Reactome | UniProt:P31749 AKT1

UniProt:P31749 AKT1

Type

Interactor (Protein)

Species

Homo sapiens

Synonyms

AKT1_HUMAN, B2RAM5, B7Z5R1, Q9BWB6

List of interactors in Reactome

Interactors (46)

Accession	#Entities	Reactome Entity	Confidence Score	Evidence (IntAct)
Q00987	7	MDM2 [cytosol] (R-HSA-198644) MDM2 [nucleoplasm] (R-HSA-69486) monoSUMO1-K182-MDM2 [nucleoplasm] (R-HSA-3000408) p-5S,T-MDM2 [nucleoplasm] (R-HSA-6804954) p-S166,S188,T218-MDM2 [nucleoplasm] (R-HSA-6792862) p-S166,S188-MDM2 [cytosol] (R-HSA-198638) p-S166,S188-MDM2 [nucleoplasm] (R-HSA-6793669)	0.807	6
P49841	2	GSK3B [cytosol] (R-HSA-2997551) GSK3B [nucleoplasm] (R-HSA-2022823)	0.779	4
O15530	3	p-S241-PDPK1 [cytosol] (R-HSA-9860799) PDPK1 [cytosol] (R-HSA-202210) PDPK1 [plasma membrane] (R-HSA-61459)	0.767	4
P67775	1	PPP2CA [cytosol] (R-HSA-165971)	0.756	4
P08670	7	VIM [cytosol] (R-HSA-201600) VIM(2-259) [cytosol] (R-HSA-350323) VIM(2-429) [cytosol] (R-HSA-350317) VIM(2-85) [cytosol] (R-HSA-350264) VIM(260-466) [cytosol] (R-HSA-350314) VIM(430-466) [cytosol] (R-HSA-350316) VIM(86-466) [cytosol] (R-HSA-350294)	0.706	29
O43524	11	Ac-K242,K259,K271,K290,K569-FOXO3 [nucleoplasm] (R-HSA-9620514) Ac-K271,K290-FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841849) FOXO3 [cytosol] (R-HSA-5687032) FOXO3 [nucleoplasm] (R-HSA-199305) FOXO3(?-673) [mitochondrial matrix] (R-HSA-9841824) p-S215 FOXO3 [cytosol] (R-HSA-5687014) p-S215 FOXO3 [nucleoplasm] (R-HSA-5687010) p-S43,S173,S294,S325-FOXO3 [cytosol] (R-HSA-8870560) p-S43,S173,S294,S325-FOXO3 [nucleoplasm] (R-HSA-8870627) p-T32,S253,S315-FOXO3 [cytosol] (R-HSA-9614413) p-T32,S253,S315-FOXO3 [nucleoplasm] (R-HSA-199289)	0.692	3
O95999	3	BCL10 [cytosol] (R-HSA-202447) K48polyUb-BCL10 [cytosol] (R-HSA-8939329) p-BCL10 [cytosol] (R-HSA-202488)	0.69	5
Q6GPH4	1	XAF1 [cytosol] (R-HSA-1015680)	0.666	4
P31751	1	p-T309,S474-AKT2 [plasma membrane] (R-HSA-202056)	0.641	3
P23443	2	p-T412-RPS6KB1 [cytosol] (R-HSA-165714) RPS6KB1 [cytosol] (R-HSA-165716)	0.64	3
Q15047	1	SETDB1 [nucleoplasm] (R-HSA-417136)	0.639	9
Q86V81	2	ALYREF [cytosol] (R-HSA-158482) ALYREF [nucleoplasm] (R-HSA-156649)	0.639	5
P46527	5	CDKN1B [cytosol] (R-HSA-198622) CDKN1B [nucleoplasm] (R-HSA-182563) p-S10 CDKN1B [cytosol] (R-HSA-9632829) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-Y88-CDKN1B [cytosol] (R-HSA-8848438)	0.63	3
Q13043	1	STK4(327-487) [cytosol] (R-HSA-2028668)	0.619	13
P26358	2	DNMT1 [nucleoplasm] (R-HSA-212181) monoSUMO1-K-DNMT1 [nucleoplasm] (R-HSA-4655353)	0.611	6
P31749	8	AKT1 [cytosol] (R-HSA-58252) AKT1 E17K [cytosol] (R-HSA-2219526) p-S473-AKT1 [cytosol] (R-HSA-9841264) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.609	3
P19174	4	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) PLCG1 [cytosol] (R-HSA-202320) PLCG1 [plasma membrane] (R-HSA-167682)	0.602	9
Q96EB6	1	SIRT1 [nucleoplasm] (R-HSA-427531)	0.602	5
O60437	1	PPL [cytosol] (R-HSA-6810850)	0.573	2
P62136	1	PPP1CA [cytosol] (R-HSA-163525)	0.571	4
Q12778	5	Ac-K245,K248,K265-FOXO1 [nucleoplasm] (R-HSA-9626942) FOXO1 [nucleoplasm] (R-HSA-199300) p-S218-FOXO1 [nucleoplasm] (R-HSA-5692651) p-T24,S256,S319-FOXO1 [cytosol] (R-HSA-211158) p-T24,S256,S319-FOXO1 [nucleoplasm] (R-HSA-199306)	0.571	2
P08238	1	HSP90AB1 [cytosol] (R-HSA-419617)	0.564	3
Q5S007	1	LRRK2 [cytosol] (R-HSA-5661173)	0.558	6
Q99683	1	MAP3K5 [cytosol] (R-HSA-167709)	0.558	2
P06241	3	FYN [cytosol] (R-HSA-200917) p-Y420-FYN [cytosol] (R-HSA-391821) p-Y531-FYN [cytosol] (R-HSA-391819)	0.556	3
P10599	4	2xHC-TXN [cytosol] (R-HSA-73668) 2xHC-TXN [nucleoplasm] (R-HSA-9617733) TXN [cytosol] (R-HSA-66000) TXN [nucleoplasm] (R-HSA-9617732)	0.556	3
P17612	2	PRKACA [cytosol] (R-HSA-57844) PRKACA [mitochondrial matrix] (R-HSA-9838291)	0.556	3
P22466	1	GAL [extracellular region] (R-HSA-389038)	0.556	3
P42858	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
P00533	2	EGFR [plasma membrane] (R-HSA-179837) EGFRvIII [plasma membrane] (R-HSA-1214162)	0.553	2
P05771	1	PRKCB [cytosol] (R-HSA-58198)	0.547	2
P49327	2	FASN [cytosol] (R-HSA-199233) FASN [cytosol] (R-HSA-54659)	0.547	2
Q05513	1	PRKCZ [cytosol] (R-HSA-58218)	0.544	2
Q92547	1	TOPBP1 [nucleoplasm] (R-HSA-5684878)	0.544	2
P04049	3	hyperphosphorylated RAF1 [plasma membrane] (R-HSA-5675193) p-S338,Y341,T491,S494,S621 RAF1 [plasma membrane] (R-HSA-5672665) RAF1 [cytosol] (R-HSA-167205)	0.536	2
P07900	1	HSP90AA1 [cytosol] (R-HSA-192864)	0.527	3
P24468	1	NR2F2 [nucleoplasm] (R-HSA-1183002)	0.527	2
P38646	2	HSPA9 [mitochondrial matrix] (R-HSA-8878802) HSPA9(1-679) [mitochondrial intermembrane space] (R-HSA-1267968)	0.527	3
P20248	1	CCNA2 [nucleoplasm] (R-HSA-68905)	0.524	2
P29067	1	Arrb2 [cytosol] (R-RNO-416464)	0.524	2
Q9UKG1	1	APPL1 [endosome membrane] (R-HSA-373630)	0.519	2
P10636	3	MAPT [cytosol] (R-HSA-201574) MAPT(2-421) [cytosol] (R-HSA-350628) MAPT(422-758) [cytosol] (R-HSA-350642)	0.499	2
Q92793	3	CREBBP [cytosol] (R-HSA-9756493) CREBBP [nucleoplasm] (R-HSA-193545) monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm] (R-HSA-3927877)	0.499	3
P04792	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.483	3
P11021	2	HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [extracellular region] (R-HSA-351322)	0.471	2
P10276	2	polySUMO2-K166,K171,K399-RARA [nucleoplasm] (R-HSA-4341042) RARA [nucleoplasm] (R-HSA-446164)	0.463	2

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