Reactome | p-Y493-ZAP70 [cytosol]

p-Y493-ZAP70 [cytosol]

Stable Identifier

R-HSA-202368

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

ZAP-70 phosphorylated at Tyr 493

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Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P43403 ZAP70

Gene Names

ZAP70, SRK

Chain

chain:1-619

Reference Genes

BioGPS Gene:7535 ZAP70

COSMIC (genes):ZAP70 ZAP70

CTD Gene:7535 ZAP70

dbSNP Gene:7535 ZAP70

ENSEMBL:ENSG00000115085 ZAP70

ENSEMBL_homo_sapiens_GENE:ENSG00000115085.15 ZAP70

ENSEMBL_homo_sapiens_GENE:ENSG00000291603.1 ZAP70

HGNC:12858 ZAP70

KEGG Gene (Homo sapiens):7535 ZAP70

Monarch:7535 ZAP70

NCBI Gene:7535 ZAP70

OMIM:176947 ZAP70

UCSC:P43403 ZAP70

Reference Transcript

Other Identifiers

11728779_a_at

11728780_a_at

1498_at

1555613_PM_a_at

1555613_a_at

16883232

214032_PM_at

214032_at

2495188

2495189

2495190

2495197

2495199

2495205

2495207

2495208

2495210

2495212

2495217

2495218

2495219

2495220

2495222

2495224

2495225

2495226

2495227

7535

8043725

A_23_P39682

A_24_P169234

GE80046

GO:0000166

GO:0001772

GO:0001784

GO:0002250

GO:0002376

GO:0002696

GO:0003824

GO:0004672

GO:0004713

GO:0004715

GO:0005102

GO:0005515

GO:0005524

GO:0005737

GO:0005829

GO:0005886

GO:0005911

GO:0006468

GO:0006955

GO:0007155

GO:0007169

GO:0016020

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0019722

GO:0023052

GO:0030154

GO:0030217

GO:0031234

GO:0035556

GO:0036211

GO:0042101

GO:0042110

GO:0042113

GO:0043366

GO:0045059

GO:0045060

GO:0045061

GO:0045087

GO:0045121

GO:0045582

GO:0046632

GO:0046638

GO:0046641

GO:0048856

GO:0048870

GO:0050778

GO:0050850

GO:0050852

GO:0070489

GO:0072678

GO:0098542

GO:0140096

HMNXSV003054871

Hs.234569.0.S1_3p_at

Hs.234569.0.S1_3p_x_at

Hs2.234569.2.S1_3p_s_at

ILMN_1674838

ILMN_1719756

ILMN_1804104

L05148_at

PH_hs_0027314

TC02000594.hg

Participates

as a component of

phospho tyrosine ZAP-70 [plasma membrane] (Homo sapiens)

Other forms of this molecule

ZAP70 [cytosol]

p-Y315,Y493-ZAP70 [cytosol]

Inferred To

phospho-ZAP70 [cytosol] (Canis familiaris)

Ghost homologue of p-Y493-ZAP70 [cytosol] (Sus scrofa)

phospho-p-Y493-ZAP70 [cytosol] (Bos taurus)

phospho-p-Y493-ZAP70 [cytosol] (Gallus gallus)

phospho-p-Y493-ZAP70 [cytosol] (Mus musculus)

phospho-p-Y493-ZAP70 [cytosol] (Rattus norvegicus)

Modified Residues

Name

O4'-phospho-L-tyrosine at 493

Coordinate

493

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001070.2, NP_997402.1

ZINC - World Drugs

ZAP70_HUMAN

Guide to Pharmacology - Targets

2285

OpenTargets

ENSG00000115085

ZINC - FDA approved

ZAP70_HUMAN

ZINC - Substances

ZAP70_HUMAN

ZINC - Biogenic

ZAP70_HUMAN

ZINC target

P43403

PRO

P43403

PDB

2CBL, 1M61, 1U59, 4A4C, 4XZ1, 4K2R, 1FBV, 3ZNI, 2OQ1, 4A4B, 2OZO, 4XZ0, 2Y1N, 7SIY, 5O76

ZINC - Investigational

ZAP70_HUMAN

IntEnz

2.7.10.2

GeneCards

P43403

HPA

ENSG00000115085-ZAP70

Ensembl

ENSP00000513759, ENST00000264972, ENST00000698508, ENSG00000115085, ENSP00000264972, ENST00000451498, ENSP00000400475

Pharos - Targets

P43403

ZINC - Predictions - Purchasable

ZAP70_HUMAN

Orphanet

15738

HMDB Protein

HMDBP01515

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P20963 CD247			0.918	23
UniProt:P06239 LCK	4	p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.702	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.692	3
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.611	3
UniProt:Q9Y2R2 PTPN22	1	PTPN22 [cytosol] (R-HSA-8852205)	0.602	4
UniProt:Q8N1K5-1 THEMIS			0.591	3
UniProt:Q8BGG7 UBS3B			0.591	10
UniProt:P07766 CD3E	2	CD3E [plasma membrane] (R-HSA-197906) p-Y188,Y199-CD3E [plasma membrane] (R-HSA-202228)	0.527	3
UniProt:Q8TDQ0 HAVCR2	1	HAVCR2 [plasma membrane] (R-HSA-5340408)	0.462	2

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