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p-T14,T161-CDK1 [nucleoplasm]
Stable Identifier
R-HSA-170078
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
phospho-(Thr 14, Thr 161)Cdc2
Icon
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle Checkpoints (Homo sapiens)
G2/M Checkpoints (Homo sapiens)
G2/M DNA damage checkpoint (Homo sapiens)
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex (Homo sapiens)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Homo sapiens)
CCNB1:p-T14,T161-CDK1 [nucleoplasm] (Homo sapiens)
p-T14,T161-CDK1 [nucleoplasm] (Homo sapiens)
G2/M DNA replication checkpoint (Homo sapiens)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Homo sapiens)
CCNB1:p-T14,T161-CDK1 [nucleoplasm] (Homo sapiens)
p-T14,T161-CDK1 [nucleoplasm] (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
Mitotic G2-G2/M phases (Homo sapiens)
G2/M Transition (Homo sapiens)
Cyclin A/B1/B2 associated events during G2/M transition (Homo sapiens)
CAK-mediated phosphorylation of Cyclin A:Cdc2 complexes (Homo sapiens)
CCNA:p-T14,T161-CDK1 [nucleoplasm] (Homo sapiens)
p-T14,T161-CDK1 [nucleoplasm] (Homo sapiens)
CAK-mediated phosphorylation of Cyclin B1:Cdc2 complexes (Homo sapiens)
CCNB1:p-T14,T161-CDK1 [nucleoplasm] (Homo sapiens)
p-T14,T161-CDK1 [nucleoplasm] (Homo sapiens)
Wee1-mediated phosphorylation of Cyclin A:phospho-Cdc2 complexes (Homo sapiens)
CCNA:p-T14,T161-CDK1 [nucleoplasm] (Homo sapiens)
p-T14,T161-CDK1 [nucleoplasm] (Homo sapiens)
Wee1-mediated phosphorylation of Cyclin B1:phospho-Cdc2 complexes (Homo sapiens)
CCNB1:p-T14,T161-CDK1 [nucleoplasm] (Homo sapiens)
p-T14,T161-CDK1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P06493 CDK1
Gene Names
CDK1, CDC2, CDC28A, CDKN1, P34CDC2
Chain
chain:1-297
Reference Genes
BioGPS Gene:983 CDK1
COSMIC (genes):CDK1 CDK1
CTD Gene:983 CDK1
dbSNP Gene:983 CDK1
ENSEMBL:ENSG00000170312 CDK1
HGNC:1722 CDK1
KEGG:hsa:983 CDK1
Monarch:983 CDK1
NCBI Gene:983 CDK1
OMIM:116940 CDK1
UCSC:P06493 CDK1
Reference Transcript
RefSeq:XM_005270303.3 CDK1
RefSeq:NM_001786.4 CDK1
RefSeq:NM_033379.4 CDK1
RefSeq:NM_001320918.1 CDK1
Other Identifiers
11726617_s_at
11745843_a_at
11760142_at
16705159
1803_at
203213_PM_at
203213_at
203214_PM_x_at
203214_x_at
210559_PM_s_at
210559_s_at
3248301
3248302
3248303
3248304
3248306
3248307
3248308
3248309
3248310
3248311
3248312
3248313
3248314
3248315
3248316
3248318
3248319
3248320
3248322
33324_s_at
40915_r_at
7927710
91194_at
983
A_14_P116805
A_21_P0000076
A_23_P138507
GE63002
GO:0000082
GO:0000086
GO:0000226
GO:0000307
GO:0000781
GO:0001618
GO:0003682
GO:0003824
GO:0004672
GO:0004674
GO:0004693
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005759
GO:0005789
GO:0005813
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0005876
GO:0006260
GO:0006281
GO:0006325
GO:0006338
GO:0006355
GO:0006357
GO:0006468
GO:0006915
GO:0006974
GO:0007010
GO:0007077
GO:0007095
GO:0007098
GO:0007344
GO:0008353
GO:0009410
GO:0009636
GO:0010628
GO:0010629
GO:0010971
GO:0012501
GO:0014038
GO:0014070
GO:0014075
GO:0014823
GO:0016020
GO:0016301
GO:0016477
GO:0016579
GO:0016740
GO:0018105
GO:0018107
GO:0030154
GO:0030261
GO:0030332
GO:0030496
GO:0030544
GO:0030855
GO:0031100
GO:0034501
GO:0035173
GO:0042307
GO:0042542
GO:0042752
GO:0043066
GO:0043226
GO:0044772
GO:0045471
GO:0045740
GO:0045931
GO:0045995
GO:0046686
GO:0046688
GO:0046718
GO:0048144
GO:0048511
GO:0048678
GO:0048856
GO:0048870
GO:0051301
GO:0055015
GO:0060045
GO:0061024
GO:0062033
GO:0065003
GO:0070062
GO:0070301
GO:0070371
GO:0071407
GO:0072686
GO:0090166
GO:0097121
GO:0097122
GO:0097125
GO:0097472
GO:0106310
GO:0140096
GO:1900182
GO:1902423
GO:1902850
GO:1905448
HMNXSV003002530
HMNXSV003023507
Hs.184572.0.S2_3p_at
ILMN_1710428
ILMN_1747911
PH_hs_0016443
TC10000373.hg
X05360_at
g3126638_3p_a_at
Participates
as a component of
CCNA:p-T14,T161-CDK1 [nucleoplasm] (Homo sapiens)
CCNB1:p-T14,T161-CDK1 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
p-T161-CDK1 [nucleoplasm]
p-T14,Y15,T161-CDK1 [nucleoplasm]
p-T161-CDK1 [cytosol]
p-T14,Y15,T161-CDK1 [cytosol]
CDK1 [cytosol]
CDK1 [nucleoplasm]
p-T14-CDK1 [cytosol]
p-T14-CDK1 [nucleoplasm]
p-Y4-CDK1 [cytosol]
CDK1 [endoplasmic reticulum membrane]
Inferred To
phospho-p-T14,T161-CDK1 [nucleoplasm]
(Bos taurus)
phospho-p-T14,T161-CDK1 [nucleoplasm]
(Caenorhabditis elegans)
phospho-p-T14,T161-CDK1 [nucleoplasm]
(Danio rerio)
phospho-p-T14,T161-CDK1 [nucleoplasm]
(Drosophila melanogaster)
phospho-p-T14,T161-CDK1 [nucleoplasm]
(Mus musculus)
phospho-p-T14,T161-CDK1 [nucleoplasm]
(Rattus norvegicus)
phospho-p-T14,T161-CDK1 [nucleoplasm]
(Sus scrofa)
phospho-p-T14,T161-CDK1 [nucleoplasm]
(Xenopus tropicalis)
phospho-CDK1 [nucleoplasm]
(Canis familiaris)
phospho-CDK1 [nucleoplasm]
(Gallus gallus)
Modified Residues
Name
O-phospho-L-threonine at 14
Coordinate
14
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-threonine at 161
Coordinate
161
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Cross References
RefSeq
NP_001307847.1
,
NP_203698.1
,
NP_001777.1
,
XP_005270360.1
ZINC - World Drugs
CDK1_HUMAN
Guide to Pharmacology - Targets
1961
OpenTargets
ENSG00000170312
ENSEMBL
ENST00000373809
,
ENSP00000378699
,
ENST00000316629
,
ENSP00000362915
,
ENST00000395284
,
ENSP00000325970
ZINC - Substances
CDK1_HUMAN
ZINC - Biogenic
CDK1_HUMAN
ZINC target
P06493
PRO
P06493
GlyGen
P06493
PDB
6GU4
,
4Y72
,
4YC6
,
6GU7
,
5HQ0
,
6GU6
,
5LQF
,
4YC3
,
6TWN
,
7NJ0
,
6GU3
,
6GU2
ZINC - Investigational
CDK1_HUMAN
ZINC - Metabolites
CDK1_HUMAN
HPA
ENSG00000170312-CDK1
Pharos - Targets
P06493
ZINC - Predictions - Purchasable
CDK1_HUMAN
HMDB Protein
HMDBP01364
Interactors (37)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14635 CCNB1
4
CCNB1 [nucleoplasm]
(R-HSA-68901)
p-4S-CCNB1 [cytosol]
(R-HSA-170058)
p-4S-CCNB1 [nucleoplasm]
(R-HSA-170049)
CCNB1 [cytosol]
(R-HSA-157451)
0.976
28
UniProt:P61024 CKS1B
1
CKS1B [nucleoplasm]
(R-HSA-187533)
0.924
13
UniProt:P38936 CDKN1A
5
p-S130-CDKN1A [nucleoplasm]
(R-HSA-187857)
CDKN1A [nucleoplasm]
(R-HSA-182585)
CDKN1A [cytosol]
(R-HSA-182512)
p-Y77-CDKN1A [cytosol]
(R-HSA-8942601)
p-T145-CDKN1A [cytosol]
(R-HSA-198614)
0.903
10
UniProt:Q99640 PKMYT1
3
PKMYT1 [cytosol]
(R-HSA-157457)
p-PKMYT1 [nucleoplasm]
(R-HSA-162650)
PKMYT1 [nucleoplasm]
(R-HSA-74386)
0.893
9
UniProt:P46527 CDKN1B
8
p-T187-CDKN1B [nucleoplasm]
(R-HSA-187525)
CDKN1B [nucleoplasm]
(R-HSA-182563)
p-Y88-CDKN1B [nucleoplasm]
(R-HSA-8942808)
p-Y88-CDKN1B [cytosol]
(R-HSA-8848438)
CDKN1B [cytosol]
(R-HSA-198622)
p-T157-CDKN1B [cytosol]
(R-HSA-198629)
p-S10 CDKN1B [nucleoplasm]
(R-HSA-9632832)
p-S10 CDKN1B [cytosol]
(R-HSA-9632829)
0.886
9
UniProt:P33552 CKS2
0.837
9
UniProt:P20248 CCNA2
3
CCNA2 [nucleoplasm]
(R-HSA-68905)
CCNA2 [cytosol]
(R-HSA-157444)
PolyUb-CCNA2 [nucleoplasm]
(R-HSA-6783099)
0.837
9
UniProt:O95067 CCNB2
1
CCNB2 [cytosol]
(R-HSA-68897)
0.837
10
UniProt:Q13309 SKP2
3
SKP2 [nucleoplasm]
(R-HSA-975554)
PolyUb-SKP2 [nucleoplasm]
(R-HSA-9687073)
SKP2 [cytosol]
(R-HSA-975495)
0.725
6
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.667
3
UniProt:Q12778 FOXO1
5
FOXO1 [nucleoplasm]
(R-HSA-199300)
p-T24,S256,S319-FOXO1 [nucleoplasm]
(R-HSA-199306)
p-T24,S256,S319-FOXO1 [cytosol]
(R-HSA-211158)
Ac-K245,K248,K265-FOXO1 [nucleoplasm]
(R-HSA-9626942)
p-S218-FOXO1 [nucleoplasm]
(R-HSA-5692651)
0.645
5
UniProt:P30281 CCND3
2
CCND3 [nucleoplasm]
(R-HSA-113835)
CCND3 [cytosol]
(R-HSA-68333)
0.643
4
UniProt:P24385 CCND1
4
CCND1 [nucleoplasm]
(R-HSA-113832)
CCND1 [cytosol]
(R-HSA-68328)
p-T286-CCND1 [cytosol]
(R-HSA-75813)
p-T286-CCND1 [nucleoplasm]
(R-HSA-75811)
0.643
3
UniProt:O95835 LATS1
2
LATS1 [cytosol]
(R-HSA-2028562)
p-S909,T1079-LATS1 [cytosol]
(R-HSA-2028551)
0.632
3
UniProt:P30307 CDC25C
8
p-S198-CDC25C [nucleoplasm]
(R-HSA-156668)
p-S198-CDC25C [cytosol]
(R-HSA-8981697)
CDC25C [cytosol]
(R-HSA-157879)
CDC25C [nucleoplasm]
(R-HSA-69741)
p-S216-CDC25C [nucleoplasm]
(R-HSA-156496)
p-S216-CDC25C [cytosol]
(R-HSA-75003)
p-S191-CDC25C [nucleoplasm]
(R-HSA-6802968)
p-T48,T67,S122,T130,S168,S214-CDC25C [cytosol]
(R-HSA-8863654)
0.623
3
UniProt:P27986-2 PIK3R1
0.556
3
UniProt:O43508 TNFSF12
2
TNFSF12 [plasma membrane]
(R-HSA-5667154)
sTNFSF12 [extracellular region]
(R-HSA-5675974)
0.556
3
UniProt:P05067 APP
20
APP(672-713) [extracellular region]
(R-HSA-879340)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
0.556
3
UniProt:Q16667 CDKN3
0.553
2
UniProt:P48643 CCT5
1
CCT5 [cytosol]
(R-HSA-390447)
0.527
2
UniProt:Q00537 CDK17
0.527
3
UniProt:P50991 CCT4
1
CCT4 [cytosol]
(R-HSA-390458)
0.527
2
UniProt:Q99832 CCT7
1
CCT7 [cytosol]
(R-HSA-390451)
0.527
2
UniProt:O75496 GMNN
2
GMNN [nucleoplasm]
(R-HSA-113554)
PolyUb-GMNN [nucleoplasm]
(R-HSA-68585)
0.527
2
UniProt:Q9H211 CDT1
1
CDT1 [nucleoplasm]
(R-HSA-68536)
0.527
2
UniProt:Q00526 CDK3
0.527
3
UniProt:Q99741 CDC6
4
CDC6 [cytosol]
(R-HSA-113566)
p-CDC6 [cytosol]
(R-HSA-68583)
p-CDC6 [nucleoplasm]
(R-HSA-5661317)
CDC6 [nucleoplasm]
(R-HSA-68542)
0.524
2
UniProt:Q86V81 ALYREF
2
ALYREF [cytosol]
(R-HSA-158482)
ALYREF [nucleoplasm]
(R-HSA-156649)
0.499
4
UniProt:P21796 VDAC1
7
p-S65-Ub:VDAC1 [mitochondrial outer membrane]
(R-HSA-9834991)
K63polyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-9834037)
K48polyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-5205624)
Ub-VDAC1 [mitochondrial outer membrane]
(R-HSA-9834989)
VDAC1 [mitochondrial outer membrane]
(R-HSA-1267988)
VDAC1 [mitochondrial intermembrane space]
(R-HSA-1267960)
PolyUb-VDAC1 [mitochondrial outer membrane]
(R-HSA-6783079)
0.499
3
UniProt:O75618-1 DEDD
0.499
2
UniProt:P36957 DLST
5
Lipo-K110-DLST [mitochondrial matrix]
(R-HSA-69993)
SuccinyllipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9853502)
LipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9853485)
DLST [mitochondrial matrix]
(R-HSA-6792574)
GlutaryllipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9858581)
0.499
3
UniProt:P01732 CD8A
1
CD8A [plasma membrane]
(R-HSA-197601)
0.488
2
UniProt:P11362 FGFR1
9
FGFR1 [plasma membrane]
(R-HSA-9756433)
p-8Y- FGFR1 R576W [plasma membrane]
(R-HSA-2023361)
p-8Y-FGFR1 N546K [plasma membrane]
(R-HSA-2023358)
p-8Y-FGFR1 K656E [plasma membrane]
(R-HSA-2023356)
p-6Y-FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853142)
FGFR1 R576W [plasma membrane]
(R-HSA-2011844)
FGFR1 N546K [plasma membrane]
(R-HSA-1614377)
FGFR1 K656E [plasma membrane]
(R-HSA-1614373)
FGFR1(22-763):TACC1(571-805) fusion [plasma membrane]
(R-HSA-8853241)
0.483
3
UniProt:Q96GD4 AURKB
3
AURKB [cytosol]
(R-HSA-174231)
AURKB [nucleoplasm]
(R-HSA-4655360)
polySUMO2,3-K202-AURKB [cytosol]
(R-HSA-4655414)
0.463
5
UniProt:O15392 BIRC5
3
BIRC5 [cytosol]
(R-HSA-50851)
BIRC5 [nucleoplasm]
(R-HSA-4655344)
ub-BIRC5 [cytosol]
(R-HSA-8955933)
0.463
6
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.463
2
UniProt:A0A096LP01 SIM26
0.462
2
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