p-Y-ERBB2 V777M [plasma membrane]

Stable Identifier
R-HSA-9654398
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
Synonyms
p-Y-HER2 V777M, p-Y-ERBB2 Val777Met, p-Y-HER2 Val777Met
p-Y-ERBB2 V777M [plasma membrane] icon
Locations in the PathwayBrowser
Literature References
PubMed ID Title Journal Year
27284958 Nonamplification ERBB2 genomic alterations in 5605 cases of recurrent and metastatic breast cancer: An emerging opportunity for anti-HER2 targeted therapies

Suh, J, Ali, SM, Gay, LM, Waintraub, S, Lipson, D, Wang, K, Ross, JS, Leyland-Jones, B, Elvin, JA, Vergilio, JA, Stephens, PJ, Miller, VA, Chumsri, S, Chmielecki, J, Yelensky, R, Bose, R

Cancer 2016
16397024 Somatic mutations of ERBB2 kinase domain in gastric, colorectal, and breast carcinomas

Park, CH, Nam, SW, Kim, SY, Park, K, Kim, SH, Lee, JY, Lee, SH, Seo, SH, Soung, YH, Yoo, NJ, Park, WS, Wang, YP, Lee, JW

Clin. Cancer Res. 2006
28481359 Mutational landscape of metastatic cancer revealed from prospective clinical sequencing of 10,000 patients

Ladanyi, M, Wills, J, Rema, AB, Syed, A, Srinivasan, P, Raj, N, Mullaney, KA, Vakiani, E, Nafa, K, Shah, RH, Kundra, R, Razumova, A, Ochoa, A, Phillips, S, Jordan, EJ, Morris, LGT, Berger, MF, Thomas, SB, Camacho, N, Hellmann, MD, Hechtman, JF, Feldman, DR, Coleman, J, Mohanty, AS, Ptashkin, RN, Syed, MH, Wang, J, Saltz, LB, Reales, DN, Cheng, DT, Arcila, ME, Eubank, M, Benayed, R, Chakravarty, D, Harding, JJ, Prasad, M, Bochner, B, Durany, R, Zehir, A, Gross, BE, Zhang, H, Janjigian, YY, Iyer, G, DeLair, DF, Klimstra, DS, Robson, ME, Chen, HW, Cercek, A, Kelly, CM, Varghese, AM, Taylor, BS, Yaeger, R, Schultz, N, Hyman, DM, Won, HH, Solit, DB, Razavi, P, Chang, MT, Riely, GJ, Abeshouse, AA, Kiecka, IJ, Jayakumaran, G, Chandramohan, R, Casanova, J, Bacares, R, Abida, W, Gao, J, Soumerai, TE, Lowery, MA, Stewart, L, Ross, DS, Shukla, N, Yao, J, Al-Ahmadie, H, Penson, AV, Kim, HR, Baldi, T, Mandelker, DL, Gardos, SM, Galle, J, Heins, ZJ, Barron, DA, Shoushtari, AN, Scher, HI, Sadowska, J, Jonsson, P, Hakimi, AA, Omuro, AM, Son, JB, Sabbatini, PJ, Borsu, L, Dogan, S, Devlin, SM, Cambria, R, Hameed, M, Baselga, J, Liu, ZY, Schram, AM, Gounder, MM, Middha, S

Nat. Med. 2017
External Reference Information
External Reference
Gene Names
ERBB2, HER2, MLN19, NEU, NGL
Chain
signal peptide:1-22, chain:23-1255
Other Identifiers
0106040504
11736472_a_at
11750611_a_at
11751416_a_at
11755005_a_at
11762165_x_at
16833839
1802_s_at
1901_s_at
2064
210930_3p_s_at
210930_PM_s_at
210930_s_at
216836_PM_s_at
216836_s_at
33218_at
3720403
3720404
3720405
3720406
3720407
3720408
3720410
3720411
3720412
3720413
3720417
3720420
3720422
3720423
3720425
3720427
3720428
3720431
3720432
3720433
3720434
3720436
3720438
3720440
3720442
3720444
3720446
3720447
3720449
3720452
3720454
3720455
3720457
3720458
3720460
3720461
3720462
3720463
3720464
3720465
3720466
3720467
3720468
3720469
3720470
3720471
8006906
A_14_P101724
A_14_P126019
A_23_P89249
A_24_P284420
A_33_P3292596
GE57810
GO:0000166
GO:0001042
GO:0001934
GO:0002376
GO:0003674
GO:0004672
GO:0004712
GO:0004713
GO:0004714
GO:0004888
GO:0005515
GO:0005524
GO:0005575
GO:0005622
GO:0005634
GO:0005737
GO:0005768
GO:0005769
GO:0005829
GO:0005886
GO:0005887
GO:0006351
GO:0006355
GO:0006468
GO:0006886
GO:0007155
GO:0007165
GO:0007166
GO:0007167
GO:0007169
GO:0007399
GO:0007422
GO:0007507
GO:0007528
GO:0008022
GO:0008045
GO:0008150
GO:0008284
GO:0009925
GO:0010008
GO:0010628
GO:0014065
GO:0016020
GO:0016021
GO:0016301
GO:0016310
GO:0016323
GO:0016324
GO:0016740
GO:0018108
GO:0019838
GO:0019899
GO:0019903
GO:0023052
GO:0030154
GO:0030182
GO:0030307
GO:0031410
GO:0032886
GO:0032991
GO:0033080
GO:0033088
GO:0033674
GO:0034330
GO:0035556
GO:0036211
GO:0038133
GO:0038134
GO:0038135
GO:0038143
GO:0042060
GO:0042127
GO:0042552
GO:0042802
GO:0043125
GO:0043167
GO:0043209
GO:0043226
GO:0043235
GO:0043406
GO:0043410
GO:0043547
GO:0044214
GO:0045727
GO:0045765
GO:0045785
GO:0045943
GO:0046777
GO:0046982
GO:0048471
GO:0048709
GO:0048856
GO:0050679
GO:0070372
GO:0071363
GO:0071364
GO:0090314
GO:0098590
HMNXSV003015366
HMNXSV003026104
HMNXSV003035749
Hs.323910.2.A1_3p_a_at
ILMN_1694303
ILMN_1717902
ILMN_1728761
ILMN_2352131
ILMN_3268199
PH_hs_0021933
TC17000480.hg
X03363_s_at
g10181232_3p_a_at
Participates
Other forms of this molecule
Modified Residues
Name
L-valine 777 replaced with L-methionine
Coordinate
777
PsiMod
A protein modification that effectively converts a source amino acid residue to L-methionine.
A protein modification that effectively removes or replaces an L-valine.
Name
O4'-phospho-L-tyrosine at unknown position
PsiMod Name
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Disease
Name Identifier Synonyms
bladder carcinoma DOID:4007 carcinoma of urinary bladder, carcinoma bladder, carcinoma OF BLADDER, carcinoma of bladder (disorder), carcinoma bladder
stomach cancer DOID:10534 malignant neoplasm of greater curvature of stomach, unspecified, malignant neoplasm of lesser curvature of stomach, NOS, malignant tumor of body of stomach (disorder), neoplasm of stomach (disorder), Ca lesser curvature - stomach (disorder), malignant neoplasm of greater curve of stomach unspecified (disorder), Ca body - stomach, ca lesser curvature of stomach, ca greater curvature of stomach, malignant neoplasm of lesser curvature of stomach, unspecified, malignant tumor of lesser curve of stomach (disorder), malignant neoplasm of body of stomach, gastric neoplasm, malignant neoplasm of greater curvature of stomach, NOS, Ca body - stomach (disorder), stomach neoplasm, Ca greater curvature - stomach (disorder), malignant neoplasm of lesser curve of stomach unspecified (disorder), malignant tumor of greater curve of stomach (disorder)
cancer DOID:162 malignant tumor, malignant neoplasm, primary cancer
breast cancer DOID:1612 malignant tumor of the breast, mammary cancer, malignant neoplasm of breast, mammary tumor, primary breast cancer, breast cancer, Ca breast - NOS, breast tumor
large intestine cancer DOID:5672 malignant Colorectal tumor, malignant neoplasm of large intestine, NOS, malignant tumor of large intestine (disorder), malignant neoplasm of colon with rectum, malignant neoplasm of large intestine NOS
Cross References
ZINC - World Drugs
Guide to Pharmacology - Targets
OpenTargets
ZINC - FDA approved
ZINC - Substances
ZINC target
ZINC - Biogenic
PRO
ZINC - Investigational
ZINC - Metabolites
GeneCards
Pharos - Targets
ZINC - Predictions - Purchasable
HMDB Protein
Interactors (72)
Accession #Entities Entities Confidence Score Evidence (IntAct)
 UniProt:P21860 ERBB3      0.972 29
 UniProt:P00533 EGFR  20 0.954 25
 UniProt:P04626 ERBB2  20 0.926 12
 UniProt:P62993 GRB2  1 0.916 8
 UniProt:P07900 HSP90AA1  8 0.856 6
 UniProt:P29353 SHC1  5 0.821 16
 UniProt:Q15303 ERBB4      0.816 5
 UniProt:P08238 HSP90AB1  6 0.793 5
 UniProt:Q14451 GRB7  1 0.779 5
 UniProt:P40763 STAT3  12 0.775 9
 UniProt:P27986 PIK3R1  15 0.759 12
 UniProt:Q96JA1 LRIG1  2 0.748 7
 UniProt:P12931 SRC  6 0.708 11
 UniProt:O00459 PIK3R2  2 0.702 8
 UniProt:Q16543 CDC37  1 0.695 5
 UniProt:O95292 VAPB  2 0.671 4
 UniProt:P02786 TFRC  5 0.671 4
 UniProt:Q9UJM3 ERRFI      0.659 4
 UniProt:P11021 HSPA5  6 0.659 3
 UniProt:P05023 ATP1A1  1 0.643 3
 UniProt:Q13882 PTK6  5 0.628 4
 UniProt:P46940 IQGAP1  3 0.602 5
 IntAct:EBI-11820565 HSPA1A      0.594 3
 UniProt:Q9UQF2 JIP1      0.592 4
 UniProt:Q05209 PTPN12  2 0.592 4
 UniProt:Q06124 PTPN11  4 0.592 3
 UniProt:P20936 RASA1  1 0.592 8
 UniProt:Q92569 PIK3R3  2 0.59 10
 UniProt:P42679 MATK  1 0.59 2
 IntAct:EBI-4399559 UBIQ      0.589 2
 UniProt:Q9HB71 CYBP      0.573 2
 UniProt:P31948 STIP1  1 0.573 2
 UniProt:O75791 GRAP2  1 0.571 2
 UniProt:P42224 STAT1  7 0.571 3
 UniProt:P16885 PLCG2  8 0.571 3
 UniProt:O60884 DNAJA2  1 0.569 3
 UniProt:P27824 CANX  2 0.569 3
 UniProt:Q15075 EEA1  1 0.567 5
 UniProt:Q14974 KPNB1  5 0.567 14
 UniProt:O95602 POLR1A  1 0.567 16
 UniProt:O14980 XPO1  2 0.564 3
 UniProt:P06241 FYN  6 0.558 2
 UniProt:Q99952 PTPN18  2 0.558 6
 UniProt:O95980 RECK  2 0.556 4
 UniProt:O75367 H2AY      0.556 6
 UniProt:Q9P2T1 GMPR2  1 0.553 2
 UniProt:P04406 GAPDH  1 0.553 2
 UniProt:Q9UBN7 HDAC6  4 0.553 2
 UniProt:Q9P0L0 VAPA  4 0.547 2
 UniProt:Q14318 FKBP8  2 0.547 2
 UniProt:P60709 ACTB  5 0.537 10
 UniProt:Q05397 PTK2  11 0.536 2
 UniProt:P31689 DNAJA1  1 0.527 2
 UniProt:P61619 SEC61A1  2 0.527 2
 UniProt:P36542 ATP5F1C  1 0.527 2
 UniProt:O00483 NDUFA4  1 0.527 2
 UniProt:O95573 ACSL3  2 0.527 2
 UniProt:Q8WUY1 THEM6      0.527 2
 UniProt:Q9NVI7 ATD3A      0.527 2
 UniProt:P42704 LRPPRC  1 0.527 2
 UniProt:Q00325 MPCP      0.527 2
 UniProt:Q9BVV7 TIMM21  1 0.527 2
 UniProt:Q92504 SLC39A7  1 0.527 2
 UniProt:P0DTD8 NS7B      0.527 2
 UniProt:Q3ZCQ8 TIMM50  1 0.527 2
 UniProt:O00750 PIK3C2B  1 0.525 2
 UniProt:Q99952-1 PTPN18      0.524 5
 IntAct:EBI-5590949 HAS      0.524 2
 UniProt:Q15256 PTPRR      0.508 2
 UniProt:P15309 ACP3  2 0.472 2
 UniProt:P98172 EFNB1  2 0.463 11
 UniProt:P49792 RANBP2  6 0.463 3
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