Reactome | p-Y772,Y814-AXL [plasma membrane]

p-Y772,Y814-AXL

Stable Identifier

R-HSA-5357460

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P30530 AXL

Gene Names

AXL, UFO

Chain

signal peptide:1-25, chain:26-894

Reference Genes

BioGPS Gene:558 AXL

COSMIC (genes):AXL AXL

CTD Gene:558 AXL

dbSNP Gene:558 AXL

ENSEMBL:ENSG00000167601 AXL

HGNC:905 AXL

KEGG Gene (Homo sapiens):hsa:558 AXL

Monarch:558 AXL

NCBI Gene:558 AXL

OMIM:109135 AXL

UCSC:P30530 AXL

Reference Transcript

Other Identifiers

0006370128

11716586_a_at

11716587_at

1233_s_at

1278_at

16862439

202685_s_at

202686_s_at

2C5D

32501

37422

37423

3834048

3834049

3834050

3834051

3834052

3834054

3834055

3834056

3834058

3834059

3834060

3834062

3834064

3834065

3834069

3834071

3834074

3834075

3834076

3834078

3834080

3834082

3834083

3834084

3834085

3834086

3834087

3834088

38433_at

4RA0

558

5U6B

5VXZ

8029006

A_23_P208389

AAA61243

AAB20305

AAH32229

AC011510

AXL

AXL-201

AXL-202

BC032229

CAA40338

CAB032501

CCDS12574

CCDS12575

ENSG00000167601

ENSP00000301178

ENSP00000351995

ENST00000301178

ENST00000359092

EntrezGene:558

g11863122_3p_a_at

GE81057

GO:0000003

GO:0000166

GO:0000902

GO:0001618

GO:0001764

GO:0001779

GO:0001786

GO:0001818

GO:0001961

GO:0001974

GO:0002376

GO:0003674

GO:0004672

GO:0004713

GO:0004714

GO:0004871

GO:0005515

GO:0005524

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005623

GO:0005886

GO:0005887

GO:0006464

GO:0006468

GO:0006810

GO:0006909

GO:0006950

GO:0006954

GO:0007155

GO:0007165

GO:0007167

GO:0007283

GO:0008092

GO:0008150

GO:0008219

GO:0008289

GO:0009986

GO:0016020

GO:0016021

GO:0016032

GO:0016192

GO:0016301

GO:0016310

GO:0016740

GO:0018108

GO:0021700

GO:0021885

GO:0030154

GO:0030168

GO:0031100

GO:0031668

GO:0032036

GO:0032689

GO:0032720

GO:0032825

GO:0032940

GO:0034101

GO:0034446

GO:0035457

GO:0040011

GO:0042592

GO:0042698

GO:0043066

GO:0043167

GO:0043226

GO:0043277

GO:0043491

GO:0043524

GO:0043548

GO:0044228

GO:0044403

GO:0045087

GO:0046718

GO:0046982

GO:0048010

GO:0048469

GO:0048549

GO:0048856

GO:0048870

GO:0051250

GO:0051897

GO:0060068

GO:0070062

GO:0070301

GO:0071222

GO:0097028

GO:0097350

GO:2000669

HGNC:905

HPA037422

HPA037423

Hs.83341.1.A1_3p_a_at

ILMN_1701877

ILMN_2364521

IPR000719

IPR001245

IPR003599

IPR003961

IPR007110

IPR008266

IPR011009

IPR013783

IPR017441

IPR020635

IPR036116

IPR036179

M0R0W6

M76125

M76125_s_at

MIM:109135

MIM:146110

NM_001699

NM_021913

NP_001690

NP_068713

PF00041

PF07714

PF13927

PH_hs_0004757

PR00109

S65125

SM00060

SM00219

SM00409

TC19000576.hg

uc010ehj.5

uc010ehk.5

UPI000014319B

UPI000015FDF5

X57019

Participant Of

hasComponent

VEGFA:p-6Y-VEGFR2:SH2D2A:p-Y418-SRC-1:p-Y772,Y814-AXL [plasma membrane]

Other forms of this molecule

AXL [plasma membrane]

Inferred To

Homologues of p-Y772,Y814-AXL [plasma membrane] (Caenorhabditis elegans)

Homologues of p-Y772,Y814-AXL [plasma membrane] (Danio rerio)

Homologues of p-Y772,Y814-AXL [plasma membrane] (Rattus norvegicus)

Homologues of p-Y772,Y814-AXL [plasma membrane] (Xenopus tropicalis)

phospho-p-Y772,Y814-AXL [plasma membrane] (Bos taurus)

phospho-p-Y772,Y814-AXL [plasma membrane] (Caenorhabditis elegans)

phospho-p-Y772,Y814-AXL [plasma membrane] (Canis familiaris)

phospho-p-Y772,Y814-AXL [plasma membrane] (Danio rerio)

phospho-p-Y772,Y814-AXL [plasma membrane] (Mus musculus)

phospho-p-Y772,Y814-AXL [plasma membrane] (Rattus norvegicus)

phospho-p-Y772,Y814-AXL [plasma membrane] (Sus scrofa)

phospho-p-Y772,Y814-AXL [plasma membrane] (Xenopus tropicalis)

Ghost homologue of p-Y772,Y814-AXL [plasma membrane] (Gallus gallus)

Ghost homologue of p-Y772,Y814-AXL [plasma membrane] (Taeniopygia guttata)

Modified Residues

Name

O4'-phospho-L-tyrosine at 772

Coordinate

772

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Name

O4'-phospho-L-tyrosine at 814

Coordinate

814

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001690.2, NP_068713.2

ZINC - World Drugs

UFO_HUMAN

ZINC - FDA approved

UFO_HUMAN

ZINC - Substances

UFO_HUMAN

ZINC target

P30530

ZINC - Biogenic

UFO_HUMAN

PRO

P30530

PDB

4RA0, 5VXZ, 2C5D, 5U6B

ZINC - Metabolites

UFO_HUMAN

GeneCards

P30530

BRENDA (Homo sapiens)

2.7.10.1

ZINC - Predictions - Purchasable

UFO_HUMAN

HMDB Protein

HMDBP09451

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	58	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.524	4
UniProt:P19174 PLCG1	6	p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.462	2
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.462	3
UniProt:P27986 PIK3R1	15	PIK3R1 K379E [plasma membrane] (R-HSA-8944148) PIK3R1 G376R [plasma membrane] (R-HSA-2399717) PIK3R1 Y463_L466del [plasma membrane] (R-HSA-2399546) PIK3R1 H450_E451del [plasma membrane] (R-HSA-2399545) PIK3R1 R574_T576del [plasma membrane] (R-HSA-2399544) PIK3R1 D560Y [plasma membrane] (R-HSA-2399421) PIK3R1 N564D [plasma membrane] (R-HSA-2399427) PIK3R1 K459del [plasma membrane] (R-HSA-2399554) PIK3R1 N564K [plasma membrane] (R-HSA-2399431) PIK3R1 D560H [plasma membrane] (R-HSA-2399432) PIK3R1 R574I [plasma membrane] (R-HSA-2399536) PIK3R1 R574T [plasma membrane] (R-HSA-2399540) K63polyUb-PIK3R1 [cytosol] (R-HSA-3080572) PIK3R1 [plasma membrane] (R-HSA-198365) PIK3R1 [cytosol] (R-HSA-74789)	0.462	2