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SOS2 [cytosol]
Stable Identifier
R-HSA-167221
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Son of sevenless protein homolog 2, SOS-2
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Activation of RAC1 (Homo sapiens)
Activation of RAC1 by SOS (Homo sapiens)
SLIT2:ROBO1:NCK:SOS [plasma membrane] (Homo sapiens)
SOS [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
SOS [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
Recruitment of SOS to plasma membrane (Homo sapiens)
SLIT2:ROBO1:NCK:SOS [plasma membrane] (Homo sapiens)
SOS [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
SOS [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin-15 signaling (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
SOS1, SOS2 [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
SOS1, SOS2 [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signalling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
GEFs activate RhoA,B,C (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
Rho GTPase cycle (Homo sapiens)
GEFs activate Rho GTPase:GDP (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q07890 SOS2
Gene Names
SOS2
Chain
chain:1-1332
Reference Genes
BioGPS Gene:6655 SOS2
COSMIC (genes):SOS2 SOS2
CTD Gene:6655 SOS2
dbSNP Gene:6655 SOS2
ENSEMBL:ENSG00000100485 SOS2
HGNC:11188 SOS2
KEGG Gene (Homo sapiens):6655 SOS2
Monarch:6655 SOS2
NCBI Gene:6655 SOS2
OMIM:601247 SOS2
UCSC:Q07890 SOS2
Reference Transcript
RefSeq:NM_006939.3 SOS2
Other Identifiers
0003710497
11719429_a_at
11719430_at
11756963_a_at
16792650
16792659
211665_s_at
212870_at
217576_x_at
217644_s_at
304_at
305_g_at
32857_at
3563707
3563708
3563709
3563710
3563711
3563729
3563731
3563733
3563735
3563736
3563737
3563740
3563746
3563747
3563749
3563751
3563752
3563753
3563754
3563755
3563758
3563761
3563762
3563763
3563764
3563765
3563770
3563773
3563774
3563775
3563779
3563783
3563788
3563798
3563799
3563800
6655
7978932
A_23_P117546
GE52964
GE62533
GO:0000786
GO:0003674
GO:0003677
GO:0005085
GO:0005515
GO:0005575
GO:0005622
GO:0005694
GO:0005737
GO:0005829
GO:0007165
GO:0007186
GO:0007264
GO:0008150
GO:0008219
GO:0019899
GO:0032991
GO:0043065
GO:0043226
GO:0046982
GO:0051056
GO:0051057
Hs.326392.0.A2_3p_at
Hs.333042.1.S1_3p_s_at
Hs.333042.2.S1_3p_s_at
ILMN_1764414
PH_hs_0034606
TC14001116.hg
g1220367_3p_s_at
Participant Of
hasMember
GEFs [cytosol]
SOS [cytosol]
hasCandidate
SOS1, SOS2 [cytosol]
Inferred To
sos2 [cytosol] (Danio rerio)
gefS [cytosol] (Dictyostelium discoideum)
gefB [cytosol] (Dictyostelium discoideum)
Homologues of SOS2 [cytosol] (Dictyostelium discoideum)
Sos2 [cytosol] (Mus musculus)
Sos2 [cytosol] (Rattus norvegicus)
gefC [cytosol] (Dictyostelium discoideum)
gefY [cytosol] (Dictyostelium discoideum)
gflB [cytosol] (Dictyostelium discoideum)
gefN [cytosol] (Dictyostelium discoideum)
gefE [cytosol] (Dictyostelium discoideum)
gefW [cytosol] (Dictyostelium discoideum)
SOS2 [cytosol] (Canis familiaris)
SOS2 [cytosol] (Dictyostelium discoideum)
SOS2 [cytosol] (Gallus gallus)
SOS2 [cytosol] (Sus scrofa)
gefD [cytosol] (Dictyostelium discoideum)
gefM [cytosol] (Dictyostelium discoideum)
gefO [cytosol] (Dictyostelium discoideum)
gefG [cytosol] (Dictyostelium discoideum)
sos-1 [cytosol] (Caenorhabditis elegans)
cldnd1 [cytosol] (Xenopus tropicalis)
Sos [cytosol] (Drosophila melanogaster)
gefL [cytosol] (Dictyostelium discoideum)
gefQ [cytosol] (Dictyostelium discoideum)
gefK [cytosol] (Dictyostelium discoideum)
Cross References
RefSeq
NP_008870.2
OpenTargets
ENSG00000100485
HPA
ENSG00000100485-SOS2
GeneCards
Q07890
Ensembl
ENST00000216373
,
ENST00000543680
,
ENSG00000100485
,
ENSP00000216373
,
ENSP00000445328
PRO
Q07890
Orphanet
23280
PDB
6EIE
HMDB Protein
HMDBP08581
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.933
11
UniProt:P19174 PLCG1
6
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
0.602
4
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.564
2
UniProt:P00533 EGFR
59
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR A289V [plasma membrane]
(R-HSA-1996334)
p-6Y-EGFR T263P [plasma membrane]
(R-HSA-1996336)
p-6Y-EGFR G598V [plasma membrane]
(R-HSA-1996339)
p-6Y-EGFR R108K [plasma membrane]
(R-HSA-1996338)
p-6Y-EGFR A289T [plasma membrane]
(R-HSA-1996341)
p-6Y-EGFR G719C [plasma membrane]
(R-HSA-1177530)
p-6Y-EGFR A289D [plasma membrane]
(R-HSA-1996340)
p-6Y-EGFR G719A [plasma membrane]
(R-HSA-1177528)
EGFR L858R;T790M [plasma membrane]
(R-HSA-1181386)
EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1181399)
EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996322)
EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996325)
EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996326)
EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996317)
EGFR L858R [plasma membrane]
(R-HSA-1173212)
EGFR G719S [plasma membrane]
(R-HSA-1169418)
EGFR E746_A750del [plasma membrane]
(R-HSA-1181211)
EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228010)
EGFR A289V [plasma membrane]
(R-HSA-1996321)
EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228012)
EGFR L747_T751del [plasma membrane]
(R-HSA-1228015)
EGFR A289D [plasma membrane]
(R-HSA-1996327)
EGFR L861Q [plasma membrane]
(R-HSA-1177542)
EGFR R108K [plasma membrane]
(R-HSA-1996330)
EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228034)
EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228031)
EGFR G719A [plasma membrane]
(R-HSA-1177532)
EGFR A289T [plasma membrane]
(R-HSA-1996306)
EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228025)
EGFR G719C [plasma membrane]
(R-HSA-1177531)
EGFR T263P [plasma membrane]
(R-HSA-1996315)
EGFR G598V [plasma membrane]
(R-HSA-1996314)
EGFR L747_S752del [plasma membrane]
(R-HSA-1228016)
EGFR [endosome membrane]
(R-HSA-9611160)
p-4Y-EGFR [plasma membrane]
(R-HSA-180287)
p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane]
(R-HSA-8864019)
p-Y1086,Y1101-EGFR [plasma membrane]
(R-HSA-179868)
EGFR [plasma membrane]
(R-HSA-179837)
p-6Y-EGFR [plasma membrane]
(R-HSA-179803)
0.553
2
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