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SOS2 [cytosol]
Stable Identifier
R-HSA-167221
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Son of sevenless protein homolog 2, SOS-2
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Activation of RAC1 (Homo sapiens)
Activation of RAC1 by SOS (Homo sapiens)
SLIT2:ROBO1:NCK:SOS [plasma membrane] (Homo sapiens)
SOS [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
SOS [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
Recruitment of SOS to plasma membrane (Homo sapiens)
SLIT2:ROBO1:NCK:SOS [plasma membrane] (Homo sapiens)
SOS [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
SOS [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin-15 signaling (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
SOS1, SOS2 [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
SOS1, SOS2 [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signalling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
GEFs activate RhoA,B,C (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
Rho GTPase cycle (Homo sapiens)
GEFs activate Rho GTPase:GDP (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q07890 SOS2
Gene Names
SOS2
Chain
chain:1-1332
Reference Genes
BioGPS Gene:6655 SOS2
COSMIC (genes):SOS2 SOS2
CTD Gene:6655 SOS2
dbSNP Gene:6655 SOS2
ENSEMBL:ENSG00000100485 SOS2
ENSEMBL_homo_sapiens_GENE:ENSG00000100485 SOS2
HGNC:11188 SOS2
KEGG Gene (Homo sapiens):6655 SOS2
Monarch:6655 SOS2
NCBI Gene:6655 SOS2
OMIM:601247 SOS2
UCSC:Q07890 SOS2
Reference Transcript
RefSeq:NM_006939.3 SOS2
Other Identifiers
0003710497
11719429_a_at
11719430_at
11756963_a_at
16792659
211665_s_at
212870_at
217576_x_at
217644_s_at
304_at
305_g_at
32857_at
3563731
3563733
3563735
3563736
3563737
3563740
3563746
3563747
3563749
3563751
3563752
3563753
3563754
3563755
3563758
3563761
3563762
3563763
3563764
3563765
3563770
3563773
3563774
3563775
3563779
3563783
3563788
3563798
3563799
4577
47368
52689
6655
7978932
A_23_P117546
AAA35914
AAA91852
AAI17262
AAI43368
AL109758
BC117261
BC143367
CAB004577
CCDS9697
CH471078
EAW65727
EAW65728
ENSG00000100485
ENSP00000216373
ENSP00000445328
ENST00000216373
ENST00000543680
EntrezGene:6655
g1220367_3p_s_at
G3V5W3
GE62533
GO:0000786
GO:0003674
GO:0003677
GO:0005085
GO:0005089
GO:0005515
GO:0005575
GO:0005622
GO:0005623
GO:0005694
GO:0005737
GO:0005829
GO:0007165
GO:0007186
GO:0007264
GO:0008150
GO:0008219
GO:0019899
GO:0032991
GO:0035023
GO:0043065
GO:0043226
GO:0046982
GO:0051056
GO:0051057
HGNC:11188
HPA047368
HPA052689
Hs.326392.0.A2_3p_at
Hs.333042.1.S1_3p_s_at
Hs.333042.2.S1_3p_s_at
ILMN_1764414
IPR000219
IPR000651
IPR001849
IPR001895
IPR007125
IPR009072
IPR011993
IPR019804
IPR023578
IPR035899
IPR036964
L13858
L20686
MIM:601247
MIM:616559
NM_006939
NP_008870
PF00125
PF00169
PF00617
PF00618
PF00621
PH_hs_0034606
SM00147
SM00229
SM00233
SM00325
SOS2
SOS2-201
SOS2-202
TC14001116.hg
uc001wxs.5
uc010tql.3
UPI000013C6E8
UPI000189A72C
Participant Of
hasCandidate
SOS1, SOS2 [cytosol]
hasMember
GEFs [cytosol]
SOS [cytosol]
Inferred To
SOS2 [cytosol] (Bos taurus)
SOS2 [cytosol] (Caenorhabditis elegans)
SOS2 [cytosol] (Canis familiaris)
SOS2 [cytosol] (Danio rerio)
SOS2 [cytosol] (Dictyostelium discoideum)
SOS2 [cytosol] (Drosophila melanogaster)
SOS2 [cytosol] (Gallus gallus)
SOS2 [cytosol] (Mus musculus)
SOS2 [cytosol] (Rattus norvegicus)
SOS2 [cytosol] (Saccharomyces cerevisiae)
SOS2 [cytosol] (Schizosaccharomyces pombe)
SOS2 [cytosol] (Sus scrofa)
SOS2 [cytosol] (Taeniopygia guttata)
SOS2 [cytosol] (Xenopus tropicalis)
Homologues of SOS2 [cytosol] (Dictyostelium discoideum)
Homologues of SOS2 [cytosol] (Rattus norvegicus)
Homologues of SOS2 [cytosol] (Schizosaccharomyces pombe)
Homologues of SOS2 [cytosol] (Sus scrofa)
Cross References
RefSeq
NP_008870.2
OpenTargets
ENSG00000100485
GeneCards
Q07890
PRO
Q07890
Orphanet
23280
HMDB Protein
HMDBP08581
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.896
8
UniProt:P19174 PLCG1
6
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [cytosol]
(R-HSA-202320)
PLCG1 [plasma membrane]
(R-HSA-167682)
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
0.602
4
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.564
2
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