]
(R-HSA-351869)
CASP8(385-479) [mitochondrial outer membrane]
(R-HSA-351828)
CASP8(385-479) [cytosol]
(R-HSA-76158)
CASP8(375-384) [cytosol]
(R-HSA-933460)
CASP8(217-374) [cytosol]
(R-HSA-75975)
CASP8(1-216) [cytosol]
(R-HSA-933456)
CASP8(1-479) [cytosol]
(R-HSA-57031)
0.524
3
UniProt:P08069 IGF1R
3
IGF1R(741-1367) [plasma membrane]
(R-HSA-2404180)
IGF1R(31-736) [plasma membrane]
(R-HSA-2404169)
p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane]
(R-HSA-2404172)
0.508
3
UniProt:Q03135 CAV1
5
CAV1 [Golgi membrane]
(R-HSA-204504)
CAV1 [plasma membrane]
(R-HSA-534994)
CAV1 [early endosome membrane]
(R-HSA-5368451)
CAV1 [lipid droplet]
(R-HSA-163510)
CAV1 [endocytic vesicle membrane]
(R-HSA-535009)
0.499
2
UniProt:O35274 NEB2
0.499
2
UniProt:P11049 CD37
0.499
4
UniProt:P20273 CD22
3
NAc-CD22 [plasma membrane]
(R-HSA-5690736)
CD22 [plasma membrane]
(R-HSA-197703)
p-Y762,807,822-CD22 [plasma membrane]
(R-HSA-5690726)
0.499
4
UniProt:Q8N1K5 THMS1
0.499
4
UniProt:P32927 CSF2RB
6
CSF2RB S271L [plasma membrane]
(R-HSA-5688879)
p-Y593,Y628-CSF2RB [plasma membrane]
(R-HSA-912312)
CSF2RB [plasma membrane]
(R-HSA-879960)
p-S585-CSF2RB [plasma membrane]
(R-HSA-914170)
p-Y593-CSF2RB [plasma membrane]
(R-HSA-914092)
CSF2RB R211Efs*54 [plasma membrane]
(R-HSA-5688863)
0.471
2
UniProt:P43626 KIR2DL1
1
KIR2DL1 [plasma membrane]
(R-HSA-199538)
0.462
4
UniProt:P27986 PIK3R1
16
p-Y-PIK3R1 [cytosol]
(R-HSA-9680647)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.462
2
UniProt:P78314 3BP2
0.462
2
UniProt:P16284 PECAM1
5
PECAM1 [platelet alpha granule membrane]
(R-HSA-61489)
PECAM1 [plasma membrane]
(R-HSA-114686)
PECAM1 [secretory granule membrane]
(R-HSA-6804778)
p-Y663,Y686-PECAM1(27-?) [plasma membrane]
(R-HSA-210007)
p-Y713-PECAM1 [plasma membrane]
(R-HSA-9860772)
0.462
4
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