Reactome | SOS2 [cytosol]

SOS2 [cytosol]

Stable Identifier

R-HSA-167221

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Son of sevenless protein homolog 2, SOS-2

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External Reference Information

External Reference

UniProt:Q07890 SOS2

Gene Names

SOS2

Chain

chain:1-1332

Reference Genes

BioGPS Gene:6655 SOS2

COSMIC (genes):SOS2 SOS2

CTD Gene:6655 SOS2

dbSNP Gene:6655 SOS2

ENSEMBL:ENSG00000100485.12 SOS2

HGNC:11188 SOS2

KEGG Gene (Homo sapiens):6655 SOS2

Monarch:6655 SOS2

NCBI Gene:6655 SOS2

OMIM:601247 SOS2

UCSC:Q07890 SOS2

Reference Transcript

RefSeq:NM_006939.3 SOS2

Other Identifiers

0003710497

11719429_a_at

11719430_at

11756963_a_at

16792650

16792659

211665_PM_s_at

211665_s_at

212870_PM_at

212870_at

217576_PM_x_at

217576_x_at

217644_PM_s_at

217644_s_at

304_at

305_g_at

32857_at

3563707

3563708

3563709

3563710

3563711

3563729

3563731

3563733

3563735

3563736

3563737

3563740

3563746

3563747

3563749

3563751

3563752

3563753

3563754

3563755

3563758

3563761

3563762

3563763

3563764

3563765

3563770

3563773

3563774

3563775

3563779

3563783

3563788

3563798

3563799

3563800

6655

7978932

A_23_P117546

GE52964

GE62533

GO:0001782

GO:0002260

GO:0002376

GO:0003677

GO:0005085

GO:0005515

GO:0005622

GO:0005737

GO:0005829

GO:0005886

GO:0007264

GO:0007265

GO:0023052

GO:0030154

GO:0033081

GO:0042129

GO:0043547

GO:0046982

GO:0048856

GO:0051057

GO:0098772

GO:2000973

HMNXSV003034726

Hs.326392.0.A2_3p_at

Hs.333042.1.S1_3p_s_at

Hs.333042.2.S1_3p_s_at

ILMN_1764414

PH_hs_0034606

TC14001116.hg

g1220367_3p_s_at

Participates

as a candidate of

as a member of

Inferred To

sos2 [cytosol] (Xenopus tropicalis)

gefV [cytosol] (Dictyostelium discoideum)

gefW [cytosol] (Dictyostelium discoideum)

SOS2 [cytosol] (Bos taurus)

SOS2 [cytosol] (Canis familiaris)

SOS2 [cytosol] (Danio rerio)

SOS2 [cytosol] (Gallus gallus)

SOS2 [cytosol] (Sus scrofa)

CDC25 [cytosol] (Saccharomyces cerevisiae)

Homologues of SOS2 [cytosol] (Dictyostelium discoideum)

sos-1 [cytosol] (Caenorhabditis elegans)

Sos2 [cytosol] (Mus musculus)

Sos2 [cytosol] (Rattus norvegicus)

Sos [cytosol] (Drosophila melanogaster)

efc25 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_008870.2

OpenTargets

ENSG00000100485

HPA

ENSG00000100485-SOS2

GeneCards

Q07890

Ensembl

ENSP00000216373, ENST00000543680, ENSP00000445328, ENSG00000100485, ENST00000216373

PRO

Q07890

Pharos - Targets

Q07890

Orphanet

23280

HMDB Protein

HMDBP08581

PDB

6EIE

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.933	11
UniProt:P46108 CRK	1	CRK [cytosol] (R-HSA-2980677)	0.702	3
UniProt:P19174 PLCG1	6	p-4Y-PLCG1 [plasma membrane] (R-HSA-167679) PLCG1 [plasma membrane] (R-HSA-167682) PLCG1 [cytosol] (R-HSA-202320) p-Y771,Y783,Y1254-PLCG1 [cytosol] (R-HSA-202357) p-Y771,Y783-PLCG1 [plasma membrane] (R-HSA-1169084) p-Y-PLCG1 [cytosol] (R-HSA-9029082)	0.602	4
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2