Reactome | FRK [azurophil granule lumen]

FRK [azurophil granule lumen]

Stable Identifier

R-HSA-6799142

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

azurophil granule lumen

Synonyms

Tyrosine-protein kinase FRK ecNumber2.7.10.2/ecNumber, FRK_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P42685 FRK

Gene Names

FRK, PTK5, RAK

Chain

chain:1-505

Reference Genes

BioGPS Gene:2444 FRK

COSMIC (genes):FRK FRK

CTD Gene:2444 FRK

dbSNP Gene:2444 FRK

ENSEMBL:ENSG00000111816 FRK

HGNC:3955 FRK

KEGG:hsa:2444 FRK

Monarch:2444 FRK

NCBI Gene:2444 FRK

OMIM:606573 FRK

UCSC:P42685 FRK

Reference Transcript

Other Identifiers

11740398_a_at

11750652_a_at

11751533_a_at

17022916

207178_PM_s_at

207178_s_at

235924_PM_at

235924_at

2444

2970898

2970899

2970900

2970901

2970902

2970903

2970904

2970905

2970906

2970907

2970915

2970926

2970927

2970929

2970931

2970933

35023_at

46333_r_at

511_s_at

8129071

A_23_P133665

A_32_P23525

GE536600

GE58839

GO:0000122

GO:0002376

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005102

GO:0005515

GO:0005524

GO:0005576

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0005886

GO:0006355

GO:0006468

GO:0007169

GO:0016740

GO:0030154

GO:0035578

GO:0035580

GO:0043226

GO:0045087

GO:0070062

GO:0098542

GO:0140096

HMNXSV003006534

Hs.36288.0.A1_3p_at

ILMN_1727605

PH_hs_0004981

TC06002043.hg

U22322_s_at

g4503786_3p_a_at

Participates

as a member of

Azurophil granule lumen proteins [azurophil granule lumen] (Homo sapiens)

Other forms of this molecule

p-Y387-FRK [cytosol]

FRK [specific granule lumen]

FRK [extracellular region]

Inferred To

FRK [azurophil granule lumen] (Bos taurus)

FRK [azurophil granule lumen] (Caenorhabditis elegans)

FRK [azurophil granule lumen] (Canis familiaris)

FRK [azurophil granule lumen] (Drosophila melanogaster)

FRK [azurophil granule lumen] (Gallus gallus)

FRK [azurophil granule lumen] (Mus musculus)

FRK [azurophil granule lumen] (Rattus norvegicus)

FRK [azurophil granule lumen] (Sus scrofa)

FRK [azurophil granule lumen] (Xenopus tropicalis)

Cross References

RefSeq

XP_011533956.1, XP_005266939.1, XP_016866134.1, XP_011533957.1, XP_005266937.1, XP_005266938.1, NP_002022.1, XP_011533955.1

ZINC - World Drugs

FRK_HUMAN

Guide to Pharmacology - Targets

2025

OpenTargets

ENSG00000111816

ENSEMBL

ENSP00000476145, ENST00000606080

ZINC - FDA approved

FRK_HUMAN

ZINC - Substances

FRK_HUMAN

ZINC target

P42685

ZINC - Biogenic

FRK_HUMAN

PRO

P42685

ZINC - Investigational

FRK_HUMAN

HPA

ENSG00000111816-FRK

Pharos - Targets

P42685

ZINC - Predictions - Purchasable

FRK_HUMAN

HMDB Protein

HMDBP01478

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q12982 BNIP2	1	BNIP2 [cytosol] (R-HSA-200792)	0.83	8
UniProt:Q15427 SF3B4	1	SF3B4 [nucleoplasm] (R-HSA-71975)	0.666	4
UniProt:P41240 CSK	2	CSK [cytosol] (R-HSA-203776) CSK [plasma membrane] (R-HSA-180499)	0.643	3
UniProt:P60484 PTEN	20	K48polyUb-PTEN [cytosol] (R-HSA-8874327) PolyUb-PTEN [nucleoplasm] (R-HSA-6782515) PTEN H93R [cytosol] (R-HSA-2318524) PTEN C124R [cytosol] (R-HSA-2317439) PTEN H93Y [cytosol] (R-HSA-2318520) PTEN R130G [cytosol] (R-HSA-2317339) PTEN H93D [cytosol] (R-HSA-2318550) PTEN R130L [cytosol] (R-HSA-2317430) PTEN H93A [cytosol] (R-HSA-2318544) PTEN G129E [cytosol] (R-HSA-2318509) PTEN S170N [cytosol] (R-HSA-2318408) PTEN R173P [cytosol] (R-HSA-2317480) PTEN R130Q [cytosol] (R-HSA-2317416) PTEN H93Q [cytosol] (R-HSA-2318565) PTEN G129R [cytosol] (R-HSA-2318501) PTEN H123Y [cytosol] (R-HSA-2318469) PTEN S170R [cytosol] (R-HSA-2318437) PTEN R173C [cytosol] (R-HSA-2317478) PTEN R173H [cytosol] (R-HSA-2317473) PTEN C124S [cytosol] (R-HSA-2317379)	0.639	7
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2
UniProt:P06400 RB1	20	RB1 R661W [nucleoplasm] (R-HSA-9659801) RB1 C706F [nucleoplasm] (R-HSA-9659812) RB1 N480del [nucleoplasm] (R-HSA-9659792) RB1 C706Y [nucleoplasm] (R-HSA-9659821) RB1 R661Q [nucleoplasm] (R-HSA-9659807) RB1 I703_E737del [nucleoplasm] (R-HSA-9661065) RB1 R830_G887del [cytosol] (R-HSA-9661059) RB1 K791* [cytosol] (R-HSA-9662284) RB1 Q176* [cytosol] (R-HSA-9661774) RB1 S114* [cytosol] (R-HSA-9661775) RB1 K765* [cytosol] (R-HSA-9662281) RB1 W99* [cytosol] (R-HSA-9661769) RB1 S149* [cytosol] (R-HSA-9661770) RB1 E166* [cytosol] (R-HSA-9661767) RB1 G100* [cytosol] (R-HSA-9661763) RB1 E125* [cytosol] (R-HSA-9661784) RB1 Q121* [cytosol] (R-HSA-9661780) RB1 E184* [cytosol] (R-HSA-9661781) RB1 E137* [cytosol] (R-HSA-9661782) RB1 K745* [cytosol] (R-HSA-9662288)	0.544	3
UniProt:Q15365 PCBP1	1	PCBP1 [nucleoplasm] (R-HSA-71919)	0.527	2

Cite Us!