Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Author/Reviewer Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
Docs
User Guide
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
Data Model
Computational inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyze Data
Species Comparison
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Author/Reviewer Search
Site map
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Download
Search ...
Go!
PTPRA
Stable Identifier
R-HSA-388755
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
Receptor-type tyrosine-protein phosphatase alpha, PTPRA_HUMAN
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Axon guidance (Homo sapiens)
NCAM signaling for neurite out-growth (Homo sapiens)
Autophosphorylation of NCAM1 bound Fyn (Homo sapiens)
Fyn:NCAM1:RPTP-alpha [plasma membrane] (Homo sapiens)
PTPRA [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
PTPRA [plasma membrane] (Homo sapiens)
Dephosphorylation of NCAM1 bound pFyn (Homo sapiens)
Fyn:NCAM1:RPTP-alpha [plasma membrane] (Homo sapiens)
PTPRA [plasma membrane] (Homo sapiens)
PTPRA [plasma membrane] (Homo sapiens)
NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras (Homo sapiens)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
PTPRA [plasma membrane] (Homo sapiens)
Phosphorylation of FAK by Src kinase (Homo sapiens)
Multiple phosphorylated FAK bound to NCAM:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
PTPRA [plasma membrane] (Homo sapiens)
pFAK (391) bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
PTPRA [plasma membrane] (Homo sapiens)
Recruitment of FAK to NCAM1:Fyn in lipid rafts (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
PTPRA [plasma membrane] (Homo sapiens)
pFAK (391) bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
PTPRA [plasma membrane] (Homo sapiens)
Recruitment of Grb2 to pFAK:NCAM1 (Homo sapiens)
Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
PTPRA [plasma membrane] (Homo sapiens)
Multiple phosphorylated FAK bound to NCAM:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
PTPRA [plasma membrane] (Homo sapiens)
SOS binds Grb2 bound to pFAK:NCAM1 (Homo sapiens)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
PTPRA [plasma membrane] (Homo sapiens)
Grb2:pFAK bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
PTPRA [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
MAPK family signaling cascades (Homo sapiens)
MAPK1/MAPK3 signaling (Homo sapiens)
RAF/MAP kinase cascade (Homo sapiens)
RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
RAS GEFs [plasma membrane] (Homo sapiens)
Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
PTPRA [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P18433 PTPRA
Gene Names
PTPRA, PTPA, PTPRL2
Chain
signal peptide:1-19, chain:20-802
Reference Genes
BioGPS Gene:5786 PTPRA
COSMIC (genes):PTPRA PTPRA
CTD Gene:5786 PTPRA
dbSNP Gene:5786 PTPRA
ENSEMBL:ENSG00000132670 PTPRA
HGNC:9664 PTPRA
KEGG Gene (Homo sapiens):hsa:5786 PTPRA
Monarch:5786 PTPRA
NCBI Gene:5786 PTPRA
OMIM:176884 PTPRA
UCSC:P18433 PTPRA
Reference Transcript
RefSeq:NM_080841.2 PTPRA
RefSeq:NM_080840.2 PTPRA
RefSeq:NM_002836.3 PTPRA
Other Identifiers
0000870324
0003360008
0003440601
11742217_a_at
11746947_a_at
11749026_a_at
1496_at
16910888
213795_s_at
213799_3p_s_at
213799_s_at
239419_at
29412
34366
3874054
3874055
3874056
3874057
3874058
3874074
3874075
3874076
3874093
3874096
3874101
3874102
3874103
3874104
3874105
3874114
3874116
3874118
3874126
3874129
3874133
3874134
3874135
3874137
3874140
3874142
3874143
3874144
3874147
3874155
3874156
3874158
3874160
3874161
3874162
3874163
3874164
5786
69480
73216_r_at
A_14_P135265
A_23_P28869
CCDS13038
CCDS13039
ENSG00000132670
ENSP00000216877
ENSP00000314568
ENSP00000348468
ENSP00000369756
ENSP00000382787
ENST00000216877
ENST00000318266
ENST00000356147
ENST00000380393
ENST00000399903
EntrezGene:5786
GE57944
GO:0000165
GO:0004721
GO:0004725
GO:0005001
GO:0005088
GO:0005515
GO:0005622
GO:0005886
GO:0005887
GO:0006468
GO:0006470
GO:0007411
GO:0008286
GO:0016020
GO:0016021
GO:0016311
GO:0016787
GO:0016791
GO:0035335
GO:0043235
GO:0043547
GO:0065009
GO:0070062
HGNC:9664
Hs.154004.0.A1_3p_at
Hs.26045.1.S1_3p_a_at
Hs.26045.1.S1_3p_s_at
Hs.26045.1.S2_3p_a_at
Hs.269577
ILMN_1695461
ILMN_1723156
ILMN_1762766
ILMN_2296776
ILMN_2411794
M34668_at
MIM:176884
NM_002836
NM_080840
NM_080841
NP_002827
NP_543030
NP_543031
PF00102
PR00700
PTPRA
PTPRA-201
PTPRA-202
PTPRA-203
PTPRA-204
PTPRA-205
SM00194
SM00404
TC20001064.hg
TC20001728.hg
uc002whj.4
uc002whk.4
uc002whn.4
uc061vcr.1
uc061vcu.1
UPI00000012A8
UPI000007155E
Participant Of
input
Dephosphorylation of NCAM1 bound pFyn
hasComponent
Fyn:NCAM1:RPTP-alpha [plasma membrane]
NCAM1 complexed with pFyn-Y420 [plasma membrane]
Inferred To
PTPRA [plasma membrane] (Bos taurus)
PTPRA [plasma membrane] (Canis familiaris)
PTPRA [plasma membrane] (Danio rerio)
PTPRA [plasma membrane] (Gallus gallus)
PTPRA [plasma membrane] (Mus musculus)
PTPRA [plasma membrane] (Rattus norvegicus)
PTPRA [plasma membrane] (Sus scrofa)
PTPRA [plasma membrane] (Taeniopygia guttata)
PTPRA [plasma membrane] (Xenopus tropicalis)
Ghost homologue of PTPRA [plasma membrane] (Caenorhabditis elegans)
Ghost homologue of PTPRA [plasma membrane] (Drosophila melanogaster)
Homologues of PTPRA [plasma membrane] (Danio rerio)
Homologues of PTPRA [plasma membrane] (Rattus norvegicus)
Cross References
RefSeq
NP_543030.1
,
NP_543031.1
,
NP_002827.1
Brenda
3.1.3.48
GeneCards
P18433
ZINC - Substances
PTPRA_HUMAN
ZINC target
P18433
PRO
P18433
ZINC - Predictions - Purchasable
PTPRA_HUMAN
HMDB Protein
HMDBP02719
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.793
8
UniProt:P12931 SRC
4
p-Y419-SRC [nucleoplasm]
(R-HSA-8937690)
MyrG-SRC [plasma membrane]
(R-HSA-8876922)
MyrG,p-Y530-SRC [plasma membrane]
(R-HSA-377598)
MyrG-p-Y419-SRC [plasma membrane]
(R-HSA-1810408)
0.656
4
UniProt:P00523 SRC
8
Src [cytosol]
(R-GGA-3928468)
MyrG-SRC [plasma membrane]
(R-GGA-8876922)
SRC-1 [plasma membrane]
(R-GGA-65043)
phospho-p-Y419-SRC [cytosol]
(R-GGA-377592)
phospho-MyrG,p-Y530-SRC [plasma membrane]
(R-GGA-377598)
phospho-p-Y419-SRC-1 [plasma membrane]
(R-GGA-112331)
SRC-2 [cytosol]
(R-GGA-191648)
phospho-MyrG-p-Y419-SRC [plasma membrane]
(R-GGA-1810408)
0.59
4
UniProt:P39688 Fyn
8
phospho-MyrG-p-Y420-FYN [plasma membrane]
(R-MMU-1810410)
Fyn [cytosol]
(R-MMU-420333)
phospho-p-Y420-FYN [cytosol]
(R-MMU-391821)
phospho-MyrG,p-Y420-FYN-1 [plasma membrane]
(R-MMU-9032530)
MyrG,p-Y420-Fyn [plasma membrane]
(R-MMU-9037733)
pFyn (420) [cytosol]
(R-MMU-420335)
pFyn(Y531) [cytosol]
(R-MMU-420350)
phospho-p-S21,Y420-FYN [cytosol]
(R-MMU-5218745)
0.524
2
UniProt:P18433 PTPRA
1
PTPRA [plasma membrane]
(R-HSA-388755)
0.509
2
UniProt:Q9P2Y5 UVRAG
1
UVRAG [cytosol]
(R-HSA-5668884)
0.499
3
UniProt:P14781 CNTN1
1
CNTN1_CHICK [plasma membrane]
(R-GGA-443614)
0.463
3
© 2018
Reactome