Reactome | RGS4 [plasma membrane]

RGS4 [plasma membrane]

Stable Identifier

R-HSA-921135

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Regulator of G-protein signaling 4, RGS4_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P49798 RGS4

Gene Names

RGS4

Chain

chain:1-205

Reference Genes

BioGPS Gene:5999 RGS4

COSMIC (genes):RGS4 RGS4

CTD Gene:5999 RGS4

dbSNP Gene:5999 RGS4

ENSEMBL:ENSG00000117152 RGS4

HGNC:10000 RGS4

KEGG Gene (Homo sapiens):5999 RGS4

Monarch:5999 RGS4

NCBI Gene:5999 RGS4

OMIM:602516 RGS4

UCSC:P49798 RGS4

Reference Transcript

Other Identifiers

0006900066

11732993_a_at

11732994_a_at

11732995_a_at

11741572_a_at

16673126

204337_at

204338_s_at

204339_s_at

2364383

2364384

2364385

2364386

2364387

2364388

2364390

2364391

2364395

2364396

34272_at

34273_at

47486_at

5999

7906919

A_23_P200737

A_23_P433855

GE80427

GE87372

GO:0000188

GO:0001965

GO:0001975

GO:0003013

GO:0003674

GO:0003924

GO:0005096

GO:0005516

GO:0005575

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005886

GO:0006464

GO:0006810

GO:0007010

GO:0007165

GO:0007186

GO:0007267

GO:0007420

GO:0008150

GO:0008277

GO:0009968

GO:0010460

GO:0016020

GO:0030154

GO:0030234

GO:0032991

GO:0040007

GO:0042220

GO:0043226

GO:0043278

GO:0043547

GO:0045471

GO:0045744

GO:0048856

GO:0050877

GO:0051924

GO:0055085

GO:0060160

GO:0061052

GO:0110053

GO:1900924

GO:1901379

GO:1901380

GO:1990791

GO:2000463

Hs.227571.0.S3_3p_at

ILMN_1758067

PH_hs_0029997

TC01001427.hg

U27768_at

g11184227_3p_a_at

g12653888_3p_a_at

Participant Of

hasMember

Inferred To

Homologues of RGS4 [plasma membrane] (Caenorhabditis elegans)

Homologues of RGS4 [plasma membrane] (Dictyostelium discoideum)

rgs-10 [plasma membrane] (Caenorhabditis elegans)

rgs-6 [plasma membrane] (Caenorhabditis elegans)

Rgs4 [plasma membrane] (Mus musculus)

Rgs4 [plasma membrane] (Rattus norvegicus)

SST2 [plasma membrane] (Saccharomyces cerevisiae)

rgs-3 [plasma membrane] (Caenorhabditis elegans)

rgs4 [plasma membrane] (Danio rerio)

rgs4 [plasma membrane] (Xenopus tropicalis)

rgs1 [plasma membrane] (Schizosaccharomyces pombe)

rgs-8.1 [plasma membrane] (Caenorhabditis elegans)

rgs-11 [plasma membrane] (Caenorhabditis elegans)

RGS4 [plasma membrane] (Canis familiaris)

RGS4 [plasma membrane] (Dictyostelium discoideum)

RGS4 [plasma membrane] (Sus scrofa)

rgs-7 [plasma membrane] (Caenorhabditis elegans)

rgs-9 [plasma membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001106852.1, NP_001095915.1, NP_001106851.1, NP_005604.1

OpenTargets

ENSG00000117152

GeneCards

P49798

ZINC - Substances

RGS4_HUMAN

HPA

ENSG00000117152-RGS4

ZINC target

P49798

Ensembl

ENSP00000356885, ENSP00000397181, ENST00000367908, ENSP00000356884, ENSP00000433261, ENSG00000117152, ENSP00000356882, ENST00000527809, ENST00000421743, ENST00000367909, ENST00000367906

PRO

P49798

ZINC - Predictions - Purchasable

RGS4_HUMAN

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	59	p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR M766_A767insASV [plasma membrane] (R-HSA-1996343) p-6Y-EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996342) p-6Y-EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541) p-6Y-EGFR A289V [plasma membrane] (R-HSA-1996334) p-6Y-EGFR T263P [plasma membrane] (R-HSA-1996336) p-6Y-EGFR G598V [plasma membrane] (R-HSA-1996339) p-6Y-EGFR R108K [plasma membrane] (R-HSA-1996338) p-6Y-EGFR A289T [plasma membrane] (R-HSA-1996341) p-6Y-EGFR G719C [plasma membrane] (R-HSA-1177530) p-6Y-EGFR A289D [plasma membrane] (R-HSA-1996340) p-6Y-EGFR G719A [plasma membrane] (R-HSA-1177528) EGFR L858R;T790M [plasma membrane] (R-HSA-1181386) EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1181399) EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996322) EGFR V738_K739insKIPVAI [plasma membrane] (R-HSA-1996325) EGFR M766_A767insASV [plasma membrane] (R-HSA-1996326) EGFR D770_N771insNPH [plasma membrane] (R-HSA-1996317) EGFR L858R [plasma membrane] (R-HSA-1173212) EGFR G719S [plasma membrane] (R-HSA-1169418) EGFR E746_A750del [plasma membrane] (R-HSA-1181211) EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228010) EGFR A289V [plasma membrane] (R-HSA-1996321) EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228012) EGFR L747_T751del [plasma membrane] (R-HSA-1228015) EGFR A289D [plasma membrane] (R-HSA-1996327) EGFR L861Q [plasma membrane] (R-HSA-1177542) EGFR R108K [plasma membrane] (R-HSA-1996330) EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228034) EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228031) EGFR G719A [plasma membrane] (R-HSA-1177532) EGFR A289T [plasma membrane] (R-HSA-1996306) EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228025) EGFR G719C [plasma membrane] (R-HSA-1177531) EGFR T263P [plasma membrane] (R-HSA-1996315) EGFR G598V [plasma membrane] (R-HSA-1996314) EGFR L747_S752del [plasma membrane] (R-HSA-1228016) EGFR [endosome membrane] (R-HSA-9611160) p-4Y-EGFR [plasma membrane] (R-HSA-180287) p-Y992,Y1045,Y1068,Y1086,Y1173-EGFR [plasma membrane] (R-HSA-8864019) p-Y1086,Y1101-EGFR [plasma membrane] (R-HSA-179868) EGFR [plasma membrane] (R-HSA-179837) p-6Y-EGFR [plasma membrane] (R-HSA-179803)	0.553	2

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