Reactome | DOK3 [ficolin-1-rich granule membrane]

DOK3 [ficolin-1-rich granule membrane]

Stable Identifier

R-HSA-6801409

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

ficolin-1-rich granule membrane

Synonyms

Docking protein 3, DOK3_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q7L591 DOK3

Gene Names

DOK3

Chain

chain:1-496

Reference Genes

BioGPS Gene:79930 DOK3

COSMIC (genes):DOK3 DOK3

CTD Gene:79930 DOK3

dbSNP Gene:79930 DOK3

ENSEMBL:ENSG00000146094 DOK3

HGNC:24583 DOK3

KEGG:hsa:79930 DOK3

Monarch:79930 DOK3

NCBI Gene:79930 DOK3

OMIM:611435 DOK3

UCSC:Q7L591 DOK3

Reference Transcript

Participates

as a member of

Ficolin-rich granule membrane proteins [ficolin-1-rich granule membrane] (Homo sapiens)

Other forms of this molecule

DOK3 [plasma membrane]

DOK3 [secretory granule membrane]

Inferred To

Dok [ficolin-1-rich granule membrane] (Drosophila melanogaster)

dok2 [ficolin-1-rich granule membrane] (Xenopus tropicalis)

DOK3 [ficolin-1-rich granule membrane] (Bos taurus)

DOK3 [ficolin-1-rich granule membrane] (Canis familiaris)

DOK3 [ficolin-1-rich granule membrane] (Gallus gallus)

Dok3 [ficolin-1-rich granule membrane] (Mus musculus)

Dok3 [ficolin-1-rich granule membrane] (Rattus norvegicus)

DDX41 [ficolin-1-rich granule membrane] (Sus scrofa)

Cross References

RefSeq

NP_001295164.1, NP_001295165.1, XP_005266044.1, NP_001362727.1, XP_047273728.1, NP_001362728.1, XP_047273729.1, XP_047273730.1, NP_001138348.1, XP_047273731.1, NP_001138347.1, NP_079148.2

OpenTargets

ENSG00000146094

ENSEMBL

ENST00000312943, ENSP00000325174, ENSG00000146094, ENST00000377112, ENSP00000366316

HPA

ENSG00000146094-DOK3

GeneCards

DOK3

PRO

Q7L591

Pharos - Targets

Q7L591

GlyGen

Q7L591

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.666	4
UniProt:P00533 EGFR	20	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334)	0.508	2

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