Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
SOS2 [cytosol]
Stable Identifier
R-HSA-167221
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Son of sevenless protein homolog 2, SOS-2
Icon
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
Signaling by ROBO receptors (Homo sapiens)
Activation of RAC1 (Homo sapiens)
Activation of RAC1 by SOS (Homo sapiens)
SLIT2:ROBO1:NCK:SOS [plasma membrane] (Homo sapiens)
SOS [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
SOS [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
Recruitment of SOS to plasma membrane (Homo sapiens)
SLIT2:ROBO1:NCK:SOS [plasma membrane] (Homo sapiens)
SOS [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
SOS [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-2 family signaling (Homo sapiens)
Interleukin-15 signaling (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2 binds SOS1,SOS2 (Homo sapiens)
IL15:IL15RA:p-Y-IL2RB:p-Y-JAK1:p-Y-IL2RG:p-Y-JAK3:p-Y-SHC1:GRB2:SOS [plasma membrane] (Homo sapiens)
SOS1, SOS2 [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
SOS1, SOS2 [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Death Receptor Signalling (Homo sapiens)
p75 NTR receptor-mediated signalling (Homo sapiens)
Cell death signalling via NRAGE, NRIF and NADE (Homo sapiens)
NRAGE signals death through JNK (Homo sapiens)
p75NTR indirectly activates RAC and Cdc42 via a guanyl-nucleotide exchange factor (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
Signaling by GPCR (Homo sapiens)
GPCR downstream signalling (Homo sapiens)
G alpha (12/13) signalling events (Homo sapiens)
GEFs activate RhoA,B,C (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
Signaling by Rho GTPases, Miro GTPases and RHOBTB3 (Homo sapiens)
Signaling by Rho GTPases (Homo sapiens)
RHO GTPase cycle (Homo sapiens)
RAC1 GTPase cycle (Homo sapiens)
RAC1 GEFs activate RAC1 (Homo sapiens)
RAC1 GEFs [cytosol] (Homo sapiens)
SOS2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q07890 SOS2
Gene Names
SOS2
Chain
chain:1-1332
Reference Genes
BioGPS Gene:6655 SOS2
COSMIC (genes):SOS2 SOS2
CTD Gene:6655 SOS2
dbSNP Gene:6655 SOS2
ENSEMBL:ENSG00000100485 SOS2
HGNC:11188 SOS2
KEGG Gene (Homo sapiens):6655 SOS2
Monarch:6655 SOS2
NCBI Gene:6655 SOS2
OMIM:601247 SOS2
UCSC:Q07890 SOS2
Reference Transcript
RefSeq:NM_006939.3 SOS2
Other Identifiers
0003710497
11719429_a_at
11719430_at
11756963_a_at
16792650
16792659
211665_s_at
212870_at
217576_x_at
217644_s_at
304_at
305_g_at
32857_at
3563707
3563708
3563709
3563710
3563711
3563729
3563731
3563733
3563735
3563736
3563737
3563740
3563746
3563747
3563749
3563751
3563752
3563753
3563754
3563755
3563758
3563761
3563762
3563763
3563764
3563765
3563770
3563773
3563774
3563775
3563779
3563783
3563788
3563798
3563799
3563800
6655
7978932
A_23_P117546
GE52964
GE62533
GO:0001782
GO:0002260
GO:0002376
GO:0003674
GO:0003677
GO:0005085
GO:0005515
GO:0005575
GO:0005622
GO:0005737
GO:0005829
GO:0007165
GO:0007186
GO:0007264
GO:0008150
GO:0008219
GO:0008283
GO:0019899
GO:0030154
GO:0033081
GO:0042129
GO:0042592
GO:0043065
GO:0046982
GO:0048856
GO:0050790
GO:0051056
GO:0051057
GO:2000973
HMNXSV003034726
Hs.326392.0.A2_3p_at
Hs.333042.1.S1_3p_s_at
Hs.333042.2.S1_3p_s_at
ILMN_1764414
PH_hs_0034606
TC14001116.hg
g1220367_3p_s_at
Participates
as a member of
SOS [cytosol] (Homo sapiens)
GEFs [cytosol] (Homo sapiens)
as a candidate of
RAC1 GEFs [cytosol] (Homo sapiens)
SOS1, SOS2 [cytosol] (Homo sapiens)
Inferred To
gefA [cytosol]
(Dictyostelium discoideum)
gefS [cytosol]
(Dictyostelium discoideum)
gefJ [cytosol]
(Dictyostelium discoideum)
Sos2 [cytosol]
(Mus musculus)
Sos2 [cytosol]
(Rattus norvegicus)
gefC [cytosol]
(Dictyostelium discoideum)
ste6 [cytosol]
(Schizosaccharomyces pombe)
efc25 [cytosol]
(Schizosaccharomyces pombe)
gefH [cytosol]
(Dictyostelium discoideum)
gefW [cytosol]
(Dictyostelium discoideum)
SOS2 [cytosol]
(Canis familiaris)
SOS2 [cytosol]
(Dictyostelium discoideum)
SOS2 [cytosol]
(Gallus gallus)
SOS2 [cytosol]
(Sus scrofa)
SOS2 [cytosol]
(Xenopus tropicalis)
gefD [cytosol]
(Dictyostelium discoideum)
gefM [cytosol]
(Dictyostelium discoideum)
gefP [cytosol]
(Dictyostelium discoideum)
BUD5 [cytosol]
(Saccharomyces cerevisiae)
Sos [cytosol]
(Drosophila melanogaster)
gefF [cytosol]
(Dictyostelium discoideum)
gefK [cytosol]
(Dictyostelium discoideum)
gefR [cytosol]
(Dictyostelium discoideum)
sos2 [cytosol]
(Danio rerio)
gefI [cytosol]
(Dictyostelium discoideum)
gefB [cytosol]
(Dictyostelium discoideum)
CDC25 [cytosol]
(Saccharomyces cerevisiae)
Homologues of SOS2 [cytosol]
(Dictyostelium discoideum)
Homologues of SOS2 [cytosol]
(Saccharomyces cerevisiae)
Homologues of SOS2 [cytosol]
(Schizosaccharomyces pombe)
LTE1 [cytosol]
(Saccharomyces cerevisiae)
gefY [cytosol]
(Dictyostelium discoideum)
gflB [cytosol]
(Dictyostelium discoideum)
gefN [cytosol]
(Dictyostelium discoideum)
gefE [cytosol]
(Dictyostelium discoideum)
gefV [cytosol]
(Dictyostelium discoideum)
gefO [cytosol]
(Dictyostelium discoideum)
gefG [cytosol]
(Dictyostelium discoideum)
sos-1 [cytosol]
(Caenorhabditis elegans)
gefL [cytosol]
(Dictyostelium discoideum)
gefQ [cytosol]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_008870.2
OpenTargets
ENSG00000100485
GeneCards
Q07890
HPA
ENSG00000100485-SOS2
Ensembl
ENSG00000100485
,
ENST00000543680
,
ENSP00000216373
,
ENSP00000445328
,
ENST00000216373
PRO
Q07890
Pharos - Targets
Q07890
Orphanet
23280
HMDB Protein
HMDBP08581
PDB
6EIE
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.933
11
UniProt:P19174 PLCG1
6
p-Y771,Y783-PLCG1 [plasma membrane]
(R-HSA-1169084)
p-Y771,Y783,Y1254-PLCG1 [cytosol]
(R-HSA-202357)
p-Y-PLCG1 [cytosol]
(R-HSA-9029082)
PLCG1 [cytosol]
(R-HSA-202320)
p-4Y-PLCG1 [plasma membrane]
(R-HSA-167679)
PLCG1 [plasma membrane]
(R-HSA-167682)
0.602
4
UniProt:P46108 CRK
1
CRK [cytosol]
(R-HSA-2980677)
0.564
2
UniProt:P00533 EGFR
20
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR M766_A767insASV [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR D770_N771insNPH [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR V738_K739insKIPVAI [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
0.553
2
© 2022
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
![SOS2 [cytosol] icon](/icon/R-ICO-013715.svg){kind=icon}
