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p-5Y,S479-NTRK2 [plasma membrane]
Stable Identifier
R-HSA-9032864
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
p-S479,Y516,Y702,Y706,Y707,Y817-NTRK2, p-5Y,S479-TrKB, p-S479,Y516,Y702,Y706,Y707,Y817-TRKB
Icon
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK2 (TRKB) (Homo sapiens)
Activated NTRK2 signals through CDK5 (Homo sapiens)
CDK5 phosphorylates NTRK2 (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
NTRK2 and CDK5 promote activation of RAC1 by TIAM1 (Homo sapiens)
BDNF:p-5Y,S479-NTRK2:p-Y829-TIAM1 [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
NTRK2 binds TIAM1 (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 homodimer:TIAM1 [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
NTRK2 promotes TIAM1 phosphorylation (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 homodimer:TIAM1 [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2:p-Y829-TIAM1 [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 homodimer [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q16620 NTRK2
Gene Names
NTRK2, TRKB
Chain
signal peptide:1-31, chain:32-822
Reference Genes
BioGPS Gene:4915 NTRK2
COSMIC (genes):NTRK2 NTRK2
CTD Gene:4915 NTRK2
dbSNP Gene:4915 NTRK2
ENSEMBL:ENSG00000148053 NTRK2
HGNC:8032 NTRK2
KEGG:hsa:4915 NTRK2
Monarch:4915 NTRK2
NCBI Gene:4915 NTRK2
OMIM:600456 NTRK2
UCSC:Q16620 NTRK2
Reference Transcript
RefSeq:XM_017014751.1 NTRK2
RefSeq:XM_005252006.3 NTRK2
RefSeq:NM_001018066.2 NTRK2
RefSeq:XM_011518720.2 NTRK2
RefSeq:XM_005252003.2 NTRK2
RefSeq:XM_005252007.3 NTRK2
RefSeq:XM_017014752.1 NTRK2
RefSeq:XM_011518718.2 NTRK2
RefSeq:XM_017014753.1 NTRK2
RefSeq:XM_017014761.1 NTRK2
RefSeq:NM_001018065.2 NTRK2
RefSeq:XM_017014758.1 NTRK2
RefSeq:XM_017014756.1 NTRK2
RefSeq:NM_001007097.2 NTRK2
RefSeq:NM_006180.4 NTRK2
RefSeq:NM_001018064.2 NTRK2
RefSeq:XM_017014754.1 NTRK2
RefSeq:XM_005252001.2 NTRK2
RefSeq:XM_017014760.1 NTRK2
RefSeq:XM_017014757.1 NTRK2
RefSeq:XM_005252004.2 NTRK2
RefSeq:XM_017014755.1 NTRK2
RefSeq:XM_017014759.1 NTRK2
Other Identifiers
11720078_a_at
11720079_at
11720080_at
11727859_a_at
11739677_a_at
11739678_a_at
11739679_a_at
11740093_a_at
11756914_a_at
11759339_at
1354_at
1355_g_at
17086386
207152_PM_at
207152_at
214680_3p_at
214680_PM_at
214680_at
221795_PM_at
221795_at
221796_PM_at
221796_at
229463_PM_at
229463_at
236095_PM_at
236095_at
3177113
3177114
3177115
3177116
3177117
3177118
3177119
3177120
3177121
3177122
3177123
3177124
3177126
3177127
3177128
3177129
3177130
3177131
3177132
3177133
3177135
3177136
3177137
3177138
3177139
3177140
3177148
3177149
3177150
3177151
3177155
3177156
3177159
3177160
3177161
3177170
3177172
3177174
3177176
3177177
3177178
3177179
3177180
3177185
3177187
3177188
3177189
3177232
3177238
3177262
33182_at
36042_at
38280_s_at
45522_at
47469_at
4915
60443_at
62942_at
8156134
A_14_P106332
A_14_P111721
A_23_P216779
A_24_P343559
A_24_P415195
A_33_P3322784
A_33_P3322804
GE58930
GE755588
GE873496
GO:0001570
GO:0001764
GO:0001934
GO:0002020
GO:0003824
GO:0004672
GO:0004713
GO:0004714
GO:0005030
GO:0005515
GO:0005524
GO:0005737
GO:0005768
GO:0005769
GO:0005829
GO:0005886
GO:0006468
GO:0007154
GO:0007169
GO:0007399
GO:0007612
GO:0007623
GO:0007631
GO:0008284
GO:0010628
GO:0010976
GO:0014047
GO:0014069
GO:0016020
GO:0016301
GO:0016740
GO:0019222
GO:0019227
GO:0021954
GO:0021987
GO:0022011
GO:0023052
GO:0030154
GO:0030182
GO:0030424
GO:0030425
GO:0031410
GO:0031547
GO:0031901
GO:0033138
GO:0038179
GO:0042490
GO:0042803
GO:0042995
GO:0043087
GO:0043121
GO:0043195
GO:0043197
GO:0043226
GO:0043235
GO:0043410
GO:0043524
GO:0043679
GO:0045202
GO:0046548
GO:0046777
GO:0046872
GO:0048403
GO:0048471
GO:0048709
GO:0048856
GO:0048870
GO:0048935
GO:0050772
GO:0050877
GO:0051896
GO:0051897
GO:0051965
GO:0060041
GO:0060089
GO:0060175
GO:0060291
GO:0071230
GO:0099183
GO:0099551
GO:0140096
GO:1902430
GO:1990416
GO:2000811
HMNXSV003048631
Hs.12569.0.A1_3p_at
Hs.172717.0.A1_3p_at
Hs.298998.1.S1_3p_at
Hs.298998.1.S2_3p_at
Hs.47860.1.S1_3p_at
Hs.47860.1.S1_3p_s_at
Hs.47860.1.S1_3p_x_at
ILMN_1651984
ILMN_1702822
ILMN_1714067
ILMN_2357855
PH_hs_0025725
PH_hs_0038836
S76473_s_at
TC09000388.hg
U12140_at
X75958_at
g5453811_3p_at
Participates
as a component of
BDNF:p-5Y,S479-NTRK2 [plasma membrane] (Homo sapiens)
BDNF:p-5Y,S479-NTRK2 homodimer [plasma membrane] (Homo sapiens)
Other forms of this molecule
p-5Y-NTRK2 [plasma membrane]
NTRK2 [plasma membrane]
p-Y706,Y707-NTRK2 [plasma membrane]
NTRK2 [Golgi membrane]
p-5Y-NTRK2 [Golgi membrane]
Modified Residues
Name
O4'-phospho-L-tyrosine at 516
Coordinate
516
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 702
Coordinate
702
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 706
Coordinate
706
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 707
Coordinate
707
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O4'-phospho-L-tyrosine at 817
Coordinate
817
PsiMod Name
O4'-phospho-L-tyrosine [MOD:00048]
PsiMod Definition
A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.
Name
O-phospho-L-serine at 479
Coordinate
479
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
XP_016870250.1
,
NP_001018074.1
,
XP_005252058.1
,
XP_016870240.1
,
XP_016870241.1
,
XP_011517020.1
,
XP_005252060.1
,
NP_001007098.1
,
XP_005252061.1
,
XP_005252063.1
,
NP_001018076.1
,
NP_001018075.1
,
XP_005252064.1
,
XP_016870247.1
,
XP_016870246.1
,
XP_011517022.1
,
XP_016870248.1
,
XP_016870249.1
,
XP_016870242.1
,
XP_016870243.1
,
NP_006171.2
,
XP_016870244.1
,
XP_016870245.1
ZINC - World Drugs
NTRK2_HUMAN
Guide to Pharmacology - Targets
1818
OpenTargets
ENSG00000148053
ENSEMBL
ENSP00000379221
,
ENST00000685720
,
ENST00000693109
,
ENSP00000510717
,
ENSP00000509169
,
ENSP00000508497
,
ENST00000693539
,
ENST00000690281
,
ENST00000692762
,
ENST00000691415
,
ENST00000692389
,
ENSP00000306167
,
ENST00000689815
,
ENSP00000509058
,
ENST00000376213
,
ENSP00000508829
,
ENST00000686324
,
ENST00000686443
,
ENSP00000509093
,
ENST00000376208
,
ENSP00000510757
,
ENSP00000508622
,
ENST00000687148
,
ENST00000359847
,
ENSP00000510451
,
ENSP00000510032
,
ENST00000395882
,
ENST00000686496
,
ENST00000689685
,
ENST00000688013
,
ENST00000686259
,
ENST00000691788
,
ENSP00000352906
,
ENSP00000510640
,
ENSP00000365386
,
ENSP00000365381
,
ENSP00000509401
,
ENSP00000510619
,
ENSP00000509743
,
ENSP00000510060
,
ENSP00000277120
,
ENST00000692181
,
ENST00000692506
,
ENST00000687636
,
ENST00000277120
,
ENST00000304053
,
ENST00000687596
,
ENSP00000509031
,
ENSP00000510071
,
ENST00000686322
,
ENSP00000509999
,
ENSP00000508443
,
ENSP00000509456
,
ENSP00000510134
ZINC - FDA approved
NTRK2_HUMAN
ZINC - Substances
NTRK2_HUMAN
ZINC - Biogenic
NTRK2_HUMAN
ZINC target
Q16620
PRO
Q16620
GlyGen
Q16620
PDB
8OYD
,
1WWB
,
2MFQ
,
4ASZ
,
5MO9
,
4AT3
,
4AT4
,
1HCF
,
4AT5
ZINC - Investigational
NTRK2_HUMAN
HPA
ENSG00000148053-NTRK2
Pharos - Targets
Q16620
Orphanet
NTRK2
ZINC - Predictions - Purchasable
NTRK2_HUMAN
HMDB Protein
HMDBP01149
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q03114 Cdk5
4
CDK5 [nucleoplasm]
(R-RNO-8863586)
phospho-p-Y15,S159-CDK5 [nucleoplasm]
(R-RNO-6805249)
Cdk5 [cytosol]
(R-RNO-9032896)
p-Y15-Cdk5 [cytosol]
(R-RNO-9032966)
0.558
3
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:Q16288 NTRK3
6
p-5Y-NTRK3 [plasma membrane]
(R-HSA-9034718)
NTRK3 [plasma membrane]
(R-HSA-6798240)
NTRK3(496-641) [cytosol]
(R-HSA-9603542)
NTRK3(496-641) [mitochondrial outer membrane]
(R-HSA-9603557)
NTRK3(642-839) [cytosol]
(R-HSA-9603540)
NTRK3(32-495) [plasma membrane]
(R-HSA-9603541)
0.539
3
UniProt:Q16620 NTRK2
6
p-5Y-NTRK2 [plasma membrane]
(R-HSA-9026475)
NTRK2 [plasma membrane]
(R-HSA-6798236)
p-Y706,Y707-NTRK2 [plasma membrane]
(R-HSA-9037044)
NTRK2 [Golgi membrane]
(R-HSA-3008801)
p-5Y-NTRK2 [Golgi membrane]
(R-HSA-3008809)
p-5Y,S479-NTRK2 [plasma membrane]
(R-HSA-9032864)
0.488
2
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