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p-Y772,Y814-AXL
Stable Identifier
R-HSA-5357460
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by VEGF (Homo sapiens)
VEGFA-VEGFR2 Pathway (Homo sapiens)
AXL autophosphorylates on Y772 and Y814 (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL [plasma membrane] (Homo sapiens)
p-Y772,Y814-AXL [plasma membrane] (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K phosphorylates PIP2 to PIP3 (Homo sapiens)
VEGFA dimer:p-6Y-VEGFR2 dimer:PI3K/VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL [plasma membrane] (Homo sapiens)
p-Y772,Y814-AXL [plasma membrane] (Homo sapiens)
p-AXL binds PI3K (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL [plasma membrane] (Homo sapiens)
p-Y772,Y814-AXL [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL:PI3K [plasma membrane] (Homo sapiens)
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL [plasma membrane] (Homo sapiens)
p-Y772,Y814-AXL [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P30530 AXL
Gene Names
AXL, UFO
Chain
signal peptide:1-25, chain:26-894
Reference Genes
BioGPS Gene:558 AXL
COSMIC (genes):AXL AXL
CTD Gene:558 AXL
dbSNP Gene:558 AXL
ENSEMBL:ENSG00000167601 AXL
HGNC:905 AXL
KEGG Gene (Homo sapiens):hsa:558 AXL
Monarch:558 AXL
NCBI Gene:558 AXL
OMIM:109135 AXL
UCSC:P30530 AXL
Reference Transcript
RefSeq:NM_021913.4 AXL
RefSeq:NM_001699.5 AXL
Other Identifiers
0006370128
11716586_a_at
11716587_at
1233_s_at
1278_at
16862439
202685_s_at
202686_s_at
32501
37422
37423
3834048
3834049
3834050
3834051
3834052
3834054
3834055
3834056
3834058
3834059
3834060
3834062
3834064
3834065
3834069
3834071
3834074
3834075
3834076
3834078
3834080
3834082
3834083
3834084
3834085
3834086
3834087
3834088
38433_at
558
8029006
A_23_P208389
AXL
AXL-201
AXL-202
CCDS12574
CCDS12575
ENSG00000167601
ENSP00000301178
ENSP00000351995
ENST00000301178
ENST00000359092
EntrezGene:558
g11863122_3p_a_at
GE81057
GO:0000166
GO:0001618
GO:0001764
GO:0001779
GO:0001786
GO:0001818
GO:0001961
GO:0001974
GO:0002376
GO:0004672
GO:0004713
GO:0004714
GO:0005515
GO:0005524
GO:0005615
GO:0005622
GO:0005886
GO:0005887
GO:0006468
GO:0006909
GO:0006954
GO:0007165
GO:0007167
GO:0007283
GO:0009986
GO:0016020
GO:0016021
GO:0016032
GO:0016301
GO:0016310
GO:0016740
GO:0018108
GO:0021885
GO:0030154
GO:0030168
GO:0031100
GO:0031668
GO:0032036
GO:0032689
GO:0032720
GO:0032825
GO:0032940
GO:0034101
GO:0034446
GO:0035457
GO:0042698
GO:0043066
GO:0043277
GO:0043491
GO:0043524
GO:0043548
GO:0044228
GO:0045087
GO:0046718
GO:0046982
GO:0048010
GO:0048469
GO:0048549
GO:0051250
GO:0051897
GO:0060068
GO:0070062
GO:0070301
GO:0071222
GO:0097028
GO:0097350
GO:2000669
HGNC:905
Hs.590970
Hs.83341.1.A1_3p_a_at
ILMN_1701877
ILMN_2364521
M76125_s_at
MIM:109135
MIM:146110
NM_001699
NM_021913
NP_001690
NP_068713
PF00041
PF07714
PF13927
PH_hs_0004757
PR00109
SM00060
SM00219
SM00409
TC19000576.hg
uc010ehj.5
uc010ehk.5
UPI000014319B
UPI000015FDF5
Participant Of
hasComponent
VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL [plasma membrane]
Other forms of this molecule
AXL [plasma membrane]
Inferred To
Homologues of p-Y772,Y814-AXL [plasma membrane] (Rattus norvegicus)
Homologues of p-Y772,Y814-AXL [plasma membrane] (Xenopus tropicalis)
phospho-p-Y772,Y814-AXL [plasma membrane] (Bos taurus)
phospho-p-Y772,Y814-AXL [plasma membrane] (Canis familiaris)
phospho-p-Y772,Y814-AXL [plasma membrane] (Mus musculus)
phospho-p-Y772,Y814-AXL [plasma membrane] (Rattus norvegicus)
phospho-p-Y772,Y814-AXL [plasma membrane] (Sus scrofa)
phospho-p-Y772,Y814-AXL [plasma membrane] (Xenopus tropicalis)
Ghost homologue of p-Y772,Y814-AXL [plasma membrane] (Danio rerio)
Ghost homologue of p-Y772,Y814-AXL [plasma membrane] (Gallus gallus)
Modified Residues
Name
O4'-phospho-L-tyrosine at 814
Coordinate
814
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 772
Coordinate
772
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Cross References
RefSeq
NP_068713.2
,
NP_001690.2
ZINC - World Drugs
UFO_HUMAN
Brenda
2.7.10.1
ZINC - FDA approved
UFO_HUMAN
ZINC - Substances
UFO_HUMAN
ZINC - Biogenic
UFO_HUMAN
ZINC target
P30530
PRO
P30530
PDB
5VXZ
,
2C5D
,
4RA0
,
5U6B
ZINC - Metabolites
UFO_HUMAN
GeneCards
P30530
DOCK Blaster
2C5D
,
4RA0
ZINC - Predictions - Purchasable
UFO_HUMAN
HMDB Protein
HMDBP09451
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
58
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.524
4
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.462
3
UniProt:P19174 PLCG1
6
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y-PLCG1 [plasma membrane]
(R-HSA-593686)
0.462
2
UniProt:P27986 PIK3R1
15
PIK3R1 K379E [plasma membrane]
(R-HSA-8944148)
PIK3R1 G376R [plasma membrane]
(R-HSA-2399717)
PIK3R1 Y463_L466del [plasma membrane]
(R-HSA-2399546)
PIK3R1 H450_E451del [plasma membrane]
(R-HSA-2399545)
PIK3R1 R574_T576del [plasma membrane]
(R-HSA-2399544)
PIK3R1 D560Y [plasma membrane]
(R-HSA-2399421)
PIK3R1 N564D [plasma membrane]
(R-HSA-2399427)
PIK3R1 K459del [plasma membrane]
(R-HSA-2399554)
PIK3R1 N564K [plasma membrane]
(R-HSA-2399431)
PIK3R1 D560H [plasma membrane]
(R-HSA-2399432)
PIK3R1 R574I [plasma membrane]
(R-HSA-2399536)
PIK3R1 R574T [plasma membrane]
(R-HSA-2399540)
K63polyUb-PIK3R1 [cytosol]
(R-HSA-3080572)
PIK3R1 [cytosol]
(R-HSA-74789)
PIK3R1 [plasma membrane]
(R-HSA-198365)
0.462
2
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