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HBEGF(20-208) [clathrin-coated endocytic vesicle membrane]
Stable Identifier
R-HSA-5334782
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
clathrin-coated endocytic vesicle membrane
Synonyms
HBEGF, pro-HBEGF, Proheparin-binding EGF-like growth factor
Icon
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Bacterial Infection Pathways (Homo sapiens)
Uptake and actions of bacterial toxins (Homo sapiens)
Uptake and function of diphtheria toxin (Homo sapiens)
Clathrin-mediated endocytosis of DT:HBEGF:CD9 (Homo sapiens)
DT:HBEGF:CD9 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
HBEGF(20-208) [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
DT:HBEGF:CD9 is transported from clathrin-coated vesicle to endosome (Homo sapiens)
DT:HBEGF:CD9 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
HBEGF(20-208) [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q99075 HBEGF
Gene Names
HBEGF, DTR, DTS, HEGFL
Chain
signal peptide:1-19, chain:20-208, propeptide:20-62, chain:63-148, propeptide:149-208
Reference Genes
BioGPS Gene:1839 HBEGF
COSMIC (genes):HBEGF HBEGF
CTD Gene:1839 HBEGF
dbSNP Gene:1839 HBEGF
ENSEMBL:ENSG00000113070 HBEGF
ENSEMBL_homo_sapiens_GENE:ENSG00000113070.8 HBEGF
HGNC:3059 HBEGF
KEGG Gene (Homo sapiens):1839 HBEGF
Monarch:1839 HBEGF
NCBI Gene:1839 HBEGF
OMIM:126150 HBEGF
UCSC:Q99075 HBEGF
Reference Transcript
RefSeq:NM_001945.2 HBEGF
Other Identifiers
11719898_s_at
11755981_a_at
17000724
1839
203821_PM_at
203821_at
2878274
2878275
2878276
2878278
2878281
2878283
2878284
2878285
2878286
38037_PM_at
38037_at
8114572
A_23_P213944
A_24_P140608
GE81091
GO:0003013
GO:0005102
GO:0005154
GO:0005515
GO:0005576
GO:0005615
GO:0005886
GO:0007165
GO:0007173
GO:0007517
GO:0008016
GO:0008083
GO:0008201
GO:0008284
GO:0009986
GO:0016020
GO:0016477
GO:0023052
GO:0030297
GO:0030307
GO:0030335
GO:0030666
GO:0030669
GO:0031410
GO:0035313
GO:0036211
GO:0038134
GO:0038135
GO:0042060
GO:0043226
GO:0048018
GO:0048661
GO:0048856
GO:0048870
GO:0050731
GO:0051545
GO:0051549
GO:0051897
GO:0060326
GO:0090303
GO:0098772
GO:1901135
HMNXSV003003454
ILMN_2121408
M60278_at
PH_hs_0000094
TC05001854.hg
g4503412_3p_s_at
Participates
as a component of
DT:HBEGF:CD9 [clathrin-coated endocytic vesicle membrane] (Homo sapiens)
Other forms of this molecule
HBEGF(63-148) [clathrin-coated endocytic vesicle membrane]
HBEGF(20-208) [endocytic vesicle membrane]
HB-EGF(161-208) [plasma membrane]
HBEGF(20-62) [extracellular region]
HBEGF(149-208) [extracellular region]
HBEGF(20-208) [plasma membrane]
HBEGF(63-148) [extracellular region]
Cross References
RefSeq
NP_001936.1
OpenTargets
ENSG00000113070
HPA
ENSG00000113070-HBEGF
GeneCards
Q99075
Ensembl
ENSP00000230990
,
ENST00000230990
,
ENSG00000113070
PRO
Q99075
Pharos - Targets
Q99075
PDB
2M8S
,
1XDT
HMDB Protein
HMDBP02701
Interactors (3)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.609
3
UniProt:P22607 FGFR3
20
FGFR3(23-760)-TACC3(612-838) fusion [plasma membrane]
(R-HSA-8853144)
FGFR3(23-760)-BAIAP2L1(18-522) fusion [plasma membrane]
(R-HSA-8853131)
FGFR3(23-793)-TACC3(143-838) fusion [plasma membrane]
(R-HSA-8853152)
FGFR3(23-758)-TACC3(549-838) fusion [plasma membrane]
(R-HSA-8853124)
FGFR3(23-758)-TACC3(649-838) fusion [plasma membrane]
(R-HSA-8853125)
FGFR3(23-760)-TACC3(647-838) fusion [plasma membrane]
(R-HSA-8853127)
FGFR3 K650T [plasma membrane]
(R-HSA-1614411)
FGFR3 K650N [plasma membrane]
(R-HSA-1614406)
FGFR3 K650M [plasma membrane]
(R-HSA-1614402)
FGFR3 K650Q [plasma membrane]
(R-HSA-1614410)
FGFR3 A391E [plasma membrane]
(R-HSA-1614390)
FGFR3 K650E [plasma membrane]
(R-HSA-1614400)
FGFR3 G380R [plasma membrane]
(R-HSA-1614398)
FGFR3 G382D [plasma membrane]
(R-HSA-2018740)
FGFR3 805fs*141 [plasma membrane]
(R-HSA-1614387)
FGFR3 [plasma membrane]
(R-HSA-2038357)
FGFR3 S371C [plasma membrane]
(R-HSA-1614421)
FGFR3 Y373C [plasma membrane]
(R-HSA-1614424)
FGFR3 G370C [plasma membrane]
(R-HSA-1614394)
FGFR3 R248C [plasma membrane]
(R-HSA-1614419)
0.556
3
UniProt:P06396 GSN
7
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
0.556
3
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