Reactome | PTPRA [plasma membrane]

PTPRA [plasma membrane]

Stable Identifier

R-HSA-388755

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Receptor-type tyrosine-protein phosphatase alpha, PTPRA_HUMAN

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Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - FLT3 Signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
        
        RAS GEFs [plasma membrane] (Homo sapiens)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
        
        PTPRA [plasma membrane] (Homo sapiens)

Signal Transduction (Homo sapiens)

- MAPK family signaling cascades (Homo sapiens)
  - MAPK1/MAPK3 signaling (Homo sapiens)
    - RAF/MAP kinase cascade (Homo sapiens)
      - RAS GEFs promote RAS nucleotide exchange (Homo sapiens)
        
        RAS GEFs [plasma membrane] (Homo sapiens)
        
        Grb2:Sos:pFAK bound to NCAM1:pFyn [plasma membrane] (Homo sapiens)
        
        NCAM1 complexed with pFyn-Y420 [plasma membrane] (Homo sapiens)
        
        PTPRA [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P18433 PTPRA

Gene Names

PTPRA, PTPA, PTPRL2

Chain

signal peptide:1-19, chain:20-802

Reference Genes

BioGPS Gene:5786 PTPRA

COSMIC (genes):PTPRA PTPRA

CTD Gene:5786 PTPRA

dbSNP Gene:5786 PTPRA

ENSEMBL:ENSG00000132670 PTPRA

HGNC:9664 PTPRA

KEGG Gene (Homo sapiens):5786 PTPRA

Monarch:5786 PTPRA

NCBI Gene:5786 PTPRA

OMIM:176884 PTPRA

UCSC:P18433 PTPRA

Reference Transcript

Other Identifiers

0000870324

0002690102

0003360008

0003440601

11742217_a_at

11746947_a_at

11749026_a_at

1496_at

16910888

213795_s_at

213799_3p_s_at

213799_s_at

239419_at

29412

34366

3874050

3874051

3874052

3874053

3874054

3874055

3874056

3874057

3874058

3874073

3874074

3874075

3874076

3874092

3874093

3874096

3874101

3874102

3874103

3874104

3874105

3874114

3874116

3874118

3874126

3874129

3874133

3874134

3874135

3874137

3874140

3874142

3874143

3874144

3874147

3874155

3874156

3874158

3874160

3874161

3874162

3874163

3874164

3874165

5786

69480

73216_r_at

8060539

83463_at

A_14_P135265

A_23_P28869

AAA36528

AAH27308

AK290233

AL121905

BAF82922

BC027308

BX571753

CAA37447

CAA38065

CAA38662

CAB034366

CAE11878

CCDS13038

CCDS13039

CH471133

EAX10562

EAX10563

ENSG00000132670

ENSP00000216877

ENSP00000314568

ENSP00000348468

ENSP00000369756

ENSP00000382787

ENST00000216877

ENST00000216877.10

ENST00000318266

ENST00000318266.9

ENST00000356147

ENST00000356147.3

ENST00000380393

ENST00000380393.7

ENST00000399903

ENST00000399903.6

EntrezGene:5786

EntrezGene:PTPRA

GE57944

GO:0000165

GO:0000902

GO:0003674

GO:0004721

GO:0004725

GO:0005001

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005623

GO:0005886

GO:0005887

GO:0006464

GO:0006468

GO:0006470

GO:0007165

GO:0007267

GO:0007411

GO:0008150

GO:0008286

GO:0016020

GO:0016021

GO:0016311

GO:0016787

GO:0016791

GO:0030154

GO:0032991

GO:0035335

GO:0040011

GO:0043226

GO:0043235

GO:0048856

GO:0050804

GO:0070062

GO:0098685

GO:0099699

HGNC:9664

HPA029412

HPA069480

Hs.154004.0.A1_3p_at

Hs.26045.1.S1_3p_a_at

Hs.26045.1.S1_3p_s_at

Hs.26045.1.S2_3p_a_at

ILMN_1695461

ILMN_1723156

ILMN_1739440

ILMN_1762766

ILMN_2296776

ILMN_2411794

IPR000242

IPR000387

IPR003595

IPR016130

IPR016336

IPR027262

IPR029021

M34668

M34668_at

MIM:176884

NM_002836

NM_080840

NM_080841

NP_002827

NP_543030

NP_543031

PF00102

PR00700

PTPRA

PTPRA-201

PTPRA-202

PTPRA-203

PTPRA-204

PTPRA-205

Q5JWG0

Q5JWG2

Q5JWG3

SM00194

SM00404

TC20001064.hg

TC20001728.hg

UPI00000012A8

UPI000007155E

X53364

X54130

X54890

Participant Of

input

Dephosphorylation of NCAM1 bound pFyn

hasComponent

Inferred To

clr-1 [plasma membrane] (Caenorhabditis elegans)

Ptpra [plasma membrane] (Mus musculus)

Ptpra [plasma membrane] (Rattus norvegicus)

PTPRA [plasma membrane] (Bos taurus)

PTPRA [plasma membrane] (Canis familiaris)

PTPRA [plasma membrane] (Sus scrofa)

ptpra [plasma membrane] (Danio rerio)

ptpra [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_002827.1, NP_543030.1, NP_543031.1

OpenTargets

ENSG00000132670

HPA

ENSG00000132670-PTPRA

GeneCards

P18433

ZINC - Substances

PTPRA_HUMAN

ZINC target

P18433

Ensembl

ENST00000318266, ENST00000356147, ENSP00000369756, ENST00000216877, ENST00000399903, ENSP00000216877, ENSP00000314568, ENSP00000348468, ENST00000380393, ENSG00000132670, ENSP00000382787

PRO

P18433

ZINC - Predictions - Purchasable

PTPRA_HUMAN

HMDB Protein

HMDBP02719

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.921	13
UniProt:P12931 SRC	6	p-Y416-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.656	4
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.635	3
UniProt:P00523 SRC	9	phospho-SRC [cytosol] (R-GGA-8964276) SRC [cytosol] (R-GGA-9628701) SRC [plasma membrane] (R-GGA-8876922) Src [cytosol] (R-GGA-3928468) phospho-SRC [cytosol] (R-GGA-377592) SRC [plasma membrane] (R-GGA-65043) phospho-SRC [plasma membrane] (R-GGA-377598) phospho-SRC [plasma membrane] (R-GGA-1810408) SRC [cytosol] (R-GGA-191648)	0.59	4
UniProt:P39688 Fyn	6	Fyn [cytosol] (R-MMU-420333) MyrG,p-Y420-Fyn [plasma membrane] (R-MMU-9037733) phospho-Fyn [cytosol] (R-MMU-391821) pFyn (420) [cytosol] (R-MMU-420335) pFyn(Y531) [cytosol] (R-MMU-420350) phospho-Fyn [cytosol] (R-MMU-5218745)	0.524	2
UniProt:P18433 PTPRA	1	PTPRA [plasma membrane] (R-HSA-388755)	0.509	2
UniProt:Q9P2Y5 UVRAG	1	UVRAG [cytosol] (R-HSA-5668884)	0.499	3
UniProt:P14781 CNTN1	1	CNTN1_CHICK [plasma membrane] (R-GGA-443614)	0.463	2

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