Reactome | p-Y779,Y821-AXL [plasma membrane]

p-Y779,Y821-AXL [plasma membrane]

Stable Identifier

R-HSA-5357460

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P30530 AXL

Gene Names

AXL, UFO

Chain

signal peptide:1-25, chain:26-894

Reference Genes

BioGPS Gene:558 AXL

COSMIC (genes):AXL AXL

CTD Gene:558 AXL

dbSNP Gene:558 AXL

ENSEMBL:ENSG00000167601.12 AXL

HGNC:905 AXL

KEGG Gene (Homo sapiens):558 AXL

Monarch:558 AXL

NCBI Gene:558 AXL

OMIM:109135 AXL

UCSC:P30530 AXL

Reference Transcript

Other Identifiers

11716586_a_at

11716587_at

1233_s_at

1278_at

16862439

202685_PM_s_at

202685_s_at

202686_PM_s_at

202686_s_at

3834048

3834049

3834050

3834051

3834052

3834054

3834055

3834056

3834058

3834059

3834060

3834062

3834064

3834065

3834069

3834071

3834074

3834075

3834076

3834078

3834080

3834082

3834083

3834084

3834085

3834086

3834087

3834088

3834090

3834091

3834092

3834145

38433_at

558

8029006

A_23_P208389

GE81057

GO:0000166

GO:0001618

GO:0001764

GO:0001779

GO:0001786

GO:0001818

GO:0001961

GO:0001974

GO:0002376

GO:0003824

GO:0004672

GO:0004713

GO:0004714

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005856

GO:0005886

GO:0006468

GO:0006909

GO:0006915

GO:0006954

GO:0007155

GO:0007165

GO:0007167

GO:0007169

GO:0007283

GO:0007399

GO:0008092

GO:0008289

GO:0009986

GO:0010936

GO:0012501

GO:0015629

GO:0016020

GO:0016192

GO:0016301

GO:0016310

GO:0016477

GO:0016740

GO:0018108

GO:0021885

GO:0022414

GO:0023052

GO:0030154

GO:0030168

GO:0031100

GO:0031668

GO:0032036

GO:0032689

GO:0032720

GO:0032825

GO:0032940

GO:0033674

GO:0034101

GO:0034446

GO:0035457

GO:0036211

GO:0042060

GO:0042698

GO:0043066

GO:0043226

GO:0043231

GO:0043235

GO:0043277

GO:0043491

GO:0043524

GO:0043548

GO:0045087

GO:0046649

GO:0046718

GO:0048010

GO:0048469

GO:0048549

GO:0048678

GO:0048856

GO:0048870

GO:0051250

GO:0051402

GO:0051649

GO:0051897

GO:0060068

GO:0060089

GO:0070062

GO:0070301

GO:0071222

GO:0097028

GO:0097350

GO:0098542

GO:0140096

GO:1903902

GO:2000669

Hs.83341.1.A1_3p_a_at

ILMN_1701877

ILMN_2364521

M76125_s_at

PH_hs_0004757

TC19000576.hg

g11863122_3p_a_at

Participates

as a component of

VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y779,Y821-AXL [plasma membrane] (Homo sapiens)

Other forms of this molecule

AXL [plasma membrane]

Inferred To

Ghost homologue of p-Y779,Y821-AXL [plasma membrane] (Gallus gallus)

Ghost homologue of p-Y779,Y821-AXL [plasma membrane] (Xenopus tropicalis)

phospho-p-Y779,Y821-AXL [plasma membrane] (Bos taurus)

phospho-p-Y779,Y821-AXL [plasma membrane] (Canis familiaris)

phospho-p-Y779,Y821-AXL [plasma membrane] (Danio rerio)

phospho-p-Y779,Y821-AXL [plasma membrane] (Mus musculus)

phospho-p-Y779,Y821-AXL [plasma membrane] (Rattus norvegicus)

phospho-p-Y779,Y821-AXL [plasma membrane] (Sus scrofa)

Modified Residues

Name

O4'-phospho-L-tyrosine at 779

Coordinate

779

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 821

Coordinate

821

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001690.2, NP_068713.2

ZINC - World Drugs

UFO_HUMAN

Guide to Pharmacology - Targets

1835

OpenTargets

ENSG00000167601

ZINC - FDA approved

UFO_HUMAN

ZINC - Substances

UFO_HUMAN

ZINC - Biogenic

UFO_HUMAN

ZINC target

P30530

PRO

P30530

PDB

4RA0, 5VXZ, 2C5D, 5U6B

ZINC - Investigational

UFO_HUMAN

ZINC - Metabolites

UFO_HUMAN

GeneCards

P30530

HPA

ENSG00000167601-AXL

Ensembl

ENST00000359092, ENSG00000167601, ENSP00000351995, ENST00000301178, ENSP00000301178

Pharos - Targets

P30530

ZINC - Predictions - Purchasable

UFO_HUMAN

HMDB Protein

HMDBP09451

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTC2 S	20	S(686-815) [plasma membrane] (R-COV-9770188) Spike S2' Fragment [plasma membrane] (R-COV-9770189) S1 [plasma membrane] (R-COV-9769950) fully glycosylated Spike [plasma membrane] (R-COV-9733472) nascent Spike [endoplasmic reticulum lumen] (R-COV-9694796) 14-sugar N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9694459) Man(9) N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696892) high-mannose N-glycan unfolded Spike [endoplasmic reticulum lumen] (R-COV-9696875) high-mannose N-glycan folded Spike [endoplasmic reticulum lumen] (R-COV-9696880) high-mannose N-glycan folded Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9766369) high-mannose N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696943) di-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696920) tri-antennary N-glycan-PALM-Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9697006) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment] (R-COV-9696997) complex N-glycan-PALM-Spike S2 Fragment [plasma membrane] (R-COV-9769952) fully glycosylated Spike [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9698330) fully glycosylated Spike [virion membrane] (R-COV-9698327) complex N-glycan-PALM-Spike S1 Fragment [endocytic vesicle membrane] (R-COV-9694745) complex N-glycan-PALM-Spike S2 Fragment [endocytic vesicle membrane] (R-COV-9694343) complex N-glycan-PALM-Spike S2 Fragment [virion membrane] (R-COV-9694791)	0.655	9
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.597	4
UniProt:P27986 PIK3R1	16	p-Y-PIK3R1 [cytosol] (R-HSA-9680647) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [cytosol] (R-HSA-74789) PIK3R1 [plasma membrane] (R-HSA-198365)	0.597	3
IntAct:EBI-11820565 HSPA1A			0.569	4
UniProt:P08238 HSP90AB1	6	HSP90AB1 [secretory granule lumen] (R-HSA-6801477) HSP90AB1 [extracellular region] (R-HSA-6806463) HSP90AB1 [ficolin-1-rich granule lumen] (R-HSA-6801491) HSP90AB1 [cytosol] (R-HSA-419617) HSP90AB1 [nucleoplasm] (R-HSA-5082399) HSP90AB1 [lysosomal lumen] (R-HSA-9622846)	0.564	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.527	3
UniProt:P29317 EPHA2	2	EPHA2 [plasma membrane] (R-HSA-211422) p-Y588,Y594-EPHA2 [plasma membrane] (R-HSA-3928380)	0.499	2
UniProt:Q92665 MRPS31	1	MRPS31 [mitochondrial inner membrane] (R-HSA-5368198)	0.483	2
UniProt:P27824 CANX	2	CANX [integral component of lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.483	2
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.471	4
UniProt:P19174 PLCG1	6	p-Y-PLCG1 [cytosol] (R-HSA-9029082) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [plasma membrane] (R-HSA-167682) PLCG1 [cytosol] (R-HSA-202320) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084)	0.462	2

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